Author results

2VNA
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STRUCTURE OF HUMAN ZINC-BINDING ALCOHOL DEHYDROGENASE 1 (ZADH1)
Descriptor:PROSTAGLANDIN REDUCTASE 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Shafqat, N., Kavanagh, K., Pike, A.C.W., Muniz, J.R.C., Pilka, E., Roos, A.K., Picaud, S., Johansson, C., Smee, C., Fedorov, O., Kochan, G., Edwards, A., Arrowsmith, C.H., Weigelt, J., Bountra, C., von Delft, F., Opperman, U.
Deposit date:2008-02-01
Release date:2009-02-17
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Structure of Human Zinc-Binding Alcohol Dehydrogenase 1 (Zadh1)
To be Published
2W4Q
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CRYSTAL STRUCTURE OF HUMAN ZINC-BINDING ALCOHOL DEHYDROGENASE 1 (ZADH1) IN TERNARY COMPLEX WITH NADP AND 18BETA-GLYCYRRHETINIC ACID
Descriptor:PROSTAGLANDIN REDUCTASE 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (3BETA,5BETA,14BETA)-3-HYDROXY-11-OXOOLEAN-12-EN-29-OIC ACID, ...
Authors:Shafqat, N., Yue, W.W., Ugochukwu, E., Picaud, S., Niesen, F., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2008-11-30
Release date:2009-01-20
Last modified:2013-12-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of Human Zinc-Binding Alcohol Dehydrogenase 1
To be Published
2W98
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CRYSTAL STRUCTURE OF HUMAN ZINC-BINDING ALCOHOL DEHYDROGENASE 1 (ZADH1) IN TERNARY COMPLEX WITH NADP AND PHENYLBUTAZONE
Descriptor:PROSTAGLANDIN REDUCTASE 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-BUTYL-1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE, ...
Authors:Shafqat, N., Yue, W.W., Muniz, J., Picaud, S., Niesen, F., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-01-22
Release date:2009-04-07
Last modified:2013-12-04
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of Human Zinc-Binding Alcohol Dehydrogenase 1
To be Published
2WEK
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CRYSTAL STRUCTURE OF THE HUMAN MGC45594 GENE PRODUCT IN COMPLEX WITH DICLOFENAC
Descriptor:ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, ...
Authors:Shafqat, N., Yue, W.W., Ugochukwu, E., Niesen, F., Smee, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-03-31
Release date:2009-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Human Mgc45594 Gene Product in Complex with Diclofenac
To be Published
2X1H
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CRYSTAL STRUCTURE OF THE HUMAN MGC45594 GENE PRODUCT IN COMPLEX WITH RALOXIFENE
Descriptor:ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2, 1,2-ETHANEDIOL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Shafqat, N., Yue, W.W., Pike, A.C.W., Niesen, F., Ugochukwu, E., Krojer, T., Chaikuad, A., Smee, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-12-24
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of the Human Mgc45594 Gene Product in Complex with Raloxifene
To be Published
2X7H
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CRYSTAL STRUCTURE OF THE HUMAN MGC45594 GENE PRODUCT IN COMPLEX WITH FENOPROFEN
Descriptor:ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2, FENOPROFEN, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Shafqat, N., Yue, W.W., Ugochukwu, E., Niesen, F., Vollmar, M., Chaikuad, A., Pike, A.C.W., von Delft, F., Smee, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-02-26
Release date:2010-12-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of the Human Mgc45594 Gene Product in Complex with Fenoprofen
To be Published
2P8U
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CRYSTAL STRUCTURE OF HUMAN 3-HYDROXY-3-METHYLGLUTARYL COA SYNTHASE I
Descriptor:Hydroxymethylglutaryl-CoA synthase, cytoplasmic, COENZYME A, ...
Authors:Turnbull, A., Shafqat, N., Salah, E., Niesen, F.H., Burgess, N., Bunkoczi, G., Debreczeni, J., Pike, A.C.W., Umeano, C., Gorrec, F., von Delft, F., Weigelt, J., Arrowsmith, C.H., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-03-23
Release date:2007-04-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of human HMG-CoA synthase isoforms provide insights into inherited ketogenesis disorders and inhibitor design.
J.Mol.Biol., 398, 2010
2WH5
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA BINDING DOMAIN 4 COMPLEXED WITH STEAROYL-COA
Descriptor:ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4, STEARIC ACID, STEAROYL-COENZYME A, ...
Authors:Yue, W.W., Shafqat, N., Ugochukwu, E., Savitsky, P., Johansson, C., Salah, E., Roos, A.K., Chaikuad, A., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-04-30
Release date:2009-07-28
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Human Acyl-Coa Binding Domain 4
To be Published
2WYA
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CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL 3-HYDROXY-3-METHYLGLUTARYL- COENZYME A SYNTHASE 2 (HMGCS2)
Descriptor:HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ...
Authors:Yue, W.W., Shafqat, N., Savitsky, P., Roos, A.K., Cooper, C., Murray, J.W., von Delft, F., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-11-13
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structures of Human Hmg-Coa Synthase Isoforms Provide Insights Into Inherited Ketogenesis Disorders and Inhibitor Design.
J.Mol.Biol., 398, 2010
2YDX
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CRYSTAL STRUCTURE OF HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 2, BETA SUBUNIT
Descriptor:METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA, RESVERATROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Muniz, J.R.C., Shafqat, N., Pike, A.C.W., Yue, W.W., Vollmar, M., Papagriogriou, V., Roos, A., Gileadi, O., von Delft, F., Kavanagh, K.L., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U.
Deposit date:2011-03-25
Release date:2011-04-27
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insight Into S-Adenosylmethionine Biosynthesis from the Crystal Structures of the Human Methionine Adenosyltransferase Catalytic and Regulatory Subunits.
Biochem.J., 452, 2013
2YDY
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CRYSTAL STRUCTURE OF HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 2, BETA SUBUNIT IN ORTHORHOMBIC CRYSTAL FORM
Descriptor:METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA, SULFATE ION, CHLORIDE ION
Authors:Yue, W.W., Shafqat, N., Muniz, J.R.C., Pike, A.C.W., Chaikuad, A., Allerston, C.K., Gileadi, O., von Delft, F., Kavanagh, K.L., Arrowsmith, C.H., Edwards, A.M., Weigelt, J., Bountra, C., Oppermann, U.
Deposit date:2011-03-25
Release date:2011-04-20
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Insight Into S-Adenosylmethionine Biosynthesis from the Crystal Structures of the Human Methionine Adenosyltransferase Catalytic and Regulatory Subunits.
Biochem.J., 452, 2013
2VSV
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CRYSTAL STRUCTURE OF THE PDZ DOMAIN OF HUMAN RHOPHILIN-2
Descriptor:RHOPHILIN-2
Authors:Pike, A.C.W., Kochan, G., Sun, Z., Shafqat, N., Pilka, E.S., Roos, A., Elkins, J., Burgess-Brown, N., Murray, J.W., von Delft, F., Wikstrom, M., Edwards, A., Arrowsmith, C.H., Bountra, C., Oppermann, U.
Deposit date:2008-04-29
Release date:2008-07-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure of the Pdz Domain of Human Rhophilin-2
To be Published
2WM8
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CRYSTAL STRUCTURE OF HUMAN MAGNESIUM-DEPENDENT PHOSPHATASE 1 OF THE HALOACID DEHALOGENASE SUPERFAMILY (MGC5987)
Descriptor:MAGNESIUM-DEPENDENT PHOSPHATASE 1, 1,2-ETHANEDIOL
Authors:Yue, W.W., Shafqat, N., Pike, A.C.W., Chaikuad, A., Bray, J.E., Pilka, E.W., Burgess-Brown, N., Hapka, E., Filippakopoulos, P., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-06-30
Release date:2009-07-28
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structure of Human Magnesium-Dependent Phosphatase 1 of the Haloacid Dehalogenase Superfamily (Mgc5987)
To be Published
1ZBQ
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CRYSTAL STRUCTURE OF HUMAN 17-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 4 IN COMPLEX WITH NAD
Descriptor:17-beta-hydroxysteroid dehydrogenase 4, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Lukacik, P., Shafqat, N., Kavanagh, K., Bray, J., von Delft, F., Edwards, A., Arrowsmith, C., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-04-08
Release date:2005-04-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Crystal Structure Of Human 17-Beta-Hydroxysteroid Dehydrogenase Type 4 In Complex With NAD
To be Published
1ZSY
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THE STRUCTURE OF HUMAN MITOCHONDRIAL 2-ENOYL THIOESTER REDUCTASE (CGI-63)
Descriptor:MITOCHONDRIAL 2-ENOYL THIOESTER REDUCTASE, SULFATE ION, GLYCEROL
Authors:Lukacik, P., Shafqat, N., Kavanagh, K.L., Johansson, C., Smee, C., Edwards, A., Arrowsmith, C., Sundstrom, M., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-05-25
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structure of human mitochondrial 2-enoyl thioester reductase (CGI-63)
To be Published
2C0C
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STRUCTURE OF THE MGC45594 GENE PRODUCT
Descriptor:ZINC BINDING ALCOHOL DEHYDROGENASE, DOMAIN CONTAINING 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Bunkoczi, G., Shafqat, N., Guo, K., Smee, C., Arrowsmith, C., Edwards, A., Weigelt, J., Sundstrom, M., Gileadi, O., von Delft, F., Oppermann, U.
Deposit date:2005-08-30
Release date:2005-09-12
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Structure of Mgc45594 Gene Product
To be Published
2DFD
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CRYSTAL STRUCTURE OF HUMAN MALATE DEHYDROGENASE TYPE 2
Descriptor:Malate dehydrogenase, D-MALATE, CHLORIDE ION, ...
Authors:Ugochukwu, E., Shafqat, N., Rojkova, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-02-28
Release date:2006-03-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of Human Malate Dehydrogenase Type 2
To be Published
2F6Q
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THE CRYSTAL STRUCTURE OF HUMAN PEROXISOMAL DELTA3, DELTA2 ENOYL COA ISOMERASE (PECI)
Descriptor:Peroxisomal 3,2-trans-enoyl-CoA isomerase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Turnbull, A., Lukacik, P., Shafqat, N., Smee, C., Berridge, G., Guo, K., von Delft, F., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Gileadi, O., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2005-11-29
Release date:2005-12-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The crystal structure of human peroxisomal delta3, delta2 enoyl CoA isomerase (PECI)
To be Published
2H5G
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CRYSTAL STRUCTURE OF HUMAN PYRROLINE-5-CARBOXYLATE SYNTHETASE
Descriptor:Delta 1-pyrroline-5-carboxylate synthetase, SULFATE ION
Authors:Papagrigoriou, E., Shafqat, N., Turnbull, A.P., Berridge, G., Hozjan, V., Kavanagh, K., Gileadi, O., Smee, C., Bray, J., Gorrec, F., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-05-26
Release date:2006-06-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal structure of human pyrroline-5-carboxylate synthetase
To be published
2J8Z
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CRYSTAL STRUCTURE OF HUMAN P53 INDUCIBLE OXIDOREDUCTASE (TP53I3,PIG3)
Descriptor:QUINONE OXIDOREDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Pike, A.C.W., Shafqat, N., Debreczeni, J., Johansson, C., Haroniti, A., Gileadi, O., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., von Delft, F., Porte, S., Fita, I., Pares, J., Pares, X., Oppermann, U.
Deposit date:2006-10-31
Release date:2006-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Three-Dimensional Structure and Enzymatic Function of Proapoptotic Human P53-Inducible Quinone Oxidoreductase Pig3.
J.Biol.Chem., 284, 2009
2O23
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THE STRUCTURE OF WILD-TYPE HUMAN HADH2 (17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 10) BOUND TO NAD+ AT 1.2 A
Descriptor:HADH2 protein, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, GLYCEROL
Authors:Kavanagh, K.L., Shafqat, N., Scholer, K., Debreczeni, J., Zschocke, J., von Delft, F., Weigelt, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-11-29
Release date:2006-12-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:The structure of wild-type human HADH2 (17beta-hydroxysteroid dehydrogenase type 10) bound to NAD+ at 1.2 A
To be Published
2OBV
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CRYSTAL STRUCTURE OF THE HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 1 IN COMPLEX WITH THE PRODUCT
Descriptor:S-adenosylmethionine synthetase isoform type-1, SODIUM ION, S-ADENOSYLMETHIONINE, ...
Authors:Pilka, E.S., Shafqat, N., Kavanagh, K.L., Cooper, C., Hozjan, V., Turnbull, A., von Delft, F., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-12-20
Release date:2007-01-02
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of the human S-adenosylmethionine synthetase 1 in complex with the product.
To be Published
2OBY
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CRYSTAL STRUCTURE OF HUMAN P53 INDUCIBLE OXIDOREDUCTASE (TP53I3,PIG3)
Descriptor:Putative quinone oxidoreductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Porte, S., Valencia, E., Farres, J., Fita, I., Pike, A.C.W., Shafqat, N., Debreczeni, J., Johansson, C., Haroniti, A., Gileadi, O., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., von Delft, F., Oppermann, U., Pares, X.
Deposit date:2006-12-20
Release date:2007-01-30
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human P53 inducible oxidoreductase (TP53I3, PIG3)
To be Published
2P02
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CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF HUMAN S-ADENOSYLMETHIONINE SYNTHETASE 2
Descriptor:S-adenosylmethionine synthetase isoform type-2, CHLORIDE ION, S-ADENOSYLMETHIONINE
Authors:Papagrigoriou, E., Shafqat, N., Rojkova, A., Niessen, F.H., Kavanagh, K.L., von Delft, F., Gorrec, F., Ugochukwu, E., Arrowsmith, C.H., Edwards, A., Weigelt, J., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-02-28
Release date:2007-03-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Crystal structure of the alpha subunit of human S-adenosylmethionine synthetase 2
To be Published
2VSP
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CRYSTAL STRUCTURE OF THE FOURTH PDZ DOMAIN OF PDZ DOMAIN-CONTAINING PROTEIN 1
Descriptor:PDZ DOMAIN-CONTAINING PROTEIN 1
Authors:Yue, W.W., Shafqat, N., Pilka, E.S., Johansson, C., Murray, J.W., Elkins, J., Roos, A., Cooper, C., Phillips, C., Salah, E., von Delft, F., Doyle, D., Edwards, A., Wikstrom, M., Arrowsmith, C., Bountra, C., Oppermann, U.
Deposit date:2008-04-28
Release date:2009-03-03
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Crystal Structure of the Fourth Pdz Domain of Pdz Domain-Containing Protein 1
To be Published
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