Author results

4E94
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CRYSTAL STRUCTURE OF MCCF-LIKE PROTEIN FROM STREPTOCOCCUS PNEUMONIAE
Descriptor:MccC family protein, SULFATE ION, GLYCEROL
Authors:Nocek, B., Tikhonov, A., Kwon, K., Severinov, K., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-03-20
Release date:2012-05-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.651 Å)
Cite:Crystal structure of MccF-like protein from Streptococcus pneumoniae
TO BE PUBLISHED
5W4K
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH KLEBSAZOLICIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.7A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Metelev, M., Osterman, I.A., Ghilarov, D., Khabibullina, N.F., Yakimov, A., Shabalin, K., Utkina, I., Travin, D.Y., Komarova, E.S., Serebryakova, M., Artamonova, T., Khodorkovskii, M., Konevega, A.L., Sergiev, P.V., Severinov, K., Polikanov, Y.S.
Deposit date:2017-06-12
Release date:2017-08-30
Last modified:2018-06-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel.
Nat. Chem. Biol., 13, 2017
5UI6
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SOLUTION NMR STRUCTURE OF LASSO PEPTIDE ACINETODIN
Descriptor:Acinetodin
Authors:Bushin, L.B., Metelev, M., Severinov, K., Seyedsayamdost, M.R.
Deposit date:2017-01-12
Release date:2017-02-08
Last modified:2017-03-29
Method:SOLUTION NMR
Cite:Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae.
ACS Chem. Biol., 12, 2017
5UI7
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SOLUTION NMR STRUCTURE OF LASSO PEPTIDE KLEBSIDIN
Descriptor:Klebsidin
Authors:Bushin, L.B., Metelev, M., Severinov, K., Seyedsayamdost, M.R.
Deposit date:2017-01-13
Release date:2017-02-08
Last modified:2017-03-29
Method:SOLUTION NMR
Cite:Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae.
ACS Chem. Biol., 12, 2017
1YNN
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TAQ RNA POLYMERASE-RIFAMPICIN COMPLEX
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Campbell, E.A., Pavlova, O., Zenkin, N., Leon, F., Irschik, H., Jansen, R., Severinov, K., Darst, S.A.
Deposit date:2005-01-24
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
1HQM
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CRYSTAL STRUCTURE OF THERMUS AQUATICUS CORE RNA POLYMERASE-INCLUDES COMPLETE STRUCTURE WITH SIDE-CHAINS (EXCEPT FOR DISORDERED REGIONS)-FURTHER REFINED FROM ORIGINAL DEPOSITION-CONTAINS ADDITIONAL SEQUENCE INFORMATION
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Minakhin, L., Bhagat, S., Brunning, A., Campbell, E.A., Darst, S.A., Ebright, R.H., Severinov, K.
Deposit date:2000-12-18
Release date:2001-02-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly.
Proc.Natl.Acad.Sci.USA, 98, 2001
1YNJ
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TAQ RNA POLYMERASE-SORANGICIN COMPLEX
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Campbell, E.A., Pavlova, O., Zenkin, N., Leon, F., Irschik, H., Jansen, R., Severinov, K., Darst, S.A.
Deposit date:2005-01-24
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
2A6H
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC STERPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Temiakov, D., Zenkin, N., Vassylyeva, M.N., Perederina, A., Tahirov, T.H., Savkina, M., Zorov, S., Nikiforov, V., Igarashi, N., Matsugaki, N., Wakatsuki, S., Severinov, K., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of transcription inhibition by antibiotic streptolydigin.
Mol.Cell, 19, 2005
2MC5
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A BACTERIOPHAGE TRANSCRIPTION REGULATOR INHIBITS BACTERIAL TRANSCRIPTION INITIATION BY -FACTOR DISPLACEMENT
Descriptor:45L
Authors:Liu, B., Shadrin, A., Sheppard, C., Xu, Y., Severinov, K., Matthews, S., Wigneshweraraj, S.
Deposit date:2013-08-14
Release date:2014-03-26
Last modified:2014-04-30
Method:SOLUTION NMR
Cite:A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement.
Nucleic Acids Res., 42, 2014
2MC6
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A BACTERIOPHAGE TRANSCRIPTION REGULATOR INHIBITS BACTERIAL TRANSCRIPTION INITIATION BY SIGMA-FACTOR DISPLACEMENT
Descriptor:RNA polymerase inhibitor p7, DNA-directed RNA polymerase subunit beta'
Authors:Liu, B., Shadrin, A., Sheppard, C., Xu, Y., Severinov, K., Matthews, S., Wigneshweraraj, S.
Deposit date:2013-08-15
Release date:2014-04-02
Last modified:2014-05-07
Method:SOLUTION NMR
Cite:A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement.
Nucleic Acids Res., 42, 2014
2MW3
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SOLUTION NMR STRUCTURE OF THE LASSO PEPTIDE STREPTOMONOMICIN
Descriptor:Lasso peptide
Authors:Tietz, J.I., Zhu, L., Mitchell, D.A., Metelev, M., Melby, J.O., Blair, P.M., Livnat, I., Severinov, K.
Deposit date:2014-10-24
Release date:2015-01-28
Last modified:2015-03-04
Method:SOLUTION NMR
Cite:Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete.
Chem.Biol., 22, 2015
3WOD
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RNA POLYMERASE-GP39 COMPLEX
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Tagami, S., Sekine, S., Minakhin, L., Esyunina, D., Akasaka, R., Shirouzu, M., Kulbachinskiy, A., Severinov, K., Yokoyama, S.
Deposit date:2013-12-26
Release date:2014-03-12
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
Genes Dev., 28, 2014
3WOE
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CRYSTAL STRUCTURE OF P23-45 GP39 (6-109) BOUND TO THERMUS THERMOPHILUS RNA POLYMERASE BETA-FLAP DOMAIN
Descriptor:DNA-directed RNA polymerase subunit beta, Putative uncharacterized protein
Authors:Tagami, S., Sekine, S., Minakhin, L., Esyunina, D., Akasaka, R., Shirouzu, M., Kulbachinskiy, A., Severinov, K., Yokoyama, S.
Deposit date:2013-12-26
Release date:2014-03-12
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.351 Å)
Cite:Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
Genes Dev., 28, 2014
3WOF
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CRYSTAL STRUCTURE OF P23-45 GP39 (6-132) BOUND TO THERMUS THERMOPHILUS RNA POLYMERASE BETA-FLAP DOMAIN
Descriptor:DNA-directed RNA polymerase subunit beta, Putative uncharacterized protein
Authors:Tagami, S., Sekine, S., Minakhin, L., Esyunina, D., Akasaka, R., Shirouzu, M., Kulbachinskiy, A., Severinov, K., Yokoyama, S.
Deposit date:2013-12-26
Release date:2014-03-12
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3.298 Å)
Cite:Structural basis for promoter specificity switching of RNA polymerase by a phage factor.
Genes Dev., 28, 2014
4INJ
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CRYSTAL STRUCTURE OF THE S111A MUTANT OF MEMBER OF MCCF CLADE FROM LISTERIA MONOCYTOGENES EGD-E WITH PRODUCT
Descriptor:Lmo1638 protein, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDRO-2-FURANYL]METHYL SULFAMATE, MAGNESIUM ION, ...
Authors:Nocek, B., Tikhonov, A., Severinov, K., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2013-01-04
Release date:2013-02-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the S111A mutant of member of MccF clade from Listeria monocytogenes EGD-e with product
To be Published
4JVO
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CRYSTAL STRUCTURE OF THE DOUBLE MUTANT (S112A, H303A) OF B.ANTHRACIS MYCROCINE IMMUNITY PROTEIN (MCCF) WITH ALANYL SULFAMOYL ADENYLATES
Descriptor:Microcin immunity protein MccF, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, GLYCEROL
Authors:Nocek, B., Tikhonov, A., Severinov, K., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2013-03-25
Release date:2013-06-12
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of the double mutant (S112A, H303A) of B.anthracis mycrocine immunity protein (MccF) with alanyl sulfamoyl adenylates
TO BE PUBLISHED
4MI1
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CRYSTAL STRUCTURE OF THE DOUBLE MUTANT (S112A, H303A) OF B.ANTHRACIS MYCROCINE IMMUNITY PROTEIN (MCCF) WITH ASPARTYL SULFAMOYL ADENYLATES
Descriptor:Microcin immunity protein MccF, 5'-O-(L-alpha-aspartylsulfamoyl)adenosine, SULFATE ION
Authors:Nocek, B., Severinov, K., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2013-08-30
Release date:2014-04-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the double mutant (S112A, H303A) of B.anthracis mycrocine immunity protein (MccF) with aspartyl sulfamoyl adenylates
TO BE PUBLISHED
4ZJN
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CRYSTAL STRUCTURE OF THE BACTERIOPHAGE G20C PORTAL PROTEIN
Descriptor:Portal protein, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Williams, L.S., Turkenburg, J.P., Levdikov, V.M., Minakhin, L., Severinov, K., Antson, A.A.
Deposit date:2015-04-29
Release date:2015-05-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structure of the bacteriophage G20C portal protein
To be published
5F5X
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CRYSTAL STRUCTURE OF S116A BA3275 WITH AMP BOUND
Descriptor:MccC family protein Ba3275, ADENOSINE MONOPHOSPHATE
Authors:Nocek, B., Severinov, K., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2015-12-04
Release date:2015-12-30
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.006 Å)
Cite:Crystal structure of Ba3275-AMP complex from Bacillus cereus ATCC 10987
To Be Published
5F9M
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CRYSTAL STRUCTURE OF NATIVE B3275, MEMBER OF MCCF FAMILY OF ENZYMES
Descriptor:MccC family protein
Authors:Nocek, B., Severinov, K., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2015-12-09
Release date:2015-12-30
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Crystal structure of native B3275, member of MccF family of enzymes.
To Be Published
5FCD
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CRYSTAL STRUCTURE OF MCCD PROTEIN
Descriptor:UNK-UNK-UNK-MSE-UNK, UNK-UNK-UNK-UNK-MSE-UNK, MccD, ...
Authors:Nocek, B., Jedrzejczak, R., Anderson, W.F., Severinov, K., Dubiley, S., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2015-12-15
Release date:2015-12-30
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of MccD protein.
To Be Published
5FD8
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CRYSTAL STRUCTURE OF MCCF-LIKE PROTEIN (BA_5613) IN COMPLEX WITH ASA (ALANYL SULFAMOYL ADENYLATES)
Descriptor:LD-carboxypeptidase family protein, '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE
Authors:Nocek, B., Severinov, K., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2015-12-15
Release date:2015-12-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of MccF-like Protein (BA_5613) in complex with ASA ( (alanyl sulfamoyl adenylates)
To Be Published
5K99
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CRYSTAL STRUCTURE OF MICROCIN IMMUNITY PROTEIN MCCF FROM BACILLUS ANTHRACIS IN COMPLEX WITH MCC
Descriptor:Microcin C7 self-immunity protein mccF, Microcin C
Authors:Nocek, B., Kulikovsky, A., Severinov, K., Dubiley, S., Joachimiak, A., Anderson, W.F., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-05-31
Release date:2017-03-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of microcin immunity protein MccF from Bacillus anthracis in complex with McC
To Be Published
5NJ5
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E. COLI MICROCIN-PROCESSING METALLOPROTEASE TLDD/E WITH PHOSPHATE BOUND
Descriptor:Metalloprotease TldD, Metalloprotease PmbA, ZINC ION, ...
Authors:Ghilarov, D., Serebryakova, M., Stevenson, C.E.M., Hearnshaw, S.J., Volkov, D., Maxwell, A., Lawson, D.M., Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017
5NJ9
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E. COLI MICROCIN-PROCESSING METALLOPROTEASE TLDD/E WITH DRVY ANGIOTENSIN FRAGMENT BOUND
Descriptor:Metalloprotease TldD, Metalloprotease PmbA, ASP-ARG-VAL-TYR, ...
Authors:Ghilarov, D., Serebryakova, M., Stevenson, C.E.M., Hearnshaw, S.J., Volkov, D., Maxwell, A., Lawson, D.M., Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017