Author results

2M20
  • Download 2m20
  • View 2m20
Molmil generated image of 2m20
EGFR TRANSMEMBRANE - JUXTAMEMBRANE (TM-JM) SEGMENT IN BICELLES: MD GUIDED NMR REFINED STRUCTURE.
Descriptor:Epidermal growth factor receptor
Authors:Endres, N.F., Das, R., Smith, A., Arkhipov, A., Kovacs, E., Huang, Y., Pelton, J.G., Shan, Y., Shaw, D.E., Wemmer, D.E., Groves, J.T., Kuriyan, J.
Deposit date:2012-12-11
Release date:2013-02-20
Method:SOLUTION NMR
Cite:Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor.
Cell(Cambridge,Mass.), 152, 2013
4F3L
  • Download 4f3l
  • View 4f3l
Molmil generated image of 4f3l
CRYSTAL STRUCTURE OF THE HETERODIMERIC CLOCK:BMAL1 TRANSCRIPTIONAL ACTIVATOR COMPLEX
Descriptor:BMAL1b, Circadian locomoter output cycles protein kaput
Authors:Huang, N., Chelliah, Y., Shan, Y., Taylor, C., Yoo, S., Partch, C., Green, C.B., Zhang, H., Takahashi, J.
Deposit date:2012-05-09
Release date:2012-06-06
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.268 Å)
Cite:Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
Science, 337, 2012
3G6G
  • Download 3g6g
  • View 3g6g
Molmil generated image of 3g6g
EQUALLY POTENT INHIBITION OF C-SRC AND ABL BY COMPOUNDS THAT RECOGNIZE INACTIVE KINASE CONFORMATIONS
Descriptor:Proto-oncogene tyrosine-protein kinase Src, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide, GLYCEROL
Authors:Seeliger, M.A., Ranjitkar, P., Kasap, C., Shan, Y., Shaw, D.E., Shah, N.P., Kuriyan, J., Maly, D.J.
Deposit date:2009-02-06
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Cancer Res., 69, 2009
3G6H
  • Download 3g6h
  • View 3g6h
Molmil generated image of 3g6h
SRC THR338ILE INHIBITED IN THE DFG-ASP-OUT CONFORMATION
Descriptor:Proto-oncogene tyrosine-protein kinase Src, N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide
Authors:Seeliger, M.A., Ranjitkar, P., Kasap, C., Shan, Y., Shaw, D.E., Shah, N.P., Kuriyan, J., Maly, D.J.
Deposit date:2009-02-06
Release date:2009-03-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Cancer Res., 69, 2009
3KEX
  • Download 3kex
  • View 3kex
Molmil generated image of 3kex
CRYSTAL STRUCTURE OF THE CATALYTICALLY INACTIVE KINASE DOMAIN OF THE HUMAN EPIDERMAL GROWTH FACTOR RECEPTOR 3 (HER3)
Descriptor:Receptor tyrosine-protein kinase erbB-3, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, MAGNESIUM ION
Authors:Jura, N., Shan, Y., Cao, X., Shaw, D.E., Kuriyan, J.
Deposit date:2009-10-26
Release date:2009-12-22
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.797 Å)
Cite:Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
Proc.Natl.Acad.Sci.USA, 106, 2009
5TJX
  • Download 5tjx
  • View 5tjx
Molmil generated image of 5tjx
STRUCTURE OF HUMAN PLASMA KALLIKREIN
Descriptor:Plasma kallikrein, (8E)-3-amino-1-methyl-15-[(1H-pyrazol-1-yl)methyl]-7,10,11,12,24,25-hexahydro-6H,18H,23H-19,22-(metheno)pyrido[4,3-j][1,9,13,17,18]benzodioxatriazacyclohenicosin-23-one, PHOSPHATE ION
Authors:Partridge, J.R., Choy, R.M., Li, Z.
Deposit date:2016-10-05
Release date:2016-12-21
Last modified:2017-03-01
Method:X-RAY DIFFRACTION (1.408 Å)
Cite:Structure-Guided Design of Novel, Potent, and Selective Macrocyclic Plasma Kallikrein Inhibitors.
ACS Med Chem Lett, 8, 2017
5GW0
  • Download 5gw0
  • View 5gw0
Molmil generated image of 5gw0
CRYSTAL STRUCTURE OF SNX16 PX-COILED COIL
Descriptor:Sorting nexin-16
Authors:Xu, J., Liu, J.
Deposit date:2016-09-08
Release date:2017-09-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding.
Structure, 25, 2017
5GW1
  • Download 5gw1
  • View 5gw1
Molmil generated image of 5gw1
CRYSTAL STRUCTURE OF SNX16 PX-COILED COIL IN SPACE GROUP P212121
Descriptor:Sorting nexin-16
Authors:Xu, J., Liu, J.
Deposit date:2016-09-08
Release date:2017-09-13
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:SNX16 Regulates the Recycling of E-Cadherin through a Unique Mechanism of Coordinated Membrane and Cargo Binding.
Structure, 25, 2017
4FVP
  • Download 4fvp
  • View 4fvp
Molmil generated image of 4fvp
CRYSTAL STRUCTURE OF THE JAK2 PSEUDOKINASE DOMAIN (APO FORM)
Descriptor:Tyrosine-protein kinase JAK2, GLYCEROL
Authors:Bandaranayake, R.M., Hubbard, S.R.
Deposit date:2012-06-29
Release date:2012-07-25
Last modified:2012-08-22
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Nat.Struct.Mol.Biol., 19, 2012
4FVQ
  • Download 4fvq
  • View 4fvq
Molmil generated image of 4fvq
CRYSTAL STRUCTURE OF THE JAK2 PSEUDOKINASE DOMAIN (MG-ATP-BOUND FORM)
Descriptor:Tyrosine-protein kinase JAK2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Bandaranayake, R.M., Hubbard, S.R.
Deposit date:2012-06-29
Release date:2012-07-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Nat.Struct.Mol.Biol., 19, 2012
4FVR
  • Download 4fvr
  • View 4fvr
Molmil generated image of 4fvr
CRYSTAL STRUCTURE OF THE JAK2 PSEUDOKINASE DOMAIN MUTANT V617F (MG-ATP-BOUND FORM)
Descriptor:Tyrosine-protein kinase JAK2, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION
Authors:Bandaranayake, R.M., Hubbard, S.R.
Deposit date:2012-06-29
Release date:2012-07-25
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the JAK2 pseudokinase domain and the pathogenic mutant V617F.
Nat.Struct.Mol.Biol., 19, 2012
4HE0
  • Download 4he0
  • View 4he0
Molmil generated image of 4he0
CRYSTAL STRUCTURE OF HUMAN MUSCLE FRUCTOSE-1,6-BISPHOSPHATASE
Descriptor:Fructose-1,6-bisphosphatase isozyme 2, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Shi, R., Zhu, D.W., Lin, S.X.
Deposit date:2012-10-03
Release date:2013-10-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway.
Plos One, 8, 2013
4HE1
  • Download 4he1
  • View 4he1
Molmil generated image of 4he1
CRYSTAL STRUCTURE OF HUMAN MUSCLE FRUCTOSE-1,6-BISPHOSPHATASE Q32R MUTANT COMPLEX WITH FRUCTOSE-6-PHOSPHATE AND PHOSPHATE
Descriptor:Fructose-1,6-bisphosphatase isozyme 2, FRUCTOSE-6-PHOSPHATE, PHOSPHATE ION, ...
Authors:Shi, R., Zhu, D.W., Lin, S.X.
Deposit date:2012-10-03
Release date:2013-10-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway.
Plos One, 8, 2013
4HE2
  • Download 4he2
  • View 4he2
Molmil generated image of 4he2
CRYSTAL STRUCTURE OF HUMAN MUSCLE FRUCTOSE-1,6-BISPHOSPHATASE Q32R MUTANT COMPLEX WITH AMP
Descriptor:Fructose-1,6-bisphosphatase isozyme 2, ADENOSINE MONOPHOSPHATE, PHOSPHITE ION, ...
Authors:Shi, R., Zhu, D.W., Lin, S.X.
Deposit date:2012-10-03
Release date:2013-10-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structures of Human Muscle Fructose-1,6-Bisphosphatase: Novel Quaternary States, Enhanced AMP Affinity, and Allosteric Signal Transmission Pathway.
Plos One, 8, 2013
4RIW
  • Download 4riw
  • View 4riw
Molmil generated image of 4riw
CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER
Descriptor:Receptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Littlefield, P., Jura, N.
Deposit date:2014-10-07
Release date:2014-12-10
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7, 2014
4RIX
  • Download 4rix
  • View 4rix
Molmil generated image of 4rix
CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER CONTAINING THE CANCER-ASSOCIATED HER3-Q790R MUTATION
Descriptor:Receptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Littlefield, P., Liu, L., Jura, N.
Deposit date:2014-10-07
Release date:2014-12-10
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7, 2014
4RIY
  • Download 4riy
  • View 4riy
Molmil generated image of 4riy
CRYSTAL STRUCTURE OF AN EGFR/HER3 KINASE DOMAIN HETERODIMER CONTAINING THE CANCER-ASSOCIATED HER3-E909G MUTATION
Descriptor:Receptor tyrosine-protein kinase erbB-3, Epidermal growth factor receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Littlefield, P., Liu, L., Jura, N.
Deposit date:2014-10-07
Release date:2014-12-10
Last modified:2014-12-17
Method:X-RAY DIFFRACTION (2.981 Å)
Cite:Structural analysis of the EGFR/HER3 heterodimer reveals the molecular basis for activating HER3 mutations.
Sci.Signal., 7, 2014
4U97
  • Download 4u97
  • View 4u97
Molmil generated image of 4u97
CRYSTAL STRUCTURE OF ASYMMETRIC IRAK4 DIMER
Descriptor:Interleukin-1 receptor-associated kinase 4, STAUROSPORINE, SULFATE ION
Authors:Ferrao, R., Wu, H.
Deposit date:2014-08-05
Release date:2014-09-24
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
Mol.Cell, 55, 2014
4U9A
  • Download 4u9a
  • View 4u9a
Molmil generated image of 4u9a
SULPHUR ANOMALOUS CRYSTAL STRUCTURE OF ASYMMETRIC IRAK4 DIMER
Descriptor:Interleukin-1 receptor-associated kinase 4, STAUROSPORINE, SULFATE ION
Authors:Ferrao, R., Liu, Q., Wu, H.
Deposit date:2014-08-05
Release date:2014-09-24
Last modified:2014-10-01
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:IRAK4 Dimerization and trans-Autophosphorylation Are Induced by Myddosome Assembly.
Mol.Cell, 55, 2014
4YGA
  • Download 4yga
  • View 4yga
Molmil generated image of 4yga
CDPK1, FROM TOXOPLASMA GONDII, BOUND TO INHIBITORY VHH-1B7
Descriptor:Calmodulin-domain protein kinase 1, VHH-1B7, CALCIUM ION
Authors:Knockenhauer, K.E., Schwartz, T.U.
Deposit date:2015-02-26
Release date:2015-08-26
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.94 Å)
Cite:Allosteric activation of apicomplexan calcium-dependent protein kinases.
Proc.Natl.Acad.Sci.USA, 112, 2015
5TZ9
  • Download 5tz9
  • View 5tz9
Molmil generated image of 5tz9
STRUCTURE OF PLASMA KALLIKREIN PROTEASE DOMAIN WITH INHIBITOR
Descriptor:Plasma kallikrein, N-[(6-amino-2,4-dimethylpyridin-3-yl)methyl]-1-({4-[(1H-pyrazol-1-yl)methyl]phenyl}methyl)-1H-pyrazole-4-carboxamide
Authors:Partridge, J.R., Choy, R.
Deposit date:2016-11-21
Release date:2017-08-30
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:

5ET5
  • Download 5et5
  • View 5et5
Molmil generated image of 5et5
HUMAN MUSCLE FRUCTOSE-1,6-BISPHOSPHATASE IN ACTIVE R-STATE
Descriptor:Fructose-1,6-bisphosphatase isozyme 2
Authors:Barciszewski, J., Wisniewski, J., Kolodziejczyk, R., Dzugaj, A., Jaskolski, M., Rakus, D.
Deposit date:2015-11-17
Release date:2016-04-13
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (1.67 Å)
Cite:T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure.
Acta Crystallogr D Struct Biol, 72, 2016
5ET6
  • Download 5et6
  • View 5et6
Molmil generated image of 5et6
HUMAN MUSCLE FRUCTOSE-1,6-BISPHOSPHATASE IN INACTIVE T-STATE IN COMPLEX WITH AMP
Descriptor:Fructose-1,6-bisphosphatase isozyme 2, ADENOSINE MONOPHOSPHATE
Authors:Barciszewski, J., Wisniewski, J., Kolodziejczyk, R., Dzugaj, A., Jaskolski, M., Rakus, D.
Deposit date:2015-11-17
Release date:2016-04-13
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (1.845 Å)
Cite:T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure.
Acta Crystallogr D Struct Biol, 72, 2016
5ET7
  • Download 5et7
  • View 5et7
Molmil generated image of 5et7
HUMAN MUSCLE FRUCTOSE-1,6-BISPHOSPHATASE IN INACTIVE T-STATE
Descriptor:Fructose-1,6-bisphosphatase isozyme 2
Authors:Barciszewski, J., Wisniewski, J., Kolodziejczyk, R., Dzugaj, A., Jaskolski, M., Rakus, D.
Deposit date:2015-11-17
Release date:2016-04-13
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (2.989 Å)
Cite:T-to-R switch of muscle fructose-1,6-bisphosphatase involves fundamental changes of secondary and quaternary structure.
Acta Crystallogr D Struct Biol, 72, 2016
5ET8
  • Download 5et8
  • View 5et8
Molmil generated image of 5et8
HUMAN MUSCLE FRUCTOSE-1,6-BISPHOSPHATASE IN ACTIVE R-STATE IN COMPLEX WITH FRUCTOSE-6-PHOSPHATE
Descriptor:Fructose-1,6-bisphosphatase isozyme 2, FRUCTOSE-6-PHOSPHATE
Authors:Barciszewski, J., Wisniewski, J., Kolodziejczyk, R., Dzugaj, A., Jaskolski, M., Rakus, D.
Deposit date:2015-11-17
Release date:2016-11-23
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:T-to-R switch of muscle FBPase involves extreme changes of secondary and quaternary structure
To Be Published
<12>
PDBj@FacebookPDBj@TwitterwwPDBwwPDB Foundation

Copyright © 2013-2019 Protein Data Bank Japan