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5ZQK
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DENGUE VIRUS NON STRUCTURAL PROTEIN 5
Descriptor:Non Structural Protein 5, S-ADENOSYLMETHIONINE, GLYCEROL, ...
Authors:El Sahili, A., Soh, T.S., Schiltz, J., Gharbi-Ayachi, A., Goh, B.C., Seh, C.C., Dedon, P.C., Shi, P.Y., Lim, S.P., Lescar, J.
Deposit date:2018-04-19
Release date:2019-06-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A conformation of Dengue virus serotype 2 NS5 akin to its ZIKV and JEV homologues.
To Be Published
3H1U
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STRUCTURE OF UBIQUITIN IN COMPLEX WITH CD IONS
Descriptor:Ubiquitin, CADMIUM ION
Authors:Qureshi, I.A., Ferron, F., Cheung, P., Lescar, J.
Deposit date:2009-04-14
Release date:2009-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystallographic structure of ubiquitin in complex with cadmium ions
BMC RES NOTES, 2, 2009
3U1I
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DENGUE VIRUS PROTEASE COVALENTLY BOUND TO A PEPTIDE
Descriptor:Serine protease subunit NS2B, Serine protease NS3, peptide of (BEZ)(NLE)KR(OAR), ...
Authors:Noble, C.G.
Deposit date:2011-09-29
Release date:2011-11-09
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Ligand-bound structures of the dengue virus protease reveal the active conformation
J.Virol., 86, 2012
3U1J
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APROTININ BOUND TO DENGUE VIRUS PROTEASE
Descriptor:Serine protease subunit NS2B, Serine protease NS3, Pancreatic trypsin inhibitor
Authors:Noble, C.G.
Deposit date:2011-09-30
Release date:2011-11-09
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Ligand-bound structures of the dengue virus protease reveal the active conformation
J.Virol., 86, 2012
4C11
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DENGUE VIRUS RNA DEPENDENT RNA POLYMERASE WITH RESIDUES FROM THE NS5 LINKER REGION
Descriptor:DENGUE VIRUS TYPE 3 RNA DEPENDENT RNA POLYMERASE, ZINC ION
Authors:Lim, S.P., Lescar, J.
Deposit date:2013-08-09
Release date:2013-08-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Crystal Structure of the Dengue Virus Ns5 Polymerase Delineates Inter-Domain Amino Acids Residues that Enhance its Thermostability and De Novo Initiation Activities.
J.Biol.Chem., 288, 2013
5F3T
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO JF-31-MG46
Descriptor:RNA-DEPENDENT RNA POLYMERASE, ZINC ION, 2-(4-methoxy-3-phenyl-phenyl)ethanoic acid
Authors:Noble, C.G.
Deposit date:2015-12-03
Release date:2016-02-24
Last modified:2016-05-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening.
J.Biol.Chem., 291, 2016
5F3Z
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO PC-79-SH52
Descriptor:Genome polyprotein, ZINC ION, 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid
Authors:Noble, C.G.
Deposit date:2015-12-03
Release date:2016-02-24
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening
J.Biol.Chem., 291, 2016
5F41
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO FD-83-KI26
Descriptor:Genome polyprotein, ZINC ION, 2-(4-methoxy-3-thiophen-3-yl-phenyl)ethanoic acid
Authors:Noble, C.G.
Deposit date:2015-12-03
Release date:2016-02-24
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening
J.Biol.Chem., 291, 2016
5I3P
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 27
Descriptor:Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide
Authors:Noble, C.G.
Deposit date:2016-02-10
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5I3Q
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DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO COMPOUND 29
Descriptor:Genome polyprotein, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide
Authors:Noble, C.G.
Deposit date:2016-02-10
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5JJR
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DENGUE 3 NS5 PROTEIN WITH COMPOUND 29
Descriptor:Genome polyprotein, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Lescar, J., El Sahili, A.
Deposit date:2016-04-25
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5JJS
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DENGUE 3 NS5 PROTEIN WITH COMPOUND 27
Descriptor:Genome polyprotein, ZINC ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Lescar, J., El Sahili, A.
Deposit date:2016-04-25
Release date:2016-07-06
Last modified:2016-08-24
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling
Plos Pathog., 12, 2016
5K5M
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CO-CRYSTAL STRUCTURE OF DENGUE VIRUS SEROTYPE 2 RNA DEPENDENT RNA POLYMERASE WITH COMPOUND 27
Descriptor:RNA Dependent RNA Polymerase, ZINC ION, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-[(3-methoxyphenyl)sulfonyl]benzamide, ...
Authors:Arora, R., Benson, T.E.
Deposit date:2016-05-23
Release date:2016-08-24
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling.
Plos Pathog., 12, 2016