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1PQ2
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CRYSTAL STRUCTURE OF HUMAN DRUG METABOLIZING CYTOCHROME P450 2C8
Descriptor:Cytochrome P450 2C8, PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Schoch, G.A., Yano, J.K., Wester, M.R., Griffin, K.J., Stout, C.D., Johnson, E.F.
Deposit date:2003-06-17
Release date:2004-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of human microsomal cytochrome P450 2C8. Evidence for a peripheral fatty acid binding site
J.Biol.Chem., 279, 2004
2NNH
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CYP2C8DH COMPLEXED WITH 2 MOLECULES OF 9-CIS RETINOIC ACID
Descriptor:Cytochrome P450 2C8, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Schoch, G.A., Yano, J.K., Stout, C.D., Johnson, E.F.
Deposit date:2006-10-24
Release date:2007-10-23
Last modified:2016-11-16
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.
J.Biol.Chem., 283, 2008
2NNI
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CYP2C8DH COMPLEXED WITH MONTELUKAST
Descriptor:Cytochrome P450 2C8, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Schoch, G.A., Yano, J.K., Stout, C.D., Johnson, E.F.
Deposit date:2006-10-24
Release date:2007-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.
J.Biol.Chem., 283, 2008
2NNJ
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CYP2C8DH COMPLEXED WITH FELODIPINE
Descriptor:Cytochrome P450 2C8, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Schoch, G.A., Yano, J.K., Stout, C.D., Johnson, E.F.
Deposit date:2006-10-24
Release date:2007-10-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.
J.Biol.Chem., 283, 2008
2VN0
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CYP2C8DH COMPLEXED WITH TROGLITAZONE
Descriptor:CYTOCHROME P450 2C8, PROTOPORPHYRIN IX CONTAINING FE, (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE, ...
Authors:Schoch, G.A., Yano, J.K., Sansen, S., Stout, C.D., Johnson, E.F.
Deposit date:2008-01-30
Release date:2008-04-29
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Determinants of cytochrome P450 2C8 substrate binding: structures of complexes with montelukast, troglitazone, felodipine, and 9-cis-retinoic acid.
J. Biol. Chem., 283, 2008
3H52
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CRYSTAL STRUCTURE OF THE ANTAGONIST FORM OF HUMAN GLUCOCORTICOID RECEPTOR
Descriptor:Glucocorticoid receptor, Nuclear receptor corepressor 1, 11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTA[A]PHENANTHREN-3-ONE, ...
Authors:Schoch, G.A., Benz, J., D'Arcy, B., Stihle, M., Burger, D., Thoma, R., Ruf, A.
Deposit date:2009-04-21
Release date:2009-12-01
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular switch in the glucocorticoid receptor: active and passive antagonist conformations
J.Mol.Biol., 395, 2010
1ZV4
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING 17 (RGSZ2)
Descriptor:Regulator of G-protein signaling 17
Authors:Schoch, G.A., Jansson, A., Elkins, J.M., Haroniti, A., Niesen, F.H., Bunkoczi, G., Lee, W.H., Turnbull, A.P., Yang, X., Sundstrom, M., Arrowsmith, C., Edwards, A., Marsden, B., Gileadi, O., Ball, L., von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-06-01
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2A72
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING DOMAIN OF RGS7
Descriptor:Regulator of G-protein signalling 7, CHLORIDE ION
Authors:Schoch, G.A., Johansson, C., Phillips, C., Debreczeni, J., Smee, C., Elkins, J.M., Sundstrom, M., Edwards, A., Arrowsmith, C., von Delft, F., Gileadi, O., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-07-04
Release date:2005-07-12
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2ES0
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING DOMAIN OF RGS6
Descriptor:regulator of G-protein signalling 6
Authors:Schoch, G.A., Phillips, C., Turnbull, A., Niesen, F., Johansson, C., Elkins, J.M., Longman, E., Gilealdi, C., Sobott, F., Ball, L., Sundstrom, M., Edwards, A., Arrowsmith, C., von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-10-25
Release date:2005-11-29
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3MNE
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CRYSTAL STRUCTURE OF THE AGONIST FORM OF MOUSE GLUCOCORTICOID RECEPTOR STABILIZED BY F608S MUTATION AT 1.96A
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2 peptide, GLYCEROL, ...
Authors:Schoch, G.A., Seitz, T., Benz, J., Banner, D., Stihle, M., D'Arcy, B., Thoma, R., Sterner, R., Hennig, M., Ruf, A.
Deposit date:2010-04-21
Release date:2010-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening.
J.Mol.Biol., 403, 2010
3MNO
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CRYSTAL STRUCTURE OF THE AGONIST FORM OF MOUSE GLUCOCORTICOID RECEPTOR STABILIZED BY (A611V, F608S) MUTATIONS AT 1.55A
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2 peptide, GLYCEROL, ...
Authors:Schoch, G.A., Seitz, T., Benz, J., Banner, D., Stihle, M., D'Arcy, B., Thoma, R., Sterner, R., Hennig, M., Ruf, A.
Deposit date:2010-04-22
Release date:2010-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening.
J.Mol.Biol., 403, 2010
3MNP
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CRYSTAL STRUCTURE OF THE AGONIST FORM OF MOUSE GLUCOCORTICOID RECEPTOR STABILIZED BY (A611V, V708A, E711G) MUTATIONS AT 1.50A
Descriptor:Glucocorticoid receptor, Nuclear receptor coactivator 2 peptide, GLYCEROL, ...
Authors:Schoch, G.A., Seitz, T., Benz, J., Banner, D., Stihle, M., D'Arcy, B., Thoma, R., Sterner, R., Hennig, M., Ruf, A.
Deposit date:2010-04-22
Release date:2010-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening.
J.Mol.Biol., 403, 2010
1R9O
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CRYSTAL STRUCTURE OF P4502C9 WITH FLURBIPROFEN BOUND
Descriptor:Cytochrome P450 2C9, PROTOPORPHYRIN IX CONTAINING FE, FLURBIPROFEN, ...
Authors:Wester, M.R., Yano, J.K., Schoch, G.A., Griffin, K.J., Stout, C.D., Johnson, E.F.
Deposit date:2003-10-30
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Structure of Human Cytochrome P450 2C9 Complexed with Flurbiprofen at 2.0 A Resolution
J.Biol.Chem., 279, 2004
1TQN
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CRYSTAL STRUCTURE OF HUMAN MICROSOMAL P450 3A4
Descriptor:cytochrome P450 3A4, PROTOPORPHYRIN IX CONTAINING FE
Authors:Yano, J.K., Wester, M.R., Schoch, G.A., Griffin, K.J., Stout, C.D., Johnson, E.F.
Deposit date:2004-06-17
Release date:2004-07-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The Structure of Human Microsomal Cytochrome P450 3A4 Determined by X-ray Crystallography to 2.05-A Resolution
J.Biol.Chem., 279, 2004
2BV1
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REGULATOR OF G-PROTEIN SIGNALLING 1 (HUMAN)
Descriptor:REGULATOR OF G-PROTEIN SIGNALLING 1
Authors:Elkins, J.M., Yang, X., Soundararajan, M., Schoch, G.A., Haroniti, A., Sundstrom, M., Edwards, A., Arrowsmith, C., Doyle, D.A.
Deposit date:2005-06-20
Release date:2005-06-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc. Natl. Acad. Sci. U.S.A., 105, 2008
2JNU
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SOLUTION STRUCTURE OF THE RGS DOMAIN OF HUMAN RGS14
Descriptor:Regulator of G-protein signaling 14
Authors:Dowler, E.F., Diehl, A., Bray, J., Elkins, J., Soundararajan, M., Doyle, D.A., Gileadi, C., Phillips, C., Schoch, G.A., Yang, X., Brockmann, C., Leidert, M., Rehbein, K., Schmieder, P., Kuhne, R., Higman, V.A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
Deposit date:2007-02-02
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
4WG0
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CRYSTAL STRUCTURE OF A TRIDECAMERIC SUPERHELIX
Descriptor:Nuclear receptor coactivator 2, SULFATE ION, CHOLIC ACID
Authors:Rudolph, M.G., Uson, I., Schoch, G.
Deposit date:2014-09-17
Release date:2015-01-21
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structure of a 13-fold superhelix (almost) determined from first principles.
Iucrj, 2, 2015
2HI4
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CRYSTAL STRUCTURE OF HUMAN MICROSOMAL P450 1A2 IN COMPLEX WITH ALPHA-NAPHTHOFLAVONE
Descriptor:Cytochrome P450 1A2, PROTOPORPHYRIN IX CONTAINING FE, 2-PHENYL-4H-BENZO[H]CHROMEN-4-ONE
Authors:Sansen, S., Yano, J.K., Reynald, R.L., Schoch, G.S., Stout, C.D., Johnson, E.F.
Deposit date:2006-06-29
Release date:2007-02-20
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2.
J.Biol.Chem., 282, 2007
2JM5
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SOLUTION STRUCTURE OF THE RGS DOMAIN FROM HUMAN RGS18
Descriptor:Regulator of G-protein signaling 18
Authors:Higman, V.A., Leidert, M., Bray, J., Elkins, J., Soundararajan, M., Doyle, D.A., Gileadi, C., Phillips, C., Schoch, G., Yang, X., Brockmann, C., Schmieder, P., Diehl, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
Deposit date:2006-10-11
Release date:2006-10-24
Last modified:2012-08-15
Method:SOLUTION NMR
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2OWI
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SOLUTION STRUCTURE OF THE RGS DOMAIN FROM HUMAN RGS18
Descriptor:Regulator of G-protein signaling 18
Authors:Higman, V.A., Leidert, M., Bray, J., Elkins, J., Soundararajan, M., Doyle, D.A., Gileadi, C., Phillips, C., Schoch, G., Yang, X., Brockmann, C., Schmieder, P., Diehl, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
Deposit date:2007-02-16
Release date:2007-02-27
Last modified:2012-08-15
Method:SOLUTION NMR
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2AF0
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING DOMAIN OF RGS2
Descriptor:Regulator of G-protein signaling 2
Authors:Papagrigoriou, E., Johannson, C., Phillips, C., Smee, C., Elkins, J.M., Weigelt, J., Arrowsmith, C., Edwards, A., Sundstrom, M., Von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-07-25
Release date:2005-08-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2BT2
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING 16
Descriptor:REGULATOR OF G-PROTEIN SIGNALING 16
Authors:Bunkoczi, G., Haroniti, A., Longman, E., Niesen, F., Soundararajan, M., Ball, L.J., von Delft, F., Doyle, D.A., Arrowsmith, C., Edwards, A., Sundstrom, M.
Deposit date:2005-05-25
Release date:2005-06-03
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Diversity in the Rgs Domain and its Interaction with Heterotrimeric G Protein Alpha- Subunits.
Proc.Natl.Acad.Sci.USA, 105, 2008
2BYG
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2ND PDZ DOMAIN OF DISCS LARGE HOMOLOGUE 2
Descriptor:CHANNEL ASSOCIATED PROTEIN OF SYNAPSE-110
Authors:Elkins, J.M., Schoch, G.A., Smee, C.E.A., Berridge, G., Salah, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-08-01
Release date:2005-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extensions.
Protein Sci., 16, 2007
2C23
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14-3-3 PROTEIN BETA (HUMAN) IN COMPLEX WITH EXOENZYME S PEPTIDE
Descriptor:14-3-3 BETA/ALPHA, EXOENZYME S PEPTIDE
Authors:Elkins, J.M., Schoch, G.A., Yang, X., Sundstrom, M., Arrowsmith, C., Edwards, A., Doyle, D.A.
Deposit date:2005-09-26
Release date:2005-09-29
Last modified:2013-12-04
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
Proc.Natl.Acad.Sci.USA, 103, 2006
2GTP
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CRYSTAL STRUCTURE OF THE HETERODIMERIC COMPLEX OF HUMAN RGS1 AND ACTIVATED GI ALPHA 1
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, Regulator of G-protein signaling 1, ...
Authors:Soundararajan, M., Turnbull, A.P., Ugochukwu, E., Gorrec, F., von Delft, F., Weigelt, J., Edwards, A., Arrowsmith, C., Sundstrom, M., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2006-04-28
Release date:2006-05-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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