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1ARZ
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BU of 1arz by Molmil
ESCHERICHIA COLI DIHYDRODIPICOLINATE REDUCTASE IN COMPLEX WITH NADH AND 2,6 PYRIDINE DICARBOXYLATE
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, DIHYDRODIPICOLINATE REDUCTASE, PHOSPHATE ION, ...
Authors:Scapin, G, Reddy, S.G, Zheng, R, Blanchard, J.S.
Deposit date:1997-08-08
Release date:1998-10-14
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase in complex with NADH and the inhibitor 2,6-pyridinedicarboxylate.
Biochemistry, 36, 1997
2DAP
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BU of 2dap by Molmil
C. GLUTAMICUM DAP DEHYDROGENASE IN COMPLEX WITH DAP
Descriptor: 2,6-DIAMINOPIMELIC ACID, DIAMINOPIMELIC ACID DEHYDROGENASE
Authors:Scapin, G, Cirilli, M, Reddy, S.G, Gao, Y, Vederas, J.C, Blanchard, J.S.
Deposit date:1997-12-23
Release date:1998-04-08
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase.
Biochemistry, 37, 1998
4Z9L
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BU of 4z9l by Molmil
THE STRUCTURE OF JNK3 IN COMPLEX WITH AN IMIDAZOLE-PYRIMIDINE INHIBITOR
Descriptor: CYCLOHEXYL-{4-[5-(3,4-DICHLOROPHENYL)-2-PIPERIDIN-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE, Mitogen-activated protein kinase 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Scapin, G, Patel, S.B, Lisnock, J, Becker, J.W, Lograsso, P.V, Smart, O.S, Bricogne, G.
Deposit date:2015-04-10
Release date:2015-05-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity.
Chem.Biol., 10, 2003
3DAP
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BU of 3dap by Molmil
C. GLUTAMICUM DAP DEHYDROGENASE IN COMPLEX WITH NADP+ AND THE INHIBITOR 5S-ISOXAZOLINE
Descriptor: (2S,5',S)-2-AMINO-3-(3-CARBOXY-2-ISOXAZOLIN-5-YL)PROPANOIC ACID, DIAMINOPIMELIC ACID DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Scapin, G, Cirilli, M, Reddy, S.G, Gao, Y, Vederas, J.C, Blanchard, J.S.
Deposit date:1997-12-29
Release date:1998-04-08
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Substrate and inhibitor binding sites in Corynebacterium glutamicum diaminopimelate dehydrogenase.
Biochemistry, 37, 1998
1DAP
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BU of 1dap by Molmil
C. GLUTAMICUM DAP DEHYDROGENASE IN COMPLEX WITH NADP+
Descriptor: ACETATE ION, DIAMINOPIMELIC ACID DEHYDROGENASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Scapin, G, Reddy, S.G, Blanchard, J.S.
Deposit date:1996-07-08
Release date:1997-07-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of meso-diaminopimelic acid dehydrogenase from Corynebacterium glutamicum.
Biochemistry, 35, 1996
1STO
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BU of 1sto by Molmil
CRYSTAL STRUCTURE OF OROTATE PHOSPHORIBOSYLTRANSFERASE
Descriptor: HYDROXIDE ION, OROTATE PHOSPHORIBOSYLTRANSFERASE, OROTIDINE-5'-MONOPHOSPHATE
Authors:Scapin, G, Grubmeyer, C, Sacchettini, J.C.
Deposit date:1993-12-20
Release date:1994-05-31
Last modified:2019-08-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of orotate phosphoribosyltransferase.
Biochemistry, 33, 1994
5DK3
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BU of 5dk3 by Molmil
Crystal Structure of Pembrolizumab, a full length IgG4 antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain, ...
Authors:Scapin, G, Prosise, W, Reichert, P.
Deposit date:2015-09-02
Release date:2015-11-18
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structure of full-length human anti-PD1 therapeutic IgG4 antibody pembrolizumab.
Nat.Struct.Mol.Biol., 22, 2015
6CE9
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BU of 6ce9 by Molmil
Insulin Receptor ectodomain in complex with two insulin molecules
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B.
Deposit date:2018-02-11
Release date:2018-03-14
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
6CEB
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BU of 6ceb by Molmil
Insulin Receptor ectodomain in complex with two insulin molecules - C1 symmetry
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B.
Deposit date:2018-02-11
Release date:2018-03-14
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
6CE7
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BU of 6ce7 by Molmil
Insulin Receptor ectodomain in complex with one insulin molecule
Descriptor: Insulin A chain, Insulin B chain, Insulin receptor, ...
Authors:Scapin, G, Dandey, V.P, Zhang, Z, Strickland, C, Potter, C.S, Carragher, B.
Deposit date:2018-02-11
Release date:2018-03-14
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (7.4 Å)
Cite:Structure of the insulin receptor-insulin complex by single-particle cryo-EM analysis.
Nature, 556, 2018
1OPR
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BU of 1opr by Molmil
THE CRYSTAL STRUCTURE OF THE OROTATE PHOSPHORIBOSYLTRANSFERASE COMPLEXED WITH OROTATE AND ALPHA-D-5-PHOSPHORIBOSYL-1-PYROPHOSPHATE
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, MAGNESIUM ION, OROTATE PHOSPHORIBOSYLTRANSFERASE, ...
Authors:Scapin, G, Sacchettini, J.C.
Deposit date:1995-01-06
Release date:1996-01-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate.
Biochemistry, 34, 1995
1DIH
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BU of 1dih by Molmil
THREE-DIMENSIONAL STRUCTURE OF E. COLI DIHYDRODIPICOLINATE REDUCTASE
Descriptor: DIHYDRODIPICOLINATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Scapin, G, Blanchard, J.S, Sacchettini, J.C.
Deposit date:1994-09-14
Release date:1995-09-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of Escherichia coli dihydrodipicolinate reductase.
Biochemistry, 34, 1995
1I57
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BU of 1i57 by Molmil
CRYSTAL STRUCTURE OF APO HUMAN PTP1B (C215S) MUTANT
Descriptor: CHLORIDE ION, MAGNESIUM ION, PHOSPHO-TYROSINE PHOSPHATASE 1B
Authors:Scapin, G, Patel, S, Patel, V, Kennedy, B, Asante-Appiah, E.
Deposit date:2001-02-26
Release date:2001-08-08
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of apo protein-tyrosine phosphatase 1B C215S mutant: more than just an S --> O change.
Protein Sci., 10, 2001
1IFC
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BU of 1ifc by Molmil
REFINEMENT OF THE STRUCTURE OF RECOMBINANT RAT INTESTINAL FATTY ACID-BINDING APOPROTEIN AT 1.2 ANGSTROMS RESOLUTION
Descriptor: INTESTINAL FATTY ACID BINDING PROTEIN
Authors:Scapin, G, Gordon, J.I, Sacchettini, J.C.
Deposit date:1991-12-19
Release date:1994-01-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Refinement of the structure of recombinant rat intestinal fatty acid-binding apoprotein at 1.2-A resolution.
J.Biol.Chem., 267, 1992
1PMN
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BU of 1pmn by Molmil
Crystal structure of JNK3 in complex with an imidazole-pyrimidine inhibitor
Descriptor: CYCLOPROPYL-{4-[5-(3,4-DICHLOROPHENYL)-2-[(1-METHYL)-PIPERIDIN]-4-YL-3-PROPYL-3H-IMIDAZOL-4-YL]-PYRIMIDIN-2-YL}AMINE, Mitogen-activated protein kinase 10
Authors:Scapin, G, Patel, S.B, Lisnock, J, Becker, J.W, LoGrasso, P.V.
Deposit date:2003-06-11
Release date:2003-09-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity
Chem.Biol., 10, 2003
1PMV
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BU of 1pmv by Molmil
The structure of JNK3 in complex with a dihydroanthrapyrazole inhibitor
Descriptor: 2,6-DIHYDROANTHRA/1,9-CD/PYRAZOL-6-ONE, Mitogen-activated protein kinase 10
Authors:Scapin, G, Patel, S.B, Lisnock, J, Becker, J.W, LoGrasso, P.V.
Deposit date:2003-06-11
Release date:2003-09-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity
Chem.Biol., 10, 2003
1PMU
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BU of 1pmu by Molmil
The crystal structure of JNK3 in complex with a phenantroline inhibitor
Descriptor: 9-(4-HYDROXYPHENYL)-2,7-PHENANTHROLINE, CHLORIDE ION, Mitogen-activated protein kinase 10
Authors:Scapin, G, Patel, S.B, Lisnock, J, Becker, J.W, LoGrasso, P.V.
Deposit date:2003-06-11
Release date:2003-09-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structure of JNK3 in complex with small molecule inhibitors: structural basis for potency and selectivity
Chem.Biol., 10, 2003
1Q6M
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BU of 1q6m by Molmil
THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 3
Descriptor: Protein-tyrosine phosphatase, non-receptor type 1, {[2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-2-(3,4-DIFLUOROPHENYL)PROPANE-1,3-DIYL]BIS[4,1-PHENYLENE(DIFLUOROMETHYLENE)]}BIS(PHOSPHONIC ACID)
Authors:Scapin, G, Patel, S.B, Becker, J.W, Wang, Q, Desponts, C, Waddleton, D, Skorey, K, Cromlish, W, Bayly, C, Therien, M, Gauthier, J.Y, Li, C.S, Lau, C.K, Ramachandran, C, Kennedy, B.P, Asante-Appiah, E.
Deposit date:2003-08-13
Release date:2003-09-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B
Biochemistry, 42, 2003
1Q6P
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BU of 1q6p by Molmil
THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 6
Descriptor: 4'-((2S)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-3-{4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL}-2-PHENYLPROPYL)-1,1'-BIPHENYL-3-YLPHOSPHONIC ACID, CHLORIDE ION, Protein-tyrosine phosphatase, ...
Authors:Scapin, G, Patel, S.B, Becker, J.W, Wang, Q, Desponts, C, Waddleton, D, Skorey, K, Cromlish, W, Bayly, C, Therien, M, Gauthier, J.Y, Li, C.S, Lau, C.K, Ramachandran, C, Kennedy, B.P, Asante-Appiah, E.
Deposit date:2003-08-13
Release date:2003-09-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B
Biochemistry, 42, 2003
1Q6J
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BU of 1q6j by Molmil
THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 2
Descriptor: Protein-tyrosine phosphatase, non-receptor type 1, [4-(2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-3-{4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL}-2-PHENYLPROPYL)PHENYL](DIFLUORO)METHYLPHOSPHONIC ACID
Authors:Scapin, G, Patel, S.B, Becker, J.W, Wang, Q, Desponts, C, Waddleton, D, Skorey, K, Cromlish, W, Bayly, C, Therien, M, Gauthier, J.Y, Li, C.S, Lau, C.K, Ramachandran, C, Kennedy, B.P, Asante-Appiah, E.
Deposit date:2003-08-13
Release date:2003-09-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B
Biochemistry, 42, 2003
1Q6T
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BU of 1q6t by Molmil
THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 11
Descriptor: 6-[4-((2S)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-3-{4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL}-2-PHENYLPROPYL)PHENYL]-2-[(1S)-1-METHOXY-3-METHYLBUTYL]QUINOLIN-8-YLPHOSPHONIC ACID, MAGNESIUM ION, Protein-tyrosine phosphatase, ...
Authors:Scapin, G, Patel, S.B, Becker, J.W, Wang, Q, Desponts, C, Waddleton, D, Skorey, K, Cromlish, W, Bayly, C, Therien, M, Gauthier, J.Y, Li, C.S, Lau, C.K, Ramachandran, C, Kennedy, B.P, Asante-Appiah, E.
Deposit date:2003-08-13
Release date:2003-09-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B
Biochemistry, 42, 2003
1Q6N
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BU of 1q6n by Molmil
THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 4
Descriptor: CHLORIDE ION, MAGNESIUM ION, Protein-tyrosine phosphatase, ...
Authors:Scapin, G, Patel, S.B, Becker, J.W, Wang, Q, Desponts, C, Waddleton, D, Skorey, K, Cromlish, W, Bayly, C, Therien, M, Gauthier, J.Y, Li, C.S, Lau, C.K, Ramachandran, C, Kennedy, B.P, Asante-Appiah, E.
Deposit date:2003-08-13
Release date:2003-09-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B
Biochemistry, 42, 2003
1Q6S
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BU of 1q6s by Molmil
THE STRUCTURE OF PHOSPHOTYROSINE PHOSPHATASE 1B IN COMPLEX WITH COMPOUND 9
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 6-[4-((2R)-2-(1H-1,2,3-BENZOTRIAZOL-1-YL)-3-{4-[DIFLUORO(PHOSPHONO)METHYL]PHENYL}-2-PHENYLPROPYL)PHENYL]-2-METHYLQUINOLIN-8-YLPHOSPHONIC ACID, CHLORIDE ION, ...
Authors:Scapin, G, Patel, S.B, Becker, J.W, Wang, Q, Desponts, C, Waddleton, D, Skorey, K, Cromlish, W, Bayly, C, Therien, M, Gauthier, J.Y, Li, C.S, Lau, C.K, Ramachandran, C, Kennedy, B.P, Asante-Appiah, E.
Deposit date:2003-08-13
Release date:2003-09-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structural Basis for the Selectivity of Benzotriazole Inhibitors of Ptp1B
Biochemistry, 42, 2003
1SOJ
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BU of 1soj by Molmil
CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B IN COMPLEX WITH IBMX
Descriptor: 3-ISOBUTYL-1-METHYLXANTHINE, MAGNESIUM ION, cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Authors:Scapin, G, Patel, S.B, Chung, C, Varnerin, J.P, Edmondson, S.D, Mastracchio, A, Parmee, E.R, Becker, J.W, Singh, S.B, Van Der Ploeg, L.H, Tota, M.R.
Deposit date:2004-03-15
Release date:2004-05-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity
Biochemistry, 43, 2004
1SO2
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BU of 1so2 by Molmil
CATALYTIC DOMAIN OF HUMAN PHOSPHODIESTERASE 3B In COMPLEX WITH A DIHYDROPYRIDAZINE INHIBITOR
Descriptor: 1-DEOXY-1-[(2-HYDROXYETHYL)(NONANOYL)AMINO]HEXITOL, 6-(4-{[2-(3-IODOBENZYL)-3-OXOCYCLOHEX-1-EN-1-YL]AMINO}PHENYL)-5-METHYL-4,5-DIHYDROPYRIDAZIN-3(2H)-ONE, MAGNESIUM ION, ...
Authors:Scapin, G, Patel, S.B, Chung, C, Varnerin, J.P, Edmondson, S.D, Mastracchio, A, Parmee, E.R, Becker, J.W, Singh, S.B, Van Der Ploeg, L.H, Tota, M.R.
Deposit date:2004-03-12
Release date:2004-05-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity
Biochemistry, 43, 2004

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