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2ACF
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NMR STRUCTURE OF SARS-COV NON-STRUCTURAL PROTEIN NSP3A (SARS1) FROM SARS CORONAVIRUS
Descriptor:Replicase polyprotein 1ab, GLYCEROL
Authors:Saikatendu, K.S., Joseph, J.S., Subramanian, V., Neuman, B.W., Buchmeier, M.J., Stevens, R.C., Kuhn, P., Joint Center for Structural Genomics (JCSG)
Deposit date:2005-07-18
Release date:2006-02-14
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1''-phosphate dephosphorylation by a conserved domain of nsP3.
Structure, 13, 2005
5V7T
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CRYSTAL STRUCTURE OF PARP14 BOUND TO N-{4-[4-(DIPHENYLMETHOXY)PIPERIDIN-1-YL]BUTYL}[1,2,4]TRIAZOLO[4,3-B]PYRIDAZIN-6-AMINE INHIBITOR
Descriptor:Poly [ADP-ribose] polymerase 14, N-{4-[4-(diphenylmethoxy)piperidin-1-yl]butyl}[1,2,4]triazolo[4,3-b]pyridazin-6-amine
Authors:saikatendu, k.s., Hirozane, M.
Deposit date:2017-03-20
Release date:2017-05-03
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.
Biochem. Biophys. Res. Commun., 486, 2017
5V7W
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CRYSTAL STRUCTURE OF HUMAN PARP14 BOUND TO 2-{[(1-METHYLPIPERIDIN-4-YL)METHYL]AMINO}-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE INHIBITOR
Descriptor:Poly [ADP-ribose] polymerase 14, 2-{[(1-methylpiperidin-4-yl)methyl]amino}-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidin-4(3H)-one
Authors:saikatendu, k.s., Hirozane, M.
Deposit date:2017-03-20
Release date:2017-05-10
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Identification of PARP14 inhibitors using novel methods for detecting auto-ribosylation.
Biochem. Biophys. Res. Commun., 486, 2017
6C3E
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CRYSTAL STRUCTURE OF RIP1 KINASE BOUND TO INHIBITOR
Descriptor:Receptor-interacting serine/threonine-protein kinase 1, 2-benzyl-5-nitro-1H-benzimidazole
Authors:Saikatendu, K.S., Yoshikawa, M.
Deposit date:2018-01-09
Release date:2018-03-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.
J. Med. Chem., 61, 2018
6C4D
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STRUCTURE BASED DESIGN OF RIP1 KINASE INHIBITORS
Descriptor:Receptor-interacting serine/threonine-protein kinase 1, (3S)-3-(2-benzyl-3-chloro-7-oxo-2,4,5,7-tetrahydro-6H-pyrazolo[3,4-c]pyridin-6-yl)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepine-8-carbonitrile
Authors:Saikatendu, K.S., Yoshikawa, M.
Deposit date:2018-01-11
Release date:2018-03-21
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, Orally Available, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships.
J. Med. Chem., 61, 2018
2FYG
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CRYSTAL STRUCTURE OF NSP10 FROM SARS CORONAVIRUS
Descriptor:Replicase polyprotein 1ab, ZINC ION, GLYCEROL
Authors:Joseph, J.S., Saikatendu, K.S., Subramanian, V., Neuman, B.W., Brooun, A., Griffith, M., Moy, K., Yadav, M.K., Velasquez, J., Buchmeier, M.J., Stevens, R.C., Kuhn, P.
Deposit date:2006-02-07
Release date:2006-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of nonstructural protein 10 from the severe acute respiratory syndrome coronavirus reveals a novel fold with two zinc-binding motifs.
J.Virol., 80, 2006
2GRI
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NMR STRUCTURE OF THE SARS-COV NON-STRUCTURAL PROTEIN NSP3A
Descriptor:NSP3
Authors:Serrano, P., Almeida, M.S., Johnson, M.A., Herrmann, T., Saikatendu, K.S., Joseph, J., Subramanian, V., Neuman, B.W., Buchmeier, M.J., Stevens, R.C., Kuhn, P., Wuthrich, K., Joint Center for Structural Genomics (JCSG)
Deposit date:2006-04-24
Release date:2006-12-19
Last modified:2018-01-31
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus.
J.Virol., 81, 2007
2W1V
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CRYSTAL STRUCTURE OF MOUSE NITRILASE-2 AT 1.4A RESOLUTION
Descriptor:NITRILASE HOMOLOG 2
Authors:Barglow, K.T., Saikatendu, K.S., Stevens, R.C., Cravatt, B.F.
Deposit date:2008-10-21
Release date:2008-12-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Functional Proteomic and Structural Insights Into Molecular Recognition in the Nitrilase Family Enzymes.
Biochemistry, 47, 2008
5U4X
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COACTIVATOR-ASSOCIATED ARGININE METHYLTRANSFERASE 1 WITH TP-064
Descriptor:Histone-arginine methyltransferase CARM1, S-ADENOSYL-L-HOMOCYSTEINE, N-methyl-N-[(2-{1-[2-(methylamino)ethyl]piperidin-4-yl}pyridin-4-yl)methyl]-3-phenoxybenzamide, ...
Authors:DONG, A., ZENG, H., Saikatendu, K.S., STONE, H., WALKER, J.R., Seitova, A., Hutchinson, A., Bountra, C., Arrowsmith, C.H., Edwards, A.M., BROWN, P.J., WU, H., Structural Genomics Consortium (SGC)
Deposit date:2016-12-06
Release date:2016-12-21
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:TP-064, a potent and selective small molecule inhibitor of PRMT4 for multiple myeloma.
Oncotarget, 9, 2018
2OFZ
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ULTRAHIGH RESOLUTION CRYSTAL STRUCTURE OF RNA BINDING DOMAIN OF SARS NUCLEOPCAPSID (N PROTEIN) AT 1.1 ANGSTROM RESOLUTION IN MONOCLINIC FORM.
Descriptor:Nucleocapsid protein, 1,2-ETHANEDIOL
Authors:Saikatendu, K., Joseph, J., Subramanian, V., Neuman, B., Buchmeier, M., Stevens, R.C., Kuhn, P.
Deposit date:2007-01-04
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.17 Å)
Cite:Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein.
J.Virol., 81, 2007
2OG3
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STRUCTURE OF THE RNA BINDING DOMAIN OF N PROTEIN FROM SARS CORONAVIRUS IN CUBIC CRYSTAL FORM
Descriptor:Nucleocapsid protein
Authors:Saikatendu, K., Joseph, J., Subramanian, V., Neuman, B., Buchmeier, M., Stevens, R.C., Kuhn, P.
Deposit date:2007-01-05
Release date:2007-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Ribonucleocapsid formation of severe acute respiratory syndrome coronavirus through molecular action of the N-terminal domain of N protein.
J.Virol., 81, 2007
2IDY
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NMR STRUCTURE OF THE SARS-COV NON-STRUCTURAL PROTEIN NSP3A
Descriptor:NSP3
Authors:Serrano, P., Almeida, M.S., Johnson, M.A., Horst, R., Herrmann, T., Joseph, J., Saikatendu, K., Subramanian, V., Stevens, R.C., Kuhn, P., Wuthrich, K., Joint Center for Structural Genomics (JCSG)
Deposit date:2006-09-15
Release date:2006-12-05
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance structure of the N-terminal domain of nonstructural protein 3 from the severe acute respiratory syndrome coronavirus.
J.Virol., 81, 2007
2OZK
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STRUCTURE OF AN N-TERMINAL TRUNCATED FORM OF NENDOU (NSP15) FROM SARS-CORONAVIRUS
Descriptor:Uridylate-specific endoribonuclease
Authors:Saikatendu, K., Joseph, J., Subramanian, V., Neuman, B., Buchmeier, M., Stevens, R.C., Kuhn, P.
Deposit date:2007-02-26
Release date:2007-05-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a monomeric form of severe acute respiratory syndrome coronavirus endonuclease nsp15 suggests a role for hexamerization as an allosteric switch.
J.Virol., 81, 2007
2FE8
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SARS CORONAVIRUS PAPAIN-LIKE PROTEASE: STRUCTURE OF A VIRAL DEUBIQUITINATING ENZYME
Descriptor:Replicase polyprotein 1ab, ZINC ION, BROMIDE ION, ...
Authors:Ratia, K., Santarsiero, B.D., Mesecar, A.D.
Deposit date:2005-12-15
Release date:2006-03-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Severe acute respiratory syndrome coronavirus papain-like protease: Structure of a viral deubiquitinating enzyme
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FEA
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CRYSTAL STRUCTURE OF MTNX PHOSPHATASE FROM BACILLUS SUBTILIS AT 2.00 A RESOLUTION
Descriptor:2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase, MAGNESIUM ION, ZINC ION, ...
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2005-12-15
Release date:2005-12-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 A resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate.
Proteins, 69, 2007