Author results

6CM2
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SAMHD1 HD DOMAIN BOUND TO DECITABINE TRIPHOSPHATE
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 6-amino-3-{2-deoxy-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-erythro-pentofuranosyl}-3,4-dihydro-1,3,5-triazin-2(1H)-one, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Oellerich, T., Schneider, C., Thomas, D., Knecht, K.M., Buzovetsky, O., Kaderali, L., Schliemann, C., Bohnenberger, H., Angenendt, L., Hartmann, W., Wardelmann, E., Rothenburger, T., Mohr, S., Scheich, S., Comoglio, F., Wilke, A., Strobel, P., Serve, H., Michaelis, M., Ferreiros, N., Geisslinger, G., Xiong, Y., Keppler, O.T., Cinatl, J.
Deposit date:2018-03-02
Release date:2019-06-19
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:SAMHD1 is a Resistance Factor and Predictive Biomarker for Decitabine in Acute Myeloid Leukemia
To Be Published
2MKC
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COOPERATIVE STRUCTURE OF THE HETEROTRIMERIC PRE-MRNA RETENTION AND SPLICING COMPLEX
Descriptor:U2 snRNP component IST3, Pre-mRNA leakage protein 1, Pre-mRNA-splicing factor CWC26
Authors:Wysoczanski, P., Schneider, C., Xiang, S., Munari, F., Trowitzsch, S., Wahl, M.C., Luhrmann, R., Becker, S., Zweckstetter, M.
Deposit date:2014-02-04
Release date:2014-09-03
Last modified:2014-10-22
Method:SOLUTION NMR
Cite:Cooperative structure of the heterotrimeric pre-mRNA retention and splicing complex.
Nat.Struct.Mol.Biol., 21, 2014
6DW3
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SAMHD1 BOUND TO CYTARABINE-TP IN THE CATALYTIC POCKET
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 4-amino-1-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}pyrimidin-2(1H)-one, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ...
Authors:Knecht, K.M., Buzovetsky, O., Schneider, C., Thomas, D., Srikanth, V., Kaderali, L., Tofoleanu, F., Reiss, K., Ferreiros, N., Geisslinger, G., Batista, V.S., Ji, X., Cinatl, J., Keppler, O.T., Xiong, Y.
Deposit date:2018-06-26
Release date:2018-10-10
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DW4
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SAMHD1 BOUND TO CLADRIBINE-TP IN THE CATALYTIC POCKET AND ALLOSTERIC POCKET
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-deoxy-2-methyladenosine 5'-(tetrahydrogen triphosphate), GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Knecht, K.M., Buzovetsky, O., Schneider, C., Thomas, D., Srikanth, V., Kaderali, L., Tofoleanu, F., Reiss, K., Ferreiros, N., Geisslinger, G., Batista, V.S., Ji, X., Cinatl, J., Keppler, O.T., Xiong, Y.
Deposit date:2018-06-26
Release date:2018-10-10
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DW5
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SAMHD1 BOUND TO GEMCITABINE-TP IN THE CATALYTIC POCKET
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-deoxy-2',2'-difluorocytidine 5'-(tetrahydrogen triphosphate), GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Knecht, K.M., Buzovetsky, O., Schneider, C., Thomas, D., Srikanth, V., Kaderali, L., Tofoleanu, F., Reiss, K., Ferreiros, N., Geisslinger, G., Batista, V.S., Ji, X., Cinatl, J., Keppler, O.T., Xiong, Y.
Deposit date:2018-06-26
Release date:2018-10-10
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DW7
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SAMHD1 WITHOUT CATALYTIC NUCLEOTIDES
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Knecht, K.M., Buzovetsky, O., Schneider, C., Thomas, D., Srikanth, V., Kaderali, L., Tofoleanu, F., Reiss, K., Ferreiros, N., Geisslinger, G., Batista, V.S., Ji, X., Cinatl, J., Keppler, O.T., Xiong, Y.
Deposit date:2018-06-26
Release date:2018-10-10
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DWD
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SAMHD1 BOUND TO CLOFARABINE-TP IN THE CATALYTIC POCKET AND ALLOSTERIC POCKET
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 9-{2-deoxy-2-fluoro-5-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-2-methyl-9H-purin-6-amine, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Knecht, K.M., Buzovetsky, O., Schneider, C., Thomas, D., Srikanth, V., Kaderali, L., Tofoleanu, F., Reiss, K., Ferreiros, N., Geisslinger, G., Batista, V.S., Ji, X., Cinatl, J., Keppler, O.T., Xiong, Y.
Deposit date:2018-06-26
Release date:2018-10-10
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DWJ
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SAMHD1 BOUND TO VIDARABINE-TP IN THE CATALYTIC POCKET
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 9-{5-O-[(S)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-amine, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Knecht, K.M., Buzovetsky, O., Schneider, C., Thomas, D., Srikanth, V., Kaderali, L., Tofoleanu, F., Reiss, K., Ferreiros, N., Geisslinger, G., Batista, V.S., Ji, X., Cinatl, J., Keppler, O.T., Xiong, Y.
Deposit date:2018-06-26
Release date:2018-10-24
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6DWK
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SAMHD1 BOUND TO FLUDARABINE-TP IN THE CATALYTIC POCKET
Descriptor:Deoxynucleoside triphosphate triphosphohydrolase SAMHD1, 2-fluoro-9-{5-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl]-beta-D-arabinofuranosyl}-9H-purin-6-amine, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:Knecht, K.M., Buzovetsky, O., Schneider, C., Thomas, D., Srikanth, V., Kaderali, L., Tofoleanu, F., Reiss, K., Ferreiros, N., Geisslinger, G., Batista, V.S., Ji, X., Cinatl, J., Keppler, O.T., Xiong, Y.
Deposit date:2018-06-26
Release date:2018-10-10
Last modified:2018-11-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
1HX1
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CRYSTAL STRUCTURE OF A BAG DOMAIN IN COMPLEX WITH THE HSC70 ATPASE DOMAIN
Descriptor:Heat shock 70 kDa protein 8, BAG family molecular chaperone regulator 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Sondermann, H., Scheufler, C., Moarefi, I.
Deposit date:2001-01-11
Release date:2001-03-07
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors.
Science, 291, 2001
1YET
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GELDANAMYCIN BOUND TO THE HSP90 GELDANAMYCIN-BINDING DOMAIN
Descriptor:HEAT SHOCK PROTEIN 90, GELDANAMYCIN
Authors:Stebbins, C.E., Russo, A.A., Pavletich, N.P.
Deposit date:1997-03-25
Release date:1998-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.
Cell(Cambridge,Mass.), 89, 1997
1YER
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HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "CLOSED" CONFORMATION
Descriptor:HEAT SHOCK PROTEIN 90
Authors:Stebbins, C.E., Russo, A.A., Pavletich, N.P.
Deposit date:1997-03-25
Release date:1998-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.
Cell(Cambridge,Mass.), 89, 1997
1YES
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HUMAN HSP90 GELDANAMYCIN-BINDING DOMAIN, "OPEN" CONFORMATION
Descriptor:HEAT SHOCK PROTEIN 90
Authors:Stebbins, C.E., Russo, A.A., Pavletich, N.P.
Deposit date:1997-03-25
Release date:1998-04-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of an Hsp90-geldanamycin complex: targeting of a protein chaperone by an antitumor agent.
Cell(Cambridge,Mass.), 89, 1997
2RGF
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RBD OF RAL GUANOSINE-NUCLEOTIDE EXCHANGE FACTOR (PROTEIN), NMR, 10 STRUCTURES
Descriptor:RALGEF-RBD
Authors:Geyer, M., Herrmann, C., Wittinghofer, A., Kalbitzer, H.R.
Deposit date:1997-02-13
Release date:1998-03-04
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the Ras-binding domain of RalGEF and implications for Ras binding and signalling.
Nat.Struct.Biol., 4, 1997
1RAX
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RA-DOMAIN OF RAL GUANOSINE-NUCLEOTIDE DISSOCIATION STIMULATOR
Descriptor:PROTEIN (RA-DOMAIN OF RAL GUANOSINE DISSOCIATION STIMULATOR)
Authors:Mueller, T.D., Handel, L., Schmieder, P., Oschkinat, H.
Deposit date:1999-03-13
Release date:1999-03-19
Last modified:2019-11-06
Method:SOLUTION NMR
Cite:High-Resolution Structure of the Ra-Domain of Human Ralgds and a Dynamics Study of its Binding Loop to Ras
To be Published
1LFD
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CRYSTAL STRUCTURE OF THE ACTIVE RAS PROTEIN COMPLEXED WITH THE RAS-INTERACTING DOMAIN OF RALGDS
Descriptor:RALGDS, RAS, MAGNESIUM ION, ...
Authors:Huang, L., Hofer, F., Martin, G.S., Kim, S.-H.
Deposit date:1998-04-29
Release date:1999-05-04
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for the interaction of Ras with RalGDS.
Nat.Struct.Biol., 5, 1998
1LXD
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CRYSTAL STRUCTURE OF THE RAS INTERACTING DOMAIN OF RALGDS, A GUANINE NUCLEOTIDE DISSOCIATION STIMULATOR OF RAL PROTEIN
Descriptor:RALGDSB
Authors:Huang, L., Weng, X.W., Hofer, F., Martin, G.S., Kim, S.H.
Deposit date:1997-03-05
Release date:1998-03-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Three-dimensional structure of the Ras-interacting domain of RalGDS.
Nat.Struct.Biol., 4, 1997