Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2A4G
DownloadVisualize
BU of 2a4g by Molmil
Hepatitis C Protease NS3-4A serine protease with Ketoamide Inhibitor SCH225724 Bound
Descriptor: ({1-[1-CARBAMOYL-PHENYL-METHYL)-CARBAMOYL]-METHYL}-AMINOOXALYL)-BUTYLCARBAMOYL)-3-METHYL-BUTYLCARBAMOYL)-CYCLOHEXYL-METHYL)-CARBAMIC ACID ISOBUTYL ESTER, NS3 protease/helicase, NS4a peptide, ...
Authors:Arasappan, A, Njoroge, F.G, Chan, T.Y, Bennett, F, Bogen, S.L, Chen, K, Gu, H, Hong, L, Jao, E, Liu, Y.T, Lovey, R.G, Parekh, T, Pike, R.E, Pinto, P, Santhanam, B, Venkatraman, S, Vaccaro, H, Wang, H, Yang, X, Zhu, Z, Mckittrick, B, Saksena, A.K, Girijavallabhan, V, Pichardo, J, Butkiewicz, N, Ingram, R, Malcolm, B, Prongay, A.J, Yao, N, Marten, B, Madison, V, Kemp, S, Levy, O, Lim-Wilby, M, Tamura, S, Ganguly, A.K.
Deposit date:2005-06-28
Release date:2006-07-04
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Hepatitis C virus NS3-4a serine protease inhibitors. SAR of P2' moiety with improved potency.
Bioorg.Med.Chem.Lett., 15, 2005
3J92
DownloadVisualize
BU of 3j92 by Molmil
Structure and assembly pathway of the ribosome quality control complex
Descriptor: 28S rRNA, 5.8S rRNA, 5S rRNA, ...
Authors:Shao, S, Brown, A, Santhanam, B, Hegde, R.S.
Deposit date:2014-12-02
Release date:2015-01-21
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structure and Assembly Pathway of the Ribosome Quality Control Complex.
Mol.Cell, 57, 2015
5NP0
DownloadVisualize
BU of 5np0 by Molmil
Closed dimer of human ATM (Ataxia telangiectasia mutated)
Descriptor: Serine-protein kinase ATM
Authors:Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L.
Deposit date:2017-04-13
Release date:2017-05-17
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Structures of closed and open conformations of dimeric human ATM.
Sci Adv, 3, 2017
5NP1
DownloadVisualize
BU of 5np1 by Molmil
Open protomer of human ATM (Ataxia telangiectasia mutated)
Descriptor: Serine-protein kinase ATM
Authors:Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L.
Deposit date:2017-04-13
Release date:2017-05-17
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Structures of closed and open conformations of dimeric human ATM.
Sci Adv, 3, 2017
6EOJ
DownloadVisualize
BU of 6eoj by Molmil
PolyA polymerase module of the cleavage and polyadenylation factor (CPF) from Saccharomyces cerevisiae
Descriptor: Polyadenylation factor subunit 2,Polyadenylation factor subunit 2, Protein CFT1, ZINC ION, ...
Authors:Casanal, A, Kumar, A, Hill, C.H, Emsley, P, Passmore, L.
Deposit date:2017-10-09
Release date:2017-11-15
Last modified:2018-01-31
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Architecture of eukaryotic mRNA 3'-end processing machinery.
Science, 358, 2017
6SB2
DownloadVisualize
BU of 6sb2 by Molmil
cryo-EM structure of mTORC1 bound to active RagA/C GTPases
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Ras-related GTP-binding protein A, ...
Authors:Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L.
Deposit date:2019-07-18
Release date:2019-10-16
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
6SB0
DownloadVisualize
BU of 6sb0 by Molmil
cryo-EM structure of mTORC1 bound to PRAS40-fused active RagA/C GTPases
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, Proline-rich AKT1 substrate 1, ...
Authors:Anandapadamanaban, M, Berndt, A, Masson, G.R, Perisic, O, Williams, R.L.
Deposit date:2019-07-18
Release date:2019-10-16
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (5.5 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
6S6D
DownloadVisualize
BU of 6s6d by Molmil
Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L.
Deposit date:2019-07-02
Release date:2019-10-16
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
6S6A
DownloadVisualize
BU of 6s6a by Molmil
Crystal structure of RagA-Q66L/RagC-T90N GTPase heterodimer complex
Descriptor: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
Authors:Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L.
Deposit date:2019-07-02
Release date:2019-10-16
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
6GZT
DownloadVisualize
BU of 6gzt by Molmil
Structure of Chlamydia trachomatis effector protein ChlaDUB1 bound to Coenzyme A
Descriptor: COENZYME A, Deubiquitinase and deneddylase Dub1, GLYCEROL, ...
Authors:Pruneda, J.N, Komander, D.
Deposit date:2018-07-05
Release date:2018-11-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.
Nat Microbiol, 3, 2018
6GZU
DownloadVisualize
BU of 6gzu by Molmil
Structure of Chlamydia abortus effector protein ChlaDUB
Descriptor: Conserved membrane protein, GLYCEROL, ZINC ION
Authors:Pruneda, J.N, Komander, D.
Deposit date:2018-07-05
Release date:2018-11-14
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.
Nat Microbiol, 3, 2018
6GZS
DownloadVisualize
BU of 6gzs by Molmil
Structure of Chlamydia trachomatis effector protein ChlaDUB1 bound to ubiquitin
Descriptor: Deubiquitinase and deneddylase Dub1, GLYCEROL, Polyubiquitin-B, ...
Authors:Pruneda, J.N, Komander, D.
Deposit date:2018-07-05
Release date:2018-11-14
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.
Nat Microbiol, 3, 2018
5HAM
DownloadVisualize
BU of 5ham by Molmil
Structure of Rickettsia bellii effector protein RickCE
Descriptor: RickCE
Authors:Pruneda, J.N, Komander, D.
Deposit date:2015-12-30
Release date:2016-07-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
5HAF
DownloadVisualize
BU of 5haf by Molmil
Structure of Salmonella enterica effector protein SseL
Descriptor: Deubiquitinase SseL, POTASSIUM ION
Authors:Pruneda, J.N, Komander, D.
Deposit date:2015-12-30
Release date:2016-07-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
5HAG
DownloadVisualize
BU of 5hag by Molmil
Structure of Chlamydia trachomatis effector protein ChlaDUB1
Descriptor: Deubiquitinase and deneddylase Dub1, GLYCEROL
Authors:Pruneda, J.N, Komander, D.
Deposit date:2015-12-30
Release date:2016-07-27
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
2A4R
DownloadVisualize
BU of 2a4r by Molmil
HCV NS3 Protease Domain with a Ketoamide Inhibitor Covalently bound.
Descriptor: NS3 protease/helicase, Ns4a peptide, ZINC ION, ...
Authors:Bogen, S, Saksena, A.K, Arasappan, A, Gu, H, Njoroge, F.G, Girijavallabhan, V, Pichardo, J, Butkiewicz, N, Prongay, A, Madison, V.
Deposit date:2005-06-29
Release date:2006-07-04
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Hepatitis C Virus NS3-4A serine protease inhibitors: Use of a P2-P1 cyclopropyl alanine combination for improved potency.
Bioorg.Med.Chem.Lett., 15, 2005
2A4Q
DownloadVisualize
BU of 2a4q by Molmil
HCV NS3 protease with NS4a peptide and a covalently bound macrocyclic ketoamide compound.
Descriptor: (2R)-({N-[(3S)-3-({[(3S,6S)-6-CYCLOHEXYL-5,8-DIOXO-4,7-DIAZABICYCLO[14.3.1]ICOSA-1(20),16,18-TRIEN-3-YL]CARBONYL}AMINO)-2-OXOHEXANOYL]GLYCYL}AMINO)(PHENYL)ACETIC ACID, BETA-MERCAPTOETHANOL, NS3 protease/helicase', ...
Authors:Chen, K.X, Njoroge, F.G, Prongay, A, Pichardo, J, Madison, V, Girijavallabhan, V.
Deposit date:2005-06-29
Release date:2006-07-04
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Synthesis and Biological Activity of Macrocyclic Inhibitors of Hepatitis C Virus (HCV) NS3 Protease
Bioorg.Med.Chem.Lett., 15, 2005
5JP3
DownloadVisualize
BU of 5jp3 by Molmil
Structure of Xanthomonas campestris effector protein XopD bound to ubiquitin
Descriptor: Polyubiquitin-B, Xanthomonas outer protein D
Authors:Pruneda, J.N, Komander, D.
Deposit date:2016-05-03
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
5JP1
DownloadVisualize
BU of 5jp1 by Molmil
Structure of Xanthomonas campestris effector protein XopD bound to tomato SUMO
Descriptor: (4S,5S)-1,2-DITHIANE-4,5-DIOL, MALONATE ION, Small ubiquitin-related modifier, ...
Authors:Pruneda, J.N, Komander, D.
Deposit date:2016-05-03
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
6ZNO
DownloadVisualize
BU of 6zno by Molmil
The pointed end complex of dynactin with the p150 projection docked
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ...
Authors:Lau, C.K, Lacey, S.E, Carter, A.P.
Deposit date:2020-07-06
Release date:2020-07-29
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end.
Embo J., 40, 2021
6ZO4
DownloadVisualize
BU of 6zo4 by Molmil
The pointed end complex of dynactin bound to BICD2
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ...
Authors:Lau, C.K, Lacey, S.E, Carter, A.P.
Deposit date:2020-07-07
Release date:2020-07-29
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (8.2 Å)
Cite:Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end.
Embo J., 40, 2021
6ZNN
DownloadVisualize
BU of 6znn by Molmil
The pointed end complex of dynactin bound to Hook3
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ...
Authors:Lau, C.K, Lacey, S.E, Carter, A.P.
Deposit date:2020-07-06
Release date:2020-07-29
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end.
Embo J., 40, 2021
6ZNL
DownloadVisualize
BU of 6znl by Molmil
Cryo-EM structure of the dynactin complex
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ...
Authors:Lau, C.K, Lacey, S.E, Carter, A.P.
Deposit date:2020-07-06
Release date:2020-07-29
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end.
Embo J., 40, 2021
6ZNM
DownloadVisualize
BU of 6znm by Molmil
The pointed end complex of dynactin bound to BICDR1
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ARP1 actin related protein 1 homolog A, ...
Authors:Lau, C.K, Lacey, S.E, Carter, A.P.
Deposit date:2020-07-06
Release date:2020-07-29
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM reveals the complex architecture of dynactin's shoulder region and pointed end.
Embo J., 40, 2021
2OC7
DownloadVisualize
BU of 2oc7 by Molmil
Structure of Hepatitis C Viral NS3 protease domain complexed with NS4A peptide and ketoamide SCH571696
Descriptor: BETA-MERCAPTOETHANOL, Hepatitis C Virus, TERT-BUTYL {(1S)-2-[(1R,2S,5R)-2-({[(1S)-3-AMINO-1-(CYCLOBUTYLMETHYL)-2,3-DIOXOPROPYL]AMINO}CARBONYL)-7,7-DIMETHYL-6-OXA-3-AZABICYCLO[3.2.0]HEPT-3-YL]-1-CYCLOHEXYL-2-OXOETHYL}CARBAMATE, ...
Authors:Prongay, A.J, Guo, Z, Yao, N, Fischmann, T, Strickland, C, Myers Jr, J, Weber, P.C, Malcolm, B, Beyer, B.M, Ingram, R, Pichardo, J, Hong, Z, Prosise, W.W, Ramanathan, L, Taremi, S.S, Yarosh-Tomaine, T, Zhang, R, Senior, M, Yang, R, Arasappan, A, Bennett, F, Bogen, S.F, Chen, K, Jao, E, Liu, Y, Love, R.G, Saksena, A.K, Venkatraman, S, Girijavallabhan, V, Njoroge, F.G, Madison, V.
Deposit date:2006-12-20
Release date:2007-07-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization.
J.Med.Chem., 50, 2007

 

12>

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon