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3FWE
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CRYSTAL STRUCTURE OF THE APO D138L CAP MUTANT
Descriptor:Catabolite gene activator, PROLINE
Authors:Sharma, H., Wang, J., Kong, J., Yu, S., Steitz, T.
Deposit date:2009-01-17
Release date:2009-09-08
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding
Proc.Natl.Acad.Sci.USA, 106, 2009
4ECK
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CRYSTAL STRUCTURE OF THE TOXOPLASMA GONDII TS-DHFR
Descriptor:Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ...
Authors:Sharma, H., Anderson, K.S.
Deposit date:2012-03-26
Release date:2013-10-02
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.516 Å)
Cite:First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase-Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling.
Biochemistry, 52, 2013
4EIL
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CRYSTAL STRUCTURE OF THE LOOP TRUNCATED TOXOPLASMA GONDII TS-DHFR
Descriptor:Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 10-PROPARGYL-5,8-DIDEAZAFOLIC ACID, ...
Authors:Sharma, H.
Deposit date:2012-04-05
Release date:2013-10-09
Last modified:2013-10-30
Method:X-RAY DIFFRACTION (2.1971 Å)
Cite:First Three-Dimensional Structure of Toxoplasma gondii Thymidylate Synthase-Dihydrofolate Reductase: Insights for Catalysis, Interdomain Interactions, and Substrate Channeling.
Biochemistry, 52, 2013
3HIF
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THE CRYSTAL STRUCTURE OF APO WILD TYPE CAP AT 3.6 A RESOLUTION.
Descriptor:Catabolite gene activator
Authors:Steitz, T.A., Sharma, H., Wang, J., Kong, J., Yu, S.
Deposit date:2009-05-19
Release date:2009-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.59 Å)
Cite:Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding.
Proc.Natl.Acad.Sci.USA, 106, 2009
4KY4
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CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 2 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR
Descriptor:Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, Aminopterin, ...
Authors:Sharma, H., Anderson, K.S.
Deposit date:2013-05-28
Release date:2014-08-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.
ACS Med Chem Lett, 4, 2013
4KYA
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CRYSTAL STRUCTURE OF NON-CLASSICAL TS INHIBITOR 3 IN COMPLEX WITH TOXOPLASMA GONDII TS-DHFR
Descriptor:Bifunctional dihydrofolate reductase-thymidylate synthase, 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-Amino-5-(1-naphthylsulfanyl)-3,9-dihydro-4H-pyrimido[4,5-b]indol-4-one, ...
Authors:Sharma, H., Anderson, K.S.
Deposit date:2013-05-28
Release date:2014-08-06
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.263 Å)
Cite:Discovery of potent and selective inhibitors of Toxoplasma gondii thymidylate synthase for opportunistic infections.
ACS Med Chem Lett, 4, 2013
2GTL
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LUMBRICUS ERYTHROCRUORIN AT 3.5A RESOLUTION
Descriptor:Extracellular globin 4, Extracellular globin 2, Extracellular globin-3, ...
Authors:Royer Jr., W.E., Sharma, H., Strand, K., Knapp, J.E., Bhyravbhatla, B.
Deposit date:2006-04-28
Release date:2006-07-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Lumbricus erythrocruorin at 3.5 a resolution: architecture of a megadalton respiratory complex.
Structure, 14, 2006