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1MDQ
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REFINED STRUCTURES OF TWO INSERTION(SLASH)DELETION MUTANTS PROBE FUNCTION OF THE MALTODEXTRIN BINDING PROTEIN
Descriptor:MALTODEXTRIN BINDING PROTEIN, MALTOSE
Authors:Sharff, A.J., Quiocho, F.A.
Deposit date:1994-08-10
Release date:1994-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Refined structures of two insertion/deletion mutants probe function of the maltodextrin binding protein.
J.Mol.Biol., 246, 1995
1DMB
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REFINED 1.8 ANGSTROMS STRUCTURE REVEALS THE MECHANISM OF BINDING OF A CYCLIC SUGAR, BETA-CYCLODEXTRIN, TO THE MALTODEXTRIN BINDING PROTEIN
Descriptor:D-MALTODEXTRIN BINDING PROTEIN, BETA-CYCLODEXTRIN
Authors:Sharff, A.J., Quiocho, F.A.
Deposit date:1993-06-10
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Refined 1.8-A structure reveals the mode of binding of beta-cyclodextrin to the maltodextrin binding protein.
Biochemistry, 32, 1993
1MDP
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REFINED STRUCTURES OF TWO INSERTION(SLASH)DELETION MUTANTS PROBE FUNCTION OF THE MALTODEXTRIN BINDING PROTEIN
Descriptor:MALTODEXTRIN BINDING PROTEIN, MALTOSE
Authors:Sharff, A.J., Quiocho, F.A.
Deposit date:1994-08-10
Release date:1994-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Refined structures of two insertion/deletion mutants probe function of the maltodextrin binding protein.
J.Mol.Biol., 246, 1995
1OMP
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CRYSTALLOGRAPHIC EVIDENCE OF A LARGE LIGAND-INDUCED HINGE-TWIST MOTION BETWEEN THE TWO DOMAINS OF THE MALTODEXTRIN-BINDING PROTEIN INVOLVED IN ACTIVE TRANSPORT AND CHEMOTAXIS
Descriptor:D-MALTODEXTRIN BINDING PROTEIN
Authors:Sharff, A.J., Quiocho, F.A.
Deposit date:1992-09-14
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystallographic evidence of a large ligand-induced hinge-twist motion between the two domains of the maltodextrin binding protein involved in active transport and chemotaxis.
Biochemistry, 31, 1992
1EK9
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2.1A X-RAY STRUCTURE OF TOLC: AN INTEGRAL OUTER MEMBRANE PROTEIN AND EFFLUX PUMP COMPONENT FROM ESCHERICHIA COLI
Descriptor:OUTER MEMBRANE PROTEIN TOLC
Authors:Koronakis, V., Sharff, A.J., Koronakis, E., Luisi, B., Hughes, C.
Deposit date:2000-03-07
Release date:2000-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export.
Nature, 405, 2000
3P38
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CRYSTAL STRUCTURE OF THE NS1 EFFECTOR DOMAIN W182A MUTANT FROM INFLUENZA A/VIETNAM/1203/2004 (H5N1) VIRUS
Descriptor:Nonstructural protein 1
Authors:Chen, S., Xiao, Y.B., Bricogne, G., Sharff, A.J., Hilgenfeld, R.
Deposit date:2010-10-04
Release date:2011-10-05
Method:X-RAY DIFFRACTION (2.76 Å)
Cite:X-ray structures of the NS1 effector domain from highly pathogenic influenza A/Vietnam/1203/2004 (H5N1) virus
To be Published
3P39
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CRYSTAL STRUCTURE OF THE NS1 EFFECTOR DOMAIN W182A MUTANT FROM INFLUENZA A/VIETNAM/1203/2004 (H5N1) VIRUS
Descriptor:Nonstructural protein 1
Authors:Chen, S., Xiao, Y.B., Bricogne, G., Sharff, A.J., Hilgenfeld, R.
Deposit date:2010-10-04
Release date:2011-10-05
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:X-ray structures of the NS1 effector domain from highly pathogenic influenza A/Vietnam/1203/2004 (H5N1) virus
To be Published
3U8Z
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HUMAN MERLIN FERM DOMAIN
Descriptor:Merlin
Authors:Yogesha, S.D., Sharff, A.J., Giovannini, M., Bricogne, G., Izard, T.
Deposit date:2011-10-17
Release date:2011-11-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor.
Protein Sci., 20, 2011
6CDS
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HUMAN NEUROFIBROMIN 2/MERLIN/SCHWANNOMIN RESIDUES 1-339 IN COMPLEX WITH PIP2
Descriptor:Merlin, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, PHOSPHATE ION, ...
Authors:Chinthalapudi, K., Sharff, A.J., Bricogne, G., Izard, T.
Deposit date:2018-02-09
Release date:2018-07-18
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Lipid binding promotes the open conformation and tumor-suppressive activity of neurofibromin 2.
Nat Commun, 9, 2018
2Q11
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STRUCTURE OF BACE COMPLEXED TO COMPOUND 1
Descriptor:Beta-secretase 1, 3-(2-AMINO-6-BENZOYLQUINAZOLIN-3(4H)-YL)-N-CYCLOHEXYL-N-METHYLPROPANAMIDE
Authors:Sharff, A.J.
Deposit date:2007-05-23
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
J.Med.Chem., 50, 2007
2Q15
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STRUCTURE OF BACE COMPLEXED TO COMPOUND 3A
Descriptor:Beta-secretase 1, (4S)-4-(2-AMINO-6-PHENOXYQUINAZOLIN-3(4H)-YL)-N,4-DICYCLOHEXYL-N-METHYLBUTANAMIDE
Authors:Sharff, A.J.
Deposit date:2007-05-23
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-Site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead.
J.Med.Chem., 50, 2007
2XQY
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CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6.3
Descriptor:ENVELOPE GLYCOPROTEIN H, A13-D6.3 MONOCLONAL ANTIBODY, N-ACETYL-D-GLUCOSAMINE
Authors:Backovic, M., Dubois, R., Cockburn, J., Sharff, A., Vaney, M., Granzow, H., Klupp, B., Bricogne, G., Mettenleiter, T., Rey, F.
Deposit date:2010-09-08
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of a Core Fragment of Glycoprotein H from Pseudorabies Virus in Complex with Antibody.
Proc.Natl.Acad.Sci.USA, 107, 2010
1ANF
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MALTODEXTRIN BINDING PROTEIN WITH BOUND MALTOSE
Descriptor:MALTODEXTRIN-BINDING PROTEIN, ALPHA-D-GLUCOSE
Authors:Spurlino, J.C., Quiocho, F.A.
Deposit date:1997-06-25
Release date:1997-12-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor.
Structure, 5, 1997
3MBP
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MALTODEXTRIN-BINDING PROTEIN WITH BOUND MALTOTRIOSE
Descriptor:MALTODEXTRIN-BINDING PROTEIN, ALPHA-D-GLUCOSE
Authors:Spurlino, J.C., Quiocho, F.A.
Deposit date:1997-06-25
Release date:1997-12-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor.
Structure, 5, 1997
4MBP
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MALTODEXTRIN BINDING PROTEIN WITH BOUND MALTETROSE
Descriptor:MALTODEXTRIN BINDING PROTEIN, ALPHA-D-GLUCOSE
Authors:Spurlino, J.C., Quiocho, F.A.
Deposit date:1997-08-17
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Extensive features of tight oligosaccharide binding revealed in high-resolution structures of the maltodextrin transport/chemosensory receptor.
Structure, 5, 1997
1A4L
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ADA STRUCTURE COMPLEXED WITH DEOXYCOFORMYCIN AT PH 7.0
Descriptor:ADENOSINE DEAMINASE, ZINC ION, 2'-DEOXYCOFORMYCIN
Authors:Wang, Z., Quiocho, F.A.
Deposit date:1998-01-31
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.
Biochemistry, 37, 1998
1A4M
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ADA STRUCTURE COMPLEXED WITH PURINE RIBOSIDE AT PH 7.0
Descriptor:ADENOSINE DEAMINASE, ZINC ION, 6-HYDROXY-1,6-DIHYDRO PURINE NUCLEOSIDE
Authors:Wang, Z., Quiocho, F.A.
Deposit date:1998-01-31
Release date:1998-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.
Biochemistry, 37, 1998
1LLS
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CRYSTAL STRUCTURE OF UNLIGANDED MALTOSE BINDING PROTEIN WITH XENON
Descriptor:Maltose-binding periplasmic protein, XENON
Authors:Rubin, S.M., Lee, S.-Y., Ruiz, E.J., Pines, A., Wemmer, D.E.
Deposit date:2002-04-30
Release date:2002-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DETECTION AND CHARACTERIZATION OF XENON-BINDING SITES IN PROTEINS BY 129XE NMR SPECTROSCOPY
J.MOL.BIOL., 322, 2002
2ADA
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ATOMIC STRUCTURE OF ADENOSINE DEAMINASE COMPLEXED WITH A TRANSITION-STATE ANALOG: UNDERSTANDING CATALYSIS AND IMMUNODEFICIENCY MUTATIONS
Descriptor:ADENOSINE DEAMINASE, ZINC ION, 6-HYDROXY-7,8-DIHYDRO PURINE NUCLEOSIDE
Authors:Wilson, D.K., Quiocho, F.A.
Deposit date:1994-12-02
Release date:1995-03-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Atomic structure of adenosine deaminase complexed with a transition-state analog: understanding catalysis and immunodeficiency mutations.
Science, 252, 1991