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crystal structure of P-TEFb complex with AFF4 and Tat
Descriptor:	ADENOSINE, AF4/FMR2 family member 4, Cyclin-T1, ...
Authors:	Schulze-Gahmen, U, Alber, T.
Deposit date:	2014-01-16
Release date:	2014-05-07
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	AFF4 binding to Tat-P-TEFb indirectly stimulates TAR recognition of super elongation complexes at the HIV promoter. Elife, 3, 2014

PAK1 complex with ST2001
Descriptor:	(5S,6R,7R,9R)-12-HYDROXY-6-METHOXY-5-METHYL-7-(METHYLAMINO)-6,7,8,9-TETRAHYDRO-5H,14H-5,9-EPOXY-4B,9A,15-TRIAZADIBENZO[ B,H]CYCLONONA[1,2,3,4-JKL]CYCLOPENTA[E]-AS-INDACEN-14-ONE, Serine/threonine-protein kinase PAK 1
Authors:	Schulze-Gahmen, U, Lu, H.
Deposit date:	2006-08-04
Release date:	2006-11-07
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Crystal Structure of the Complex Between Human Pak1-kinase and 3-Hydroxystaurosporine To be Published

X-ray structure of human CDK6-Vcyclinwith the inhibitor aminopurvalanol
Descriptor:	(2S)-2-({6-[(3-AMINO-5-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL, Cell division protein kinase 6, Cyclin homolog, ...
Authors:	Schulze-Gahmen, U, Lu, H.
Deposit date:	2005-11-16
Release date:	2006-06-13
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition. J.Med.Chem., 49, 2006

X-ray structure of human CDK6-Vcyclin in complex with the inhibitor PD0332991
Descriptor:	6-ACETYL-8-CYCLOPENTYL-5-METHYL-2-[(5-PIPERAZIN-1-YLPYRIDIN-2-YL)AMINO]PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, ACETATE ION, CALCIUM ION, ...
Authors:	Schulze-Gahmen, U, Lu, H.
Deposit date:	2005-10-28
Release date:	2006-07-04
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	Toward understanding the structural basis of cyclin-dependent kinase 6 specific inhibition. J.Med.Chem., 49, 2006