Author results

2UV4
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CRYSTAL STRUCTURE OF A CBS DOMAIN PAIR FROM THE REGULATORY GAMMA1 SUBUNIT OF HUMAN AMPK IN COMPLEX WITH AMP
分子名称:5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ADENOSINE MONOPHOSPHATE
著者Day, P., Sharff, A., PArra, L., Cleasby, A., Williams, M., Horer, S., Nar, H., Redemann, N., Tickle, I., Yon, J.
登録日2007-03-09
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献Structure of a Cbs-Domain Pair from the Regulatory Gamma1 Subunit of Human Ampk in Complex with AMP and Zmp.
Acta Crystallogr.,Sect.D, 63, 2007
2UV5
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CRYSTAL STRUCTURE OF A CBS DOMAIN PAIR FROM THE REGULATORY GAMMA1 SUBUNIT OF HUMAN AMPK IN COMPLEX WITH AMP
分子名称:5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE
著者Day, P., Sharff, A., Parra, L., Cleasby, A., Williams, M., Horer, S., Nar, H., Redemann, N., Tickle, I., Yon, J.
登録日2007-03-09
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.69 Å)
主引用文献Structure of a Cbs-Domain Pair from the Regulatory Gamma1 Subunit of Human Ampk in Complex with AMP and Zmp.
Acta Crystallogr.,Sect.D, 63, 2007
2UV6
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CRYSTAL STRUCTURE OF A CBS DOMAIN PAIR FROM THE REGULATORY GAMMA1 SUBUNIT OF HUMAN AMPK IN COMPLEX WITH AMP
分子名称:5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ADENOSINE MONOPHOSPHATE
著者Day, P., Sharff, A., Parra, L., Cleasby, A., Williams, M., Horer, S., Nar, H., Redemann, N., Tickle, I., Yon, J.
登録日2007-03-09
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of a Cbs-Domain Pair from the Regulatory Gamma1 Subunit of Human Ampk in Complex with AMP and Zmp.
Acta Crystallogr.,Sect.D, 63, 2007
2UV7
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CRYSTAL STRUCTURE OF A CBS DOMAIN PAIR FROM THE REGULATORY GAMMA1 SUBUNIT OF HUMAN AMPK IN COMPLEX WITH AMP
分子名称:5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1, ADENOSINE MONOPHOSPHATE
著者Day, P., Sharff, A., Parra, L., Cleasby, A., Williams, M., Horer, S., Nar, H., Redemann, N., Tickle, I., Yon, J.
登録日2007-03-09
公開日2007-05-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structure of a Cbs-Domain Pair from the Regulatory Gamma1 Subunit of Human Ampk in Complex with AMP and Zmp.
Acta Crystallogr.,Sect.D, 63, 2007
3URP
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RE-REFINEMENT OF PDB ENTRY 5RNT - RIBONUCLEASE T1 WITH GUANOSINE-3',5'-DIPHOSPHATE AND PHOSPHATE ION BOUND
分子名称:Guanyl-specific ribonuclease T1, GUANOSINE-3',5'-DIPHOSPHATE, PHOSPHATE ION, ...
著者Smart, O.S., Womack, T.O., Flensburg, C., Keller, P., Sharff, A., Paciorek, W., Vonrhein, C., Bricogne, G.
登録日2011-11-22
公開日2012-03-28
最終更新日2013-02-20
実験手法X-RAY DIFFRACTION (3.19 Å)
主引用文献Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER.
Acta Crystallogr.,Sect.D, 68, 2012
2XEM
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INDUCED-FIT AND ALLOSTERIC EFFECTS UPON POLYENE BINDING REVEALED BY CRYSTAL STRUCTURES OF THE DYNEMICIN THIOESTERASE
分子名称:DYNE7, (3E,5E,7E,9E,11E,13E)-pentadeca-3,5,7,9,11,13-hexaen-2-one
著者Liew, C.W., Sharff, A., Kotaka, M., Kong, R., Bricogne, G., Liang, Z.X., Lescar, J.
登録日2010-05-17
公開日2010-10-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Induced-Fit Upon Ligand Binding Revealed by Crystal Structures of the Hot-Dog Fold Thioesterase in Dynemicin Biosynthesis.
J.Mol.Biol., 404, 2010
2XFL
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INDUCED-FIT AND ALLOSTERIC EFFECTS UPON POLYENE BINDING REVEALED BY CRYSTAL STRUCTURES OF THE DYNEMICIN THIOESTERASE
分子名称:DYNE7
著者Liew, C.W., Sharff, A., Kotaka, M., Kong, R., Sun, H., Bricogne, G., Liang, Z., Lescar, J.
登録日2010-05-26
公開日2010-10-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Induced-Fit Upon Ligand Binding Revealed by Crystal Structures of the Hot-Dog Fold Thioesterase in Dynemicin Biosynthesis.
J.Mol.Biol., 404, 2010
3RF3
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SHIGELLA IPAA-VBS3 IN COMPLEX WITH HUMAN VINCULIN
分子名称:Vinculin, Invasin ipaA, CACODYLATE ION
著者Park, H., Sharff, A., Izard, T.
登録日2011-04-05
公開日2011-04-27
最終更新日2012-05-23
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Novel vinculin binding site of the IpaA invasin of Shigella.
J.Biol.Chem., 286, 2011
3S90
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HUMAN VINCULIN HEAD DOMAIN VH1 (RESIDUES 1-252) IN COMPLEX WITH MURINE TALIN (VBS33; RESIDUES 1512-1546)
分子名称:Vinculin, Talin-1
著者Yogesha, S.D., Sharff, A., Bricogne, G., Izard, T.
登録日2011-05-31
公開日2011-06-22
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin.
Protein Sci., 20, 2011
3V56
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RE-REFINEMENT OF PDB ENTRY 1OSG - COMPLEX BETWEEN BAFF AND A BR3 DERIVED PEPTIDE PRESENTED IN A BETA-HAIRPIN SCAFFOLD - REVEALS AN ADDITONAL COPY OF THE PEPTIDE.
分子名称:Tumor necrosis factor ligand superfamily member 13B, BR3 derived peptive, SULFATE ION
著者Smart, O.S., Womack, T.O., Flensburg, C., Keller, P., Sharff, A., Paciorek, W., Vonrhein, C., Bricogne, G.
登録日2011-12-16
公開日2012-03-28
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER.
Acta Crystallogr.,Sect.D, 68, 2012
4CTJ
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 3A9
分子名称:NON-STRUCTURAL PROTEIN 5, S-ADENOSYLMETHIONINE, 2,3-dihydro-1-benzofuran-5-carboxylic acid, ...
著者Barral, K., Bricogne, G., Sharff, A.
登録日2014-03-14
公開日2014-04-16
最終更新日2014-05-28
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Assessment of Dengue Virus Helicase and Methyltransferase as Targets for Fragment-Based Drug Discovery.
Antiviral Res., 106, 2014
4CTK
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND FRAGMENT 2A4
分子名称:POLYPROTEIN, S-ADENOSYLMETHIONINE, thieno[2,3-b]pyrazin-7-amine, ...
著者Barral, K., Bricogne, G., Sharff, A.
登録日2014-03-14
公開日2014-04-16
最終更新日2017-03-29
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Assessment of Dengue Virus Helicase and Methyltransferase as Targets for Fragment-Based Drug Discovery.
Antiviral Res., 106, 2014
4D2P
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STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS
分子名称:MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 7-({4-[(3-hydroxy-5-methoxyphenyl)amino]benzoyl}amino)-1,2,3,4-tetrahydroisoquinolinium
著者Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.
登録日2014-05-12
公開日2014-10-08
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Acs Med.Chem.Lett., 6, 2015
4D2T
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STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS
分子名称:MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 3-[2-(phenylcarbamoyl)-5-(1H-pyrazol-4-yl)phenoxy]propan-1-aminium
著者Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.
登録日2014-05-13
公開日2014-10-15
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Acs Med.Chem.Lett., 6, 2015
4D2V
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STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS
分子名称:MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 7-{[2-methoxy-4-(1H-pyrazol-4-yl)benzoyl]amino}-2,3,4,5-tetrahydro-1H-3-benzazepinium
著者Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.
登録日2014-05-13
公開日2014-10-15
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Acs Med.Chem.Lett., 6, 2015
4D2W
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STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS
分子名称:MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 4-bromo-N-(2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)benzamide
著者Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.
登録日2014-05-13
公開日2014-10-08
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Acs Med.Chem.Lett., 6, 2015
4UMP
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STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS
分子名称:MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 3-(isoquinolin-7-yl)prop-2-yn-1-ol
著者Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.
登録日2014-05-20
公開日2014-10-08
最終更新日2018-04-04
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Acs Med.Chem.Lett., 6, 2015
4UMQ
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STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS
分子名称:MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 3-{5-[(3-hydroxy-5-methoxyphenyl)amino]-2-(phenylcarbamoyl)phenoxy}propan-1-aminium
著者Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.
登録日2014-05-20
公開日2014-10-08
最終更新日2015-01-28
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Acs Med.Chem.Lett., 6, 2015
4UMR
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STRUCTURE OF MELK IN COMPLEX WITH INHIBITORS
分子名称:MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, 4-fluoro-N-(1,2,3,4-tetrahydroisoquinolin-7-yl)benzamide
著者Johnson, C.N., Berdini, V., Beke, L., Bonnet, P., Brehmer, D., Coyle, J.E., Day, P.J., Frederickson, M., Freyne, E.J.E., Gilissen, R.A.H.J., Hamlett, C.C.F., Howard, S., Meerpoel, L., McMenamin, R., Patel, S., Rees, D.C., Sharff, A., Sommen, F., Wu, T., Linders, J.T.M.
登録日2014-05-20
公開日2014-10-08
最終更新日2015-01-28
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Fragment-Based Discovery of Type I Inhibitors of Maternal Embryonic Leucine Zipper Kinase
Acs Med.Chem.Lett., 6, 2015
1EK9
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2.1A X-RAY STRUCTURE OF TOLC: AN INTEGRAL OUTER MEMBRANE PROTEIN AND EFFLUX PUMP COMPONENT FROM ESCHERICHIA COLI
分子名称:OUTER MEMBRANE PROTEIN TOLC
著者Koronakis, V., Sharff, A.J., Koronakis, E., Luisi, B., Hughes, C.
登録日2000-03-07
公開日2000-06-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the bacterial membrane protein TolC central to multidrug efflux and protein export.
Nature, 405, 2000
2XQY
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CRYSTAL STRUCTURE OF PSEUDORABIES CORE FRAGMENT OF GLYCOPROTEIN H IN COMPLEX WITH FAB D6.3
分子名称:ENVELOPE GLYCOPROTEIN H, A13-D6.3 MONOCLONAL ANTIBODY, N-ACETYL-D-GLUCOSAMINE
著者Backovic, M., Dubois, R., Cockburn, J., Sharff, A., Vaney, M., Granzow, H., Klupp, B., Bricogne, G., Mettenleiter, T., Rey, F.
登録日2010-09-08
公開日2010-12-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structure of a Core Fragment of Glycoprotein H from Pseudorabies Virus in Complex with Antibody.
Proc.Natl.Acad.Sci.USA, 107, 2010
5E9Q
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND MOLECULE BF174
分子名称:Genome polyprotein, S-ADENOSYLMETHIONINE, 2-({[2-amino-4-(trifluoromethyl)phenyl]carbamoyl}amino)-4-methylbenzoic acid
著者Barral, K., Bricogne, G., Sharff, A.
登録日2015-10-15
公開日2016-10-26
最終更新日2018-11-21
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
5EC8
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND COMPOUND BF175
分子名称:Genome polyprotein, S-ADENOSYLMETHIONINE, 2-[(2-azanyl-4-chloranyl-phenyl)carbamoylamino]-4-methyl-benzoic acid
著者Barral, K., Bricogne, G., Sharff, A.
登録日2015-10-20
公開日2016-10-26
最終更新日2017-08-30
実験手法X-RAY DIFFRACTION (1.714 Å)
主引用文献Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
5EHG
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND MOLECULE BF341
分子名称:RNA-directed RNA polymerase NS5, S-ADENOSYLMETHIONINE, 4-[3-[(2-azanyl-4-chloranyl-phenyl)carbamoylamino]phenyl]sulfonyloxybenzoic acid
著者Barral, K., Bricogne, G., Sharff, A.
登録日2015-10-28
公開日2016-10-26
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (2.02 Å)
主引用文献Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
5EHI
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DENGUE 3 NS5 METHYLTRANSFERASE BOUND TO S-ADENOSYL METHIONINE AND MOLECULE BF287
分子名称:NS5 methyltransferase dengue virus, S-ADENOSYLMETHIONINE, 4-[[3-[(2-azanyl-4-chloranyl-phenyl)carbamoylamino]phenyl]sulfonylamino]benzoic acid
著者Barral, K., Bricogne, G., Sharff, A.
登録日2015-10-28
公開日2016-10-26
最終更新日2017-09-06
実験手法X-RAY DIFFRACTION (1.303 Å)
主引用文献Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design.
Eur.J.Med.Chem., 125, 2016
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