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2P5W
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BU of 2p5w by Molmil
Crystal structures of high affinity human T-cell receptors bound to pMHC reveal native diagonal binding geometry
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, CALCIUM ION, ...
Authors:Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K.
Deposit date:2007-03-16
Release date:2007-09-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
2P5E
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BU of 2p5e by Molmil
Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC Reveal Native Diagonal Binding Geometry
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, Cancer/testis antigen 1B, ...
Authors:Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K.
Deposit date:2007-03-15
Release date:2007-09-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
2PYF
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BU of 2pyf by Molmil
Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC RevealNative Diagonal Binding Geometry Unbound TCR Clone 5-1
Descriptor: SULFATE ION, T-Cell Receptor, Alpha Chain, ...
Authors:Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K.
Deposit date:2007-05-16
Release date:2007-09-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
2PYE
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BU of 2pye by Molmil
Crystal Structures of High Affinity Human T-Cell Receptors Bound to pMHC RevealNative Diagonal Binding Geometry TCR Clone C5C1 Complexed with MHC
Descriptor: 2-(2-(2-(2-(2-(2-ETHOXYETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHOXY)ETHANOL, Beta-2-microglobulin, Cancer/testis antigen 1B, ...
Authors:Sami, M, Rizkallah, P.J, Dunn, S, Li, Y, Moysey, R, Vuidepot, A, Baston, E, Todorov, P, Molloy, P, Gao, F, Boulter, J.M, Jakobsen, B.K.
Deposit date:2007-05-16
Release date:2007-09-25
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry
Protein Eng.Des.Sel., 20, 2007
5BS0
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BU of 5bs0 by Molmil
MAGE-A3 Reactive TCR in complex with Titin Epitope in HLA-A1
Descriptor: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ...
Authors:Raman, M.C.C, Rizkallah, P.J, Simmons, R, Donellan, Z, Dukes, J, Bossi, G, LeProvost, G, Mahon, T, Hickman, E, Lomax, M, Oates, J, Hassan, N, Vuidepot, A, Sami, M, Cole, D.K, Jakobsen, B.K.
Deposit date:2015-06-01
Release date:2016-03-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Sci Rep, 6, 2016
5BRZ
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BU of 5brz by Molmil
MAGE-A3 reactive TCR in complex with MAGE-A3 in HLA-A1
Descriptor: Beta-2-microglobulin, GLU-VAL-ASP-PRO-ILE-GLY-HIS-LEU-TYR, HLA class I histocompatibility antigen, ...
Authors:Raman, M.C.C, Rizkallah, P.J, Simmons, R, Donnellan, Z, Dukes, J, Bossi, G, LeProvost, G, Mahon, T, Hickman, E, LomaX, M, Oates, J, Hassan, N, Vuidepot, A, Sami, M, Cole, D.K, Jakobsen, B.K.
Deposit date:2015-06-01
Release date:2016-03-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Sci Rep, 6, 2016
6R2L
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BU of 6r2l by Molmil
NYBR1-A2-SLSKILDTV
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J, Cole, D.K, Sami, M.
Deposit date:2019-03-18
Release date:2020-02-26
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:NYBR1-A2-SLSKILDTV
To Be Published
2F54
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BU of 2f54 by Molmil
Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity
Descriptor: Beta-2-microglobulin, Cancer/testis antigen 1B, HLA class I histocompatibility antigen, ...
Authors:Rizkallah, P.J, Jakobsen, B.K, Dunn, S.M, Sami, M.
Deposit date:2005-11-25
Release date:2006-04-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein Sci., 15, 2006
2F53
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BU of 2f53 by Molmil
Directed Evolution of Human T-cell Receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without apparent cross-reactivity
Descriptor: Beta-2-microglobulin, Cancer/testis antigen 1B, GLYCEROL, ...
Authors:Rizkallah, P.J, Jakobsen, B.K, Dunn, S.M, Sami, M.
Deposit date:2005-11-25
Release date:2006-04-25
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Directed evolution of human T cell receptor CDR2 residues by phage display dramatically enhances affinity for cognate peptide-MHC without increasing apparent cross-reactivity.
Protein Sci., 15, 2006
2BNU
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BU of 2bnu by Molmil
Structural and kinetic basis for heightened immunogenicity of T cell vaccines
Descriptor: T-CELL RECEPTOR ALPHA CHAIN C REGION, T-CELL RECEPTOR BETA CHAIN C REGION
Authors:Chen, J.-L, Stewart-Jones, G, Bossi, G, Lissin, N.M, Wooldridge, L, Choi, E.M.L, Held, G, Dunbar, P.R, Esnouf, R.M, Sami, M, Boultier, J.M, Rizkallah, P.J, Renner, C, Sewell, A, Van Der Merwe, P.A, Jackobsen, B.K, Griffiths, G, Jones, E.Y, Cerundolo, V.
Deposit date:2005-04-04
Release date:2005-05-24
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines.
J.Exp.Med., 201, 2005
2BJS
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BU of 2bjs by Molmil
Isopenicillin N synthase C-terminal truncation mutant
Descriptor: FE (III) ION, ISOPENICILLIN N SYNTHETASE, L-D-(A-AMINOADIPOYL)-L-CYSTEINYL-D-VALINE, ...
Authors:McNeill, L.A, Sami, M, Clifton, I.J, Burzlaff, N.I.
Deposit date:2005-02-07
Release date:2006-03-09
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Terminally Truncated Isopenicillin N Synthase Generates a Dithioester Product: Evidence for a Thioaldehyde Intermediate during Catalysis and a New Mode of Reaction for Non-Heme Iron Oxidases.
Chemistry, 23, 2017
2BNR
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BU of 2bnr by Molmil
Structural and kinetic basis for heightened immunogenicity of T cell vaccines
Descriptor: BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, SYNTHETIC PEPTIDE, ...
Authors:Chen, J.-L, Stewart-Jones, G, Bossi, G, Lissin, N.M, Wooldridge, L, Choi, E.M.L, Held, G, Dunbar, P.R, Esnouf, R.M, Sami, M, Boultier, J.M, Rizkallah, P.J, Renner, C, Sewell, A, van der Merwe, P.A, Jackobsen, B.K, Griffiths, G, Jones, E.Y, Cerundolo, V.
Deposit date:2005-03-31
Release date:2005-05-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
2BNQ
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BU of 2bnq by Molmil
Structural and kinetic basis for heightened immunogenicity of T cell vaccines
Descriptor: BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, SYNTHETIC PEPTIDE, ...
Authors:Chen, J.-L, Stewart-Jones, G, Bossi, G, Lissin, N.M, Wooldridge, L, Choi, E.M.L, Held, G, Dunbar, P.R, Esnouf, R.M, Sami, M, Boultier, J.M, Rizkallah, P.J, Renner, C, Sewell, A, van der Merwe, P.A, Jackobsen, B.K, Griffiths, G, Jones, E.Y, Cerundolo, V.
Deposit date:2005-03-31
Release date:2005-05-23
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and Kinetic Basis for Heightened Immunogenicity of T Cell Vaccines
J.Exp.Med., 201, 2005
6RSY
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BU of 6rsy by Molmil
The complex between TCR a7b2 and human Class I MHC HLA-A0201-WT1 with the bound RMFPNAPYL peptide.
Descriptor: 1,2-ETHANEDIOL, ARG-MET-PHE-PRO-ASN-ALA-PRO-TYR-LEU, Beta-2-microglobulin, ...
Authors:Srikannathasan, V, Robinson, R.A.
Deposit date:2019-05-22
Release date:2020-04-15
Last modified:2020-05-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Specificity of bispecific T cell receptors and antibodies targeting peptide-HLA.
J.Clin.Invest., 130, 2020
6EQB
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BU of 6eqb by Molmil
HLA class I histocompatibility antigen
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL, ...
Authors:Rizkallah, P.J, Cole, D.K.
Deposit date:2017-10-12
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:TCR-induced alteration of primary MHC peptide anchor residue.
Eur.J.Immunol., 49, 2019
6EQA
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BU of 6eqa by Molmil
HLA class I histocompatibility antigen
Descriptor: ALA-ALA-GLY-ILE-GLY-ILE-LEU-THR-VAL, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
Authors:Rizkallah, P.J, Cole, D.K.
Deposit date:2017-10-12
Release date:2018-10-10
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:TCR-induced alteration of primary MHC peptide anchor residue.
Eur.J.Immunol., 49, 2019
4MNQ
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BU of 4mnq by Molmil
TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, GLYCEROL, ...
Authors:Rizkallah, P.J, Cole, D.K, Sewell, A.K, Jakobsen, B.K.
Deposit date:2013-09-11
Release date:2013-11-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (2.742 Å)
Cite:T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions.
J.Biol.Chem., 289, 2014
2HP4
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BU of 2hp4 by Molmil
Computational design and crystal structure of an enhanced affinity mutant human CD8-alpha-alpha co-receptor
Descriptor: GLYCEROL, SULFATE ION, T-cell surface glycoprotein CD8 alpha chain
Authors:Rizkallah, P.J, Cole, D.K, Jakobsen, B.K, Boulter, J.M, Glick, M, Gao, G.F.
Deposit date:2006-07-17
Release date:2007-02-06
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Computational design and crystal structure of an enhanced affinity mutant human CD8 alphaalpha coreceptor
Proteins, 67, 2007
4JFH
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BU of 4jfh by Molmil
High Affinity alpha24-beta17 T Cell Receptor for A2 HLA-Melanoma peptide complex
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, SULFATE ION, ...
Authors:Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFP
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BU of 4jfp by Molmil
A2 HLA complex with G4A heteroclitic variant of Melanoma peptide
Descriptor: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, ...
Authors:Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFO
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BU of 4jfo by Molmil
A2 HLA complex with E1A heteroclitic variant of Melanoma peptide
Descriptor: Beta-2-microglobulin, E1A heteroclitic Melanoma peptide, GLYCEROL, ...
Authors:Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K, Baker, B.M.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFD
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BU of 4jfd by Molmil
Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR
Descriptor: Beta-2-microglobulin, HLA class I histocompatibility antigen, A-2 alpha chain, ...
Authors:Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFF
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BU of 4jff by Molmil
Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Beta-2-microglobulin, HLA class I histocompatibility antigen, ...
Authors:Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFQ
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A2 HLA complex with L8A heteroclitic variant of Melanoma peptide
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-2-microglobulin, GLYCEROL, ...
Authors:Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K, Baker, B.M.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013
4JFE
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BU of 4jfe by Molmil
Preservation of peptide specificity during TCR-MHC contact dominated affinity enhancement of a melanoma-specific TCR
Descriptor: Beta-2-microglobulin, GLYCEROL, HLA class I histocompatibility antigen, ...
Authors:Rizkallah, P.J, Cole, D.K, Madura, F, Sewell, A.K.
Deposit date:2013-02-28
Release date:2013-05-29
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:T-cell receptor specificity maintained by altered thermodynamics.
J.Biol.Chem., 288, 2013

 

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