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1HQM
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CRYSTAL STRUCTURE OF THERMUS AQUATICUS CORE RNA POLYMERASE-INCLUDES COMPLETE STRUCTURE WITH SIDE-CHAINS (EXCEPT FOR DISORDERED REGIONS)-FURTHER REFINED FROM ORIGINAL DEPOSITION-CONTAINS ADDITIONAL SEQUENCE INFORMATION
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Minakhin, L., Bhagat, S., Brunning, A., Campbell, E.A., Darst, S.A., Ebright, R.H., Severinov, K.
Deposit date:2000-12-18
Release date:2001-02-07
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly.
Proc.Natl.Acad.Sci.USA, 98, 2001
1SIG
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CRYSTAL STRUCTURE OF A SIGMA70 SUBUNIT FRAGMENT FROM ESCHERICHIA COLI RNA POLYMERASE
Descriptor:RNA POLYMERASE PRIMARY SIGMA FACTOR
Authors:Malhotra, A., Severinova, E., Darst, S.A.
Deposit date:1997-02-18
Release date:1997-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a sigma 70 subunit fragment from E. coli RNA polymerase.
Cell(Cambridge,Mass.), 87, 1996
1YNJ
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TAQ RNA POLYMERASE-SORANGICIN COMPLEX
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Campbell, E.A., Pavlova, O., Zenkin, N., Leon, F., Irschik, H., Jansen, R., Severinov, K., Darst, S.A.
Deposit date:2005-01-24
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
1YNN
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TAQ RNA POLYMERASE-RIFAMPICIN COMPLEX
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Campbell, E.A., Pavlova, O., Zenkin, N., Leon, F., Irschik, H., Jansen, R., Severinov, K., Darst, S.A.
Deposit date:2005-01-24
Release date:2005-03-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
2A6E
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Artsimovitch, I., Vassylyeva, M.N., Svetlov, D., Svetlov, V., Perederina, A., Igarashi, N., Matsugaki, N., Wakatsuki, S., Tahirov, T.H., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Allosteric modulation of the RNA polymerase catalytic reaction is an essential component of transcription control by rifamycins.
Cell(Cambridge,Mass.), 122, 2005
2A6H
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CRYSTAL STRUCTURE OF THE T. THERMOPHILUS RNA POLYMERASE HOLOENZYME IN COMPLEX WITH ANTIBIOTIC STERPTOLYDIGIN
Descriptor:DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Temiakov, D., Zenkin, N., Vassylyeva, M.N., Perederina, A., Tahirov, T.H., Savkina, M., Zorov, S., Nikiforov, V., Igarashi, N., Matsugaki, N., Wakatsuki, S., Severinov, K., Vassylyev, D.G., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of transcription inhibition by antibiotic streptolydigin.
Mol.Cell, 19, 2005
2GHO
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RECOMBINANT THERMUS AQUATICUS RNA POLYMERASE FOR STRUCTURAL STUDIES
Descriptor:DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta',DNA-directed RNA polymerase subunit beta'
Authors:Lamour, V., Darst, S.A.
Deposit date:2006-03-27
Release date:2006-05-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (5 Å)
Cite:Recombinant Thermus aquaticus RNA Polymerase for Structural Studies.
J.Mol.Biol., 359, 2006
2LMC
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STRUCTURE OF T7 TRANSCRIPTION FACTOR GP2-E. COLI RNAP JAW DOMAIN COMPLEX
Descriptor:Bacterial RNA polymerase inhibitor, DNA-directed RNA polymerase subunit beta
Authors:Liu, M.
Deposit date:2011-11-29
Release date:2012-03-14
Last modified:2012-10-03
Method:SOLUTION NMR
Cite:Structural and Mechanistic Basis for the Inhibition of Escherichia coli RNA Polymerase by T7 Gp2.
Mol.Cell, 47, 2012
2MC5
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A BACTERIOPHAGE TRANSCRIPTION REGULATOR INHIBITS BACTERIAL TRANSCRIPTION INITIATION BY -FACTOR DISPLACEMENT
Descriptor:45L
Authors:Liu, B., Shadrin, A., Sheppard, C., Xu, Y., Severinov, K., Matthews, S., Wigneshweraraj, S.
Deposit date:2013-08-14
Release date:2014-03-26
Last modified:2014-04-30
Method:SOLUTION NMR
Cite:A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement.
Nucleic Acids Res., 42, 2014
2MC6
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A BACTERIOPHAGE TRANSCRIPTION REGULATOR INHIBITS BACTERIAL TRANSCRIPTION INITIATION BY SIGMA-FACTOR DISPLACEMENT
Descriptor:RNA polymerase inhibitor p7, DNA-directed RNA polymerase subunit beta'
Authors:Liu, B., Shadrin, A., Sheppard, C., Xu, Y., Severinov, K., Matthews, S., Wigneshweraraj, S.
Deposit date:2013-08-15
Release date:2014-04-02
Last modified:2014-05-07
Method:SOLUTION NMR
Cite:A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement.
Nucleic Acids Res., 42, 2014
2MW3
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SOLUTION NMR STRUCTURE OF THE LASSO PEPTIDE STREPTOMONOMICIN
Descriptor:Lasso peptide
Authors:Tietz, J.I., Zhu, L., Mitchell, D.A., Metelev, M., Melby, J.O., Blair, P.M., Livnat, I., Severinov, K.
Deposit date:2014-10-24
Release date:2015-01-28
Last modified:2015-03-04
Method:SOLUTION NMR
Cite:Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete.
Chem.Biol., 22, 2015
2WNM
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SOLUTION STRUCTURE OF GP2
Descriptor:GENE 2
Authors:Camara, B., Liu, M., Shadrinc, A., Liu, B., Simpson, P., Weinzierl, R., Severinovc, K., Cota, E., Matthews, S., Wigneshweraraj, S.R.
Deposit date:2009-07-13
Release date:2010-02-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:T7 Phage Protein Gp2 Inhibits the Escherichia Coli RNA Polymerase by Antagonizing Stable DNA Strand Separation Near the Transcription Start Site.
Proc.Natl.Acad.Sci.USA, 107, 2010
3BMB
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CRYSTAL STRUCTURE OF A NEW RNA POLYMERASE INTERACTING PROTEIN
Descriptor:Regulator of nucleoside diphosphate kinase, SULFATE ION, CHLORIDE ION
Authors:Darst, S.A., Lamour, V.
Deposit date:2007-12-12
Release date:2008-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Crystal structure of Escherichia coli Rnk, a new RNA polymerase-interacting protein.
J.Mol.Biol., 383, 2008
3GJZ
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CRYSTAL STRUCTURE OF MICROCIN IMMUNITY PROTEIN MCCF FROM BACILLUS ANTHRACIS STR. AMES
Descriptor:Microcin immunity protein MccF
Authors:Nocek, B., Zhou, M., Kwon, K., Anderson, W., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2009-03-09
Release date:2009-04-14
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Functional Characterization of Microcin C Resistance Peptidase MccF from Bacillus anthracis.
J.Mol.Biol., 420, 2012
3R95
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CRYSTAL STRUCTURE OF MICROCIN C7 SELF IMMUNITY ACETYLTRANSFERASE MCCE IN COMPLEX WITH ACETYL-COA
Descriptor:MccE protein, ACETYL COENZYME *A
Authors:Nair, S.K., Agarwal, V.
Deposit date:2011-03-24
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for Microcin C7 Inactivation by the MccE Acetyltransferase.
J.Biol.Chem., 286, 2011
3R96
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CRYSTAL STRUCTURE OF MICROCIN C7 SELF IMMUNITY ACETYLTRANSFERASE MCCE IN COMPLEX WITH ACETYL-COA AND AMP
Descriptor:MccE protein, ACETYL COENZYME *A, ADENOSINE MONOPHOSPHATE
Authors:Nair, S.K., Agarwal, V.
Deposit date:2011-03-24
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural Basis for Microcin C7 Inactivation by the MccE Acetyltransferase.
J.Biol.Chem., 286, 2011
3R9E
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CRYSTAL STRUCTURE OF MICROCIN C7 SELF IMMUNITY ACETYLTRANSFERASE MCCE IN COMPLEX WITH COENZYME A AND ASPARTYL SULFAMOYL ADENOSINE (DSA)
Descriptor:MccE protein, COENZYME A, 5'-O-(L-alpha-aspartylsulfamoyl)adenosine
Authors:Nair, S.K., Agarwal, V.
Deposit date:2011-03-25
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural Basis for Microcin C7 Inactivation by the MccE Acetyltransferase.
J.Biol.Chem., 286, 2011
3R9F
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CRYSTAL STRUCTURE OF MICROCIN C7 SELF IMMUNITY ACETYLTRANSFERASE MCCE IN COMPLEX WITH COENZYME A AND GLUTAMYL SULFAMOYL ADENOSINE (ESA)
Descriptor:MccE protein, COENZYME A, O5'-(L-GLUTAMYL-SULFAMOYL)-ADENOSINE
Authors:Nair, S.K., Agarwal, V.
Deposit date:2011-03-25
Release date:2011-04-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structural Basis for Microcin C7 Inactivation by the MccE Acetyltransferase.
J.Biol.Chem., 286, 2011
3R9G
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CRYSTAL STRUCTURE OF MICROCIN C7 SELF IMMUNITY ACETYLTRANSFERASE MCCE IN COMPLEX WITH COENZYME A AND PROCESSED MICROCIN C7 ANTIBIOTIC
Descriptor:MccE protein, COENZYME A, 5'-O-[(R)-[(N-acetyl-L-alpha-aspartyl)amino](3-aminopropoxy)phosphoryl]adenosine
Authors:Nair, S.K., Agarwal, V.
Deposit date:2011-03-25
Release date:2011-04-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural Basis for Microcin C7 Inactivation by the MccE Acetyltransferase.
J.Biol.Chem., 286, 2011
3SR3
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CRYSTAL STRUCTURE OF THE W180A MUTANT OF MICROCIN IMMUNITY PROTEIN MCCF FROM BACILLUS ANTHRACIS SHOWS THE ACTIVE SITE LOOP IN THE OPEN CONFORMATION.
Descriptor:Microcin immunity protein MccF
Authors:Nocek, B., Zhou, M., Gu, M., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-07-06
Release date:2011-08-10
Last modified:2013-01-09
Method:X-RAY DIFFRACTION (1.495 Å)
Cite:Structural and functional characterization of microcin C resistance peptidase MccF from Bacillus anthracis.
J.Mol.Biol., 420, 2012
3T5M
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CRYSTAL STRUCTURE OF THE S112A MUTANT OF MYCROCINE IMMUNITY PROTEIN (MCCF) WITH AMP
Descriptor:Microcin immunity protein MccF, ADENOSINE MONOPHOSPHATE, GLYCEROL
Authors:Nocek, B., Zhou, M., Gu, M., Anderson, W.F., Joachimiak, A., Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2011-07-27
Release date:2011-09-07
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (1.749 Å)
Cite:Structural and Functional Characterization of Microcin C Resistance Peptidase MccF from Bacillus anthracis.
J.Mol.Biol., 420, 2012
3TLA
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MICROCIN C7 SELF IMMUNITY PROTEIN MCCF IN THE WILD TYPE APO STATE
Descriptor:MccF, 1,2-ETHANEDIOL
Authors:Agarwal, V., Nair, S.K.
Deposit date:2011-08-29
Release date:2012-02-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.201 Å)
Cite:Structure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7.
Proc.Natl.Acad.Sci.USA, 109, 2012
3TLB
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MICROCIN C7 SELF IMMUNITY PROTEIN MCCF IN COMPLEX ASPARTYL SULFAMOYL ADENOSINE
Descriptor:MccF, 5'-O-(L-alpha-aspartylsulfamoyl)adenosine
Authors:Agarwal, V., Nair, S.K.
Deposit date:2011-08-29
Release date:2012-02-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.501 Å)
Cite:Structure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7.
Proc.Natl.Acad.Sci.USA, 109, 2012
3TLC
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MICROCIN C7 SELF IMMUNITY PROTEIN MCCF IN COMPLEX WITH MICROCIN C7 ANTIBIOTIC
Descriptor:MccF, 5'-O-[(R)-(3-aminopropoxy)(L-alpha-aspartylamino)phosphoryl]adenosine, 1,2-ETHANEDIOL
Authors:Agarwal, V., Nair, S.K.
Deposit date:2011-08-29
Release date:2012-02-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7.
Proc.Natl.Acad.Sci.USA, 109, 2012
3TLE
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MICROCIN C7 SELF IMMUNITY PROTEIN MCCF IN COMPLEX WITH GLUTAMYL SULFAMOYL ADENYLATE
Descriptor:MccF, O5'-(L-GLUTAMYL-SULFAMOYL)-ADENOSINE, 1,2-ETHANEDIOL
Authors:Agarwal, V., Nair, S.K.
Deposit date:2011-08-29
Release date:2012-02-29
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structure and function of a serine carboxypeptidase adapted for degradation of the protein synthesis antibiotic microcin C7.
Proc.Natl.Acad.Sci.USA, 109, 2012