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1KI2
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CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH GANCICLOVIR
Descriptor:THYMIDINE KINASE, SULFATE ION, 9-(1,3-DIHYDROXY-PROPOXYMETHANE)GUANINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Brown, D.G., Visse, R., Sandhu, G., Davies, A., Rizkallah, P.J., Melitz, C., Summers, W.C., Sanderson, M.R.
Deposit date:1998-05-15
Release date:1998-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1KI3
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CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH PENCICLOVIR
Descriptor:THYMIDINE KINASE, SULFATE ION, 9-(4-HYDROXY-3-(HYDROXYMETHYL)BUT-1-YL)GUANINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Jarvest, R.L., Summers, W.C., Sanderson, M.R.
Deposit date:1998-05-15
Release date:1999-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1KI4
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CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-BROMOTHIENYLDEOXYURIDINE
Descriptor:THYMIDINE KINASE, SULFATE ION, 5-BROMOTHIENYLDEOXYURIDINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Summers, W.C., Sanderson, M.R.
Deposit date:1998-05-18
Release date:1998-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1KI6
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CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH A 5-IODOURACIL ANHYDROHEXITOL NUCLEOSIDE
Descriptor:THYMIDINE KINASE, SULFATE ION, 1',5'-ANHYDRO-2',3'-DIDEOXY-2'-(5-IODOURACIL-1-YL)-D-ABABINO-HEXITOL
Authors:Champness, J.N., Bennett, M.S., Wien, F., Herdewijn, P., Ostrowski, T., Summers, W.C., Sanderson, M.R.
Deposit date:1998-05-18
Release date:1998-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1KI7
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CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-IODODEOXYURIDINE
Descriptor:THYMIDINE KINASE, SULFATE ION, 5-IODODEOXYURIDINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Summers, W.C., Sanderson, M.R.
Deposit date:1998-05-15
Release date:1998-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1KI8
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CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH 5-BROMOVINYLDEOXYURIDINE
Descriptor:THYMIDINE KINASE, SULFATE ION, 5-BROMOVINYLDEOXYURIDINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Visse, R., Summers, W.C., Sanderson, M.R.
Deposit date:1998-05-15
Release date:1998-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1KIM
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CRYSTAL STRUCTURE OF THYMIDINE KINASE FROM HERPES SIMPLEX VIRUS TYPE I COMPLEXED WITH DEOXYTHYMIDINE
Descriptor:THYMIDINE KINASE, SULFATE ION, THYMIDINE
Authors:Champness, J.N., Bennett, M.S., Wien, F., Brown, D.G., Visse, R., Sandhu, G., Davies, A., Rizkallah, P.J., Melitz, C., Summers, W.C., Sanderson, M.R.
Deposit date:1997-11-12
Release date:1998-05-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.
Proteins, 32, 1998
1D63
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CRYSTAL STRUCTURE OF A BERENIL-D(CGCAAATTTGCG) COMPLEX; AN EXAMPLE OF DRUG-DNA RECOGNITION BASED ON SEQUENCE-DEPENDENT STRUCTURAL FEATURES
Descriptor:DNA (5'-D(*CP*GP*CP*AP*AP*AP*TP*TP*TP*GP*CP*G)-3'), MAGNESIUM ION, BERENIL
Authors:Brown, D.G., Sanderson, M.R., Garman, E., Neidle, S.
Deposit date:1992-03-02
Release date:1993-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of a berenil-d(CGCAAATTTGCG) complex. An example of drug-DNA recognition based on sequence-dependent structural features.
J.Mol.Biol., 226, 1992
2NOV
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BREAKAGE-REUNION DOMAIN OF S.PNEUMONIAE TOPO IV: CRYSTAL STRUCTURE OF A GRAM-POSITIVE QUINOLONE TARGET
Descriptor:DNA topoisomerase 4 subunit A
Authors:Laponogov, I., Veselkov, D.A., Sohi, M.K., Pan, X.S., Achari, A., Yang, C., Ferrara, J.D., Fisher, L.M., Sanderson, M.R.
Deposit date:2006-10-26
Release date:2006-11-14
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Breakage-Reunion Domain of Streptococcus pneumoniae Topoisomerase IV: Crystal Structure of a Gram-Positive Quinolone Target.
PLoS ONE, 2, 2007
3K9F
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DETAILED STRUCTURAL INSIGHT INTO THE QUINOLONE-DNA CLEAVAGE COMPLEX OF TYPE IIA TOPOISOMERASES
Descriptor:DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, DNA (5'-D(*AP*CP*CP*AP*AP*GP*GP*T*CP*AP*TP*GP*AP*AP*T)-3'), ...
Authors:Laponogov, I., Pan, X.-S., Veselkov, D.A., Fisher, L.M., Sanderson, M.R.
Deposit date:2009-10-15
Release date:2009-10-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases
Plos One, 5, 2010
3KSA
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DETAILED STRUCTURAL INSIGHT INTO THE DNA CLEAVAGE COMPLEX OF TYPE IIA TOPOISOMERASES (CLEAVED FORM)
Descriptor:DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, 5'-D(*AP*CP*CP*AP*AP*GP*GP*T*CP*AP*TP*GP*AP*AP*T)-3', ...
Authors:Laponogov, I., Pan, X.-S., Veselkov, D.A., McAuley, K.E., Fisher, L.M., Sanderson, M.R.
Deposit date:2009-11-21
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases
Plos One, 5, 2010
3KSB
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DETAILED STRUCTURAL INSIGHT INTO THE DNA CLEAVAGE COMPLEX OF TYPE IIA TOPOISOMERASES (RE-SEALED FORM)
Descriptor:DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, 5'-D(*AP*CP*CP*AP*AP*GP*GP*T*CP*AP*TP*GP*AP*AP*TP*GP*AP*CP*TP*AP*TP*GP*CP*AP*CP*GP*TP*AP*AP*AP*AP*CP*AP*G)-3', ...
Authors:Laponogov, I., Pan, X.-S., Veselkov, D.A., McAuley, K.E., Fisher, L.M., Sanderson, M.R.
Deposit date:2009-11-21
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases
Plos One, 5, 2010
3LTN
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INHIBITOR-STABILIZED TOPOISOMERASE IV-DNA CLEAVAGE COMPLEX (S. PNEUMONIAE)
Descriptor:DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, 5'-D(*AP*CP*CP*AP*AP*GP*GP*T*CP*AP*TP*GP*AP*AP*T)-3', ...
Authors:Laponogov, I., Pan, X.-S., Veselkov, D.A., McAuley, K.E., Fisher, L.M., Sanderson, M.R.
Deposit date:2010-02-16
Release date:2010-05-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural Basis of Gate-DNA Breakage and Resealing by Type II Topoisomerases
Plos One, 5, 2010
1BDN
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CRYSTAL LATTICE PACKING IS IMPORTANT IN DETERMINING THE BEND OF A DNA DODECAMER CONTAINING AN ADENINE TRACT
Descriptor:DNA (5'-D(*CP*GP*CP*AP*AP*AP*AP*AP*TP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*AP*TP*TP*TP*TP*TP*GP*CP*G)-3'), MAGNESIUM ION
Authors:DiGabriele, A.D., Sanderson, M.R., Steitz, T.A.
Deposit date:1989-07-25
Release date:1991-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal lattice packing is important in determining the bend of a DNA dodecamer containing an adenine tract.
Proc.Natl.Acad.Sci.USA, 86, 1989
1DNM
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CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)
Descriptor:DNA (5'-D(*CP*GP*CP*AP*AP*GP*CP*TP*GP*GP*CP*G)-3')
Authors:Webster, G.D., Sanderson, M.R., Skelly, J.V., Neidle, S., Swann, P.F., Li, B.F., Tickle, I.J.
Deposit date:1990-06-22
Release date:1991-07-15
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).
Proc.Natl.Acad.Sci.USA, 87, 1990
1POS
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CRYSTAL STRUCTURE OF A NOVEL DISULFIDE-LINKED "TREFOIL" MOTIF FOUND IN A LARGE FAMILY OF PUTATIVE GROWTH FACTORS
Descriptor:PORCINE PANCREATIC SPASMOLYTIC POLYPEPTIDE
Authors:De, A., Brown, D., Gorman, M., Carr, M., Sanderson, M.R., Freemont, P.S.
Deposit date:1993-10-08
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors.
Proc.Natl.Acad.Sci.USA, 91, 1994
1QBG
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CRYSTAL STRUCTURE OF HUMAN DT-DIAPHORASE (NAD(P)H OXIDOREDUCTASE)
Descriptor:NAD(P)H DEHYDROGENASE [QUINONE] 1, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Skelly, J.V., Sanderson, M.R., Suter, D.A., Baumann, U., Gregory, D.S., Bennett, M., Hobbs, S.M., Neidle, S.
Deposit date:1999-04-20
Release date:2000-04-24
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human DT-diaphorase: a model for interaction with the cytotoxic prodrug 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB1954).
J.Med.Chem., 42, 1999
1QHI
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HERPES SIMPLEX VIRUS TYPE-I THYMIDINE KINASE COMPLEXED WITH A NOVEL NON-SUBSTRATE INHIBITOR, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE
Descriptor:PROTEIN (THYMIDINE KINASE), SULFATE ION, 9-(4-HYDROXYBUTYL)-N2-PHENYLGUANINE
Authors:Bennett, M.S., Wien, F., Champness, J.N., Batuwangala, T., Rutherford, T., Summers, W.C., Sun, H., Wright, G., Sanderson, M.R.
Deposit date:1999-05-12
Release date:1999-07-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.
FEBS Lett., 443, 1999
1QOJ
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CRYSTAL STRUCTURE OF E.COLI UVRB C-TERMINAL DOMAIN, AND A MODEL FOR UVRB-UVRC INTERACTION.
Descriptor:UVRB
Authors:Sohi, M., Alexandrovich, A., Moolenaar, G., Visse, R., Goosen, N., Vernede, X., Fontecilla-Camps, J., Champness, J., Sanderson, M.R.
Deposit date:1999-11-10
Release date:2000-11-10
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of E.Coli Uvrb C-Terminal Domain, and a Model for Uvrb-Uvrc Interaction
FEBS Lett., 465, 2000
295D
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CRYSTAL AND SOLUTION STRUCTURES OF THE OLIGONUCLEOTIDE D(ATGCGCAT)2: A COMBINED X-RAY AND NMR STUDY
Descriptor:DNA (5'-D(*AP*TP*GP*CP*GP*CP*AP*T)-3')
Authors:Clark, G.R., Brown, D.G., Sanderson, M.R., Chwalinski, T., Neidle, S., Veal, J.M., Jones, R.L., Wilson, W.D., Zon, G., Garman, E., Stuart, D.I.
Deposit date:1991-05-28
Release date:1996-12-04
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal and solution structures of the oligonucleotide d(ATGCGCAT)2: a combined X-ray and NMR study.
Nucleic Acids Res., 18, 1990
2DBE
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CRYSTAL STRUCTURE OF A BERENIL-DODECANUCLEOTIDE COMPLEX: THE ROLE OF WATER IN SEQUENCE-SPECIFIC LIGAND BINDING
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), BERENIL
Authors:Brown, D.G., Sanderson, M.R., Skelly, J.V., Jenkins, T.C., Brown, T., Garman, E., Stuart, D.I., Neidle, S.
Deposit date:1990-03-19
Release date:1991-07-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a berenil-dodecanucleotide complex: the role of water in sequence-specific ligand binding.
EMBO J., 9, 1990
2KI5
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HERPES SIMPLEX TYPE-1 THYMIDINE KINASE IN COMPLEX WITH THE DRUG ACICLOVIR AT 1.9A RESOLUTION
Descriptor:PROTEIN (THYMIDINE KINASE), SULFATE ION, 9-HYROXYETHOXYMETHYLGUANINE
Authors:Bennett, M.S., Wien, F., Champness, J.N., Batuwangala, T., Rutherford, T., Summers, W.C., Sun, H., Wright, G., Sanderson, M.R.
Deposit date:1999-02-12
Release date:1999-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure to 1.9 A resolution of a complex with herpes simplex virus type-1 thymidine kinase of a novel, non-substrate inhibitor: X-ray crystallographic comparison with binding of aciclovir.
FEBS Lett., 443, 1999
2MA9
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HIV-1 VIF SOCS-BOX AND ELONGIN BC SOLUTION STRUCTURE
Descriptor:Virion infectivity factor, Transcription elongation factor B polypeptide 2, Transcription elongation factor B polypeptide 1
Authors:Lu, Z., Bergeron, J.R., Atkinson, R.A., Schaller, T., Veselkov, D.A., Oregioni, A., Yang, Y., Matthews, S.J., Malim, M.H., Sanderson, M.R.
Deposit date:2013-07-01
Release date:2013-12-11
Last modified:2016-04-27
Method:SOLUTION NMR
Cite:Insight into the HIV-1 Vif SOCS-box-ElonginBC interaction.
OPEN BIOLOGY, 3, 2013
3FOE
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STRUCTURAL INSIGHT INTO THE QUINOLONE-DNA CLEAVAGE COMPLEX OF TYPE IIA TOPOISOMERASES
Descriptor:DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, DNA (5'-D(P*AP*CP*CP*AP*AP*GP*GP*TP*CP*AP*TP*GP*AP*AP*T)-3'), ...
Authors:Laponogov, I., Sohi, M.K., Veselkov, D.A., Pan, X.-S., Sawhney, R., Thompson, A.W., McAuley, K.E., Fisher, L.M., Sanderson, M.R.
Deposit date:2008-12-30
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.001 Å)
Cite:Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
Nat.Struct.Mol.Biol., 16, 2009
3FOF
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STRUCTURAL INSIGHT INTO THE QUINOLONE-DNA CLEAVAGE COMPLEX OF TYPE IIA TOPOISOMERASES
Descriptor:DNA topoisomerase 4 subunit A, DNA topoisomerase 4 subunit B, DNA (5'-D(P*AP*CP*CP*AP*AP*GP*GP*TP*CP*AP*TP*GP*AP*AP*T)-3'), ...
Authors:Laponogov, I., Sohi, M.K., Veselkov, D.A., Pan, X.-S., Sawhney, R., Thompson, A.W., McAuley, K.E., Fisher, L.M., Sanderson, M.R.
Deposit date:2008-12-30
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4 Å)
Cite:Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases
Nat.Struct.Mol.Biol., 16, 2009
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