Author results

3R4S
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CELL ENTRY OF BOTULINUM NEUROTOXIN TYPE C IS DEPENDENT UPON INTERACTION WITH TWO GANGLIOSIDE MOLECULES
Descriptor:Botulinum neurotoxin type C1, 5-N-ACETYL-BETA-D-NEURAMINIC ACID, O-SIALIC ACID
Authors:Strotmeier, J., Gu, S., Jutzi, S., Mahrhold, S., Zhou, J., Pich, A., Bigalke, H., Rummel, A., Jin, R., Binz, T.
Deposit date:2011-03-17
Release date:2011-06-08
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
Mol.Microbiol., 81, 2011
3R4U
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CELL ENTRY OF BOTULINUM NEUROTOXIN TYPE C IS DEPENDENT UPON INTERACTION WITH TWO GANGLIOSIDE MOLECULES
Descriptor:Botulinum neurotoxin type C1
Authors:Strotmeier, J., Gu, S., Jutzi, S., Mahrhold, S., Zhou, J., Pich, A., Bigalke, H., Rummel, A., Jin, R., Binz, T.
Deposit date:2011-03-17
Release date:2011-06-08
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
Mol.Microbiol., 81, 2011
4QD2
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MOLECULAR BASIS FOR DISRUPTION OF E-CADHERIN ADHESION BY BOTULINUM NEUROTOXIN A COMPLEX
Descriptor:Hemagglutinin component HA33, Hemagglutinin component HA17, Hemagglutinin component HA70, ...
Authors:Lee, K., Zhong, X., Gu, S., Kruel, A., Dorner, M.B., Perry, K., Rummel, A., Dong, M., Jin, R.
Deposit date:2014-05-13
Release date:2014-06-25
Last modified:2014-07-02
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex.
Science, 344, 2014
5JLV
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RECEPTOR BINDING DOMAIN OF BOTULINUM NEUROTOXIN A IN COMPLEX WITH HUMAN GLYCOSYLATED SV2C
Descriptor:Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C, ACETATE ION, ...
Authors:Yao, G., Zhang, S., Mahrhold, S., Lam, K., Stern, D., Bagramyan, K., Perry, K., Kalkum, M., Rummel, A., Dong, M., Jin, R.
Deposit date:2016-04-27
Release date:2016-06-15
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.
Nat.Struct.Mol.Biol., 23, 2016
5JMC
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RECEPTOR BINDING DOMAIN OF BOTULINUM NEUROTOXIN A IN COMPLEX WITH RAT SV2C
Descriptor:Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C
Authors:Yao, G., Zhang, S., Mahrhold, S., Lam, K., Stern, D., Bagramyan, K., Perry, K., Kalkum, M., Rummel, A., Dong, M., Jin, R.
Deposit date:2016-04-28
Release date:2016-06-15
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A.
Nat.Struct.Mol.Biol., 23, 2016
2NM1
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STRUCTURE OF BONT/B IN COMPLEX WITH ITS PROTEIN RECEPTOR
Descriptor:Botulinum neurotoxin type B, Synaptotagmin-2
Authors:Jin, R., Rummel, A., Binz, T., Brunger, A.T.
Deposit date:2006-10-20
Release date:2006-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity.
Nature, 444, 2006
3V0A
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2.7 ANGSTROM CRYSTAL STRUCTURE OF BONT/AI IN COMPLEX WITH NTNHA
Descriptor:BoNT/A, NTNH, Llama antibody F12, ...
Authors:Gu, S., Rumpel, S., Zhou, J., Strotmeier, J., Bigalke, H., Perry, K., Shoemaker, C.B., Rummel, A., Jin, R.
Deposit date:2011-12-07
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.703 Å)
Cite:Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
3V0B
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3.9 ANGSTROM CRYSTAL STRUCTURE OF BONT/AI IN COMPLEX WITH NTNHA
Descriptor:BoNT/A, NTNH, ZINC ION, ...
Authors:Gu, S., Rumpel, S., Zhou, J., Strotmeier, J., Bigalke, H., Perry, K., Shoemaker, C.B., Rummel, A., Jin, R.
Deposit date:2011-12-07
Release date:2012-03-14
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
3V0C
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4.3 ANGSTROM CRYSTAL STRUCTURE OF AN INACTIVE BONT/A (E224Q/R363A/Y366F)
Descriptor:BoNT/A, ZINC ION
Authors:Gu, S., Rumpel, S., Zhou, J., Strotmeier, J., Bigalke, H., Perry, K., Shoemaker, C.B., Rummel, A., Jin, R.
Deposit date:2011-12-07
Release date:2012-03-14
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Botulinum neurotoxin is shielded by NTNHA in an interlocked complex.
Science, 335, 2012
4LO0
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APO HA17-HA33
Descriptor:HA-33, HA-17
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.055 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO1
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HA17-HA33-GAL
Descriptor:HA-33, HA-17, BETA-D-GALACTOSE
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.254 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO2
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HA17-HA33-LAC
Descriptor:HA-33, HA-17, BETA-D-GALACTOSE, ...
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.254 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO3
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HA17-HA33-LACNAC
Descriptor:HA-33, HA-17, BETA-D-GALACTOSE, ...
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.249 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO4
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APO HA-70
Descriptor:HA-70, CHLORIDE ION
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.871 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO5
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HA70-ALPHA2,3-SIALC
Descriptor:HA-70, O-SIALIC ACID, BETA-D-GALACTOSE, ...
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO6
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HA70-ALPHA2,6-SIALC
Descriptor:HA-70, O-SIALIC ACID, BETA-D-GALACTOSE, ...
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO7
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HA70(D3)-HA17-HA33
Descriptor:HA-70, HA-33, HA-17
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3.73 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4LO8
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HA70(D3)-HA17
Descriptor:HA-70, HA-17
Authors:Lee, K., Gu, S., Jin, L., Le, T.T., Cheng, L.W., Strotmeier, J., Kruel, A.M., Yao, G., Perry, K., Rummel, A., Jin, R.
Deposit date:2013-07-12
Release date:2013-10-30
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity.
Plos Pathog., 9, 2013
4OUJ
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CRYSTAL STRUCTURE OF HA33B-LAC
Descriptor:Hemagglutinin component HA33, ALPHA-LACTOSE
Authors:Lee, K., Lam, K.-H., Perry, K., Rummel, A., Jin, R.
Deposit date:2014-02-17
Release date:2014-06-04
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex.
Biochem.Biophys.Res.Commun., 446, 2014
3OBR
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CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE D BINDING DOMAIN
Descriptor:Botulinum neurotoxin type D, GLYCEROL
Authors:Zong, Y., Lee, K.K., Jin, R.
Deposit date:2010-08-09
Release date:2010-09-08
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
Biochem.J., 431, 2010
3OBT
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CRYSTAL STRUCTURE OF BOTULINUM NEUROTOXIN SEROTYPE D LIGAND BINDING DOMAIN IN COMPLEX WITH N-ACETYLNEURAMINIC ACID
Descriptor:Botulinum neurotoxin type D, 5-N-ACETYL-BETA-D-NEURAMINIC ACID, GLYCEROL
Authors:Lee, K.K., Zong, Y., Jin, R.
Deposit date:2010-08-09
Release date:2010-09-08
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
Biochem.J., 431, 2010
5WIX
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CRYSTAL STRUCTURE OF P47 OF CLOSTRIDIUM BOTULINUM E1
Descriptor:p-47 protein
Authors:Lam, K., Liu, S., Qi, R., Jin, R.
Deposit date:2017-07-20
Release date:2017-10-25
Last modified:2018-05-02
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein.
Toxicon, 147, 2018
5BP5
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CRYSTAL STRUCTURE OF HA17-HA33-IPT
Descriptor:HA-33, HA-17, ISOPROPYL-1-BETA-D-THIOGALACTOSIDE
Authors:Lee, K., Lam, K., Jin, R.
Deposit date:2015-05-27
Release date:2015-09-02
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.
Toxicon, 107, 2015
5BQU
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CRYSTAL STRUCTURE OF HA17-HA33-LACTULOSE
Descriptor:HA-33, HA-17, FRUCTOSE, ...
Authors:Lee, K., Lam, K., Jin, R.
Deposit date:2015-05-29
Release date:2015-10-14
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.
Toxicon, 107, 2015
5L21
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CRYSTAL STRUCTURE OF BONT/A RECEPTOR BINDING DOMAIN IN COMPLEX WITH VHH C2
Descriptor:Botulinum neurotoxin type A, VHH-C2
Authors:Yao, G., Jin, R.
Deposit date:2016-07-29
Release date:2017-08-09
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.
Sci Rep, 7, 2017
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