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1ML1
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BU of 1ml1 by Molmil
PROTEIN ENGINEERING WITH MONOMERIC TRIOSEPHOSPHATE ISOMERASE: THE MODELLING AND STRUCTURE VERIFICATION OF A SEVEN RESIDUE LOOP
Descriptor: 2-PHOSPHOGLYCOLIC ACID, TRIOSEPHOSPHATE ISOMERASE
Authors:Thanki, N, Zeelen, J.P, Mathieu, M, Jaenicke, R, Abagyan, R.A, Wierenga, R, Schliebs, W.
Deposit date:1996-09-27
Release date:1997-03-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Protein engineering with monomeric triosephosphate isomerase (monoTIM): the modelling and structure verification of a seven-residue loop.
Protein Eng., 10, 1997
2W84
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BU of 2w84 by Molmil
Structure of Pex14 in complex with Pex5
Descriptor: PEROXISOMAL MEMBRANE PROTEIN PEX14, PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR
Authors:Neufeld, C, Filipp, F.V, Simon, B, Neuhaus, A, Schueller, N, David, C, Kooshapur, H, Madl, T, Erdmann, R, Schliebs, W, Wilmanns, M, Sattler, M.
Deposit date:2009-01-09
Release date:2009-02-17
Last modified:2018-01-17
Method:SOLUTION NMR
Cite:Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19.
EMBO J., 28, 2009
2W85
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BU of 2w85 by Molmil
Structure of Pex14 in complex with Pex19
Descriptor: PEROXIN-19, PEROXISOMAL MEMBRANE ANCHOR PROTEIN PEX14
Authors:Neufeld, C, Filipp, F.V, Simon, B, Neuhaus, A, Schueller, N, David, C, Kooshapur, H, Madl, T, Erdmann, R, Schliebs, W, Wilmanns, M, Sattler, M.
Deposit date:2009-01-09
Release date:2009-02-17
Last modified:2013-05-08
Method:SOLUTION NMR
Cite:Structural Basis for Competitive Interactions of Pex14 with the Import Receptors Pex5 and Pex19.
Embo J., 28, 2009
2WL8
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BU of 2wl8 by Molmil
X-ray crystal structure of Pex19p
Descriptor: PEROXISOMAL BIOGENESIS FACTOR 19
Authors:Schueller, N, Holton, S.J, Stanley, W.A, Song, Y.H, Konarev, P, Roessle, M, Erdmann, R, Schliebs, W, Wilmanns, M.
Deposit date:2009-06-22
Release date:2010-06-23
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The Peroxisomal Receptor Pex19P Forms a Helical Mpts Recognition Domain.
Embo J., 29, 2010
5LNF
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BU of 5lnf by Molmil
Solution NMR structure of farnesylated PEX19, C-terminal domain
Descriptor: FARNESYL, Peroxisomal biogenesis factor 19
Authors:Emmanouilidis, L, Schuetz, U, Tripsianes, K, Madl, T, Radke, J, Rucktaeschel, R, Wilmanns, M, Schliebs, W, Erdmann, R, Sattler, M.
Deposit date:2016-08-04
Release date:2017-03-15
Last modified:2019-09-11
Method:SOLUTION NMR
Cite:Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19.
Nat Commun, 8, 2017
6SPT
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BU of 6spt by Molmil
High resolution crystal structure of N-terminal domain of PEX14 from Trypanosoma brucei in complex with the fist compound with sub-micromolar trypanocidal activity
Descriptor: 5-[(4-methoxynaphthalen-1-yl)methyl]-1-[2-[(2-methyl-1-oxidanyl-propan-2-yl)amino]ethyl]-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Napolitano, V, Dawidowski, M, Kalel, V.C, Fino, R, Emmanouilidis, L, Lenhart, D, Ostertag, M, Kaiser, M, Kolonko, M, Schilebs, W, Maser, P, Tetko, I, Hadian, K, Plettenburg, O, Erdmann, R, Sattler, M, Popowicz, G.M, Dubin, G.
Deposit date:2019-09-02
Release date:2020-01-01
Last modified:2020-02-05
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.
J.Med.Chem., 63, 2020
1TTJ
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BU of 1ttj by Molmil
THREE NEW CRYSTAL STRUCTURES OF POINT MUTATION VARIANTS OF MONOTIM: CONFORMATIONAL FLEXIBILITY OF LOOP-1,LOOP-4 AND LOOP-8
Descriptor: PHOSPHOGLYCOLOHYDROXAMIC ACID, TRIOSEPHOSPHATE ISOMERASE
Authors:Radha Kishan, K.V, Wierenga, R.K.
Deposit date:1995-04-20
Release date:1995-09-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Three new crystal structures of point mutation variants of monoTIM: conformational flexibility of loop-1, loop-4 and loop-8.
Structure, 3, 1995
7Z0I
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BU of 7z0i by Molmil
human PEX13 SH3 domain
Descriptor: 1,2-ETHANEDIOL, Peroxisomal membrane protein PEX13, ZINC ION
Authors:Gaussmann, S, Zak, K, Sattler, M.
Deposit date:2022-02-23
Release date:2023-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Intramolecular autoinhibition of human PEX13 modulates peroxisomal import
Biorxiv, 2022
7Z0J
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BU of 7z0j by Molmil
human PEX13 SH3 domain in complex with internal FxxxF motif
Descriptor: 1,2-ETHANEDIOL, Peroxisomal membrane protein PEX13
Authors:Gaussmann, S, Zak, K, Kreisz, N, Sattler, M.
Deposit date:2022-02-23
Release date:2023-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Intramolecular autoinhibition of human PEX13 modulates peroxisomal import
Biorxiv, 2022
7Z0K
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BU of 7z0k by Molmil
human PEX13 SH3 in complex with PEX5 W4 (WxxxF/Y) motif
Descriptor: Peroxisomal membrane protein PEX13,Peroxisomal targeting signal 1 receptor
Authors:Gaussmann, S, Napolitano, V, sattler, M.
Deposit date:2022-02-23
Release date:2023-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Intramolecular autoinhibition of human PEX13 modulates peroxisomal import
Biorxiv, 2022
4BXU
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BU of 4bxu by Molmil
Structure of Pex14 in complex with Pex5 LVxEF motif
Descriptor: PEROXISOMAL MEMBRANE PROTEIN PEX14, PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR
Authors:Kooshapur, H, Meyer, H.N, Madl, T, Sattler, M.
Deposit date:2013-07-15
Release date:2013-11-27
Last modified:2014-01-15
Method:SOLUTION NMR
Cite:A Novel Pex14 Interacting Site of Human Pex5 is Critical for Matrix Protein Import Into Peroxisomes.
J.Biol.Chem., 289, 2014
3R9A
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BU of 3r9a by Molmil
Human alanine-glyoxylate aminotransferase in complex with the TPR domain of human PEX5P
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Peroxisomal targeting signal 1 receptor, Serine--pyruvate aminotransferase
Authors:Fodor, K, Wilmanns, M.
Deposit date:2011-03-25
Release date:2011-05-11
Last modified:2012-05-02
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular requirements for peroxisomal targeting of alanine-glyoxylate aminotransferase as an essential determinant in primary hyperoxaluria type 1
Plos Biol., 10, 2012
2C0M
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BU of 2c0m by Molmil
apo form of the TPR domain of the pex5p receptor
Descriptor: PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR
Authors:Stanley, W.A, Kursula, P, Wilmanns, M.
Deposit date:2005-09-05
Release date:2006-11-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Recognition of a Functional Peroxisome Type 1 Target by the Dynamic Import Receptor Pex5P.
Mol.Cell, 24, 2006
2C0L
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BU of 2c0l by Molmil
TPR DOMAIN OF HUMAN PEX5P IN COMPLEX WITH HUMAN MSCP2
Descriptor: NONSPECIFIC LIPID-TRANSFER PROTEIN, PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR
Authors:Stanley, W.A, Kursula, P, Wilmanns, M.
Deposit date:2005-09-05
Release date:2006-11-15
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Recognition of a Functional Peroxisome Type 1 Target by the Dynamic Import Receptor Pex5P.
Mol.Cell, 24, 2006
1TTI
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BU of 1tti by Molmil
THREE NEW CRYSTAL STRUCTURES OF POINT MUTATION VARIANTS OF MONOTIM: CONFORMATIONAL FLEXIBILITY OF LOOP-1,LOOP-4 AND LOOP-8
Descriptor: 2-PHOSPHOGLYCOLIC ACID, TRIOSEPHOSPHATE ISOMERASE
Authors:Radha Kishan, K.V, Wierenga, R.K.
Deposit date:1995-04-19
Release date:1995-10-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Three new crystal structures of point mutation variants of monoTIM: conformational flexibility of loop-1, loop-4 and loop-8.
Structure, 3, 1995
1MSS
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BU of 1mss by Molmil
LARGE SCALE STRUCTURAL REARRANGEMENTS OF THE FRONT LOOPS IN MONOMERISED TRIOSEPHOSPHATE ISOMERASE, AS DEDUCED FROM THE COMPARISON OF THE STRUCTURAL PROPERTIES OF MONOTIM AND ITS POINT MUTATION VARIANT MONOSS
Descriptor: TRIOSEPHOSPHATE ISOMERASE
Authors:Radha Kishan, K.V, Wierenga, R.K.
Deposit date:1994-07-27
Release date:1994-09-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Three new crystal structures of point mutation variants of monoTIM: conformational flexibility of loop-1, loop-4 and loop-8.
Structure, 3, 1995
4KXK
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BU of 4kxk by Molmil
Alanine-glyoxylate aminotransferase variant K390A/K391A in complex with the TPR domain of human Pex5p
Descriptor: BETA-MERCAPTOETHANOL, Peroxisomal targeting signal 1 receptor, SULFATE ION, ...
Authors:Fodor, K, Lou, Y, Wilmanns, M.
Deposit date:2013-05-27
Release date:2014-11-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Ligand-Induced Compaction of the PEX5 Receptor-Binding Cavity Impacts Protein Import Efficiency into Peroxisomes.
Traffic, 16, 2015
4KYO
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BU of 4kyo by Molmil
Alanine-glyoxylate aminotransferase variant K390A in complex with the TPR domain of human Pex5p
Descriptor: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-MERCAPTOETHANOL, Peroxisomal targeting signal 1 receptor, ...
Authors:Fodor, K, Lou, Y, Wilmanns, M.
Deposit date:2013-05-29
Release date:2014-11-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Ligand-Induced Compaction of the PEX5 Receptor-Binding Cavity Impacts Protein Import Efficiency into Peroxisomes.
Traffic, 16, 2015
5L87
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BU of 5l87 by Molmil
Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
Descriptor: 1,2-ETHANEDIOL, 5-(1~{H}-indol-3-ylmethyl)-1-methyl-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, Peroxin 14
Authors:Dawidowski, M, Emmanouilidis, L, Sattler, M, Popowicz, G.M.
Deposit date:2016-06-07
Release date:2017-03-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (0.87 Å)
Cite:Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
Science, 355, 2017
5L8A
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BU of 5l8a by Molmil
Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
Descriptor: 1,2-ETHANEDIOL, 1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-~{N}-(phenylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, GLYCINE, ...
Authors:Dawidowski, M, Emmanouilidis, L, Sattler, M, Popowicz, G.M.
Deposit date:2016-06-07
Release date:2017-03-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
Science, 355, 2017
5MMC
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BU of 5mmc by Molmil
Trypanosoma brucei Pex14 N-terminal domain
Descriptor: Peroxin 14
Authors:Emmanouilidis, L, Tripsianes, K, Sattler, M.
Deposit date:2016-12-09
Release date:2017-03-08
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
Science, 355, 2017
5N8V
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BU of 5n8v by Molmil
Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
Descriptor: 1-(2-azanylethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Dawidowski, M, Emmanouilidis, L, Sattler, M, Popowicz, G.M.
Deposit date:2017-02-24
Release date:2017-03-15
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
Science, 355, 2017
1DKW
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BU of 1dkw by Molmil
CRYSTAL STRUCTURE OF TRIOSE-PHOSPHATE ISOMERASE WITH MODIFIED SUBSTRATE BINDING SITE
Descriptor: TERTIARY-BUTYL ALCOHOL, TRIOSEPHOSPHATE ISOMERASE
Authors:Norledge, B.V, Lambeir, A.M, Abagyan, R.A, Rottman, A, Fernandez, A.M, Filimonov, V.V, Peter, M.G, Wierenga, R.K.
Deposit date:1999-12-08
Release date:2000-11-03
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Modeling, mutagenesis, and structural studies on the fully conserved phosphate-binding loop (loop 8) of triosephosphate isomerase: toward a new substrate specificity.
Proteins, 42, 2001

217705

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