1BQT
| THREE-DIMENSIONAL STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR-I (IGF-I) DETERMINED BY 1H-NMR AND DISTANCE GEOMETRY, 6 STRUCTURES | Descriptor: | INSULIN-LIKE GROWTH FACTOR-I | Authors: | Sato, A, Nishimura, S, Ohkubo, T, Kyogoku, Y, Koyama, S, Kobayashi, M, Yasuda, T, Kobayashi, Y. | Deposit date: | 1998-08-18 | Release date: | 1999-05-18 | Last modified: | 2022-02-16 | Method: | SOLUTION NMR | Cite: | Three-dimensional structure of human insulin-like growth factor-I (IGF-I) determined by 1H-NMR and distance geometry. Int.J.Pept.Protein Res., 41, 1993
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2RRD
| Structure of HRDC domain from human Bloom syndrome protein, BLM | Descriptor: | HRDC domain from Bloom syndrome protein | Authors: | Sato, A, Mishima, M, Nagai, A, Kim, S.Y, Ito, Y, Hakoshima, T, Jee, J.G, Kitano, K. | Deposit date: | 2010-07-19 | Release date: | 2010-09-08 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | Solution structure of the HRDC domain of human Bloom syndrome protein BLM J.Biochem., 148, 2010
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2RQL
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1ID7
| SOLUTION STRUCTURE OF SYR6 | Descriptor: | SYR6 | Authors: | Sato, A, Kawaguchi, K, Kimura, K, Tanimura, R, Sone, S. | Deposit date: | 2001-04-04 | Release date: | 2002-04-10 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | A peptide mimetic of IFN, the first proof of a small peptidic agonist for heterodimeric cytokine receptor To be Published
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1ID6
| SOLUTION STRUCTURES OF SYR6 | Descriptor: | SYR6 | Authors: | Sato, A, Kawaguchi, K, Kimura, K, Tanimura, R, Sone, S. | Deposit date: | 2001-04-04 | Release date: | 2002-04-10 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | A peptide mimetic of IFN, the first proof of a small peptidic agonist for heterodimeric cytokine receptor To be Published
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1X5T
| Solution structure of the second RRM domain in splicing factor = 3B | Descriptor: | Splicing factor 3B subunit 4 | Authors: | Sato, A, Kuwasako, K, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-05-16 | Release date: | 2005-11-16 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Solution structure of the second RRM domain in splicing factor = 3B To be Published
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1X5S
| Solution structure of RRM domain in A18 hnRNP | Descriptor: | Cold-inducible RNA-binding protein | Authors: | Sato, A, Muto, Y, Inoue, M, Kigawa, T, Shirouzu, M, Terada, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-05-16 | Release date: | 2005-11-16 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Solution structure of RRM domain in A18 hnRNP To be Published
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8WO8
| Crystal Structure of an RNA-binding protein, FAU-1, from Pyrococcus furiosus | Descriptor: | Probable ribonuclease FAU-1, RNA (5'-R(P*AP*UP*A)-3') | Authors: | Kawai, G, Okada, K, Baba, S, Sato, A, Sakamoto, T, Kanai, A. | Deposit date: | 2023-10-06 | Release date: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Homo-trimeric structure of the ribonuclease for rRNA processing, FAU-1, from Pyrococcus furiosus. J.Biochem., 2024
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1QR3
| Structure of porcine pancreatic elastase in complex with FR901277, a novel macrocyclic inhibitor of elastases at 1.6 angstrom resolution | Descriptor: | CALCIUM ION, Chymotrypsin-like elastase family member 1, FR901277 Inhibitor, ... | Authors: | Nakanishi, I, Kinoshita, T, Sato, A, Tada, T. | Deposit date: | 1999-06-18 | Release date: | 2000-06-21 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of porcine pancreatic elastase complexed with FR901277, a novel macrocyclic inhibitor of elastases, at 1.6 A resolution. Biopolymers, 53, 2000
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5GVQ
| Solution structure of the first RRM domain of human spliceosomal protein SF3b49 | Descriptor: | Splicing factor 3B subunit 4 | Authors: | Kuwasako, K, Nameki, N, Tsuda, K, Takahashi, M, Sato, A, Tochio, N, Inoue, M, Terada, T, Kigawa, T, Kobayashi, N, Shirouzu, M, Ito, T, Sakamoto, T, Wakamatsu, K, Guntert, P, Takahashi, S, Yokoyama, S, Muto, Y, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2016-09-06 | Release date: | 2017-04-12 | Method: | SOLUTION NMR | Cite: | Solution structure of the first RNA recognition motif domain of human spliceosomal protein SF3b49 and its mode of interaction with a SF3b145 fragment. Protein Sci., 26, 2017
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3AJI
| Structure of Gankyrin-S6ATPase photo-cross-linked site-specifically, and incoporated by genetic code expansion | Descriptor: | 26S proteasome non-ATPase regulatory subunit 10, Proteasome (Prosome, macropain) 26S subunit, ... | Authors: | Sato, S, Mimasu, S, Sato, A, Hino, N, Sakamoto, K, Umehara, T, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2010-06-07 | Release date: | 2010-12-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Crystallographic study of a site-specifically cross-linked protein complex with a genetically incorporated photoreactive amino acid Biochemistry, 50, 2011
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3ABG
| X-ray Crystal Analysis of Bilirubin Oxidase from Myrothecium verrucaria at 2.3 angstrom Resolution using a Twin Crystal | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Bilirubin oxidase, COPPER (II) ION, ... | Authors: | Mizutani, K, Toyoda, M, Sagara, K, Takahashi, N, Sato, A, Kamitaka, Y, Tsujimura, S, Nakanishi, Y, Sugiura, T, Yamaguchi, S, Kano, K, Mikami, B. | Deposit date: | 2009-12-10 | Release date: | 2010-08-18 | Last modified: | 2023-07-26 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | X-ray analysis of bilirubin oxidase from Myrothecium verrucaria at 2.3 A resolution using a twinned crystal Acta Crystallogr.,Sect.F, 66, 2010
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6B33
| Structure of RORgt in complex with a novel inverse agonist 3 | Descriptor: | (2R)-N~2~-(3-chloro-4-cyanophenyl)-N~4~-[3-(cyclopropylmethyl)-2,4-dioxo-1-(propan-2-yl)-1,2,3,4-tetrahydroquinazolin-6-yl]morpholine-2,4-dicarboxamide, Nuclear receptor ROR-gamma | Authors: | Skene, R.J, Hoffman, I, Snell, G. | Deposit date: | 2017-09-20 | Release date: | 2018-11-21 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Design and Synthesis of Conformationally Constrained ROR gamma t Inverse Agonists. Chemmedchem, 2019
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3AHP
| Crystal structure of stable protein, CutA1, from a psychrotrophic bacterium Shewanella sp. SIB1 | Descriptor: | CutA1 | Authors: | Tanaka, S, Angkawidjaja, C, Koga, Y, Takano, K, Kanaya, S. | Deposit date: | 2010-04-26 | Release date: | 2011-01-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of stable protein CutA1 from psychrotrophic bacterium Shewanella sp. SIB1 J.SYNCHROTRON RADIAT., 18, 2011
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6E3E
| Structure of RORgt in complex with a novel inverse agonist. | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 5-[(5R)-5-[(7-fluoro-1,1-dimethyl-2,3-dihydro-1H-inden-5-yl)carbamoyl]-2-methoxy-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]-5-oxopentanoic acid, Nuclear receptor ROR-gamma, ... | Authors: | Skene, R.J, Hoffman, I. | Deposit date: | 2018-07-13 | Release date: | 2019-07-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor gamma t (ROR gamma t) Agonist Structure-Based Functionality Switching Approach from In House ROR gamma t Inverse Agonist to ROR gamma t Agonist. J.Med.Chem., 62, 2019
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6E3G
| Structure of RORgt in complex with a novel agonist. | Descriptor: | (5R)-6-acetyl-2-methoxy-N-{4-[(2-methoxyphenyl)methoxy]phenyl}-5,6,7,8-tetrahydro-1,6-naphthyridine-5-carboxamide, 1,2-ETHANEDIOL, Nuclear receptor ROR-gamma, ... | Authors: | Skene, R.J, Hoffman, I. | Deposit date: | 2018-07-13 | Release date: | 2019-06-12 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Design, Synthesis, and Biological Evaluation of Retinoic Acid-Related Orphan Receptor gamma t (ROR gamma t) Agonist Structure-Based Functionality Switching Approach from In House ROR gamma t Inverse Agonist to ROR gamma t Agonist. J.Med.Chem., 62, 2019
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2FYH
| Solution structure of the 2'-5' RNA ligase-like protein from Pyrococcus furiosus | Descriptor: | putative integral membrane transport protein | Authors: | Okada, K, Matsuda, T, Sakamoto, T, Muto, Y, Yokoyama, S, Kanai, A, Kawai, G, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-02-08 | Release date: | 2007-02-20 | Last modified: | 2011-07-13 | Method: | SOLUTION NMR | Cite: | Characterization of a heat-stable enzyme possessing GTP-dependent RNA ligase activity from a hyperthermophilic archaeon, Pyrococcus furiosus Rna, 15, 2009
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7VTH
| The crystal structure of SARS-CoV-2 3CL protease in complex with compound 1 | Descriptor: | 2-[4-[[4-[bis(fluoranyl)methoxy]-2-methyl-phenyl]amino]-2,6-bis(oxidanylidene)-3-[[3,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazin-1-yl]-N-methyl-ethanamide, 3C-like proteinase | Authors: | Yamamoto, S, Tachibana, Y. | Deposit date: | 2021-10-29 | Release date: | 2022-04-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19. J.Med.Chem., 65, 2022
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7VU6
| The crystal structure of SARS-CoV-2 3CL protease in complex with compound 3 | Descriptor: | 3C-like proteinase, 6-[(6-chloranyl-2-methyl-indazol-5-yl)amino]-3-[(1-methyl-1,2,4-triazol-3-yl)methyl]-1-[[2,4,5-tris(fluoranyl)phenyl]methyl]-1,3,5-triazine-2,4-dione | Authors: | Yamamoto, S, Yamane, J, Tachibana, Y. | Deposit date: | 2021-11-01 | Release date: | 2022-04-06 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Discovery of S-217622, a Noncovalent Oral SARS-CoV-2 3CL Protease Inhibitor Clinical Candidate for Treating COVID-19. J.Med.Chem., 65, 2022
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3EBX
| REFINEMENT AT 1.4 ANGSTROMS RESOLUTION OF A MODEL OF ERABUTOXIN B. TREATMENT OF ORDERED SOLVENT AND DISCRETE DISORDER | Descriptor: | ERABUTOXIN B, SULFATE ION | Authors: | Smith, J.L, Corfield, P.W.R, Hendrickson, W.A, Low, B.W. | Deposit date: | 1988-01-15 | Release date: | 1988-04-16 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Refinement at 1.4 A resolution of a model of erabutoxin b: treatment of ordered solvent and discrete disorder. Acta Crystallogr.,Sect.A, 44, 1988
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7D1C
| Crystal structure of mouse Cryptochrome 1 in complex with compound TH303 | Descriptor: | Cryptochrome-1, N-[2-(4-methoxyphenyl)-5,5-bis(oxidanylidene)-4,6-dihydrothieno[3,4-c]pyrazol-3-yl]-4-(phenylcarbonyl)benzamide | Authors: | Miller, S.A, Hirota, T. | Deposit date: | 2020-09-14 | Release date: | 2021-01-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Photopharmacological Manipulation of Mammalian CRY1 for Regulation of the Circadian Clock. J.Am.Chem.Soc., 143, 2021
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7D19
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7C6B
| Crystal structure of Ago2 MID domain in complex with 6-(3-(2-carboxyethyl)phenyl)purine riboside monophosphate | Descriptor: | 3-[3-[9-[(2R,3R,4S,5R)-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]purin-6-yl]phenyl]propanoic acid, PHOSPHATE ION, Protein argonaute-2 | Authors: | Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F. | Deposit date: | 2020-05-21 | Release date: | 2020-11-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand. Rna, 27, 2021
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7D7U
| Crystal structure of Ago2 MID domain in complex with 8-Br-adenosin-5'-monophosphate | Descriptor: | 8-BROMO-ADENOSINE-5'-MONOPHOSPHATE, Protein argonaute-2 | Authors: | Suzuki, M, Takahashi, Y, Saito, J, Miyagi, H, Shinohara, F. | Deposit date: | 2020-10-06 | Release date: | 2020-11-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | siRNA potency enhancement via chemical modifications of nucleotide bases at the 5'-end of the siRNA guide strand. Rna, 27, 2021
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6B30
| Structure of RORgt in complex with a novel inverse agonist 1 | Descriptor: | N-[(1R)-1-(4-methoxyphenyl)-2-oxo-2-{[4-(trimethylsilyl)phenyl]amino}ethyl]-N-methyl-3-oxo-2,3-dihydro-1,2-oxazole-5-carboxamide, Nuclear receptor ROR-gamma | Authors: | Skene, R.J, Hoffman, I. | Deposit date: | 2017-09-20 | Release date: | 2018-01-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Discovery of orally efficacious ROR gamma t inverse agonists, part 1: Identification of novel phenylglycinamides as lead scaffolds. Bioorg. Med. Chem., 26, 2018
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