Author results

1OTX
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PURINE NUCLEOSIDE PHOSPHORYLASE M64V MUTANT
Descriptor:Purine nucleoside phosphorylase, PHOSPHATE ION
Authors:Ealick, S.E., Bennett, E.M., Anand, R., Secrist, J.A., Parker, W.B., Hassan, A.E., Allan, P.W., McPherson, D.T., Sorscher, E.J.
Deposit date:2003-03-23
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
1OTY
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NATIVE PNP +ALLO
Descriptor:Purine nucleoside phosphorylase, PHOSPHATE ION, 6-METHYLPURINE
Authors:Ealick, S.E., Bennett, E.M., Anand, R., Secrist, J.A., Parker, W.B., Hassan, A.E., Allan, P.W., McPherson, D.T., Sorscher, E.J.
Deposit date:2003-03-23
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
1OU4
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NATIVE PNP +TALO
Descriptor:Purine nucleoside phosphorylase, PHOSPHATE ION, 6-METHYLPURINE
Authors:Ealick, S.E., Bennett, E.M., Anand, R., Secrist, J.A., Parker, W.B., Hassan, A.E., Allan, P.W., McPherson, D.T., Sorscher, E.J.
Deposit date:2003-03-24
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
1OUM
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M64V PNP +TALO
Descriptor:Purine nucleoside phosphorylase, 9-(6-DEOXY-ALPHA-L-TALOFURANOSYL)-6-METHYLPURINE, PHOSPHATE ION
Authors:Ealick, S.E., Bennett, E.M., Anand, R., Secrist, J.A., Parker, W.B., Hassan, A.E., Allan, P.W., McPherson, D.T., Sorscher, E.J.
Deposit date:2003-03-24
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
1OV6
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M64V PNP + ALLO
Descriptor:Purine nucleoside phosphorylase, PHOSPHATE ION, 9-(6-DEOXY-BETA-D-ALLOFURANOSYL)-6-METHYLPURINE
Authors:Ealick, S.E., Bennett, E.M., Anand, R., Secrist, J.A., Parker, P.W., Hassan, A.E., Allan, P.W., McPherson, D.T., Sorscher, E.J.
Deposit date:2003-03-25
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
1OVG
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M64V PNP +MEPDR
Descriptor:Purine nucleoside phosphorylase, PHOSPHATE ION, 9-(2-DEOXY-BETA-D-RIBOFURANOSYL)-6-METHYLPURINE
Authors:Ealick, S.E., Bennett, E.M., Anand, R., Secrist, J.A., Parker, P.W., Hassan, A.E., Allan, P.W., McPherson, D.T., Sorscher, E.J.
Deposit date:2003-03-26
Release date:2004-02-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Designer gene therapy using an Escherichia coli purine nucleoside phosphorylase/prodrug system.
Chem.Biol., 10, 2003
2A7Q
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CRYSTAL STRUCTURE OF HUMAN DCK COMPLEXED WITH CLOFARABINE AND ADP
Descriptor:Deoxycytidine kinase, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Zhang, Y., Secrist III, J.A., Ealick, S.E.
Deposit date:2005-07-05
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation.
Acta Crystallogr.,Sect.D, 62, 2006
3RW9
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CRYSTAL STRUCTURE OF HUMAN SPERMIDINE SYNTHASE IN COMPLEX WITH DECARBOXYLATED S-ADENOSYLHOMOCYSTEINE
Descriptor:Spermidine synthase, 5'-S-(3-aminopropyl)-5'-thioadenosine
Authors:Seckute, J., McCloskey, D.E., Thomas, H.J., Secrist III, J.A., Pegg, A.E., Ealick, S.E.
Deposit date:2011-05-08
Release date:2011-09-21
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Binding and inhibition of human spermidine synthase by decarboxylated S-adenosylhomocysteine.
Protein Sci., 20, 2011