Author results

5GAK
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YEAST 60S RIBOSOMAL SUBUNIT WITH A-SITE TRNA, P-SITE TRNA AND EIF-5A
Descriptor:25S rRNA, 60S ribosomal protein L23-A, 5S rRNA, ...
Authors:Schmidt, C., Becker, T.
Deposit date:2015-12-09
Release date:2016-02-24
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.88 Å)
Cite:Structure of the hypusinylated eukaryotic translation factor eIF-5A bound to the ribosome.
Nucleic Acids Res., 44, 2016
5MC6
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CRYO-EM STRUCTURE OF A NATIVE RIBOSOME-SKI2-SKI3-SKI8 COMPLEX FROM S. CEREVISIAE
Descriptor:18S ribosomal RNA, 40S ribosomal protein S3, 40S ribosomal protein S5, ...
Authors:Schmidt, C., Kowalinski, E., Shanmuganathan, V., Defenouillere, Q., Braunger, K., Heuer, A., Pech, M., Namane, A., Berninghausen, O., Fromont-Racine, M., Jacquier, A., Conti, E., Becker, T., Beckmann, R.
Deposit date:2016-11-09
Release date:2017-01-18
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Science, 354, 2016
3PCQ
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FEMTOSECOND X-RAY PROTEIN NANOCRYSTALLOGRAPHY
Descriptor:Photosystem I P700 chlorophyll a apoprotein A1, Photosystem I P700 chlorophyll a apoprotein A2, Photosystem I iron-sulfur center, ...
Authors:Chapman, H.N., Fromme, P., Barty, A., White, T.A., Kirian, R.A., Aquila, A., Hunter, M.S., Schulz, J., Deponte, D.P., Weierstall, U., Doak, R.B., Maia, F.R.N.C., Martin, A.V., Schlichting, I., Lomb, L., Coppola, N., Shoeman, R.L., Epp, S.W., Hartmann, R., Rolles, D., Rudenko, A., Foucar, L., Kimmel, N., Weidenspointner, G., Holl, P., Liang, M., Barthelmess, M., Caleman, C., Boutet, S., Bogan, M.J., Krzywinski, J., Bostedt, C., Bajt, S., Gumprecht, L., Rudek, B., Erk, B., Schmidt, C., Homke, A., Reich, C., Pietschner, D., Struder, L., Hauser, G., Gorke, H., Ullrich, J., Herrmann, S., Schaller, G., Schopper, F., Soltau, H., Kuhnel, K.-U., Messerschmidt, M., Bozek, J.D., Hau-Riege, S.P., Frank, M., Hampton, C.Y., Sierra, R., Starodub, D., Williams, G.J., Hajdu, J., Timneanu, N., Seibert, M.M., Andreasson, J., Rocker, A., Jonsson, O., Svenda, M., Stern, S., Nass, K., Andritschke, R., Schroter, C.-D., Krasniqi, F., Bott, M., Schmidt, K.E., Wang, X., Grotjohann, I., Holton, J.M., Barends, T.R.M., Neutze, R., Marchesini, S., Fromme, R., Schorb, S., Rupp, D., Adolph, M., Gorkhover, T., Andersson, I., Hirsemann, H., Potdevin, G., Graafsma, H., Nilsson, B., Spence, J.C.H.
Deposit date:2010-10-21
Release date:2011-02-02
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (8.984 Å)
Cite:Femtosecond X-ray protein nanocrystallography.
Nature, 470, 2011
6YNQ
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STRUCTURE OF SARS-COV-2 MAIN PROTEASE BOUND TO 2-METHYL-1-TETRALONE.
Descriptor:Replicase polyprotein 1ab, (2~{S})-2-methyl-3,4-dihydro-2~{H}-naphthalen-1-one, DIMETHYL SULFOXIDE, ...
Authors:Guenther, S., Reinke, P., Oberthuer, D., Yefanov, O., Gelisio, L., Ginn, H., Lieske, J., Domaracky, M., Brehm, W., Rahmani Mashour, A., White, T.A., Knoska, J., Pena Esperanza, G., Koua, F., Tolstikova, A., Groessler, M., Fischer, P., Hennicke, V., Fleckenstein, H., Trost, F., Galchenkova, M., Gevorkov, Y., Li, C., Awel, S., Paulraj, L.X., Ullah, N., Falke, S., Alves Franca, B., Schwinzer, M., Brognaro, H., Werner, N., Perbandt, M., Tidow, H., Seychell, B., Beck, T., Meier, S., Doyle, J.J., Giseler, H., Melo, D., Dunkel, I., Lane, T.J., Peck, A., Saouane, S., Hakanpaeae, J., Meyer, J., Noei, H., Gribbon, P., Ellinger, B., Kuzikov, M., Wolf, M., Zhang, L., Ehrt, C., Pletzer-Zelgert, J., Wollenhaupt, J., Feiler, C., Weiss, M., Schulz, E.C., Mehrabi, P., Norton-Baker, B., Schmidt, C., Lorenzen, K., Schubert, R., Han, H., Chari, A., Fernandez Garcia, Y., Turk, D., Hilgenfeld, R., Rarey, M., Zaliani, A., Chapman, H.N., Pearson, A., Betzel, C., Meents, A.
Deposit date:2020-04-14
Release date:2020-04-29
Last modified:2020-06-17
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of SARS-CoV-2 Main Protease bound 2-Methyl-1-tetralone.
To Be Published
6YT8
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STRUCTURE OF SARS-COV-2 MAIN PROTEASE BOUND TO PYRITHIONE ZINC
Descriptor:Replicase polyprotein 1ab, 9-oxa-7-thia-1-azonia-8$l^{2}-zincabicyclo[4.3.0]nona-1,3,5-triene, IMIDAZOLE, ...
Authors:Guenther, S., Reinke, P., Oberthuer, D., Yefanov, O., Gelisio, L., Ginn, H., Lieske, J., Domaracky, M., Brehm, W., Rahmani Mashour, A., White, T.A., Knoska, J., Pena Esperanza, G., Koua, F., Tolstikova, A., Groessler, M., Fischer, P., Hennicke, V., Fleckenstein, H., Trost, F., Galchenkova, M., Gevorkov, Y., Li, C., Awel, S., Paulraj, L.X., Ullah, N., Falke, S., Alves Franca, B., Schwinzer, M., Brognaro, H., Werner, N., Perbandt, M., Tidow, H., Seychell, B., Beck, T., Meier, S., Doyle, J.J., Giseler, H., Melo, D., Dunkel, I., Lane, T.J., Peck, A., Saouane, S., Hakanpaeae, J., Meyer, J., Noei, H., Gribbon, P., Ellinger, B., Kuzikov, M., Wolf, M., Zhang, L., Ehrt, C., Pletzer-Zelgert, J., Wollenhaupt, J., Feiler, C., Weiss, M., Schulz, E.C., Mehrabi, P., Norton-Baker, B., Schmidt, C., Lorenzen, K., Schubert, R., Han, H., Chari, A., Fernandez Garcia, Y., Turk, D., Hilgenfeld, R., Rarey, M., Zaliani, A., Chapman, H.N., Pearson, A., Betzel, C., Meents, A.
Deposit date:2020-04-24
Release date:2020-05-06
Last modified:2020-05-20
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure of SARS-CoV-2 Main Protease bound 2-Methyl-1-tetralone.
To Be Published
6YVF
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STRUCTURE OF SARS-COV-2 MAIN PROTEASE BOUND TO AZD6482.
Descriptor:Replicase polyprotein 1ab, 2-[[(1R)-1-(7-methyl-2-morpholin-4-yl-4-oxidanylidene-pyrido[1,2-a]pyrimidin-9-yl)ethyl]amino]benzoic acid, CHLORIDE ION, ...
Authors:Guenther, S., Reinke, P., Oberthuer, D., Yefanov, O., Gelisio, L., Ginn, H., Lieske, J., Domaracky, M., Brehm, W., Rahmani Mashour, A., White, T.A., Knoska, J., Pena Esperanza, G., Koua, F., Tolstikova, A., Groessler, M., Fischer, P., Hennicke, V., Fleckenstein, H., Trost, F., Galchenkova, M., Gevorkov, Y., Li, C., Awel, S., Paulraj, L.X., Ullah, N., Falke, S., Alves Franca, B., Schwinzer, M., Brognaro, H., Werner, N., Perbandt, M., Tidow, H., Seychell, B., Beck, T., Meier, S., Doyle, J.J., Giseler, H., Melo, D., Dunkel, I., Lane, T.J., Peck, A., Saouane, S., Hakanpaeae, J., Meyer, J., Noei, H., Gribbon, P., Ellinger, B., Kuzikov, M., Wolf, M., Zhang, L., Ehrt, C., Pletzer-Zelgert, J., Wollenhaupt, J., Feiler, C., Weiss, M., Schulz, E.C., Mehrabi, P., Norton-Baker, B., Schmidt, C., Lorenzen, K., Schubert, R., Han, H., Chari, A., Fernandez Garcia, Y., Turk, D., Hilgenfeld, R., Rarey, M., Zaliani, A., Chapman, H.N., Pearson, A., Betzel, C., Meents, A.
Deposit date:2020-04-28
Release date:2020-05-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of SARS-CoV-2 Main Protease bound 2-Methyl-1-tetralone.
To Be Published
6YZ6
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STRUCTURE OF THE HEMIACETAL COMPLEX BETWEEN THE SARS-COV-2 MAIN PROTEASE AND LEUPEPTIN
Descriptor:Main Protease, LEUPEPTIN, DIMETHYL SULFOXIDE, ...
Authors:Guenther, S., Reinke, P.Y.A., Oberthuer, D., Yefanov, O., Gelisio, L., Ginn, H.M., Lieske, J., Domaracky, M., Brehm, W., Rahmani Mashhour, A., White, T.A., Knoska, J., Pena Esperanza, G., Koua, F., Tolstikova, A., Groessler, M., Fischer, P., Hennicke, V., Fleckenstein, H., Trost, F., Galchenkova, M., Gevorkov, Y., Li, C., Awel, S., Xavier, P.L., Ullah, N., Andaleeb, H., Falke, S., Alves Franca, B., Schwinzer, M., Brognaro, H., Werner, N., Perbandt, M., Tidow, H., Seychell, B., Beck, T., Meier, S., Zaitsev-Doyle, J.J., Rogers, C., Gieseler, H., Melo, D., Monteiro, D.C.F., Dunkel, I., Lane, T.J., Peck, A., Saouane, S., Hakanpaeae, J., Meyer, J., Noei, H., Gribbon, P., Ellinger, B., Kuzikov, M., Wolf, M., Zhang, L., Ehrt, C., Pletzer-Zelgert, J., Wollenhaupt, J., Feiler, C., Weiss, M., Schluenzen, F., Schulz, E.C., Mehrabi, P., Norton-Baker, B., Schmidt, C., Lorenzen, K., Schubert, R., Sun, X., Han, H., Chari, A., Fernandez Garcia, Y., Turk, D., Hilgenfeld, R., Rarey, M., Zaliani, A., Chapman, H.N., Pearson, A., Betzel, C., Meents, A.
Deposit date:2020-05-06
Release date:2020-05-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the hemiacetal complex between the SARS-CoV-2 Main Protease and Leupeptin
To Be Published
6FJS
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PROTEINASE~K SIRAS PHASED STRUCTURE OF ROOM-TEMPERATURE, SERIALLY COLLECTED SYNCHROTRON DATA
Descriptor:Proteinase K, CALCIUM ION
Authors:Botha, S., Baitan, D., Jungnickel, K.E.J., Oberthuer, D., Schmidt, C., Stern, S., Wiedorn, M.O., Perbandt, M., Chapman, H.N., Betzel, C.
Deposit date:2018-01-23
Release date:2018-10-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:De novoprotein structure determination by heavy-atom soaking in lipidic cubic phase and SIRAS phasing using serial synchrotron crystallography.
IUCrJ, 5, 2018
6R7F
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STRUCTURAL BASIS OF CULLIN-2 RING E3 LIGASE REGULATION BY THE COP9 SIGNALOSOME
Descriptor:COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
Authors:Faull, S.V., Lau, A.M.C., Martens, C., Ahdash, Z., Yebenes, H., Schmidt, C., Beuron, F., Cronin, N.B., Morris, E.P., Politis, A.
Deposit date:2019-03-28
Release date:2019-08-28
Last modified:2019-10-09
Method:ELECTRON MICROSCOPY (8.2 Å)
Cite:Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
6R7N
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STRUCTURAL BASIS OF CULLIN-2 RING E3 LIGASE REGULATION BY THE COP9 SIGNALOSOME
Descriptor:COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 4, COP9 signalosome complex subunit 8, ...
Authors:Faull, S.V., Lau, A.M.C., Martens, C., Ahdash, Z., Yebenes, H., Schmidt, C., Beuron, F., Cronin, N.B., Morris, E.P., Politis, A.
Deposit date:2019-03-29
Release date:2019-08-28
Last modified:2019-09-04
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
5LL6
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STRUCTURE OF THE 40S ABCE1 POST-SPLITTING COMPLEX IN RIBOSOME RECYCLING AND TRANSLATION INITIATION
Descriptor:18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ...
Authors:Heuer, A., Gerovac, M., Schmidt, C., Trowitzsch, S., Preis, A., Koetter, P., Berninghausen, O., Becker, T., Beckmann, R., Tampe, R.
Deposit date:2016-07-26
Release date:2017-04-12
Last modified:2018-11-21
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation.
Nat. Struct. Mol. Biol., 24, 2017
5TJ5
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ATOMIC MODEL FOR THE MEMBRANE-EMBEDDED MOTOR OF A EUKARYOTIC V-ATPASE
Descriptor:V-type proton ATPase subunit a, V-type proton ATPase subunit c'', V-type proton ATPase subunit c', ...
Authors:Mazhab-Jafari, M.T., Rohou, A., Schmidt, C., Bueler, S.A., Benlekbir, S., Robinson, C.V., Rubinstein, J.L.
Deposit date:2016-10-03
Release date:2016-10-26
Last modified:2020-01-15
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Atomic model for the membrane-embedded VO motor of a eukaryotic V-ATPase.
Nature, 539, 2016
6EML
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CRYO-EM STRUCTURE OF A LATE PRE-40S RIBOSOMAL SUBUNIT FROM SACCHAROMYCES CEREVISIAE
Descriptor:pre-18S ribosomal RNA, 40S ribosomal protein S12, 40S ribosomal protein S5, ...
Authors:Heuer, A., Thomson, E., Schmidt, C., Berninghausen, O., Becker, T., Hurt, E., Beckmann, R.
Deposit date:2017-10-02
Release date:2017-11-29
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of a late pre-40S ribosomal subunit fromSaccharomyces cerevisiae.
Elife, 6, 2017
5JDP
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E73V MUTANT OF THE HUMAN VOLTAGE-DEPENDENT ANION CHANNEL
Descriptor:Voltage-dependent anion-selective channel protein 1
Authors:Jaremko, M., Jaremko, L., Villinger, S., Schmidt, C., Giller, K., Griesinger, C., Becker, S., Zweckstetter, M.
Deposit date:2016-04-17
Release date:2016-08-10
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:High-Resolution NMR Determination of the Dynamic Structure of Membrane Proteins.
Angew.Chem.Int.Ed.Engl., 55, 2016
4BWD
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HUMAN SHORT COILED COIL PROTEIN
Descriptor:SHORT COILED-COIL PROTEIN
Authors:Behrens, C., Binotti, B., Chua, J.J., Kuhnel, K.
Deposit date:2013-07-01
Release date:2013-09-11
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (2.702 Å)
Cite:Crystal Structure of the Human Short Coiled Coil Protein and Insights Into Scoc-Fez1 Complex Formation.
Plos One, 8, 2013
4FE1
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IMPROVING THE ACCURACY OF MACROMOLECULAR STRUCTURE REFINEMENT AT 7 A RESOLUTION
Descriptor:Photosystem I P700 chlorophyll a apoprotein A1, Photosystem I P700 chlorophyll a apoprotein A2, Photosystem I iron-sulfur center, ...
Authors:Fromme, R., Adams, P.D., Fromme, P., Levitt, M., Schroeder, G.F., Brunger, A.T.
Deposit date:2012-05-29
Release date:2012-08-15
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (4.9228 Å)
Cite:Improving the accuracy of macromolecular structure refinement at 7 A resolution.
Structure, 20, 2012
6QVP
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CRYSTAL STRUCTURE OF THE PEPTIDOGLYCAN-BINDING DOMAIN OF SIIA FROM SALMONELLA ENTERICA
Descriptor:Inner membrane protein, PHOSPHATE ION
Authors:Kirchweger, P., Muller, Y.A.
Deposit date:2019-03-04
Release date:2019-08-28
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and functional characterization of SiiA, an auxiliary protein from the SPI4-encoded type 1 secretion system from Salmonella enterica.
Mol.Microbiol., 112, 2019
6R6H
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STRUCTURAL BASIS OF CULLIN-2 RING E3 LIGASE REGULATION BY THE COP9 SIGNALOSOME
Descriptor:COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
Authors:Morris, E.P., Faull, S.V., Lau, A.M.C., Politis, A., Beuron, F., Cronin, N.
Deposit date:2019-03-27
Release date:2019-08-28
Last modified:2019-09-04
Method:ELECTRON MICROSCOPY (8.4 Å)
Cite:Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
6R7H
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STRUCTURAL BASIS OF CULLIN-2 RING E3 LIGASE REGULATION BY THE COP9 SIGNALOSOME
Descriptor:COP9 signalosome complex subunit 1, Elongin-C, Cullin-2, ...
Authors:Faull, S.V., Lau, A.M.C., Beuron, F., Cronin, N.B., Morris, E.P., Politis, A.
Deposit date:2019-03-28
Release date:2019-08-28
Last modified:2019-09-04
Method:ELECTRON MICROSCOPY (8.8 Å)
Cite:Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
6R7I
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STRUCTURAL BASIS OF CULLIN-2 RING E3 LIGASE REGULATION BY THE COP9 SIGNALOSOME
Descriptor:COP9 signalosome complex subunit 1, COP9 signalosome complex subunit 2, COP9 signalosome complex subunit 3, ...
Authors:Faull, S.F., Lau, A.M.C., Beuron, F., Cronin, N.B., Morris, E.P., Politis, A.
Deposit date:2019-03-28
Release date:2019-08-28
Last modified:2019-09-04
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structural basis of Cullin 2 RING E3 ligase regulation by the COP9 signalosome.
Nat Commun, 10, 2019
6ENY
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STRUCTURE OF THE HUMAN PLC EDITING MODULE
Descriptor:Beta-2-microglobulin, Tapasin, Protein disulfide-isomerase A3, ...
Authors:Trowitzsch, S., Januliene, D., Blees, A., Moeller, A., Tampe, R.
Deposit date:2017-10-07
Release date:2017-11-29
Last modified:2017-12-06
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Structure of the human MHC-I peptide-loading complex.
Nature, 551, 2017
6H55
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CORE OF THE HUMAN PYRUVATE DEHYDROGENASE (E2)
Descriptor:Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial
Authors:Haselbach, D., Prajapati, S., Tittmann, K., Stark, H.
Deposit date:2018-07-23
Release date:2019-06-05
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
Structure, 27, 2019
6H60
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PSEUDO-ATOMIC STRUCTURAL MODEL OF THE E3BP COMPONENT OF THE HUMAN PYRUVATE DEHYDROGENASE MULTIENZYME COMPLEX
Descriptor:Pyruvate dehydrogenase protein X component, mitochondrial
Authors:Haselbach, D., Prajapati, S., Tittmann, K., Stark, H.
Deposit date:2018-07-25
Release date:2019-06-05
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (6 Å)
Cite:Structural and Functional Analyses of the Human PDH Complex Suggest a "Division-of-Labor" Mechanism by Local E1 and E3 Clusters.
Structure, 27, 2019
6HD5
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CRYO-EM STRUCTURE OF THE RIBOSOME-NATA COMPLEX
Descriptor:N-terminal acetyltransferase A complex subunit NAT1, N-terminal acetyltransferase A complex catalytic subunit ARD1, N-alpha-acetyltransferase NAT5
Authors:Knorr, A.G., Becker, T., Beckmann, R.
Deposit date:2018-08-17
Release date:2018-12-19
Last modified:2019-01-16
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Ribosome-NatA architecture reveals that rRNA expansion segments coordinate N-terminal acetylation.
Nat. Struct. Mol. Biol., 26, 2019
6HD7
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CRYO-EM STRUCTURE OF THE RIBOSOME-NATA COMPLEX
Descriptor:Saccharomyces cerevisiae S288C 35S pre-ribosomal RNA (RDN37-1), miscRNA, 5S rRNA, ...
Authors:Knorr, A.G., Becker, T., Beckmann, R.
Deposit date:2018-08-17
Release date:2018-12-19
Last modified:2019-01-16
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Ribosome-NatA architecture reveals that rRNA expansion segments coordinate N-terminal acetylation.
Nat. Struct. Mol. Biol., 26, 2019