Author results

4L9X
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TRIAZINE HYDROLASE FROM ARTHOBACTER AURESCENS MODIFIED FOR MAXIMUM EXPRESSION IN E.COLI
Descriptor:Triazine hydrolase, ACETATE ION
Authors:Jackson, C.J., Coppin, C.W., Alexandrov, A., Wilding, M., Liu, J.-W., Ubels, J., Paks, M., Carr, P.D., Newman, J., Russell, R.J., Field, M., Weik, M., Oakeshott, J.G., Scott, C.
Deposit date:2013-06-18
Release date:2014-05-21
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Apoenzyme stabilization results in 300-fold increased soluble production of the Zn2+-dependent dechlorinase TrzN.
Appl.Environ.Microbiol., 2014
4LH8
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TRIAZINE HYDROLASE FROM ARTHOBACTER AURESCENS MODIFIED FOR MAXIMUM EXPRESSION IN E.COLI
Descriptor:Triazine hydrolase, ZINC ION
Authors:Jackson, C.J., Coppin, C.W., Alexandrov, A., Wilding, M., Liu, J.-W., Ubels, J., Paks, M., Carr, P.D., Newman, J., Russell, R.J., Field, M., Weik, M., Oakeshott, J.G., Scott, C.
Deposit date:2013-07-01
Release date:2014-05-21
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Apoenzyme stabilization results in 300-fold increased soluble production of the Zn2+-dependent dechlorinase TrzN.
Appl.Environ.Microbiol., 2014
4P20
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CRYSTAL STRUCTURES OF THE BACTERIAL RIBOSOMAL DECODING SITE COMPLEXED WITH AMIKACIN
Descriptor:5'-R(*UP*UP*GP*CP*GP*UP*CP*AP*CP*AP*CP*CP*GP*GP*UP*GP*AP*AP*GP*UP*CP*GP*C)-3', (2S)-N-[(1R,2S,3S,4R,5S)-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-tris(oxidanyl)oxan-2-yl]oxy-5-azanyl-2-[(2S,3R,4S,5S,6R)-4-azanyl-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]oxy-3-oxidanyl-cyclohexyl]-4-azanyl-2-oxidanyl-butanamide
Authors:Kondo, J., Francois, B., Russell, R.J.M., Murray, J.B., Westhof, E.
Deposit date:2014-02-28
Release date:2014-05-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group.
Biochimie, 88, 2006
4FNM
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THE ALPHA-ESTERASE-7 CARBOXYLESTERASE, E3, FROM THE BLOWFLY LUCILIA CUPRINA
Descriptor:E3 alpha-esterase-7 carboxylesterase, DIETHYL HYDROGEN PHOSPHATE
Authors:Jackson, C.J., Liu, J.-W., Carr, P.D., Younis, F., Pandey, G., Coppin, C., Meirelles, T., Ollis, D.L., Tawfik, D.S., Weik, M., Oakeshott, J.G.
Deposit date:2012-06-20
Release date:2013-12-04
Method:X-RAY DIFFRACTION (1.804 Å)
Cite:Structure and function of an insect alpha-carboxylesterase ( alpha Esterase7) associated with insecticide resistance.
Proc.Natl.Acad.Sci.USA, 110, 2013
4KS1
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INFLUENZA NEURAMINIDASE IN COMPLEX WITH ANTIVIRAL COMPOUND (3S,4R,5R)-4-(ACETYLAMINO)-3-AMINO-5-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID
Descriptor:Neuraminidase, CALCIUM ION, (3S,4R,5R)-4-(acetylamino)-3-amino-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, ...
Authors:Kerry, P.S., Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
4KS3
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INFLUENZA NEURAMINIDASE IN COMPLEX WITH ANTIVIRAL COMPOUND (3S,4R,5R)-4-(ACETYLAMINO)-3-[4-(3-HYDROXYPROPYL)-1H-1,2,3-TRIAZOL-1-YL]-5-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID
Descriptor:Neuraminidase, (3S,4R,5R)-4-(acetylamino)-3-[4-(3-hydroxypropyl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION
Authors:Kerry, P.S., Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
4KS4
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INFLUENZA NEURAMINIDASE IN COMPLEX WITH ANTIVIRAL COMPOUND (3S,4R,5R)-4-(ACETYLAMINO)-3-{4-[(1R)-1-HYDROXYPROPYL]-1H-1,2,3-TRIAZOL-1-YL}-5-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID
Descriptor:Neuraminidase, (3S,4R,5R)-4-(acetylamino)-3-{4-[(1R)-1-hydroxypropyl]-1H-1,2,3-triazol-1-yl}-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, CALCIUM ION
Authors:Kerry, P.S., Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.495 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
4KS5
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INFLUENZA NEURAMINIDASE IN COMPLEX WITH ANTIVIRAL COMPOUND (3S,4R,5R)-4-(ACETYLAMINO)-3-[4-(2-HYDROXYPROPAN-2-YL)-1H-1,2,3-TRIAZOL-1-YL]-5-(PENTAN-3-YLOXY)CYCLOHEX-1-ENE-1-CARBOXYLIC ACID
Descriptor:Neuraminidase, CALCIUM ION, (3S,4R,5R)-4-(acetylamino)-3-[4-(2-hydroxypropan-2-yl)-1H-1,2,3-triazol-1-yl]-5-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid
Authors:Kerry, P.S., Russell, R.J.M.
Deposit date:2013-05-17
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.699 Å)
Cite:Structural basis for a class of nanomolar influenza A neuraminidase inhibitors.
Sci Rep, 3, 2013
4FNG
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THE ALPHA-ESTERASE-7 CARBOXYLESTERASE, E3, FROM THE BLOWFLY LUCILIA CUPRINA
Descriptor:E3 alpha-esterase-7 caboxylesterase
Authors:Jackson, C.J., Liu, J.-W., Carr, P.D., Younis, F., Pandey, G., Coppin, C., Meirelles, T., Ollis, D.L., Tawfik, D.S., Weik, M., Oakeshott, J.G.
Deposit date:2012-06-19
Release date:2013-06-19
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure and function of an insect alpha-carboxylesterase ( alpha Esterase7) associated with insecticide resistance.
Proc.Natl.Acad.Sci.USA, 110, 2013
4D8S
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INFLUENZA NA IN COMPLEX WITH ANTIVIRAL COMPOUND
Descriptor:Neuraminidase, CALCIUM ION, pentan-3-yl 2-(acetylamino)-2,4-dideoxy-alpha-L-threo-hex-4-enopyranosiduronic acid
Authors:Kerry, P.S., Russell, R.J.M.R.
Deposit date:2012-01-11
Release date:2013-02-13
Method:X-RAY DIFFRACTION (2.398 Å)
Cite:Exploring the interactions of unsaturated glucuronides with influenza virus sialidase.
J.Med.Chem., 55, 2012
4GB1
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SYNTHESIS AND EVALUATION OF NOVEL 3-C-ALKYLATED-NEU5AC2EN DERIVATIVES AS PROBES OF INFLUENZA VIRUS SIALIDASE 150-LOOP FLEXIBILITY
Descriptor:Neuraminidase, 5-(acetylamino)-2,6-anhydro-3,5-dideoxy-3-[(2E)-3-phenylprop-2-en-1-yl]-D-glycero-L-altro-non-2-enonic acid, CALCIUM ION
Authors:Kerry, P.S., Rudrawar, S., Rameix-Welti, M.-A., Maggioni, A., Dyason, J.C., Rose, F.J., van der Werf, S., Thomson, R.J., Naffakh, N., Russell, R.J.M., von Itzstein, M.
Deposit date:2012-07-26
Release date:2012-09-26
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Synthesis and evaluation of novel 3-C-alkylated-Neu5Ac2en derivatives as probes of influenza virus sialidase 150-loop flexibility.
Org.Biomol.Chem., 10, 2012
3RVC
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EFFECTOR DOMAIN OF NS1 FROM INFLUENZA A/PR/8/34 CONTAINING A W187A MUTATION
Descriptor:Non-structural protein 1
Authors:Kerry, P.S., Long, E., Taylor, M.A., Russell, R.J.M.
Deposit date:2011-05-06
Release date:2011-08-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Conservation of a crystallographic interface suggests a role for beta-sheet augmentation in influenza virus NS1 multifunctionality.
Acta Crystallogr.,Sect.F, 67, 2011
3O9Q
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EFFECTOR DOMAIN OF NS1 FROM A/PR/8/34 CONTAINING A W187A MUTATION
Descriptor:Nonstructural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9R
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EFFECTOR DOMAIN OF NS1 FROM INFLUENZA A/PR/8/34 CONTAINING A W187A MUTATION
Descriptor:Nonstructural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9S
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EFFECTOR DOMAIN OF INFLUENZA A/PR/8/34 NS1
Descriptor:Nonstructural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9T
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EFFECTOR DOMAIN FROM INFLUENZA A/PR/8/34 NS1
Descriptor:Nonstructural protein 1, HEXAETHYLENE GLYCOL
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9U
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EFFECTOR DOMAIN OF INFLUENZA A/PR/8/34 NS1
Descriptor:Nonstructural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-04
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3OA9
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EFFECTOR DOMAIN OF INFLUENZA A/DUCK/ALBANY/76 NS1
Descriptor:Non-structural protein 1
Authors:Kerry, P.S., Lewis, A., Hale, B.G., Hass, C., Taylor, M.A., Randall, R.E., Russell, R.J.M.
Deposit date:2010-08-05
Release date:2011-05-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Transient Homotypic Interaction Model for the Influenza A Virus NS1 Protein Effector Domain.
Plos One, 6, 2011
3O9J
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INFLUENZA NA IN COMPLEX WITH COMPOUND 5
Descriptor:Neuraminidase, 5-(acetylamino)-2,6-anhydro-3,5-dideoxy-3-prop-2-en-1-yl-D-glycero-D-galacto-non-2-enonic acid, CALCIUM ION, ...
Authors:Russell, R.J., Kerry, P.S.
Deposit date:2010-08-04
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.0002 Å)
Cite:Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase.
Nat Commun, 1, 2010
3O9K
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INFLUENZA NA IN COMPLEX WITH COMPOUND 6
Descriptor:Neuraminidase, 5-(acetylamino)-2,6-anhydro-3,5-dideoxy-3-[(2E)-3-(4-methylphenyl)prop-2-en-1-yl]-D-glycero-D-galacto-non-2-enonic acid
Authors:Russell, R.J., Kerry, P.S.
Deposit date:2010-08-04
Release date:2010-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4945 Å)
Cite:Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase.
Nat Commun, 1, 2010
3H96
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MSMEG_3358 F420 REDUCTASE
Descriptor:F420-H2 Dependent Reductase A, 1,2-ETHANEDIOL
Authors:Jackson, C.J., French, N., Newman, J., Taylor, M.C., Russell, R.J., Oakeshott, J.G.
Deposit date:2009-04-30
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and characterization of two families of F420 H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation.
Mol.Microbiol., 78, 2010
3L4Q
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STRUCTURAL INSIGHTS INTO PHOSPHOINOSITIDE 3-KINASE ACTIVATION BY THE INFLUENZA A VIRUS NS1 PROTEIN
Descriptor:Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta, GLYCEROL
Authors:Hale, B.G., Kerry, P.S., Jackson, D., Precious, B.L., Gray, A., Killip, M.J., Randall, R.E., Russell, R.J.
Deposit date:2009-12-21
Release date:2010-02-02
Last modified:2014-02-12
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural insights into phosphoinositide 3-kinase activation by the influenza A virus NS1 protein
Proc.Natl.Acad.Sci.USA, 107, 2010
2WR0
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STRUCTURES OF INFLUENZA H2 HEMAGGLUTININS
Descriptor:HEMAGGLUTININ, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE, ...
Authors:Liu, J., Stevens, D., Haire, L., Coombs, P., Russell, R., Gamblin, S., Skehel, J.
Deposit date:2009-08-28
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:From the Cover: Structures of Receptor Complexes Formed by Hemagglutinins from the Asian Influenza Pandemic of 1957.
Proc.Natl.Acad.Sci.USA, 106, 2009
2WR1
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STRUCTURE OF INFLUENZA H2 HEMAGGLUTININ WITH HUMAN RECEPTOR
Descriptor:HEMAGGLUTININ, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Liu, J., Stevens, D.J., Haire, L.F., Walker, P.A., Coombs, P.J., Russell, R.J., Gamblin, S.J., Skehel, J.J.
Deposit date:2009-08-29
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:From the Cover: Structures of Receptor Complexes Formed by Hemagglutinins from the Asian Influenza Pandemic of 1957.
Proc.Natl.Acad.Sci.USA, 106, 2009
2WR2
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STRUCTURE OF INFLUENZA H2 AVIAN HEMAGGLUTININ WITH AVIAN RECEPTOR
Descriptor:HEMAGGLUTININ, N-ACETYL-D-GLUCOSAMINE, O-SIALIC ACID, ...
Authors:Liu, J., Stevens, D.J., Haire, L.F., Walker, P.A., Coombs, P.J., Russell, R.J., Gamblin, S.J., Skehel, J.J.
Deposit date:2009-08-29
Release date:2009-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:From the Cover: Structures of Receptor Complexes Formed by Hemagglutinins from the Asian Influenza Pandemic of 1957.
Proc.Natl.Acad.Sci.USA, 106, 2009