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1DPR
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BU of 1dpr by Molmil
STRUCTURES OF THE APO-AND METAL ION ACTIVATED FORMS OF THE DIPHTHERIA TOX REPRESSOR FROM CORYNEBACTERIUM DIPHTHERIAE
Descriptor: DIPHTHERIA TOX REPRESSOR
Authors:Schiering, N, Tao, X, Murphy, J, Petsko, G.A, Ringe, D.
Deposit date:1995-02-06
Release date:1995-09-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of the apo- and the metal ion-activated forms of the diphtheria tox repressor from Corynebacterium diphtheriae.
Proc.Natl.Acad.Sci.USA, 92, 1995
5JMY
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BU of 5jmy by Molmil
NEPRILYSIN COMPLEXED WITH LBQ657
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Neprilysin, ...
Authors:Schiering, N, Wiesmann, C.
Deposit date:2016-04-29
Release date:2016-06-15
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of neprilysin in complex with the active metabolite of sacubitril.
Sci Rep, 6, 2016
1R0P
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BU of 1r0p by Molmil
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met in complex with the microbial alkaloid K-252a
Descriptor: Hepatocyte growth factor receptor, K-252A
Authors:Schiering, N, Knapp, S, Marconi, M, Flocco, M.M, Cui, J, Perego, R, Rusconi, L, Cristiani, C.
Deposit date:2003-09-22
Release date:2003-10-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a
Proc.Natl.Acad.Sci.USA, 100, 2003
1R1W
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BU of 1r1w by Molmil
CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HEPATOCYTE GROWTH FACTOR RECEPTOR C-MET
Descriptor: HEPATOCYTE GROWTH FACTOR RECEPTOR
Authors:Schiering, N, Knapp, S, Marconi, M, Flocco, M.M, Cui, J, Perego, R, Rusconi, L, Cristiani, C.
Deposit date:2003-09-25
Release date:2003-10-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor c-Met and its complex with the microbial alkaloid K-252a
Proc.Natl.Acad.Sci.USA, 100, 2003
4A92
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BU of 4a92 by Molmil
Full-length HCV NS3-4A protease-helicase in complex with a macrocyclic protease inhibitor.
Descriptor: (1'R,2R,2'S,6S,24AS)-17-FLUORO-6-(1-METHYL-2-OXOPIPERIDINE-3-CARBOXAMIDO)-19,19-DIOXIDO-5,21,24-TRIOXO-2'-VINYL-1,2,3,5,6,7,8,9,10,11,12,13,14,20,21,23,24,24A-OCTADECAHYDROSPIRO[BENZO[S]PYRROLO[2,1-G][1,2,5,8,18]THIATETRAAZACYCLOICOSINE-22,1'-CYCLOPRO-2-CARBOXYLATEPAN]-2-YL 4-FLUOROISOINDOLINE, SERINE PROTEASE NS3, ZINC ION
Authors:Schiering, N, D'Arcy, A, Simic, O, Eder, J, Raman, P, Svergun, D.I, Bodendorf, U.
Deposit date:2011-11-23
Release date:2011-12-28
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:A Macrocyclic Hcv Ns3/4A Protease Inhibitor Interacts with Protease and Helicase Residues in the Complex with its Full- Length Target.
Proc.Natl.Acad.Sci.USA, 108, 2011
1FYR
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BU of 1fyr by Molmil
DIMER FORMATION THROUGH DOMAIN SWAPPING IN THE CRYSTAL STRUCTURE OF THE GRB2-SH2 AC-PYVNV COMPLEX
Descriptor: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, HEPATOCYTE GROWTH FACTOR RECEPTOR PEPTIDE
Authors:Schiering, N, Casale, E, Caccia, P, Giordano, P, Battistini, C.
Deposit date:2000-10-03
Release date:2000-12-06
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.
Biochemistry, 39, 2000
7Z2I
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BU of 7z2i by Molmil
TRYPSIN (BOVINE) COMPLEXED WITH compound 4
Descriptor: 5-[[3-(trifluoromethyl)phenyl]methyl]-1,4,6,7-tetrahydroimidazo[4,5-c]pyridine, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Schiering, N, Dalvit, C, Vulpetti, A.
Deposit date:2022-02-27
Release date:2022-05-25
Last modified:2022-07-20
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Efficient Screening of Target-Specific Selected Compounds in Mixtures by 19 F NMR Binding Assay with Predicted 19 F NMR Chemical Shifts.
Chemmedchem, 17, 2022
7Z25
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BU of 7z25 by Molmil
TRYPSIN (BOVINE) COMPLEXED WITH compound 12
Descriptor: 2-(5-bromanyl-7-fluoranyl-2-methyl-1H-indol-3-yl)ethanamine, CALCIUM ION, DIMETHYL SULFOXIDE, ...
Authors:Schiering, N, Dalvit, C, Vulpetti, A.
Deposit date:2022-02-25
Release date:2022-05-25
Last modified:2022-07-20
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Efficient Screening of Target-Specific Selected Compounds in Mixtures by 19 F NMR Binding Assay with Predicted 19 F NMR Chemical Shifts.
Chemmedchem, 17, 2022
6R8X
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BU of 6r8x by Molmil
COAGULATION FACTOR XI CATALYTIC DOMAIN IN COMPLEX WITH FAB-PORTION OF MAA868
Descriptor: Coagulation factor XI, anti-Factor-XI Fab fragment heavy chain MAA868, anti-Factor-XI Fab fragment light chain MAA868
Authors:Schiering, N, Koch, A.
Deposit date:2019-04-02
Release date:2019-04-10
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:MAA868, a novel FXI antibody with a unique binding mode, shows durable effects on markers of anticoagulation in humans.
Blood, 133, 2019
2FP7
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BU of 2fp7 by Molmil
West Nile Virus NS2B/NS3protease in complex with Bz-Nle-Lys-Arg-Arg-H
Descriptor: Genome polyprotein, N-benzoyl-L-norleucyl-L-lysyl-N-[(2S)-5-carbamimidamido-1-hydroxypentan-2-yl]-L-argininamide
Authors:Schiering, N, D'Arcy, A, Erbel, P.
Deposit date:2006-01-16
Release date:2006-03-07
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Nat.Struct.Mol.Biol., 13, 2006
2FOM
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BU of 2fom by Molmil
Dengue Virus NS2B/NS3 Protease
Descriptor: CHLORIDE ION, GLYCEROL, polyprotein
Authors:Schiering, N, Kroemer, M, Renatus, M, Erbel, P, D'Arcy, A.
Deposit date:2006-01-13
Release date:2006-03-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
Nat.Struct.Mol.Biol., 13, 2006
4Q1N
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BU of 4q1n by Molmil
Structure-based design of 4-hydroxy-3,5-substituted piperidines as direct renin inhibitors
Descriptor: (3S,4R,5R)-N-cyclopropyl-N'-[(2R)-1-ethoxy-4-methylpentan-2-yl]-4-hydroxy-N-[5-(propan-2-yl)pyridin-2-yl]piperidine-3,5-dicarboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ...
Authors:Schiering, N, D'Arcy, A, Irie, O, Yokokawa, F.
Deposit date:2014-04-04
Release date:2014-08-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structure-based design of substituted piperidines as a new class of highly efficacious oral direct Renin inhibitors.
ACS Med Chem Lett, 5, 2014
5LH4
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BU of 5lh4 by Molmil
Trypsin inhibitors for the treatment of pancreatitis - cpd 1
Descriptor: (2~{S},4~{S})-1-[4-(aminomethyl)phenyl]carbonyl-4-(4-cyclopropyl-1,2,3-triazol-1-yl)-~{N}-(2,2-diphenylethyl)pyrrolidine-2-carboxamide, CALCIUM ION, Cationic trypsin, ...
Authors:Schiering, N, D'Arcy, A, Skaanderup, P, Simic, O, Brandl, T, Woelcke, J.
Deposit date:2016-07-08
Release date:2018-01-17
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Trypsin inhibitors for the treatment of pancreatitis.
Bioorg. Med. Chem. Lett., 26, 2016
5LGO
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BU of 5lgo by Molmil
Trypsin inhibitors for the treatment of pancreatitis - cpd 15
Descriptor: (2~{S},4~{S})-1-[4-(aminomethyl)-3-methoxy-phenyl]carbonyl-4-[4-(2-cyclopropylethoxy)-6,8-dihydro-5~{H}-pyrido[3,4-d]pyrimidin-7-yl]-~{N}-methyl-pyrrolidine-2-carboxamide, CALCIUM ION, Cationic trypsin, ...
Authors:Schiering, N, D'Arcy, A.
Deposit date:2016-07-07
Release date:2016-08-10
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Trypsin inhibitors for the treatment of pancreatitis.
Bioorg.Med.Chem.Lett., 26, 2016
5LH8
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BU of 5lh8 by Molmil
Trypsin inhibitors for the treatment of pancreatitis - cpd 8
Descriptor: (2~{S},4~{S})-1-[4-(aminomethyl)-3-methoxy-phenyl]carbonyl-4-(4-cyclopropyl-1,2,3-triazol-1-yl)-~{N}-[(1~{S},2~{R})-2-phenylcyclohexyl]pyrrolidine-2-carboxamide, CALCIUM ION, Cationic trypsin, ...
Authors:Schiering, N, D'Arcy, A, Skaanderup, P, Simic, O, Brandl, T, Woelcke, J.
Deposit date:2016-07-08
Release date:2016-08-10
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Trypsin inhibitors for the treatment of pancreatitis.
Bioorg.Med.Chem.Lett., 26, 2016
3NK8
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BU of 3nk8 by Molmil
Trypsin in complex with fluorine-containing fragment
Descriptor: 4-(trifluoromethyl)-1,5,6,7-tetrahydro-2H-cyclopenta[b]pyridin-2-one, CALCIUM ION, Cationic trypsin, ...
Authors:Schiering, N, Vulpetti, A, Dalvit, C.
Deposit date:2010-06-18
Release date:2010-11-10
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Combined use of computational chemistry, NMR screening, and X-ray crystallography for identification and characterization of fluorophilic protein environments.
Proteins, 78, 2010
3NKK
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BU of 3nkk by Molmil
Trypsin in complex with fluorine containing fragment
Descriptor: 3-fluoro-4-methylbenzenecarboximidamide, CALCIUM ION, Cationic trypsin, ...
Authors:Schiering, N, Vulpetti, A, Dalvit, C.
Deposit date:2010-06-20
Release date:2010-11-10
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Combined use of computational chemistry, NMR screening, and X-ray crystallography for identification and characterization of fluorophilic protein environments.
Proteins, 78, 2010
6THP
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BU of 6thp by Molmil
Neprilysin in complex with the inhibitor (R)-4-(1-carboxy-3-(3'-chlorobiphenyl-4-yl)propan-2-ylamino)-4-oxobutanoic acid
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[[(2~{R})-1-[4-(3-chlorophenyl)phenyl]-4-oxidanyl-4-oxidanylidene-butan-2-yl]amino]-4-oxidanylidene-butanoic acid, Neprilysin, ...
Authors:Schiering, N, Wiesmann, C.
Deposit date:2019-11-21
Release date:2020-02-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.
Acs Med.Chem.Lett., 11, 2020
2TDX
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BU of 2tdx by Molmil
DIPHTHERIA TOX REPRESSOR (C102D MUTANT) COMPLEXED WITH NICKEL
Descriptor: DIPHTHERIA TOX REPRESSOR, NICKEL (II) ION
Authors:White, A, Ding, X, Zheng, H, Schiering, N, Ringe, D, Murphy, J.R.
Deposit date:1998-06-22
Release date:1998-10-14
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the metal-ion-activated diphtheria toxin repressor/tox operator complex.
Nature, 394, 1998
6TS5
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BU of 6ts5 by Molmil
Coagulation factor XI protease domain in complex with active site inhibitor
Descriptor: 2-[2-[3-[(3~{S})-3-azanyl-2,3-dihydro-1-benzofuran-5-yl]-5-propan-2-yl-phenyl]ethoxy]-3-methoxy-benzoic acid, Coagulation factor XI, DIMETHYL SULFOXIDE, ...
Authors:Renatus, M, Schiering, N.
Deposit date:2019-12-20
Release date:2020-07-08
Last modified:2020-08-26
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
J.Med.Chem., 63, 2020
6TS6
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BU of 6ts6 by Molmil
Coagulation factor XI protease domain in complex with active site inhibitor
Descriptor: 2-[2-[[3-[(3~{S})-3-azanyl-2,3-dihydro-1-benzofuran-5-yl]-5-(2-cyanopropan-2-yl)phenyl]methoxy]phenyl]ethanoic acid, Coagulation factor XI, DIMETHYL SULFOXIDE, ...
Authors:Renatus, M, Schiering, N.
Deposit date:2019-12-20
Release date:2020-07-08
Last modified:2020-08-26
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
J.Med.Chem., 63, 2020
6TS4
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BU of 6ts4 by Molmil
Coagulation factor XI protease domain in complex with active site inhibitor
Descriptor: 2-[2-[[3-[3-(aminomethyl)phenyl]phenyl]carbonylamino]phenyl]ethanoic acid, Coagulation factor XI, DIMETHYL SULFOXIDE, ...
Authors:Renatus, M, Schiering, N.
Deposit date:2019-12-19
Release date:2020-07-08
Last modified:2020-08-26
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
J.Med.Chem., 63, 2020
6TS7
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BU of 6ts7 by Molmil
Coagulation factor XI protease domain in complex with active site inhibitor
Descriptor: 2-[2-[[3-(1,2,3,4-tetrahydroisoquinolin-7-yl)phenyl]methoxy]phenyl]ethanoic acid, Coagulation factor XI
Authors:Renatus, M, Schiering, N.
Deposit date:2019-12-20
Release date:2020-07-08
Last modified:2020-08-26
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Structure-Based Design and Preclinical Characterization of Selective and Orally Bioavailable Factor XIa Inhibitors: Demonstrating the Power of an Integrated S1 Protease Family Approach.
J.Med.Chem., 63, 2020
6YN9
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BU of 6yn9 by Molmil
MALT1(329-728) in complex with a sulfonamide containing compound
Descriptor: 5-[4-[(2,6-diethylphenyl)sulfamoyl]-3-methyl-phenyl]furan-3-carboxylic acid, Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Authors:Renatus, M.
Deposit date:2020-04-11
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.558 Å)
Cite:Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity
Advanced Therapeutics, 3, 2020
6YN8
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BU of 6yn8 by Molmil
Human MALT1(334-719) in complex with a tetrazole containing compound
Descriptor: 3-azanyl-3-methyl-~{N}-[(3~{R})-4-oxidanylidene-5-[[4-[2-(1~{H}-1,2,3,4-tetrazol-5-yl)phenyl]phenyl]methyl]-2,3-dihydro-1,5-benzoxazepin-3-yl]butanamide, Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Authors:Renatus, M.
Deposit date:2020-04-11
Release date:2020-06-24
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.052 Å)
Cite:Stabilizing Inactive Conformations of MALT1 as an Effective Approach to Inhibit Its Protease Activity
Advanced Therapeutics, 3, 2020

 

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