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1YR2
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BU of 1yr2 by Molmil
Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Inter-Domain Dynamics in Catalysis and Specificity
Descriptor: GLYCEROL, prolyl oligopeptidase
Authors:Shan, L, Mathews, I.I, Khosla, C.
Deposit date:2005-02-02
Release date:2005-03-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Interdomain Dynamics in Catalysis and Specificity
Proc.Natl.Acad.Sci.USA, 102, 2005
1U9M
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BU of 1u9m by Molmil
Crystal structure of F58W mutant of cytochrome b5
Descriptor: Cytochrome b5, PROTOPORPHYRIN IX CONTAINING FE
Authors:Shan, L, Lu, J.-X, Gan, J.-H, Wang, Y.-H, Huang, Z.-X, Xia, Z.-X.
Deposit date:2004-08-10
Release date:2005-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the F58W mutant of cytochrome b5: the mutation leads to multiple conformations and weakens stacking interactions.
Acta Crystallogr.,Sect.D, 61, 2005
1U9U
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BU of 1u9u by Molmil
Crystal structure of F58Y mutant of cytochrome b5
Descriptor: Cytochrome b5, PROTOPORPHYRIN IX CONTAINING FE
Authors:Shan, L, Lu, J.-X, Gan, J.-H, Wang, Y.-H, Huang, Z.-X, Xia, Z.-X.
Deposit date:2004-08-11
Release date:2005-02-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structure of the F58W mutant of cytochrome b5: the mutation leads to multiple conformations and weakens stacking interactions.
Acta Crystallogr.,Sect.D, 61, 2005
2PQE
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BU of 2pqe by Molmil
Solution structure of proline-free mutant of staphylococcal nuclease
Descriptor: Thermonuclease
Authors:Shan, L, Tong, Y, Xie, T, Wang, M, Wang, J.
Deposit date:2007-05-01
Release date:2007-06-19
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Restricted backbone conformational and motional flexibilities of loops containing peptidyl-proline bonds dominate the enzyme activity of staphylococcal nuclease.
Biochemistry, 46, 2007
2BKL
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BU of 2bkl by Molmil
Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Inter-Domain Dynamics in Catalysis and Specificity
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, N-[(BENZYLOXY)CARBONYL]-L-ALANYL-L-PROLINE, PROLYL ENDOPEPTIDASE, ...
Authors:Khosla, C, Shan, L, Mathews, I.I.
Deposit date:2005-02-16
Release date:2005-03-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Mechanistic Analysis of Two Prolyl Endopeptidases: Role of Interdomain Dynamics in Catalysis and Specificity
Proc.Natl.Acad.Sci.USA, 102, 2005
6WIB
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BU of 6wib by Molmil
Next generation monomeric IgG4 Fc
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin heavy constant gamma 4, ZINC ION
Authors:Oganesyan, V.Y, Shan, L, Dall'Acqua, W, van Dyk, N.
Deposit date:2020-04-09
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.
Commun Biol, 4, 2021
6WOL
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BU of 6wol by Molmil
Next generation monomeric IgG4 Fc bound to neonatal Fc receptor
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, IgG receptor FcRn large subunit p51, ...
Authors:Oganesyan, V.Y, Shan, L, van Dyk, N, Dall'Acqua, W.F.
Deposit date:2020-04-24
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.
Commun Biol, 4, 2021
6WNA
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BU of 6wna by Molmil
Next generation monomeric IgG4 Fc
Descriptor: Beta-2-microglobulin, IgG receptor FcRn large subunit p51, Immunoglobulin heavy constant gamma 4, ...
Authors:Oganesyan, V.Y, Shan, L, van Dyk, N, Dall'Acqua, W.F.
Deposit date:2020-04-22
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.
Commun Biol, 4, 2021
6WMH
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BU of 6wmh by Molmil
Next generation monomeric IgG4 Fc
Descriptor: Immunoglobulin heavy constant gamma 4
Authors:Oganesyan, V.Y, Shan, L, van Dyk, N, Dall'Acqua, W.F.
Deposit date:2020-04-21
Release date:2021-09-15
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance.
Commun Biol, 4, 2021
5HVW
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BU of 5hvw by Molmil
Monomeric IgG4 Fc
Descriptor: GLYCEROL, Ig gamma-4 chain C region, ZINC ION, ...
Authors:Oganesyan, V.Y, Shan, L, Dall'Acqua, W.F.
Deposit date:2016-01-28
Release date:2016-08-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Generation and Characterization of an IgG4 Monomeric Fc Platform.
Plos One, 11, 2016
1B2W
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BU of 1b2w by Molmil
COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY
Descriptor: PROTEIN (ANTIBODY (HEAVY CHAIN)), PROTEIN (ANTIBODY (LIGHT CHAIN))
Authors:Fan, Z, Shan, L, Goldsteen, B.Z, Guddat, L.W, Thakur, A, Landolfi, N.F, Co, M.S, Vasquez, M, Queen, C, Ramsland, P.A, Edmundson, A.B.
Deposit date:1998-12-01
Release date:1999-05-06
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-gamma-interferon antibody.
J.Mol.Recog., 12, 1999
1B4J
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BU of 1b4j by Molmil
COMPARISON OF THE THREE-DIMENSIONAL STRUCTURES OF A HUMANIZED AND A CHIMERIC FAB OF AN ANTI-GAMMA-INTERFERON ANTIBODY
Descriptor: ANTIBODY
Authors:Fan, Z, Shan, L, Goldsteen, B.Z, Guddat, L.W, Thakur, A, Landolfi, N.F, Co, M.S, Vasques, M, Queen, C, Ramsland, P.A, Edmundson, A.B.
Deposit date:1998-12-22
Release date:1999-06-15
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Comparison of the three-dimensional structures of a humanized and a chimeric Fab of an anti-gamma-interferon antibody.
J.Mol.Recog., 12, 1999
1CGS
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BU of 1cgs by Molmil
LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB
Descriptor: IGG2B-KAPPA NC6.8 FAB (HEAVY CHAIN), IGG2B-KAPPA NC6.8 FAB (LIGHT CHAIN)
Authors:Guddat, L.W, Shan, L, Edmundson, A.B.
Deposit date:1993-10-06
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Local and transmitted conformational changes on complexation of an anti-sweetener Fab.
J.Mol.Biol., 236, 1994
1ETZ
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BU of 1etz by Molmil
THE THREE-DIMENSIONAL STRUCTURE OF AN ANTI-SWEETENER FAB, NC10.14, SHOWS THE EXTENT OF STRUCTURAL DIVERSITY IN ANTIGEN RECOGNITION BY IMMUNOGLOBULINS
Descriptor: FAB NC10.14 - HEAVY CHAIN, FAB NC10.14 - LIGHT CHAIN, N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID
Authors:Guddat, L.W, Shan, L, Broomell, C, Ramsland, P.A, Fan, Z, Anchin, J.M, Linthicum, D.S, Edmundson, A.B.
Deposit date:2000-04-13
Release date:2000-10-18
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The three-dimensional structure of a complex of a murine Fab (NC10. 14) with a potent sweetener (NC174): an illustration of structural diversity in antigen recognition by immunoglobulins.
J.Mol.Biol., 302, 2000
2CGR
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BU of 2cgr by Molmil
LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB
Descriptor: IGG2B-KAPPA NC6.8 FAB (HEAVY CHAIN), IGG2B-KAPPA NC6.8 FAB (LIGHT CHAIN), N-(P-CYANOPHENYL)-N'-DIPHENYLMETHYL-GUANIDINE-ACETIC ACID
Authors:Guddat, L.W, Shan, L, Edmundson, A.B.
Deposit date:1993-11-23
Release date:1994-05-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Local and transmitted conformational changes on complexation of an anti-sweetener Fab.
J.Mol.Biol., 236, 1994
1DQL
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BU of 1dql by Molmil
CRYSTAL STRUCTURE OF AN UNLIGANDED (NATIVE) FV FROM A HUMAN IGM ANTI-PEPTIDE ANTIBODY
Descriptor: IGM MEZ IMMUNOGLOBULIN
Authors:Ramsland, P.A, Shan, L, Moomaw, C.R, Slaughter, C.A, Guddat, L.W, Edmundson, A.B.
Deposit date:2000-01-04
Release date:2000-10-04
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An unusual human IgM antibody with a protruding HCDR3 and high avidity for its peptide ligands.
Mol.Immunol., 37, 2000
1NOT
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BU of 1not by Molmil
THE 1.2 ANGSTROM STRUCTURE OF G1 ALPHA CONOTOXIN
Descriptor: GI ALPHA CONOTOXIN
Authors:Guddat, L.W, Shan, L, Martin, J.L, Edmundson, A.B, Gray, W.R.
Deposit date:1996-05-02
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Three-dimensional structure of the alpha-conotoxin GI at 1.2 A resolution
Biochemistry, 35, 1996
1JVK
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BU of 1jvk by Molmil
THREE-DIMENSIONAL STRUCTURE OF AN IMMUNOGLOBULIN LIGHT CHAIN DIMER ACTING AS A LETHAL AMYLOID PRECURSOR
Descriptor: IMMUNOGLOBULIN LAMBDA LIGHT CHAIN
Authors:Bourne, P.C, Ramsland, P.A, Shan, L, Fan, Z.-C, DeWitt, C.R, Shultz, B.B, Terzyan, S.S, Edmundson, A.B.
Deposit date:2001-08-30
Release date:2002-05-03
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Three-dimensional structure of an immunoglobulin light-chain dimer with amyloidogenic properties.
Acta Crystallogr.,Sect.D, 58, 2002
1RKN
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BU of 1rkn by Molmil
Solution structure of 1-110 fragment of Staphylococcal Nuclease with G88W mutation
Descriptor: Thermonuclease
Authors:Liu, D.S, Feng, Y.G, Ye, K.Q, Shan, L, Wang, J.F.
Deposit date:2003-11-22
Release date:2004-12-07
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Folding stability and cooperativity of the three forms of 1-110 residues fragment of staphylococcal nuclease
Biophys.J., 92, 2007
2M00
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BU of 2m00 by Molmil
Solution structure of staphylococcal nuclease E43S mutant in the presence of ssDNA and Cd2+
Descriptor: Thermonuclease
Authors:Xie, T, Feng, Y, Shan, L, Wang, J.
Deposit date:2012-10-14
Release date:2013-03-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Modeling of the [E43S]SNase-ssDNA-Cd(2+) complex: Structural insight into the action of nuclease on ssDNA.
Arch.Biochem.Biophys., 532, 2013
2F3W
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BU of 2f3w by Molmil
solution structure of 1-110 fragment of staphylococcal nuclease in 2M TMAO
Descriptor: Thermonuclease
Authors:Liu, D, Xie, T, Feng, Y, Shan, L, Ye, K, Wang, J.
Deposit date:2005-11-22
Release date:2006-12-05
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Folding stability and cooperativity of the three forms of 1-110 residues fragment of staphylococcal nuclease
Biophys.J., 92, 2007
2F3V
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BU of 2f3v by Molmil
Solution structure of 1-110 fragment of staphylococcal nuclease with V66W mutation
Descriptor: Thermonuclease
Authors:Liu, D, Xie, T, Feng, Y, Shan, L, Ye, K, Wang, J.
Deposit date:2005-11-22
Release date:2006-12-05
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Folding stability and cooperativity of the three forms of 1-110 residues fragment of staphylococcal nuclease
Biophys.J., 92, 2007
2FXZ
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BU of 2fxz by Molmil
Solution structure of 97-109 segment of staphylococcal nuclease
Descriptor: 13-mer peptide from Thermonuclease
Authors:Wang, M, Shan, L, Wang, J.F.
Deposit date:2006-02-07
Release date:2006-12-19
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Two peptide fragments G55-I72 and K97-A109 from staphylococcal nuclease exhibit different behaviors in conformational preferences for helix formation
Biopolymers, 83, 2006
2FXY
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BU of 2fxy by Molmil
Solution structure of 55-72 segment of staphylococcal nuclease
Descriptor: 18-mer peptide from Thermonuclease
Authors:Wang, M, Shan, L, Wang, J.F.
Deposit date:2006-02-07
Release date:2006-12-19
Last modified:2022-03-09
Method:SOLUTION NMR
Cite:Two peptide fragments G55-I72 and K97-A109 from staphylococcal nuclease exhibit different behaviors in conformational preferences for helix formation
Biopolymers, 83, 2006
2KHS
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BU of 2khs by Molmil
Solution structure of SNase121:SNase(111-143) complex
Descriptor: Nuclease, Thermonuclease
Authors:Geng, Y, Feng, Y, Xie, T, Shan, L, Wang, J.
Deposit date:2009-04-10
Release date:2009-10-20
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The native-like interactions between SNase121 and SNase(111-143) fragments induce the recovery of their native-like structures and the ability to degrade DNA.
Biochemistry, 48, 2009

 

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