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7ZI0
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BU of 7zi0 by Molmil
Structure of human Smoothened in complex with cholesterol and SAG
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-chloro-N-[trans-4-(methylamino)cyclohexyl]-N-{[3-(pyridin-4-yl)phenyl]methyl}-1-benzothiophene-2-carboxamide, CHOLESTEROL, ...
Authors:Byrne, E.F.X, Woolley, R.E, Ansell, B, Sansom, M.S.P, Newstead, S, Siebold, C.
Deposit date:2022-04-07
Release date:2022-06-15
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain.
Sci Adv, 8, 2022
3ZRS
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BU of 3zrs by Molmil
X-ray crystal structure of a KirBac potassium channel highlights a mechanism of channel opening at the bundle-crossing gate.
Descriptor: ATP-SENSITIVE INWARD RECTIFIER POTASSIUM CHANNEL 10, CHLORIDE ION, POTASSIUM ION
Authors:Bavro, V.N, De Zorzi, R, Schmidt, M.R, Muniz, J.R.C, Zubcevic, L, Sansom, M.S.P, Venien-Bryan, C, Tucker, S.J.
Deposit date:2011-06-17
Release date:2012-01-11
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structure of a Kirbac Potassium Channel with an Open Bundle Crossing Indicates a Mechanism of Channel Gating
Nat.Struct.Mol.Biol., 19, 2012
5FTT
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BU of 5ftt by Molmil
Octameric complex of Latrophilin 3 (Lec, Olf) , Unc5D (Ig, Ig2, TSP1) and FLRT2 (LRR)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADHESION G PROTEIN-COUPLED RECEPTOR L3, CALCIUM ION, ...
Authors:Jackson, V.A, Mehmood, S, Chavent, M, Roversi, P, Carrasquero, M, del Toro, D, Seyit-Bremer, G, Ranaivoson, F.M, Comoletti, D, Sansom, M.S.P, Robinson, C.V, Klein, R, Seiradake, E.
Deposit date:2016-01-15
Release date:2016-05-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Super-Complexes of Adhesion Gpcrs and Neural Guidance Receptors
Nat.Commun., 7, 2016
5FTU
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BU of 5ftu by Molmil
Tetrameric complex of Latrophilin 3, Unc5D and FLRT2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADHESION G PROTEIN-COUPLED RECEPTOR L3, CALCIUM ION, ...
Authors:Jackson, V.A, Mehmood, S, Chavent, M, Roversi, P, Carrasquero, M, del Toro, D, Seyit-Bremer, G, Ranaivoson, F.M, Comoletti, D, Sansom, M.S.P, Robinson, C.V, Klein, R, Seiradake, E.
Deposit date:2016-01-15
Release date:2016-05-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (6.01 Å)
Cite:Super-Complexes of Adhesion Gpcrs and Neural Guidance Receptors
Nat.Commun., 7, 2016
7A46
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BU of 7a46 by Molmil
small conductance mechanosensitive channel YbiO
Descriptor: Putative transport protein
Authors:Flegler, V.J, Rasmussen, A, Rao, S, Wu, N, Zenobi, R, Sansom, M.S.P, Hedrich, R, Rasmussen, T, Boettcher, B.
Deposit date:2020-08-19
Release date:2020-11-18
Last modified:2020-11-25
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The MscS-like channel YnaI has a gating mechanism based on flexible pore helices.
Proc.Natl.Acad.Sci.USA, 117, 2020
6ZYE
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BU of 6zye by Molmil
YnaI in an open-like conformation
Descriptor: YnaI,Low conductance mechanosensitive channel YnaI
Authors:Flegler, V.J, Rasmussen, A, Rao, S, Wu, N, Zenobi, R, Sansom, M.S.P, Hedrich, R, Rasmussen, T, Boettcher, B.
Deposit date:2020-07-31
Release date:2020-11-25
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:The MscS-like channel YnaI has a gating mechanism based on flexible pore helices.
Proc.Natl.Acad.Sci.USA, 117, 2020
6ZYD
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BU of 6zyd by Molmil
YnaI
Descriptor: 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, Low conductance mechanosensitive channel YnaI,Low conductance mechanosensitive channel YnaI
Authors:Flegler, V.J, Rasmussen, A, Rao, S, Wu, N, Zenobi, R, Sansom, M.S.P, Hedrich, R, Rasmussen, T, Boettcher, B.
Deposit date:2020-07-31
Release date:2020-11-25
Method:ELECTRON MICROSCOPY (3 Å)
Cite:The MscS-like channel YnaI has a gating mechanism based on flexible pore helices.
Proc.Natl.Acad.Sci.USA, 117, 2020
2X79
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BU of 2x79 by Molmil
Inward facing conformation of Mhp1
Descriptor: HYDANTOIN TRANSPORT PROTEIN
Authors:Shimamura, T, Weyand, S, Beckstein, O, Rutherford, N.G, Hadden, J.M, Sharples, D, Sansom, M.S.P, Iwata, S, Henderson, P.J.F, Cameron, A.D.
Deposit date:2010-02-25
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Molecular Basis of Alternating Access Membrane Transport by the Sodium-Hydantoin Transporter Mhp1.
Science, 328, 2010
2XUT
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BU of 2xut by Molmil
Crystal structure of a proton dependent oligopeptide (POT) family transporter.
Descriptor: PROTON/PEPTIDE SYMPORTER FAMILY PROTEIN
Authors:Newstead, S, Drew, D, Cameron, A.D, Postis, V.L, Xia, X, Fowler, P.W, Ingram, J.C, Carpenter, E.P, Sansom, M.S.P, McPherson, M.J, Baldwin, S.A, Iwata, S.
Deposit date:2010-10-21
Release date:2010-12-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.62 Å)
Cite:Crystal Structure of a Prokaryotic Homologue of the Mammalian Oligopeptide-Proton Symporters, Pept1 and Pept2.
Embo J., 30, 2011
6RTW
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BU of 6rtw by Molmil
Crystal structure of the Patched-1 (PTCH1) ectodomain in complex with nanobody NB64 and cholesterol-hemisuccinate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Llama-derived nanobody NB64, ...
Authors:Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C.
Deposit date:2019-05-27
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat.Chem.Biol., 15, 2019
6RVC
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BU of 6rvc by Molmil
Crystal structure of Patched-1 ectodomain 2 (PTCH1-ECD2) in complex with nanobody 75
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody NB75, Protein patched homolog 1, ...
Authors:Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C.
Deposit date:2019-05-31
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat.Chem.Biol., 15, 2019
6RTY
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BU of 6rty by Molmil
Crystal structure of the Patched ectodomain in complex with nanobody NB64
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Llama-derived nanobody NB64, Protein patched homolog 1
Authors:Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C.
Deposit date:2019-05-27
Release date:2019-10-02
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat.Chem.Biol., 15, 2019
6RTX
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BU of 6rtx by Molmil
Crystal structure of the Patched-1 (PTCH1) ectodomain 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Protein patched homolog 1
Authors:Rudolf, A.F, Kowatsch, C, El Omari, K, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C.
Deposit date:2019-05-27
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat.Chem.Biol., 15, 2019
6RVD
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BU of 6rvd by Molmil
Revised cryo-EM structure of the human 2:1 Ptch1-Shh complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:El Omari, K, Rudolf, A.F, Kowatsch, C, Malinauskas, T, Kinnebrew, M, Ansell, T.B, Bishop, B, Pardon, E, Schwab, R.A, Qian, M, Duman, R, Covey, D.F, Steyaert, J, Wagner, A, Sansom, M.S.P, Rohatgi, R, Siebold, C.
Deposit date:2019-05-31
Release date:2019-10-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism.
Nat.Chem.Biol., 15, 2019
4BBK
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BU of 4bbk by Molmil
Structural and functional characterisation of the kindlin-1 pleckstrin homology domain
Descriptor: FERMITIN FAMILY HOMOLOG 1, GLYCEROL
Authors:Yates, L.A, Lumb, C.N, Brahme, N.N, Zalyte, R, Bird, L.E, De Colibus, L, Owens, R.J, Calderwood, D.A, Sansom, M.S.P, Gilbert, R.J.C.
Deposit date:2012-09-25
Release date:2012-11-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Functional Characterisation of the Kindlin-1 Pleckstrin Homology Domain
J.Biol.Chem., 287, 2012
6VM3
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BU of 6vm3 by Molmil
Full length Glycine receptor reconstituted in lipid nanodisc in Gly/IVM-conformation (State-3)
Descriptor: (2aE,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17aR,20R,20aR,20bS)-6'-[(2S)-butan-2-yl]-20,20b-dihydroxy-5',6,8,19-tetramethyl-17 -oxo-3',4',5',6,6',10,11,14,15,17,17a,20,20a,20b-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacy clooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-O-(2,6-dideoxy-3-O-methyl-alpha-L-arabino-hexopyranosyl)-3-O-methyl-alpha-L-arabino-hexopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCINE, ...
Authors:Kumar, A, Basak, S, Chakrapani, S.
Deposit date:2020-01-27
Release date:2020-07-29
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.07 Å)
Cite:Mechanisms of activation and desensitization of full-length glycine receptor in lipid nanodiscs.
Nat Commun, 11, 2020
4LP8
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BU of 4lp8 by Molmil
A Novel Open-State Crystal Structure of the Prokaryotic Inward Rectifier KirBac3.1
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, Inward rectifier potassium channel Kirbac3.1, ...
Authors:Zubcevic, L, Bavro, V.N, Muniz, J.R.C, Schmidt, M.R, Wang, S, De Zorzi, R, Venien-Bryan, C, Sansom, M.S.P, Nichols, C.G, Tucker, S.J.
Deposit date:2013-07-15
Release date:2013-11-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Control of KirBac3.1 Potassium Channel Gating at the Interface between Cytoplasmic Domains.
J.Biol.Chem., 289, 2014
8C5V
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BU of 8c5v by Molmil
Chemotaxis core signalling unit from E protein lysed E. coli cells
Descriptor: Chemotaxis protein CheA, Chemotaxis protein CheW, Methyl-accepting chemotaxis protein I
Authors:Cassidy, C.K, Qin, Z, Zhang, P.
Deposit date:2023-01-10
Release date:2023-09-13
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (12 Å)
Cite:Structure of the native chemotaxis core signaling unit from phage E-protein lysed E. coli cells.
Mbio, 14, 2023
7Q6Z
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BU of 7q6z by Molmil
Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to IMP-1575
Descriptor: 2-(2-methylpropylamino)-1-[(4R)-4-(6-methylpyridin-2-yl)-6,7-dihydro-4H-thieno[3,2-c]pyridin-5-yl]ethanone, CHOLESTEROL, Megabody 177, ...
Authors:Coupland, C, Carrique, L, Siebold, C.
Deposit date:2021-11-09
Release date:2022-01-26
Method:ELECTRON MICROSCOPY (3.59 Å)
Cite:Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Mol.Cell, 81, 2021
7Q1U
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BU of 7q1u by Molmil
Structure of Hedgehog acyltransferase (HHAT) in complex with megabody 177 bound to non-hydrolysable palmitoyl-CoA (Composite Map)
Descriptor: CHOLESTEROL, MAGNESIUM ION, Megabody 177, ...
Authors:Coupland, C, Carrique, L, Siebold, C.
Deposit date:2021-10-21
Release date:2022-06-08
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structure, mechanism, and inhibition of Hedgehog acyltransferase.
Mol.Cell, 81, 2021
5L7I
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BU of 5l7i by Molmil
Structure of human Smoothened in complex with Vismodegib
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, SODIUM ION, ...
Authors:Byrne, E.X.B, Sircar, R, Miller, P.S, Hedger, G, Luchetti, G, Nachtergaele, S, Tully, M.D, Mydock-McGrane, L, Covey, D.F, Rambo, R.F, Sansom, M.S.P, Newstead, S, Rohatgi, R, Siebold, C.
Deposit date:2016-06-03
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural basis of Smoothened regulation by its extracellular domains.
Nature, 535, 2016
5L7D
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BU of 5l7d by Molmil
Structure of human Smoothened in complex with cholesterol
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, SODIUM ION, ...
Authors:Byrne, E.F.X, Sircar, R, Miller, P.S, Hedger, G, Luchetti, G, Nachtergaele, S, Tully, M.D, Mydock-McGrane, L, Covey, D.F, Rambo, R.P, Sansom, M.S.P, Newstead, S, Rohatgi, R, Siebold, C.
Deposit date:2016-06-03
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis of Smoothened regulation by its extracellular domains.
Nature, 535, 2016
6M96
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BU of 6m96 by Molmil
ATP-bound conformation of the WzmWzt O antigen ABC transporter
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, ABC transporter, ...
Authors:Caffalette, C.A, Zimmer, J.
Deposit date:2018-08-22
Release date:2019-03-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A lipid gating mechanism for the channel-forming O antigen ABC transporter.
Nat Commun, 10, 2019
6NF4
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BU of 6nf4 by Molmil
Structure of zebrafish Otop1 in nanodiscs
Descriptor: CHOLESTEROL, CHOLESTEROL HEMISUCCINATE, Otopetrin1
Authors:Saotome, K, Lee, W.H, Liman, E.R, Ward, A.B.
Deposit date:2018-12-18
Release date:2019-06-05
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.98 Å)
Cite:Structures of the otopetrin proton channels Otop1 and Otop3.
Nat.Struct.Mol.Biol., 26, 2019
6NF6
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BU of 6nf6 by Molmil
Structure of chicken Otop3 in nanodiscs
Descriptor: CHOLESTEROL HEMISUCCINATE, Otopetrin3
Authors:Saotome, K, Lee, W.H, Liman, E.R, Ward, A.B.
Deposit date:2018-12-18
Release date:2019-06-05
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.32 Å)
Cite:Structures of the otopetrin proton channels Otop1 and Otop3.
Nat.Struct.Mol.Biol., 26, 2019

 

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