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7Q0O
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E. coli NfsA
Descriptor: FLAVIN MONONUCLEOTIDE, Oxygen-insensitive NADPH nitroreductase
Authors:White, S.A, Grainger, A, Parr, R, Day, M.A, Jarrom, D, Graziano, A, Searle, P.F, Hyde, E.I.
Deposit date:2021-10-15
Release date:2022-06-22
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:The 3D-structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP + provide glimpses of its catalytic mechanism.
Febs Lett., 596, 2022
7Z0W
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BU of 7z0w by Molmil
E. coli NfsA bound to NADP+
Descriptor: 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, FLAVIN MONONUCLEOTIDE, MAGNESIUM ION, ...
Authors:White, S.A, Grainger, A, Parr, R, Day, M.A, Jarrom, D, Graziano, A, Searle, P.F, Hyde, E.I.
Deposit date:2022-02-23
Release date:2022-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:The 3D-structure, kinetics and dynamics of the E. coli nitroreductase NfsA with NADP + provide glimpses of its catalytic mechanism.
Febs Lett., 596, 2022
8OG3
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BU of 8og3 by Molmil
E. coli NfsB triple mutant T41L/N71S/F124T bound to citrate
Descriptor: 1,2-ETHANEDIOL, CITRIC ACID, FLAVIN MONONUCLEOTIDE, ...
Authors:Day, M.A, White, S.A, Hyde, E.I, Searle, P.F.
Deposit date:2023-03-17
Release date:2023-04-19
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci, 24, 2023
1YKI
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BU of 1yki by Molmil
The structure of E. coli nitroreductase bound with the antibiotic nitrofurazone
Descriptor: CITRIC ACID, DIMETHYL SULFOXIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Race, P.R, Lovering, A.L, Green, R.M, Ossor, A, White, S.A, Searle, P.F, Wrighton, C.J, Hyde, E.I.
Deposit date:2005-01-18
Release date:2005-02-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.
J.Biol.Chem., 280, 2005
1YLU
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BU of 1ylu by Molmil
The structure of E. coli nitroreductase with bound acetate, crystal form 2
Descriptor: ACETATE ION, FLAVIN MONONUCLEOTIDE, Oxygen-insensitive NAD(P)H nitroreductase
Authors:Race, P.R, Lovering, A.L, Green, R.M, Ossor, A, White, S.A, Searle, P.F, Wrighton, C.J, Hyde, E.I.
Deposit date:2005-01-19
Release date:2005-02-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.
J.Biol.Chem., 280, 2005
1YLR
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BU of 1ylr by Molmil
The structure of E.coli nitroreductase with bound acetate, crystal form 1
Descriptor: ACETATE ION, FLAVIN MONONUCLEOTIDE, Oxygen-insensitive NAD(P)H nitroreductase
Authors:Race, P.R, Lovering, A.L, Green, R.M, Ossor, A, White, S.A, Searle, P.F, Wrighton, C.J, Hyde, E.I.
Deposit date:2005-01-19
Release date:2005-02-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and mechanistic studies of Escherichia coli nitroreductase with the antibiotic nitrofurazone. Reversed binding orientations in different redox states of the enzyme.
J.Biol.Chem., 280, 2005
8CCV
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BU of 8ccv by Molmil
E. coli NfsB mutant T41LN71S with nicotinate
Descriptor: FLAVIN MONONUCLEOTIDE, NICOTINIC ACID, Oxygen-insensitive NAD(P)H nitroreductase
Authors:Day, M.A, White, S.A, Hyde, E.I, Searle, P.F.
Deposit date:2023-01-27
Release date:2023-04-19
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci, 24, 2023
1ICR
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BU of 1icr by Molmil
THE STRUCTURE OF ESCHERICHIA COLI NITROREDUCTASE COMPLEXED WITH NICOTINIC ACID
Descriptor: FLAVIN MONONUCLEOTIDE, NICOTINIC ACID, OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE
Authors:Lovering, A.L, Hyde, E.I, Searle, P.F, White, S.A.
Deposit date:2001-04-02
Release date:2001-04-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution.
J.Mol.Biol., 309, 2001
1ICV
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BU of 1icv by Molmil
THE STRUCTURE OF ESCHERICHIA COLI NITROREDUCTASE COMPLEXED WITH NICOTINIC ACID
Descriptor: FLAVIN MONONUCLEOTIDE, NICOTINIC ACID, OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE
Authors:Lovering, A.L, Hyde, E.I, Searle, P.F, White, S.A.
Deposit date:2001-04-02
Release date:2001-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution.
J.Mol.Biol., 309, 2001
1ICU
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BU of 1icu by Molmil
THE STRUCTURE OF ESCHERICHIA COLI NITROREDUCTASE COMPLEXED WITH NICOTINIC ACID
Descriptor: FLAVIN MONONUCLEOTIDE, NICOTINIC ACID, OXYGEN-INSENSITIVE NAD(P)H NITROREDUCTASE
Authors:Lovering, A.L, Hyde, E.I, Searle, P.F, White, S.A.
Deposit date:2001-04-02
Release date:2001-04-18
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structure of Escherichia coli nitroreductase complexed with nicotinic acid: three crystal forms at 1.7 A, 1.8 A and 2.4 A resolution.
J.Mol.Biol., 309, 2001
8AJX
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BU of 8ajx by Molmil
E. coli NfsA with Fumarate
Descriptor: 1,2-ETHANEDIOL, FLAVIN MONONUCLEOTIDE, FUMARIC ACID, ...
Authors:Day, M.A, Jarrom, D, White, S.A, Hyde, E.I.
Deposit date:2022-07-28
Release date:2023-01-18
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Oxygen-insensitive nitroreductase E. coli NfsA, but not NfsB, is inhibited by fumarate.
Proteins, 91, 2023
8C5E
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BU of 8c5e by Molmil
E. coli NfsB-T41Q/N71S/F124T mutant bound to nicotinic acid
Descriptor: 1,2-ETHANEDIOL, FLAVIN MONONUCLEOTIDE, NICOTINIC ACID, ...
Authors:White, S.A, Hyde, E.I, Day, M.A.
Deposit date:2023-01-06
Release date:2023-04-19
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci, 24, 2023
8C5P
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BU of 8c5p by Molmil
E. coli NfsB mutant N71S T41L with acetate
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, DIMETHYL SULFOXIDE, ...
Authors:Day, M.A, White, S.A, Hyde, E.I.
Deposit date:2023-01-10
Release date:2023-04-19
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci, 24, 2023
8C5F
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BU of 8c5f by Molmil
E. coli NfsB-T41Q/N71S/F124T mutant bound to acetate
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, FLAVIN MONONUCLEOTIDE, ...
Authors:White, S.A, Hyde, E.I, Day, M.A.
Deposit date:2023-01-07
Release date:2023-04-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci, 24, 2023
8CJ0
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BU of 8cj0 by Molmil
E. coli NfsB-T41Q/N71S/F124T/M127V mutant bound to nicotinate
Descriptor: 1,2-ETHANEDIOL, FLAVIN MONONUCLEOTIDE, NICOTINIC ACID, ...
Authors:White, S.A, Hyde, E.I, Day, M.A.
Deposit date:2023-02-11
Release date:2023-04-19
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structure and Dynamics of Three Escherichia coli NfsB Nitro-Reductase Mutants Selected for Enhanced Activity with the Cancer Prodrug CB1954.
Int J Mol Sci, 24, 2023
7NB9
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BU of 7nb9 by Molmil
E. coli NfsA with nitrofurantoin
Descriptor: 1-[(~{E})-(5-nitrofuran-2-yl)methylideneamino]imidazolidine-2,4-dione, DIMETHYL SULFOXIDE, FLAVIN MONONUCLEOTIDE, ...
Authors:Day, M.D, Jarrom, D, Grainger, A.I, Parr, R.J, Hyde, E.I, White, S.A.
Deposit date:2021-01-25
Release date:2021-07-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN.
Biochem.J., 478, 2021
7NNX
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E. coli NfsA with 1,4-benzoquinone
Descriptor: 1,2-ETHANEDIOL, 1,4-benzoquinone, CHLORIDE ION, ...
Authors:Day, M.D, Jarrom, D, Hyde, E.I, White, S.A.
Deposit date:2021-02-25
Release date:2021-07-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN.
Biochem.J., 478, 2021
7NMP
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BU of 7nmp by Molmil
E. coli NfsA with hydroquinone
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Day, M.D, Jarrom, D, Parr, R.J, Hyde, E.I, White, S.A.
Deposit date:2021-02-23
Release date:2021-07-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN.
Biochem.J., 478, 2021
7NIY
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BU of 7niy by Molmil
E. coli NfsA with FMN
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, FLAVIN MONONUCLEOTIDE, ...
Authors:Day, M.D, Jarrom, D, Hyde, E.I, White, S.A.
Deposit date:2021-02-14
Release date:2021-07-21
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.03 Å)
Cite:The structures of E. coli NfsA bound to the antibiotic nitrofurantoin; to 1,4-benzoquinone and to FMN.
Biochem.J., 478, 2021

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