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2XMB
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G117H MUTANT OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH SULFATE
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, CHLORIDE ION, ...
Authors:Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Deposit date:2010-07-27
Release date:2010-12-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge
Biochem.J., 434, 2011
2XMC
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G117H MUTANT OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH FLUORIDE ANION
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, FLUORIDE ION, ...
Authors:Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Deposit date:2010-07-27
Release date:2010-12-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge
Biochem.J., 434, 2011
2XMD
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G117H MUTANT OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH ECHOTHIOPHATE
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, DIETHYL PHOSPHONATE, ...
Authors:Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Deposit date:2010-07-27
Release date:2010-12-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge
Biochem.J., 434, 2011
2XMG
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G117H MUTANT OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH VX
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP, ...
Authors:Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Deposit date:2010-07-27
Release date:2010-12-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge
Biochem.J., 434, 2011
3DL4
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NON-AGED FORM OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY TABUN- UPDATE
Descriptor:Acetylcholinesterase, HEXAETHYLENE GLYCOL
Authors:Carletti, E., Li, H., Li, B., Ekstrom, F., Nicolet, Y., Loiodice, M., Gillon, E., Froment, M.T., Lockridge, O., Schopfer, L.M., Masson, P., Nachon, F.
Deposit date:2008-06-26
Release date:2008-12-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.
J.Am.Chem.Soc., 130, 2008
3DL7
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AGED FORM OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY TABUN- UPDATE
Descriptor:Acetylcholinesterase, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION, ...
Authors:Carletti, E., Li, H., Li, B., Ekstrom, F., Nicolet, Y., Loiodice, M., Gillon, E., Froment, M.T., Lockridge, O., Schopfer, L.M., Masson, P., Nachon, F.
Deposit date:2008-06-26
Release date:2008-12-02
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.
J.Am.Chem.Soc., 130, 2008
4BBZ
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STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY CBDP (2-MIN SOAK): CRESYL-PHOSPHOSERINE ADDUCT
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Carletti, E., Colletier, J.-P., Schopfer, L.M., Santoni, G., Masson, P., Lockridge, O., Nachon, F., Weik, M.
Deposit date:2012-09-30
Release date:2013-02-06
Last modified:2013-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Inhibition Pathways of the Potent Organophosphate Cbdp with Cholinesterases Revealed by X-Ray Crystallographic Snapshots and Mass Spectrometry
Chem.Res.Toxicol., 26, 2013
4BC0
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STRUCTURE OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY CBDP (12-H SOAK) : CRESYL-PHOSPHOSERINE ADDUCT
Descriptor:ACETYLCHOLINESTERASE, (2-methylphenyl) dihydrogen phosphate, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Carletti, E., Colletier, J.-P., Schopfer, L.M., Santoni, G., Masson, P., Lockridge, O., Nachon, F., Weik, M.
Deposit date:2012-09-30
Release date:2013-02-06
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (3.35 Å)
Cite:Inhibition Pathways of the Potent Organophosphate Cbdp with Cholinesterases Revealed by X-Ray Crystallographic Snapshots and Mass Spectrometry
Chem.Res.Toxicol., 26, 2013
4BC1
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STRUCTURE OF MOUSE ACETYLCHOLINESTERASE INHIBITED BY CBDP (30-MIN SOAK): CRESYL-SALIGENIN-PHOSPHOSERINE ADDUCT
Descriptor:ACETYLCHOLINESTERASE, O-CRESYL-SALIGENIN PHOSPHATE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Carletti, E., Colletier, J.-P., Schopfer, L.M., Santoni, G., Masson, P., Lockridge, O., Nachon, F., Weik, M.
Deposit date:2012-09-30
Release date:2013-02-06
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Inhibition Pathways of the Potent Organophosphate Cbdp with Cholinesterases Revealed by X-Ray Crystallographic Snapshots and Mass Spectrometry
Chem.Res.Toxicol., 26, 2013
6I2T
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CRYOEM RECONSTRUCTION OF FULL-LENGTH, FULLY-GLYCOSYLATED HUMAN BUTYRYLCHOLINESTERASE TETRAMER
Descriptor:Cholinesterase, lamellipodin-derived polyproline peptide, N-ACETYL-D-GLUCOSAMINE
Authors:Leung, M.R., van Bezouwen, L.S., Schopfer, L.M., Sussman, J.L., Silman, I., Lockridge, O., Zeev-Ben-Mordehai, T.
Deposit date:2018-11-01
Release date:2018-12-19
Last modified:2019-01-09
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Cryo-EM structure of the native butyrylcholinesterase tetramer reveals a dimer of dimers stabilized by a superhelical assembly.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
2Y1K
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STRUCTURE OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY CBDP (12H SOAK): PHOSPHOSERINE ADDUCT
Descriptor:CHOLINESTERASE, SULFATE ION, SODIUM ION, ...
Authors:Carletti, E., Colletier, J.P., Nachon, F., Weik, M.
Deposit date:2010-12-08
Release date:2011-06-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Reaction of Cresyl Saligenin Phosphate, the Organophosphorus Agent Implicated in Aerotoxic Syndrome, with Human Cholinesterases: Mechanistic Studies Employing Kinetics, Mass Spectrometry, and X-Ray Structure Analysis.
Chem.Res.Toxicol., 24, 2011
3DJY
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NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Carletti, E., Nachon, F.
Deposit date:2008-06-24
Release date:2008-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.
J.Am.Chem.Soc., 130, 2008
3DKK
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AGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Nachon, F., Carletti, E.
Deposit date:2008-06-25
Release date:2008-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.
J.Am.Chem.Soc., 130, 2008
1FLA
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CLOSTRIDIUM BEIJERINCKII FLAVODOXIN MUTANT: G57D REDUCED
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Ludwig, M.L., Pattridge, K.A., Metzger, A.L., Dixon, M.M., Eren, M., Feng, Y., Swenson, R.
Deposit date:1996-12-18
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.
Biochemistry, 36, 1997
1FLD
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CLOSTRIDIUM BEIJERINCKII FLAVODOXIN MUTANT: G57T OXIDIZED
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Ludwig, M.L., Pattridge, K.A., Metzger, A.L., Dixon, M.M., Eren, M., Feng, Y., Swenson, R.
Deposit date:1996-12-17
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.
Biochemistry, 36, 1997
1FLN
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CLOSTRIDIUM BEIJERINCKII FLAVODOXIN MUTANT: D58P REDUCED
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Ludwig, M.L., Pattridge, K.A., Metzger, A.L., Dixon, M.M., Eren, M., Feng, Y., Swenson, R.
Deposit date:1996-12-18
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.
Biochemistry, 36, 1997
1FVX
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CLOSTRIDIUM BEIJERINCKII FLAVODOXIN MUTANT: G57N OXIDIZED
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Ludwig, M.L., Pattridge, K.A., Metzger, A.L., Dixon, M.M., Eren, M., Feng, Y., Swenson, R.
Deposit date:1996-12-12
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.
Biochemistry, 36, 1997
2FAX
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CLOSTRIDIUM BEIJERINCKII FLAVODOXIN MUTANT: N137A OXIDIZED (150K)
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Ludwig, M.L., Pattridge, K.A., Metzger, A.L., Dixon, M.M., Eren, M., Feng, Y., Swenson, R.
Deposit date:1996-12-24
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.
Biochemistry, 36, 1997
2FDX
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CLOSTRIDIUM BEIJERINCKII FLAVODOXIN MUTANT N137A OXIDIZED
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Ludwig, M.L., Pattridge, K.A., Metzger, A.L., Dixon, M.M., Eren, M., Feng, Y., Swenson, R.
Deposit date:1996-12-24
Release date:1997-04-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.
Biochemistry, 36, 1997
2FLV
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CLOSTRIDIUM BEIJERINCKII FLAVODOXIN MUTANT: G57T REDUCED (150K)
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Ludwig, M.L., Pattridge, K.A., Metzger, A.L., Dixon, M.M., Eren, M., Feng, Y., Swenson, R.
Deposit date:1996-12-19
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.
Biochemistry, 36, 1997
2FOX
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CLOSTRIDIUM BEIJERINCKII FLAVODOXIN: SEMIQUINONE
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Ludwig, M.L., Pattridge, K.A., Metzger, A.L., Dixon, M.M., Eren, M., Feng, Y., Swenson, R.
Deposit date:1997-01-08
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.
Biochemistry, 36, 1997
2FVX
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CLOSTRIDIUM BEIJERINCKII FLAVODOXIN MUTANT: G57T REDUCED (277K)
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Ludwig, M.L., Pattridge, K.A., Metzger, A.L., Dixon, M.M., Eren, M., Feng, Y., Swenson, R.
Deposit date:1996-12-19
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.
Biochemistry, 36, 1997
3NLL
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CLOSTRIDIUM BEIJERINCKII FLAVODOXIN MUTANT: G57A OXIDIZED
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Ludwig, M.L., Pattridge, K.A., Metzger, A.L., Dixon, M.M., Eren, M., Feng, Y., Swenson, R.
Deposit date:1996-12-10
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.
Biochemistry, 36, 1997
4NLL
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CLOSTRIDIUM BEIJERINCKII FLAVODOXIN MUTANT: G57D OXIDIZED
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Ludwig, M.L., Pattridge, K.A., Metzger, A.L., Dixon, M.M., Eren, M., Feng, Y., Swenson, R.
Deposit date:1996-12-16
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.
Biochemistry, 36, 1997
4NUL
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CLOSTRIDIUM BEIJERINCKII FLAVODOXIN MUTANT: D58P OXIDIZED
Descriptor:FLAVODOXIN, FLAVIN MONONUCLEOTIDE
Authors:Ludwig, M.L., Pattridge, K.A., Metzger, A.L., Dixon, M.M., Eren, M., Feng, Y., Swenson, R.
Deposit date:1996-12-13
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Control of oxidation-reduction potentials in flavodoxin from Clostridium beijerinckii: the role of conformation changes.
Biochemistry, 36, 1997
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