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1HCP
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BU of 1hcp by Molmil
DNA RECOGNITION BY THE OESTROGEN RECEPTOR: FROM SOLUTION TO THE CRYSTAL
Descriptor: HUMAN/CHICKEN ESTROGEN RECEPTOR, ZINC ION
Authors:Schwabe, J.W.R, Rhodes, D, Neuhaus, D.
Deposit date:1993-11-23
Release date:1995-11-23
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:DNA recognition by the oestrogen receptor: from solution to the crystal.
Structure, 1, 1993
1HCQ
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BU of 1hcq by Molmil
THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS
Descriptor: DNA (5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*CP*AP*GP*TP*GP*AP*CP*CP*T P*G)-3'), DNA (5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*CP*TP*GP*TP*GP*AP*CP*CP*T P*G)-3'), PROTEIN (ESTROGEN RECEPTOR), ...
Authors:Schwabe, J.W.R, Chapman, L, Finch, J.T, Rhodes, D.
Deposit date:1995-01-04
Release date:1995-11-23
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements.
Cell(Cambridge,Mass.), 75, 1993
1H9U
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BU of 1h9u by Molmil
The structure of the human retinoid-X-receptor beta ligand binding domain in complex with the specific synthetic agonist LG100268
Descriptor: 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID, CHLORIDE ION, NICKEL (II) ION, ...
Authors:Schwabe, J.W.R, Love, J.D, Gooch, J.T.
Deposit date:2001-03-21
Release date:2002-04-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Structural Basis for the Specificity of Retinoid-X Receptor-Selective Agonists: New Insights Into the Role of Helix H12
J.Biol.Chem., 277, 2002
1HG4
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BU of 1hg4 by Molmil
Ultraspiracle ligand binding domain from Drosophila melanogaster
Descriptor: 2-(HEXADECANOYLOXY)-1-[(PHOSPHONOOXY)METHYL]ETHYL HEXADECANOATE, ULTRASPIRACLE
Authors:Schwabe, J.W.R, Clayton, G.M.
Deposit date:2000-12-12
Release date:2001-02-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Structure of the Ultraspiracle Ligand-Binding Domain Reveals a Nuclear Receptor Locked in an Inactive Conformation
Proc.Natl.Acad.Sci.USA, 98, 2001
6Z2J
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BU of 6z2j by Molmil
The structure of the dimeric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex
Descriptor: Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R.
Deposit date:2020-05-16
Release date:2020-07-08
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (4 Å)
Cite:The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure.
Nat Commun, 11, 2020
1XC5
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BU of 1xc5 by Molmil
Solution Structure of the SMRT Deacetylase Activation Domain
Descriptor: Nuclear receptor corepressor 2
Authors:Codina, A, Love, J.D, Li, Y, Lazar, M.A, Neuhaus, D, Schwabe, J.W.R.
Deposit date:2004-09-01
Release date:2005-05-03
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Structural insights into the interaction and activation of histone deacetylase 3 by nuclear receptor corepressors
Proc.Natl.Acad.Sci.Usa, 102, 2005
8AXW
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BU of 8axw by Molmil
The structure of mouse AsterC (GramD1c) with Ezetimibe
Descriptor: (3~{R},4~{S})-1-(4-fluorophenyl)-3-[(3~{S})-3-(4-fluorophenyl)-3-oxidanyl-propyl]-4-(4-hydroxyphenyl)azetidin-2-one, CHLORIDE ION, ETHANOL, ...
Authors:Fairall, L, Xiao, X, Burger, L, Tontonoz, P, Schwabe, J.W.R.
Deposit date:2022-09-01
Release date:2023-09-13
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake.
Science, 382, 2023
6GQF
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BU of 6gqf by Molmil
The structure of mouse AsterA (GramD1a) with 25-hydroxy cholesterol
Descriptor: 25-HYDROXYCHOLESTEROL, GLYCEROL, GRAM domain-containing protein 1A
Authors:Fairall, L, Gurnett, J.E, Vashi, D, Sandhu, J, Tontonoz, P, Schwabe, J.W.R.
Deposit date:2018-06-07
Release date:2018-09-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.
Cell, 175, 2018
8B69
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BU of 8b69 by Molmil
Heterotetramer of K-Ras4B(G12V) and Rgl2(RBD)
Descriptor: Isoform 2B of GTPase KRas, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Tariq, M, Fairall, L, Romartinez-Alonso, B, Dominguez, C, Schwabe, J.W.R, Tanaka, K.
Deposit date:2022-09-26
Release date:2023-08-23
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.07 Å)
Cite:Structural insights into the complex of oncogenic KRas4B G12V and Rgl2, a RalA/B activator.
Life Sci Alliance, 7, 2024
7AHJ
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BU of 7ahj by Molmil
Crystal structure of PPARgamma V290M mutant ligand binding domain in complex with farglitazar
Descriptor: 2-(2-BENZOYL-PHENYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID, Peroxisome proliferator-activated receptor gamma
Authors:Schoenmakers, E, Schwabe, B.T.W, Fairall, L, Chatterjee, K, Schwabe, J.W.R.
Deposit date:2020-09-24
Release date:2020-10-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of PPARgamma V290M mutant ligand binding domain in complex with farglitazar
To Be Published
6Z2K
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BU of 6z2k by Molmil
The structure of the tetrameric HDAC1/MIDEAS/DNTTIP1 MiDAC deacetylase complex
Descriptor: Deoxynucleotidyltransferase terminal-interacting protein 1, Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Fairall, L, Saleh, A, Ragan, T.J, Millard, C.J, Savva, C.G, Schwabe, J.W.R.
Deposit date:2020-05-16
Release date:2020-07-08
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure.
Nat Commun, 11, 2020
4A69
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BU of 4a69 by Molmil
Structure of HDAC3 bound to corepressor and inositol tetraphosphate
Descriptor: ACETATE ION, D-MYO INOSITOL 1,4,5,6 TETRAKISPHOSPHATE, GLYCEROL, ...
Authors:Watson, P.J, Fairall, L, Santos, G.M, Schwabe, J.W.R.
Deposit date:2011-11-01
Release date:2012-01-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate.
Nature, 481, 2012
4BKX
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BU of 4bkx by Molmil
The structure of HDAC1 in complex with the dimeric ELM2-SANT domain of MTA1 from the NuRD complex
Descriptor: ACETATE ION, HISTONE DEACETYLASE 1, METASTASIS-ASSOCIATED PROTEIN MTA1, ...
Authors:Millard, C.J, Watson, P.J, Celardo, I, Gordiyenko, Y, Cowley, S.M, Robinson, C.V, Fairall, L, Schwabe, J.W.R.
Deposit date:2013-04-30
Release date:2013-07-03
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Class I Hdacs Share a Common Mechanism of Regulation by Inositol Phosphates.
Mol.Cell, 51, 2013
4D6K
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BU of 4d6k by Molmil
Structure of DNTTIP1 dimerisation domain.
Descriptor: DEOXYNUCLEOTIDYLTRANSFERASE TERMINAL-INTERACTING PROTEIN 1
Authors:Itoh, T, Fairall, L, Schwabe, J.W.R.
Deposit date:2014-11-11
Release date:2015-02-18
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Functional Characterization of a Cell Cycle Associated Hdac1/2 Complex Reveals the Structural Basis for Complex Assembly and Nucleosome Targeting.
Nucleic Acids Res., 43, 2015
4CP3
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BU of 4cp3 by Molmil
The structure of BCL6 BTB (POZ) domain in complex with the ansamycin antibiotic rifabutin.
Descriptor: B-CELL LYMPHOMA 6 PROTEIN, RIFABUTIN
Authors:Evans, S.E, Fairall, L, Goult, B.T, Jamieson, A.G, Ferrigno, P.K, Ford, R, Wagner, S.D, Schwabe, J.W.R.
Deposit date:2014-01-31
Release date:2014-03-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Ansamycin Antibiotic, Rifamycin Sv, Inhibits Bcl6 Transcriptional Repression and Forms a Complex with the Bcl6-Btb/Poz Domain.
Plos One, 9, 2014
7AOA
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BU of 7aoa by Molmil
Structure of the extended MTA1/HDAC1/MBD2/RBBP4 NURD deacetylase complex
Descriptor: Histone deacetylase 1, Histone-binding protein RBBP4, INOSITOL HEXAKISPHOSPHATE, ...
Authors:Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R.
Deposit date:2020-10-14
Release date:2020-11-11
Last modified:2020-12-30
Method:ELECTRON MICROSCOPY (19.4 Å)
Cite:The topology of chromatin-binding domains in the NuRD deacetylase complex.
Nucleic Acids Res., 48, 2020
7AO9
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BU of 7ao9 by Molmil
Structure of the core MTA1/HDAC1/MBD2 NURD deacetylase complex
Descriptor: Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, Metastasis-associated protein MTA1, ...
Authors:Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R.
Deposit date:2020-10-14
Release date:2020-11-11
Last modified:2020-12-30
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:The topology of chromatin-binding domains in the NuRD deacetylase complex.
Nucleic Acids Res., 48, 2020
7AO8
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BU of 7ao8 by Molmil
Structure of the MTA1/HDAC1/MBD2 NURD deacetylase complex
Descriptor: Histone deacetylase 1, INOSITOL HEXAKISPHOSPHATE, Metastasis-associated protein MTA1, ...
Authors:Millard, C.J, Fairall, L, Ragan, T.J, Savva, C.G, Schwabe, J.W.R.
Deposit date:2020-10-14
Release date:2020-11-11
Last modified:2020-12-30
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:The topology of chromatin-binding domains in the NuRD deacetylase complex.
Nucleic Acids Res., 48, 2020
2VV3
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BU of 2vv3 by Molmil
hPPARgamma Ligand binding domain in complex with 4-oxoDHA
Descriptor: (6E,10Z,13Z,16Z,19Z)-4-oxodocosa-6,10,13,16,19-pentaenoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
Authors:Itoh, T, Fairall, L, Schwabe, J.W.R.
Deposit date:2008-06-02
Release date:2008-08-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural Basis for the Activation of Ppargamma by Oxidized Fatty Acids.
Nat.Struct.Mol.Biol., 15, 2008
2VSR
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BU of 2vsr by Molmil
hPPARgamma Ligand binding domain in complex with 9-(S)-HODE
Descriptor: (9S,10E,12Z)-9-hydroxyoctadeca-10,12-dienoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
Authors:Itoh, T, Fairall, L, Schwabe, J.W.R.
Deposit date:2008-04-29
Release date:2008-08-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
2VV4
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BU of 2vv4 by Molmil
hPPARgamma Ligand binding domain in complex with 6-oxoOTE
Descriptor: (8E,10S,12Z)-10-hydroxy-6-oxooctadeca-8,12-dienoic acid, (8R,9Z,12Z)-8-hydroxy-6-oxooctadeca-9,12-dienoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
Authors:Itoh, T, Fairall, L, Schwabe, J.W.R.
Deposit date:2008-06-02
Release date:2008-08-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
2VV0
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BU of 2vv0 by Molmil
hPPARgamma Ligand binding domain in complex with DHA
Descriptor: DOCOSA-4,7,10,13,16,19-HEXAENOIC ACID, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
Authors:Itoh, T, Fairall, L, Schwabe, J.W.R.
Deposit date:2008-06-02
Release date:2008-08-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
2VV1
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BU of 2vv1 by Molmil
hPPARgamma Ligand binding domain in complex with 4-HDHA
Descriptor: (4S,5E,7Z,10Z,13Z,16Z,19Z)-4-hydroxydocosa-5,7,10,13,16,19-hexaenoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
Authors:Itoh, T, Fairall, L, Schwabe, J.W.R.
Deposit date:2008-06-02
Release date:2008-08-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
2VST
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BU of 2vst by Molmil
hPPARgamma Ligand binding domain in complex with 13-(S)-HODE
Descriptor: (9Z,11E,13S)-13-hydroxyoctadeca-9,11-dienoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
Authors:Itoh, T, Fairall, L, Schwabe, J.W.R.
Deposit date:2008-04-29
Release date:2008-08-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008
2VV2
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BU of 2vv2 by Molmil
hPPARgamma Ligand binding domain in complex with 5-HEPA
Descriptor: (5R,6E,8Z,11Z,14Z,17Z)-5-hydroxyicosa-6,8,11,14,17-pentaenoic acid, PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA
Authors:Itoh, T, Fairall, L, Schwabe, J.W.R.
Deposit date:2008-06-02
Release date:2008-08-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural Basis for the Activation of Pparg by Oxidised Fatty Acids
Nat.Struct.Mol.Biol., 15, 2008

 

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