Author results

1XPV
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SOLUTION STRUCTURE OF NORTHEAST STRUCTURAL GENOMICS TARGET PROTEIN XCR50 FROM X. CAMPESTRIS
Descriptor:hypothetical protein XCC2852
Authors:Shao, Y., Acton, T.B., Liu, G., Ma, L., Shen, Y., Xiao, R., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-10-09
Release date:2004-12-14
Last modified:2018-01-31
Method:SOLUTION NMR
Cite:Solution Structure of Northeast Structural Genomics Target Protein XcR50 from X. Campestris
To be Published
4H4K
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STRUCTURE OF THE CMR2-CMR3 SUBCOMPLEX OF THE CMR RNA-SILENCING COMPLEX
Descriptor:CRISPR system Cmr subunit Cmr3, CRISPR system Cmr subunit Cmr2, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Shao, Y., Cocozaki, A.I., Ramia, N.F., Terns, R.M., Terns, M.P., Li, H.
Deposit date:2012-09-17
Release date:2013-03-06
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (2.804 Å)
Cite:Structure of the cmr2-cmr3 subcomplex of the cmr RNA silencing complex.
Structure, 21, 2013
4ILL
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RECOGNITION AND CLEAVAGE OF A NON-STRUCTURED CRISPR RNA BY ITS PROCESSING ENDORIBONUCLEASE CAS6
Descriptor:CRISPR-associated endoribonuclease Cas6 2, RNA (5'-R(*GP*CP*UP*AP*AP*UP*CP*UP*AP*CP*UP*AP*UP*AP*GP*AP*AP*UP*UP*GP*AP*AP*AP*G)-3')
Authors:Shao, Y., Li, H.
Deposit date:2012-12-31
Release date:2013-03-20
Last modified:2013-05-01
Method:X-RAY DIFFRACTION (2.484 Å)
Cite:Recognition and cleavage of a nonstructured CRISPR RNA by its processing endoribonuclease Cas6.
Structure, 21, 2013
4ILM
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CRISPR RNA PROCESSING ENDORIBONUCLEASE
Descriptor:CRISPR-associated endoribonuclease Cas6 2, RNA (5'-R(*GP*CP*UP*AP*AP*UP*CP*UP*AP*CP*UP*AP*UP*AP*GP*A)-3')
Authors:Shao, Y., Li, H.
Deposit date:2012-12-31
Release date:2013-03-20
Last modified:2013-05-01
Method:X-RAY DIFFRACTION (3.068 Å)
Cite:Recognition and cleavage of a nonstructured CRISPR RNA by its processing endoribonuclease Cas6.
Structure, 21, 2013
4ILR
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RECOGNITION AND CLEAVAGE OF A NON-STRUCTURED CRISPR RNA BY ITS PROCESSING ENDORIBONUCLEASE CAS6
Descriptor:CRISPR-associated endoribonuclease Cas6 2
Authors:Shao, Y., Li, H.
Deposit date:2012-12-31
Release date:2013-03-20
Last modified:2013-05-01
Method:X-RAY DIFFRACTION (3.088 Å)
Cite:Recognition and cleavage of a nonstructured CRISPR RNA by its processing endoribonuclease Cas6.
Structure, 21, 2013
4RDP
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CRYSTAL STRUCTURE OF CMR4
Descriptor:CRISPR system Cmr subunit Cmr4
Authors:Shao, Y., Tang, L., Li, H.
Deposit date:2014-09-19
Release date:2014-12-24
Last modified:2014-12-31
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Essential Structural and Functional Roles of the Cmr4 Subunit in RNA Cleavage by the Cmr CRISPR-Cas Complex.
Cell Rep, 9, 2014
5E08
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SPECIFIC RECOGNITION OF A SINGLE-STRANDED RNA SEQUENCE BY AN ENGINEERED SYNTHETIC ANTIBODY FRAGMENT
Descriptor:Fab Heavy Chain, Fab Light Chain, RNA
Authors:Huang, H., Qin, D., Li, N., Shao, Y., Staley, J.P., Kossiakoff, A.A., Koide, S., Piccirilli, J.A.
Deposit date:2015-09-28
Release date:2016-09-21
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Specific Recognition of a Single-Stranded RNA Sequence by a Synthetic Antibody Fragment.
J.Mol.Biol., 428, 2016
6DB8
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STRUCTURAL BASIS FOR PROMISCUOUS BINDING AND ACTIVATION OF FLUOROGENIC DYES BY DIR2S RNA APTAMER
Descriptor:Fab-Heavy chain, RNA (60-MER), Fab-Light chain, ...
Authors:Shao, Y., Shelke, S.A., Laski, A., Piccirilli, J.A.
Deposit date:2018-05-02
Release date:2018-11-14
Method:X-RAY DIFFRACTION (1.865413 Å)
Cite:Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif.
Nat Commun, 9, 2018
6DB9
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STRUCTURAL BASIS FOR PROMISCUOUS BINDING AND ACTIVATION OF FLUOROGENIC DYES BY DIR2S RNA APTAMER
Descriptor:RNA (60-MER), Fab-Heavy-Chain, Fab-Light-Chain, ...
Authors:Shao, Y., Shelke, S.A., Laski, A., Piccirilli, J.A.
Deposit date:2018-05-02
Release date:2018-11-14
Method:X-RAY DIFFRACTION (2.025 Å)
Cite:Structural basis for activation of fluorogenic dyes by an RNA aptamer lacking a G-quadruplex motif.
Nat Commun, 9, 2018
1J48
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CRYSTAL STRUCTURE OF APO-C1027
Descriptor:Apoprotein of C1027
Authors:Chen, Y., Li, J., Liu, Y., Bartlam, M., Gao, Y., Jin, L., Tang, H., Shao, Y., Zhen, Y., Rao, Z.
Deposit date:2001-07-30
Release date:2003-06-03
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of Apo-C1027 and Computer Modeling Analysis of C1027 Chromophore- Protein Complex
To be published
1LV0
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CRYSTAL STRUCTURE OF THE RAB EFFECTOR GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR (GDI) IN COMPLEX WITH A GERANYLGERANYL (GG) PEPTIDE
Descriptor:RAB GDP disossociation inhibitor alpha, SULFATE ION, GERAN-8-YL GERAN
Authors:An, Y., Shao, Y., Alory, C., Matteson, J., Sakisaka, T., Chen, W., Gibbs, R.A., Wilson, I.A., Balch, W.E.
Deposit date:2002-05-23
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Geranylgeranyl switching regulates GDI-Rab GTPase recycling.
Structure, 11, 2003
1MC7
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SOLUTION STRUCTURE OF MDVL1 PDZ DOMAIN
Descriptor:Segment polarity protein dishevelled homolog DVL-1
Authors:Wong, H.-C., Bourdelas, A., Shao, Y., Wu, D., Shi, D.L., Zheng, J.
Deposit date:2002-08-05
Release date:2003-09-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Direct binding of the PDZ domain of Dishevelled to a conserved internal sequence in the C-terminal region of Frizzled
Mol.Cell, 12, 2003
1TUZ
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NMR STRUCTURE OF THE DIACYLGLYCEROL KINASE ALPHA, NESGC TARGET HR532
Descriptor:diacylglycerol kinase alpha
Authors:Liu, G., Shao, Y., Xiao, R., Acton, T., Montelione, G.T., Szyperski, T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-06-25
Release date:2005-01-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure of Diacylglycerol kinase alpha, NESGC target HR532
To be Published
2JTK
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A FUNCTIONAL DOMAIN OF A WNT SIGNAL PROTEIN
Descriptor:Dickkopf-related protein 2
Authors:Chen, L., Shao, Y., Huang, J., Zheng, J.
Deposit date:2007-08-02
Release date:2008-07-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural insight into the mechanisms of wnt signaling antagonism by dkk
J.Biol.Chem., 283, 2008
3UNG
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STRUCTURE OF THE CMR2 SUBUNIT OF THE CRISPR RNA SILENCING COMPLEX
Descriptor:Cmr2dHD, CALCIUM ION, ZINC ION, ...
Authors:Cocozaki, A.I., Ramia, N.F., Shao, Y., Hale, C.R., Terns, R.M., Terns, M.P., Li, H.
Deposit date:2011-11-15
Release date:2012-03-21
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structure of the Cmr2 Subunit of the CRISPR-Cas RNA Silencing Complex.
Structure, 20, 2012
3UR3
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STRUCTURE OF THE CMR2 SUBUNIT OF THE CRISPR RNA SILENCING COMPLEX
Descriptor:Cmr2dHD, CALCIUM ION, ZINC ION
Authors:Cocozaki, A.I., Ramia, N.F., Shao, Y., Hale, C.R., Terns, R.M., Terns, M.P., Li, H.
Deposit date:2011-11-21
Release date:2012-03-21
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Structure of the Cmr2 Subunit of the CRISPR-Cas RNA Silencing Complex.
Structure, 20, 2012
3WFV
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HIV-1 CRF07 GP41
Descriptor:Envelope glycoprotein gp160
Authors:Du, J., Xue, H., Ma, J., Liu, F., Zhou, J., Shao, Y., Qiao, W., Liu, X.
Deposit date:2013-07-24
Release date:2013-10-16
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The crystal structure of HIV CRF07 B'/C gp41 reveals a hyper-mutant site in the middle of HR2 heptad repeat
Virology, 446, 2013
5C7U
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5'-MONOPHOSPHATE WT GUANINE RIBOSWITCH BOUND TO HYPOXANTHINE.
Descriptor:5'-monophosphate wt guanine riboswitch, COBALT HEXAMMINE(III), HYPOXANTHINE
Authors:Hernandez, A.R., Shao, Y., Hoshika, S., Yang, Z., Shelke, S.A., Herrou, J., Kim, H.-J., Kim, M.-J., Piccirilli, J.A., Benner, S.A.
Deposit date:2015-06-24
Release date:2015-08-12
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair.
Angew.Chem.Int.Ed.Engl., 54, 2015
5C7W
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5'-MONOPHOSPHATE Z:P GUANINE RIBOSWITCH BOUND TO HYPOXANTHINE.
Descriptor:5'-monophosphate Z:P guanine riboswitch, COBALT HEXAMMINE(III), HYPOXANTHINE
Authors:Hernandez, A.R., Shao, Y., Hoshika, S., Yang, Z., Shelke, S.A., Herrou, J., Kim, H.-J., Kim, M.-J., Piccirilli, J.A., Benner, S.A.
Deposit date:2015-06-25
Release date:2015-08-12
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair.
Angew.Chem.Int.Ed.Engl., 54, 2015
4Z7K
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CRYSTAL STRUCTURE OF CRISPR RNA PROCESSING ENDORIBONUCLEASE CAS6B
Descriptor:Cas6b, RNA/DNA Hybrid (31-MER)
Authors:Li, H.
Deposit date:2015-04-07
Release date:2016-04-13
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Non-Stem-Loop CRISPR RNA Is Processed by Dual Binding Cas6.
Structure, 24, 2016
4Z7L
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CRYSTAL STRUCTURE OF CAS6B
Descriptor:Cas6b, RNA (5'-R(*GP*CP*AP*AP*AP*AP*UP*AP*AP*CP*AP*AP*GP*C)-3'), SULFATE ION
Authors:Li, H.
Deposit date:2015-04-07
Release date:2016-04-13
Last modified:2018-08-29
Method:X-RAY DIFFRACTION (3.503 Å)
Cite:A Non-Stem-Loop CRISPR RNA Is Processed by Dual Binding Cas6.
Structure, 24, 2016
4MD6
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CRYSTAL STRUCTURE OF PDE5 IN COMPLEX WITH INHIBITOR 5R
Descriptor:cGMP-specific 3',5'-cyclic phosphodiesterase, SULFATE ION, 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one, ...
Authors:Cui, W., Huang, M., Shao, Y., Luo, H.
Deposit date:2013-08-22
Release date:2014-07-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of 3-(4-hydroxybenzyl)-1-(thiophen-2-yl)chromeno[2,3-c]pyrrol-9(2H)-one as a phosphodiesterase-5 inhibitor and its complex crystal structure.
Biochem Pharmacol, 89, 2014
4GVJ
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TYK2 (JH1) IN COMPLEX WITH ADENOSINE DI-PHOSPHATE
Descriptor:Non-receptor tyrosine-protein kinase TYK2, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION
Authors:Liang, J., Abbema, A.V., Bao, L., Barrett, K., Beresini, M., Berezhkovskiy, L., Blair, W., Chang, C., Driscoll, J., Eigenbrot, C., Ghilardi, N., Gibbons, P., Halladay, J., Johnson, A., Kohli, P.B., Lai, Y., Liimatta, M., Mantik, P., Menghrajani, K., Murray, J., Sambrone, A., Shao, Y., Shia, S., Shin, Y., Smith, J., Sohn, S., Stanley, M., Tsui, V., Ultsch, M., Wu, L., Zhang, B., Magnuson, S.
Deposit date:2012-08-30
Release date:2013-08-14
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Lead identification of novel and selective TYK2 inhibitors.
Eur.J.Med.Chem., 67, 2013
5CD3
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STRUCTURE OF IMMATURE VRC01-CLASS ANTIBODY DRVIA7
Descriptor:DRVIA7 Heavy Chain, DRVIA7 Light Chain
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-02
Release date:2016-04-06
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Immunity, 44, 2016
5CD5
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CRYSTAL STRUCTURE OF AN IMMATURE VRC01-CLASS ANTIBODY DRVIA7 FROM A CHINESE DONOR BOUND TO CLADE A/E HIV-1 GP120 CORE
Descriptor:93TH057 HIV-1 gp120 core, DRVIA7 Fab Heavy Chain, DRVIA7 Fab Light Chain, ...
Authors:Kong, L., Wilson, I.A.
Deposit date:2015-07-03
Release date:2016-04-06
Last modified:2018-09-05
Method:X-RAY DIFFRACTION (3.396 Å)
Cite:Key gp120 Glycans Pose Roadblocks to the Rapid Development of VRC01-Class Antibodies in an HIV-1-Infected Chinese Donor.
Immunity, 44, 2016
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