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1DJN
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STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF RECOMBINANT WILD TYPE TRIMETHYLAMINE DEHYDROGENASE FROM METHYLOPHILUS METHYLOTROPHUS (SP. W3A1)
Descriptor:TRIMETHYLAMINE DEHYDROGENASE, IRON/SULFUR CLUSTER, FLAVIN MONONUCLEOTIDE, ...
Authors:Trickey, P., Basran, J., Lian, L.-Y., Chen, Z.-W., Barton, J.D., Sutcliffe, M.J., Scrutton, N.S., Mathews, F.S.
Deposit date:1999-12-03
Release date:1999-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and biochemical characterization of recombinant wild type and a C30A mutant of trimethylamine dehydrogenase from methylophilus methylotrophus (sp. W(3)A(1)).
Biochemistry, 39, 2000
1DJQ
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STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF RECOMBINANT C30A MUTANT OF TRIMETHYLAMINE DEHYDROGENASE FROM METHYLOPHILUS METHYLOTROPHUS (SP. W3A1)
Descriptor:TRIMETHYLAMINE DEHYDROGENASE, IRON/SULFUR CLUSTER, FLAVIN MONONUCLEOTIDE, ...
Authors:Trickey, P., Basran, J., Lian, L.-Y., Chen, Z.-W., Barton, J.D., Sutcliffe, M.J., Scrutton, N.S., Mathews, F.S.
Deposit date:1999-12-03
Release date:1999-12-22
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and biochemical characterization of recombinant wild type and a C30A mutant of trimethylamine dehydrogenase from methylophilus methylotrophus (sp. W(3)A(1)).
Biochemistry, 39, 2000
1O94
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TERNARY COMPLEX BETWEEN TRIMETHYLAMINE DEHYDROGENASE AND ELECTRON TRANSFERRING FLAVOPROTEIN
Descriptor:TRIMETHYLAMINE DEHYDROGENASE, ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT, ELECTRON TRANSFER FLAVOPROTEIN ALPHA-SUBUNIT, ...
Authors:Leys, D., Basran, J., Talfournier, F., Sutcliffe, M.J., Scrutton, N.S.
Deposit date:2002-12-11
Release date:2003-02-06
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Extensive Conformational Sampling in a Ternary Electron Transfer Complex.
Nat.Struct.Biol., 10, 2003
1O95
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TERNARY COMPLEX BETWEEN TRIMETHYLAMINE DEHYDROGENASE AND ELECTRON TRANSFERRING FLAVOPROTEIN
Descriptor:TRIMETHYLAMINE DEHYDROGENASE, ELECTRON TRANSFER FLAVOPROTEIN BETA-SUBUNIT, ELECTRON TRANSFER FLAVOPROTEIN ALPHA-SUBUNIT, ...
Authors:Leys, D., Basran, J., Talfournier, F., Sutcliffe, M.J., Scrutton, N.S.
Deposit date:2002-12-11
Release date:2003-02-06
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Extensive Conformational Sampling in a Ternary Electron Transfer Complex.
Nat.Struct.Biol., 10, 2003
1O96
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STRUCTURE OF ELECTRON TRANSFERRING FLAVOPROTEIN FOR METHYLOPHILUS METHYLOTROPHUS.
Descriptor:ELECTRON TRANSFERRING FLAVOPROTEIN BETA-SUBUNIT, ELECTRON TRANSFERRING FLAVOPROTEIN ALPHA-SUBUNIT, ADENOSINE MONOPHOSPHATE, ...
Authors:Leys, D., Basran, J., Talfournier, F., Sutcliffe, M.J., Scrutton, N.S.
Deposit date:2002-12-11
Release date:2003-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Extensive Conformational Sampling in a Ternary Electron Transfer Complex.
Nat.Struct.Biol., 10, 2003
1O97
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STRUCTURE OF ELECTRON TRANSFERRING FLAVOPROTEIN FROM METHYLOPHILUS METHYLOTROPHUS, RECOGNITION LOOP REMOVED BY LIMITED PROTEOLYSIS
Descriptor:ELECTRON TRANSFERRING FLAVOPROTEIN BETA-SUBUNIT, ELECTRON TRANSFERRING FLAVOPROTEIN ALPHA-SUBUNIT, ADENOSINE MONOPHOSPHATE, ...
Authors:Leys, D., Basran, J., Talfournier, F., Sutcliffe, M.J., Scrutton, N.S.
Deposit date:2002-12-11
Release date:2003-02-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Extensive Conformational Sampling in a Ternary Electron Transfer Complex.
Nat.Struct.Biol., 10, 2003
1PJ5
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CRYSTAL STRUCTURE OF DIMETHYLGLYCINE OXIDASE OF ARTHROBACTER GLOBIFORMIS IN COMPLEX WITH ACETATE
Descriptor:N,N-dimethylglycine oxidase, SODIUM ION, ACETATE ION, ...
Authors:Leys, D., Basran, J., Scrutton, N.S.
Deposit date:2003-06-01
Release date:2003-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase.
Embo J., 22, 2003
1PJ6
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CRYSTAL STRUCTURE OF DIMETHYLGLYCINE OXIDASE OF ARTHROBACTER GLOBIFORMIS IN COMPLEX WITH FOLIC ACID
Descriptor:N,N-dimethylglycine oxidase, SODIUM ION, FOLIC ACID, ...
Authors:Leys, D., Basran, J., Scrutton, N.S.
Deposit date:2003-06-01
Release date:2003-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase.
Embo J., 22, 2003
1PJ7
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STRUCTURE OF DIMETHYLGLYCINE OXIDASE OF ARTHROBACTER GLOBIFORMIS IN COMPLEX WITH FOLINIC ACID
Descriptor:N,N-dimethylglycine oxidase, SODIUM ION, N-[4-({[(6S)-2-amino-5-formyl-4-oxo-3,4,5,6,7,8-hexahydropteridin-6-yl]methyl}amino)benzoyl]-L-glutamic acid, ...
Authors:Leys, D., Basran, J., Scrutton, N.S.
Deposit date:2003-06-01
Release date:2003-10-07
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Channelling and formation of 'active' formaldehyde in dimethylglycine oxidase.
Embo J., 22, 2003
1S24
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RUBREDOXIN DOMAIN II FROM PSEUDOMONAS OLEOVORANS
Descriptor:Rubredoxin 2, CADMIUM ION
Authors:Perry, A., Tambyrajah, W., Grossmann, J.G., Lian, L.Y., Scrutton, N.S.
Deposit date:2004-01-08
Release date:2004-05-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the two-iron rubredoxin of Pseudomonas oleovorans determined by NMR spectroscopy and solution X-ray scattering and interactions with rubredoxin reductase.
Biochemistry, 43, 2004
1T9G
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STRUCTURE OF THE HUMAN MCAD:ETF COMPLEX
Descriptor:Acyl-CoA dehydrogenase, medium-chain specific, mitochondrial, ...
Authors:Toogood, H.S., van Thiel, A., Basran, J., Sutcliffe, M.J., Scrutton, N.S., Leys, D.
Deposit date:2004-05-17
Release date:2004-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Extensive domain motion and electron transfer in the human electron transferring flavoprotein-medium chain Acyl-CoA dehydrogenase complex
J.Biol.Chem., 279, 2004
2A1T
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STRUCTURE OF THE HUMAN MCAD:ETF E165BETAA COMPLEX
Descriptor:Acyl-CoA dehydrogenase, medium-chain specific, mitochondrial precursor, ...
Authors:Toogood, H.S., Van Thiel, A., Scrutton, N.S., Leys, D.
Deposit date:2005-06-21
Release date:2005-07-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Stabilization of Non-productive Conformations Underpins Rapid Electron Transfer to Electron-transferring Flavoprotein
J.Biol.Chem., 280, 2005
2A1U
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CRYSTAL STRUCTURE OF THE HUMAN ETF E165BETAA MUTANT
Descriptor:Electron transfer flavoprotein alpha-subunit, mitochondrial precursor, Electron transfer flavoprotein beta-subunit, ...
Authors:Toogood, H.S., Van Thiel, A., Scrutton, N.S., Leys, D.
Deposit date:2005-06-21
Release date:2005-07-05
Last modified:2018-10-03
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Stabilization of Non-productive Conformations Underpins Rapid Electron Transfer to Electron-transferring Flavoprotein
J.Biol.Chem., 280, 2005
2ABA
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STRUCTURE OF REDUCED PETN REDUCTASE IN COMPLEX WITH PROGESTERONE
Descriptor:pentaerythritol tetranitrate reductase, FLAVIN MONONUCLEOTIDE, PROGESTERONE, ...
Authors:Khan, H., Barna, T., Bruce, N.C., Munro, A.W., Leys, D., Scrutton, N.S.
Deposit date:2005-07-15
Release date:2005-10-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase
Febs J., 272, 2005
2ABB
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STRUCTURE OF PETN REDUCTASE Y186F IN COMPLEX WITH CYANIDE
Descriptor:pentaerythritol tetranitrate reductase, THIOCYANATE ION, FLAVIN MONONUCLEOTIDE, ...
Authors:Khan, H., Barna, T., Bruce, N.C., Munro, A.W., Leys, D., Scrutton, N.S.
Deposit date:2005-07-15
Release date:2005-10-11
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (1 Å)
Cite:Proton transfer in the oxidative half-reaction of pentaerythritol tetranitrate reductase
Febs J., 272, 2005
2AGL
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CRYSTAL STRUCTURE OF THE PHENYLHYDRAZINE ADDUCT OF AROMATIC AMINE DEHYDROGENASE FROM ALCALIGENES FAECALIS
Descriptor:Aromatic amine dehydrogenase, 1-PHENYLHYDRAZINE
Authors:Masgrau, L., Roujeinikova, A., Johannissen, L.O., Hothi, P., Basran, J., Ranaghan, K.E., Mulholland, A.J., Sutcliffe, M.J., Scrutton, N.S., Leys, D.
Deposit date:2005-07-27
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Atomic description of an enzyme reaction dominated by proton tunneling
Science, 312, 2006
2AGW
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CRYSTAL STRUCTURE OF TRYPTAMINE-REDUCED AROMATIC AMINE DEHYDROGENASE (AADH) FROM ALCALIGENES FAECALIS IN COMPLEX WITH TRYPTAMINE
Descriptor:Aromatic amine dehydrogenase, 2-(1H-INDOL-3-YL)ETHANAMINE
Authors:Masgrau, L., Roujeinikova, A., Johannissen, L.O., Hothi, P., Basran, J., Ranaghan, K.E., Mulholland, A.J., Sutcliffe, M.J., Scrutton, N.S., Leys, D.
Deposit date:2005-07-27
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Atomic description of an enzyme reaction dominated by proton tunneling
Science, 312, 2006
2AGX
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CRYSTAL STRUCTURE OF THE SCHIFF BASE INTERMEDIATE IN THE REDUCTIVE HALF-REACTION OF AROMATIC AMINE DEHYDROGENASE (AADH) WITH TRYPTAMINE. P212121 FORM
Descriptor:Aromatic amine dehydrogenase, 2-(1H-INDOL-3-YL)ETHANIMINE
Authors:Masgrau, L., Roujeinikova, A., Johannissen, L.O., Hothi, P., Basran, J., Ranaghan, K.E., Mulholland, A.J., Sutcliffe, M.J., Scrutton, N.S., Leys, D.
Deposit date:2005-07-27
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Atomic description of an enzyme reaction dominated by proton tunneling
Science, 312, 2006
2AGY
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CRYSTAL STRUCTURE OF THE SCHIFF BASE INTERMEDIATE IN THE REDUCTIVE HALF-REACTION OF AROMATIC AMINE DEHYDROGENASE (AADH) WITH TRYPTAMINE. MONOCLINIC FORM
Descriptor:Aromatic amine dehydrogenase, 2-(1H-INDOL-3-YL)ETHANIMINE
Authors:Masgrau, L., Roujeinikova, A., Johannissen, L.O., Hothi, P., Basran, J., Ranaghan, K.E., Mulholland, A.J., Sutcliffe, M.J., Scrutton, N.S., Leys, D.
Deposit date:2005-07-27
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic description of an enzyme reaction dominated by proton tunneling
Science, 312, 2006
2AGZ
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CRYSTAL STRUCTURE OF THE CARBINOLAMINE INTERMEDIATE IN THE REDUCTIVE HALF-REACTION OF AROMATIC AMINE DEHYDROGENASE (AADH) WITH TRYPTAMINE. F222 FORM
Descriptor:Aromatic amine dehydrogenase, ZINC ION, (1S)-1-AMINO-2-(1H-INDOL-3-YL)ETHANOL
Authors:Masgrau, L., Roujeinikova, A., Johannissen, L.O., Hothi, P., Basran, J., Ranaghan, K.E., Mulholland, A.J., Sutcliffe, M.J., Scrutton, N.S., Leys, D.
Deposit date:2005-07-27
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Atomic description of an enzyme reaction dominated by proton tunneling
Science, 312, 2006
2AH0
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CRYSTAL STRUCTURE OF THE CARBINOLAMINE INTERMEDIATE IN THE REDUCTIVE HALF-REACTION OF AROMATIC AMINE DEHYDROGENASE (AADH) WITH TRYPTAMINE. MONOCLINIC FORM
Descriptor:Aromatic amine dehydrogenase, 2-(1H-INDOL-3-YL)ETHANIMINE, (1S)-1-AMINO-2-(1H-INDOL-3-YL)ETHANOL
Authors:Masgrau, L., Roujeinikova, A., Johannissen, L.O., Hothi, P., Basran, J., Ranaghan, K.E., Mulholland, A.J., Sutcliffe, M.J., Scrutton, N.S., Leys, D.
Deposit date:2005-07-27
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Atomic description of an enzyme reaction dominated by proton tunneling
Science, 312, 2006
2AH1
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CRYSTAL STRUCTURE OF AROMATIC AMINE DEHYDROGENASE (AADH) FROM ALCALIGENES FAECALIS
Descriptor:Aromatic amine dehydrogenase
Authors:Masgrau, L., Roujeinikova, A., Johannissen, L.O., Hothi, P., Basran, J., Ranaghan, K.E., Mulholland, A.J., Sutcliffe, M.J., Scrutton, N.S., Leys, D.
Deposit date:2005-07-27
Release date:2006-04-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Atomic description of an enzyme reaction dominated by proton tunneling
Science, 312, 2006
2O2K
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CRYSTAL STRUCTURE OF THE ACTIVATION DOMAIN OF HUMAN METHIONINE SYNTHASE ISOFORM/MUTANT D963E/K1071N
Descriptor:Methionine synthase
Authors:Wolthers, K.R., Toogood, H.S., Jowitt, T.A., Marshall, K.R., Leys, D., Scrutton, N.S.
Deposit date:2006-11-30
Release date:2006-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure and solution characterization of the activation domain of human methionine synthase
Febs J., 274, 2007
2QTL
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CRYSTAL STRUCTURE OF THE FAD-CONTAINING FNR-LIKE MODULE OF HUMAN METHIONINE SYNTHASE REDUCTASE
Descriptor:Methionine synthase reductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Wolthers, K.R., Lou, X., Toogood, H.S., Leys, D., Scrutton, N.S.
Deposit date:2007-08-02
Release date:2007-11-13
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry
Biochemistry, 46, 2007
2QTZ
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CRYSTAL STRUCTURE OF THE NADP+-BOUND FAD-CONTAINING FNR-LIKE MODULE OF HUMAN METHIONINE SYNTHASE REDUCTASE
Descriptor:Methionine synthase reductase, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Wolthers, K.R., Lou, X., Toogood, H.S., Leys, D., Scrutton, N.S.
Deposit date:2007-08-02
Release date:2007-11-13
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mechanism of Coenzyme Binding to Human Methionine Synthase Reductase Revealed through the Crystal Structure of the FNR-like Module and Isothermal Titration Calorimetry
Biochemistry, 46, 2007