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6O97
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PROPYLAMYCIN AND BOUND TO MRNA AND A-, P-, AND E-SITE TRNAS AT 2.75A RESOLUTION
Descriptor:23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ...
Authors:Matsushita, T., Sati, G.C., Kondasinghe, N., Pirrone, M.G., Kato, T., Waduge, P., Kumar, H.S., Sanchon, A.C., Dobosz-Bartoszek, M., Shcherbakov, D., Juhas, M., Hobbie, S.N., Schrepfer, T., Chow, C.S., Polikanov, Y.S., Schacht, J., Vasella, A., Bottger, E.C., Crich, D.
Deposit date:2019-03-13
Release date:2019-04-17
Last modified:2019-04-24
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Design, Multigram Synthesis, and in Vitro and in Vivo Evaluation of Propylamycin: A Semisynthetic 4,5-Deoxystreptamine Class Aminoglycoside for the Treatment of Drug-Resistant Enterobacteriaceae and Other Gram-Negative Pathogens.
J. Am. Chem. Soc., 141, 2019
4ZC7
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PAROMOMYCIN BOUND TO A LEISHMANIAL RIBOSOMAL A-SITE
Descriptor:RNA duplex, PAROMOMYCIN
Authors:Shalev, M., Rozenberg, H., Jaffe, C.L., Adir, N., Baasov, T.
Deposit date:2015-04-15
Release date:2015-08-26
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.041 Å)
Cite:Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics.
Nucleic Acids Res., 43, 2015