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1E8L
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NMR SOLUTION STRUCTURE OF HEN LYSOZYME
Descriptor:LYSOZYME
Authors:Schwalbe, H., Grimshaw, S.B., Spencer, A., Buck, M., Boyd, J., Dobson, C.M., Redfield, C., Smith, L.J.
Deposit date:2000-09-27
Release date:2000-10-09
Last modified:2018-01-24
Method:SOLUTION NMR
Cite:A refined solution structure of hen lysozyme determined using residual dipolar coupling data.
Protein Sci., 10, 2001
6F3V
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BACKBONE STRUCTURE OF BRADYKININ (BK) PEPTIDE BOUND TO HUMAN BRADYKININ 2 RECEPTOR (B2R) DETERMINED BY MAS SSNMR
Descriptor:Bradykinin (BK)
Authors:Mao, J., Lopez, J.J., Shukla, A.K., Kuenze, G., Meiler, J., Schwalbe, H., Michel, H., Glaubitz, C.
Deposit date:2017-11-29
Release date:2018-01-10
Last modified:2018-02-21
Method:SOLID-STATE NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6F3W
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BACKBONE STRUCTURE OF FREE BRADYKININ (BK) IN DDM/CHS DETERGENT MICELLE DETERMINED BY MAS SSNMR
Descriptor:Kininogen-1
Authors:Mao, J., Lopez, J.J., Shukla, A.K., Kuenze, G., Meiler, J., Schwalbe, H., Michel, H., Glaubitz, C.
Deposit date:2017-11-29
Release date:2018-01-10
Last modified:2018-02-21
Method:SOLID-STATE NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
5I9U
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE
Descriptor:Ephrin type-A receptor 2, 1,2-ETHANEDIOL
Authors:KUDLINZKI, D., LINHARD, V.L., GANDE, S.L., SREERAMULU, S., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.
Deposit date:2016-02-21
Release date:2016-11-09
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (1.889 Å)
Cite:Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9Y
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH DASATINIB
Descriptor:Ephrin type-A receptor 2, N-(2-CHLORO-6-METHYLPHENYL)-2-({6-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]-2-METHYLPYRIMIDIN-4-YL}AMINO)-1,3-THIAZOLE-5-CARBOXAMIDE, 1,2-ETHANEDIOL
Authors:KUDLINZKI, D., LINHARD, V.L., GANDE, S.L., SREERAMULU, S., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.
Deposit date:2016-02-21
Release date:2016-11-09
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.228 Å)
Cite:Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA4
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH FORETINIB (XL880)
Descriptor:Ephrin type-A receptor 2, N-(3-fluoro-4-{[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, 1,2-ETHANEDIOL
Authors:KUDLINZKI, D., LINHARD, V.L., GANDE, S.L., SREERAMULU, S., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.
Deposit date:2016-02-21
Release date:2016-11-09
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.797 Å)
Cite:Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
2K3F
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RIBOSOMAL PROTEIN L11 FROM THERMOTOGA MARITIMA
Descriptor:50S ribosomal protein L11
Authors:Jonker, H.R.A., Ilin, S., Schwalbe, H., Woehnert, J.
Deposit date:2008-05-06
Release date:2008-06-17
Last modified:2013-09-04
Method:SOLUTION NMR
Cite:Domain reorientation and induced fit upon RNA binding: solution structure and dynamics of ribosomal protein L11 from Thermotoga maritima
ChemBioChem, 6, 2005
6F2X
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STRUCTURAL CHARACTERIZATION OF THE MYCOBACTERIUM TUBERCULOSIS PROTEIN TYROSINE KINASE A (PTKA)
Descriptor:Protein Tyrosine Kinase A
Authors:Niesteruk, A., Jonker, H.R.A., Sreeramulu, S., Richter, C., Hutchison, M., Linhard, V., Schwalbe, H.
Deposit date:2017-11-27
Release date:2018-07-04
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:The domain architecture of PtkA, the first tyrosine kinase fromMycobacterium tuberculosis, differs from the conventional kinase architecture.
J. Biol. Chem., 293, 2018
1CFF
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NMR SOLUTION STRUCTURE OF A COMPLEX OF CALMODULIN WITH A BINDING PEPTIDE OF THE CA2+-PUMP
Descriptor:CALMODULIN, CALCIUM PUMP, CALCIUM ION
Authors:Elshorst, B., Hennig, M., Foersterling, H., Diener, A., Maurer, M., Schulte, P., Schwalbe, H., Krebs, J., Schmid, H., Vorherr, T., Carafoli, E., Griesinger, C.
Deposit date:1999-03-18
Release date:1999-09-24
Last modified:2018-08-29
Method:SOLUTION NMR
Cite:NMR solution structure of a complex of calmodulin with a binding peptide of the Ca2+ pump.
Biochemistry, 38, 1999
6F27
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NMR SOLUTION STRUCTURE OF NON-BOUND [DES-ARG10]-KALLIDIN (DAKD)
Descriptor:DAKD
Authors:Richter, C., Jonker, H.R.A., Schwalbe, H., Joedicke, L., Mao, J., Kuenze, G., Reinhart, C., Kalavacherla, T., Meiler, J., Preu, J., Michel, H., Glaubitz, C.
Deposit date:2017-11-23
Release date:2018-01-10
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
4J23
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LOW RESOLUTION CRYSTAL STRUCTURE OF THE FGFR2D2D3/FGF1/SR128545 COMPLEX
Descriptor:Fibroblast growth factor receptor 2, Fibroblast growth factor 1
Authors:Kudlinzki, D., Saxena, K., Sreeramulu, S., Schieborr, U., Dreyer, M., Schreuder, H., Schwalbe, H.
Deposit date:2013-02-04
Release date:2014-02-19
Last modified:2014-02-26
Method:X-RAY DIFFRACTION (3.882 Å)
Cite:Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling.
Cancer Cell, 23, 2013
5I9V
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH AGS
Descriptor:Ephrin type-A receptor 2, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:KUDLINZKI, D., LINHARD, V.L., GANDE, S.L., SREERAMULU, S., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.
Deposit date:2016-02-21
Release date:2016-11-09
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.458 Å)
Cite:Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9W
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH ANP
Descriptor:Ephrin type-A receptor 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, 1,2-ETHANEDIOL
Authors:KUDLINZKI, D., LINHARD, V.L., GANDE, S.L., SREERAMULU, S., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.
Deposit date:2016-02-21
Release date:2016-11-09
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.359 Å)
Cite:Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9X
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH BOSUTINIB (SKI-606)
Descriptor:Ephrin type-A receptor 2, 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, 1,2-ETHANEDIOL
Authors:KUDLINZKI, D., LINHARD, V.L., GANDE, S.L., SREERAMULU, S., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.
Deposit date:2016-02-21
Release date:2016-11-09
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.427 Å)
Cite:Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5I9Z
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH DANUSERTIB (PHA739358)
Descriptor:Ephrin type-A receptor 2, N-[(3E)-5-[(2R)-2-METHOXY-2-PHENYLACETYL]PYRROLO[3,4-C]PYRAZOL-3(5H)-YLIDENE]-4-(4-METHYLPIPERAZIN-1-YL)BENZAMIDE, 1,2-ETHANEDIOL
Authors:KUDLINZKI, D., LINHARD, V.L., GANDE, S.L., SREERAMULU, S., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.
Deposit date:2016-02-21
Release date:2016-11-09
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA0
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH ALISERTIB (MLN8237)
Descriptor:Ephrin type-A receptor 2, alisertib, 1,2-ETHANEDIOL
Authors:KUDLINZKI, D., LINHARD, V.L., GANDE, S.L., SREERAMULU, S., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.
Deposit date:2016-02-21
Release date:2016-11-09
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (1.948 Å)
Cite:Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA1
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH MLN8054
Descriptor:Ephrin type-A receptor 2, 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID, 1,2-ETHANEDIOL
Authors:KUDLINZKI, D., LINHARD, V.L., GANDE, S.L., SREERAMULU, S., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.
Deposit date:2016-02-21
Release date:2016-11-09
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.036 Å)
Cite:Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA2
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH COMPOUND 66
Descriptor:Ephrin type-A receptor 2, 7-(5-hydroxy-2-methylphenyl)-8-(2-methoxyphenyl)-1-methyl-1H-imidazo[2,1-f]purine-2,4(3H,8H)-dione, 1,2-ETHANEDIOL
Authors:KUDLINZKI, D., LINHARD, V.L., GANDE, S.L., SREERAMULU, S., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.
Deposit date:2016-02-21
Release date:2016-11-09
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.619 Å)
Cite:Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA3
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH PD173955
Descriptor:Ephrin type-A receptor 2, 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE
Authors:KUDLINZKI, D., LINHARD, V.L., GANDE, S.L., SREERAMULU, S., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.
Deposit date:2016-02-21
Release date:2016-11-09
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (1.788 Å)
Cite:Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
5IA5
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CRYSTAL STRUCTURE OF EPHRIN A2 (EPHA2) RECEPTOR PROTEIN KINASE WITH GOLVATINIB (E7050)
Descriptor:Ephrin type-A receptor 2, golvatinib, 1,2-ETHANEDIOL
Authors:KUDLINZKI, D., LINHARD, V.L., GANDE, S.L., SREERAMULU, S., SAXENA, K., HEINZLMEIR, S., MEDARD, G., KUESTER, B., SCHWALBE, H.
Deposit date:2016-02-21
Release date:2016-11-09
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.776 Å)
Cite:Chemical Proteomics and Structural Biology Define EPHA2 Inhibition by Clinical Kinase Drugs.
ACS Chem. Biol., 11, 2016
2JQ7
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MODEL FOR THIOSTREPTON BINDING TO THE RIBOSOMAL L11-RNA
Descriptor:50S RIBOSOMAL PROTEIN L11, RIBOSOMAL RNA, THIOSTREPTON
Authors:Jonker, H.R.A., Ilin, S., Grimm, S.K., Woehnert, J., Schwalbe, H.
Deposit date:2007-05-30
Release date:2007-07-03
Last modified:2017-11-01
Method:SOLUTION NMR
Cite:L11 Domain Rearrangement Upon Binding to RNA and Thiostrepton Studied by NMR Spectroscopy
Nucleic Acids Res., 35, 2007
2K5B
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HUMAN CDC37-HSP90 DOCKING MODEL BASED ON NMR
Descriptor:Heat shock protein HSP 90-alpha, Hsp90 co-chaperone Cdc37
Authors:Sreeramulu, S., Jonker, H.R.A., Lancaster, C.R., Richter, C., Langer, T., Schwalbe, H.
Deposit date:2008-06-26
Release date:2008-12-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The human Cdc37.Hsp90 complex studied by heteronuclear NMR spectroscopy
J.Biol.Chem., 284, 2009
2KER
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ALPHA-AMYLASE INHIBITOR PARVULUSTAT (Z-2685) FROM STREPTOMYCES PARVULUS
Descriptor:Alpha-amylase inhibitor Z-2685
Authors:Rehm, S., Han, S., Hassani, I., Sokocevic, A., Jonker, H.R.A., Engels, J.W., Schwalbe, H.
Deposit date:2009-02-02
Release date:2009-02-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The high resolution NMR structure of parvulustat (Z-2685) from Streptomyces parvulus FH-1641: comparison with tendamistat from Streptomyces tendae 4158
Chembiochem, 10, 2009
2KMJ
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HIGH RESOLUTION NMR SOLUTION STRUCTURE OF A COMPLEX OF HIV-2 TAR RNA AND A SYNTHETIC TRIPEPTIDE IN A 1:2 STOICHIOMETRY
Descriptor:RNA (28-MER), Pyrimidinylpeptide
Authors:Ferner, J., Suhartono, M., Breitung, S., Jonker, H.R.A., Hennig, M., Woehnert, J., Goebel, M., Schwalbe, H.
Deposit date:2009-07-30
Release date:2009-08-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.
Chembiochem, 10, 2009
2KOC
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NMR SOLUTION STRUCTURE OF A 14-MER HAIRPIN RNA WITH CUUCGG TETRALOOP
Descriptor:RNA (5'-R(P*GP*GP*CP*AP*CP*UP*UP*CP*GP*GP*UP*GP*CP*C)-3')
Authors:Nozinovic, S., Fuertig, B., Jonker, H.R.A., Richter, C., Schwalbe, H.
Deposit date:2009-09-17
Release date:2009-12-01
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:High-resolution NMR structure of an RNA model system: the 14-mer cUUCGg tetraloop hairpin RNA
Nucleic Acids Res., 2009