Author results

1NF1
  • Download 1nf1
  • View 1nf1
Molmil generated image of 1nf1
THE GAP RELATED DOMAIN OF NEUROFIBROMIN
分子名称:PROTEIN (NEUROFIBROMIN)
著者Scheffzek, K., Ahmadian, M.R., Wiesmueller, L., Kabsch, W., Stege, P., Schmitz, F., Wittinghofer, A.
登録日1998-07-08
公開日1999-07-20
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural analysis of the GAP-related domain from neurofibromin and its implications.
EMBO J., 17, 1998
1WQ1
  • Download 1wq1
  • View 1wq1
Molmil generated image of 1wq1
RAS-RASGAP COMPLEX
分子名称:H-RAS, P120GAP, MAGNESIUM ION, ...
著者Scheffzek, K., Ahmadian, M.R., Kabsch, W., Wiesmueller, L., Lautwein, A., Schmitz, F., Wittinghofer, A.
登録日1997-07-03
公開日1998-07-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants.
Science, 277, 1997
1WER
  • Download 1wer
  • View 1wer
Molmil generated image of 1wer
RAS-GTPASE-ACTIVATING DOMAIN OF HUMAN P120GAP
分子名称:P120GAP
著者Scheffzek, K., Lautwein, A., Kabsch, W., Ahmadian, M.R., Wittinghofer, A.
登録日1996-11-20
公開日1997-12-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Crystal structure of the GTPase-activating domain of human p120GAP and implications for the interaction with Ras.
Nature, 384, 1996
1UKE
  • Download 1uke
  • View 1uke
Molmil generated image of 1uke
UMP/CMP KINASE FROM SLIME MOLD
分子名称:URIDYLMONOPHOSPHATE/CYTIDYLMONOPHOSPHATE KINASE, MAGNESIUM ION, P1-(ADENOSINE-5'-P5-(URIDINE-5')PENTAPHOSPHATE
著者Scheffzek, K., Kliche, W., Wiesmueller, L., Reinstein, J.
登録日1998-01-07
公開日1998-04-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5'-adenosyl) P5-(5'-uridyl) pentaphosphate (UP5A) and Mg2+ at 2.2 A: implications for water-mediated specificity.
Biochemistry, 35, 1996
1DS6
  • Download 1ds6
  • View 1ds6
Molmil generated image of 1ds6
CRYSTAL STRUCTURE OF A RAC-RHOGDI COMPLEX
分子名称:RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2, RHO GDP-DISSOCIATION INHIBITOR 2, MAGNESIUM ION, ...
著者Scheffzek, K., Stephan, I., Jensen, O.N., Illenberger, D., Gierschik, P.
登録日2000-01-07
公開日2000-07-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献The Rac-RhoGDI complex and the structural basis for the regulation of Rho proteins by RhoGDI.
Nat.Struct.Biol., 7, 2000
1K8R
  • Download 1k8r
  • View 1k8r
Molmil generated image of 1k8r
CRYSTAL STRUCTURE OF RAS-BRY2RBD COMPLEX
分子名称:Transforming protein P21/H-RAS-1, Protein kinase byr2, MAGNESIUM ION, ...
著者Scheffzek, K., Gruenewald, P., Wohlgemuth, S., Kabsch, W., Tu, H., Wigler, M., Wittinghofer, A., Herrmann, C.
登録日2001-10-25
公開日2002-03-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast.
Structure, 9, 2001
6EHP
  • Download 6ehp
  • View 6ehp
Molmil generated image of 6ehp
THE CRYSTAL STRUCTURE OF THE HUMAN LAMTOR COMPLEX
分子名称:Ragulator complex protein LAMTOR3, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR5, ...
著者Scheffzek, K., Naschberger, A.
登録日2017-09-14
公開日2017-10-04
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
Science, 358, 2017
6EHR
  • Download 6ehr
  • View 6ehr
Molmil generated image of 6ehr
THE CRYSTAL STRUCTURE OF THE HUMAN LAMTOR-RAGA CTD-RAGC CTD COMPLEX
分子名称:Ragulator complex protein LAMTOR3, Ragulator complex protein LAMTOR2, Ragulator complex protein LAMTOR5, ...
著者Scheffzek, K., Naschberger, A.
登録日2017-09-14
公開日2017-10-04
最終更新日2018-02-28
実験手法X-RAY DIFFRACTION (2.898 Å)
主引用文献Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling.
Science, 358, 2017
1CLU
  • Download 1clu
  • View 1clu
Molmil generated image of 1clu
H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP
分子名称:TRANSFORMING PROTEIN P21/H-RAS-1, MAGNESIUM ION, 3-AMINOBENZOPHENONE-4-YL-AMINOHYDROXYPHOSPHINYLAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Ahmadian, M.R., Zor, T., Vogt, D., Kabsch, W., Selinger, Z., Wittinghofer, A., Scheffzek, K.
登録日1999-05-03
公開日1999-05-28
最終更新日2018-03-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Proc.Natl.Acad.Sci.USA, 96, 1999
1RVD
  • Download 1rvd
  • View 1rvd
Molmil generated image of 1rvd
H-RAS COMPLEXED WITH DIAMINOBENZOPHENONE-BETA,GAMMA-IMIDO-GTP
分子名称:TRANSFORMING PROTEIN P21/H-RAS-1, MAGNESIUM ION, 3-AMINOBENZOPHENONE-4-YL-AMINOHYDROXYPHOSPHINYLAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Ahmadian, M.R., Zor, T., Vogt, D., Kabsch, W., Selinger, Z., Wittinghofer, A., Scheffzek, K.
登録日1999-05-03
公開日1999-05-28
最終更新日2018-03-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Guanosine triphosphatase stimulation of oncogenic Ras mutants.
Proc.Natl.Acad.Sci.USA, 96, 1999
2D4Q
  • Download 2d4q
  • View 2d4q
Molmil generated image of 2d4q
CRYSTAL STRUCTURE OF THE SEC-PH DOMAIN OF THE HUMAN NEUROFIBROMATOSIS TYPE 1 PROTEIN
分子名称:Neurofibromin, OXTOXYNOL-10, PYROPHOSPHATE 2-
著者D'angelo, I., Welti, S., Bonneau, F., Scheffzek, K.
登録日2005-10-22
公開日2006-03-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A novel bipartite phospholipid-binding module in the neurofibromatosis type 1 protein
Embo Rep., 7, 2006
2E2X
  • Download 2e2x
  • View 2e2x
Molmil generated image of 2e2x
SEC14 HOMOLOGY MODULE OF NEUROFIBROMIN IN COMPLEX WITH PHOSPHATITYLETHANOLAMINE
分子名称:Neurofibromin, (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, PYROPHOSPHATE 2-
著者D'Angelo, I., Welti, S., Scheffzek, K.
登録日2006-11-18
公開日2007-10-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The sec14 homology module of neurofibromin binds cellular glycerophospholipids: mass spectrometry and structure of a lipid complex
J.Mol.Biol., 366, 2007
3DXB
  • Download 3dxb
  • View 3dxb
Molmil generated image of 3dxb
STRUCTURE OF THE UHM DOMAIN OF PUF60 FUSED TO THIOREDOXIN
分子名称:thioredoxin N-terminally fused to Puf60(UHM), CHLORIDE ION, 1,2-ETHANEDIOL
著者Corsini, L., Hothorn, M., Scheffzek, K., Stier, G., Sattler, M.
登録日2008-07-24
公開日2008-10-28
最終更新日2017-08-02
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Dimerization and Protein Binding Specificity of the U2AF Homology Motif of the Splicing Factor Puf60.
J.Biol.Chem., 284, 2009
2PK2
  • Download 2pk2
  • View 2pk2
Molmil generated image of 2pk2
CYCLIN BOX STRUCTURE OF THE P-TEFB SUBUNIT CYCLIN T1 DERIVED FROM A FUSION COMPLEX WITH EIAV TAT
分子名称:Cyclin-T1, Protein Tat
著者Anand, K., Schulte, A., Fujinaga, K., Scheffzek, K., Geyer, M.
登録日2007-04-17
公開日2007-07-03
最終更新日2017-07-26
実験手法X-RAY DIFFRACTION (2.67 Å)
主引用文献Cyclin Box Structure of the P-TEFb Subunit Cyclin T1 Derived from a Fusion Complex with EIAV Tat.
J.Mol.Biol., 370, 2007
2QUZ
  • Download 2quz
  • View 2quz
Molmil generated image of 2quz
CRYSTAL STRUCTURE OF THE ACTIVATING H-RASK117R MUTANT IN COSTELLO SYNDROME, BOUND TO MG-GDP
分子名称:GTPase HRas, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
著者Parret, A., Scheffzek, K.
登録日2007-08-07
公開日2007-12-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.49 Å)
主引用文献Mutation analysis in Costello syndrome: functional and structural characterization of the HRAS p.Lys117Arg mutation.
Hum.Mutat., 29, 2008
1OPJ
  • Download 1opj
  • View 1opj
Molmil generated image of 1opj
STRUCTURAL BASIS FOR THE AUTO-INHIBITION OF C-ABL TYROSINE KINASE
分子名称:Proto-oncogene tyrosine-protein kinase ABL1, CHLORIDE ION, MYRISTIC ACID, ...
著者Nagar, B., Hantschel, O., Young, M.A., Scheffzek, K., Veach, D., Bornmann, W., Clarkson, B., Superti-Furga, G., Kuriyan, J.
登録日2003-03-06
公開日2003-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
1OPK
  • Download 1opk
  • View 1opk
Molmil generated image of 1opk
STRUCTURAL BASIS FOR THE AUTO-INHIBITION OF C-ABL TYROSINE KINASE
分子名称:Proto-oncogene tyrosine-protein kinase ABL1, MYRISTIC ACID, 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, ...
著者Nagar, B., Hantschel, O., Young, M.A., Scheffzek, K., Veach, D., Bornmann, W., Clarkson, B., Superti-Furga, G., Kuriyan, J.
登録日2003-03-06
公開日2003-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
1OPL
  • Download 1opl
  • View 1opl
Molmil generated image of 1opl
STRUCTURAL BASIS FOR THE AUTO-INHIBITION OF C-ABL TYROSINE KINASE
分子名称:proto-oncogene tyrosine-protein kinase, MYRISTIC ACID, 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE
著者Nagar, B., Hantschel, O., Young, M.A., Scheffzek, K., Veach, D., Bornmann, W., Clarkson, B., Superti-Furga, G., Kuriyan, J.
登録日2003-03-06
公開日2003-04-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.42 Å)
主引用文献Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
1GZS
  • Download 1gzs
  • View 1gzs
Molmil generated image of 1gzs
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE GEF DOMAIN OF THE SALMONELLA TYPHIMURIUM SOPE TOXIN AND HUMAN CDC42
分子名称:GTP-BINDING PROTEIN, SOPE, SULFATE ION
著者Buchwald, G., Friebel, A., Galan, J.E., Hardt, W.D., Wittinghofer, A., Scheffzek, K.
登録日2002-06-05
公開日2002-09-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis for the Reversible Activation of a Rho Protein by the Bacterial Toxin Sope
Embo J., 21, 2002
1HCI
  • Download 1hci
  • View 1hci
Molmil generated image of 1hci
CRYSTAL STRUCTURE OF THE ROD DOMAIN OF ALPHA-ACTININ
分子名称:ALPHA-ACTININ 2
著者Ylanne, J., Scheffzek, K., Young, P., Saraste, M.
登録日2001-05-04
公開日2001-06-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of the Alpha-Actinin Rod Reveals an Extensive Torsional Twist
Structure, 9, 2001
1JAH
  • Download 1jah
  • View 1jah
Molmil generated image of 1jah
H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MAGNESIUM
分子名称:C-HA-RAS, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
著者Schweins, T., Scheffzek, K., Assheuer, R., Wittinghofer, A.
登録日1996-12-15
公開日1997-07-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+.
J.Mol.Biol., 266, 1997
1JAI
  • Download 1jai
  • View 1jai
Molmil generated image of 1jai
H-RAS P21 PROTEIN MUTANT G12P, COMPLEXED WITH GUANOSINE-5'-[BETA,GAMMA-METHYLENE] TRIPHOSPHATE AND MANGANESE
分子名称:C-HA-RAS, MANGANESE (II) ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER
著者Schweins, T., Scheffzek, K., Assheuer, R., Wittinghofer, A.
登録日1996-12-15
公開日1997-07-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The role of the metal ion in the p21ras catalysed GTP-hydrolysis: Mn2+ versus Mg2+.
J.Mol.Biol., 266, 1997
1KO7
  • Download 1ko7
  • View 1ko7
Molmil generated image of 1ko7
X-RAY STRUCTURE OF THE HPR KINASE/PHOSPHATASE FROM STAPHYLOCOCCUS XYLOSUS AT 1.95 A RESOLUTION
分子名称:Hpr kinase/phosphatase, PHOSPHATE ION
著者Marquez, J.A., Hasenbein, S., Koch, B., Fieulaine, S., Nessler, S., Hengstenberg, W., Scheffzek, K.
登録日2001-12-20
公開日2002-04-03
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure of the full-length HPr kinase/phosphatase from Staphylococcus xylosus at 1.95 A resolution: Mimicking the product/substrate of the phospho transfer reactions.
Proc.Natl.Acad.Sci.USA, 99, 2002
1OQJ
  • Download 1oqj
  • View 1oqj
Molmil generated image of 1oqj
CRYSTAL STRUCTURE OF THE SAND DOMAIN FROM GLUCOCORTICOID MODULATORY ELEMENT BINDING PROTEIN-1 (GMEB1)
分子名称:Glucocorticoid Modulatory Element Binding protein-1, ZINC ION
著者Surdo, P.L., Bottomley, M.J., Sattler, M., Scheffzek, K.
登録日2003-03-10
公開日2003-11-11
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Crystal structure and nuclear magnetic resonance analyses of the SAND domain from glucocorticoid modulatory element binding protein-1 reveals deoxyribonucleic acid and zinc binding regions
MOL.ENDOCRINOL., 17, 2003
1RJ1
  • Download 1rj1
  • View 1rj1
Molmil generated image of 1rj1
CRYSTAL STRUCTURE OF A CELL WALL INVERTASE INHIBITOR FROM TOBACCO
分子名称:invertase inhibitor
著者Hothorn, M., D'Angelo, I., Marquez, J.A., Greiner, S., Scheffzek, K.
登録日2003-11-18
公開日2004-02-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献The invertase inhibitor Nt-CIF from tobacco: a highly thermostable four-helix bundle with an unusual N-terminal extension
J.Mol.Biol., 335, 2004