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1ASY
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BU of 1asy by Molmil
CLASS II AMINOACYL TRANSFER RNA SYNTHETASES: CRYSTAL STRUCTURE OF YEAST ASPARTYL-TRNA SYNTHETASE COMPLEXED WITH TRNA ASP
Descriptor: ASPARTYL-tRNA SYNTHETASE, T-RNA (75-MER)
Authors:Ruff, M, Cavarelli, J, Rees, B, Krishnaswamy, S, Thierry, J.C, Moras, D.
Deposit date:1995-01-19
Release date:1995-05-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp).
Science, 252, 1991
7BB9
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BU of 7bb9 by Molmil
Crystal structure of Lugdulysin E242Q Y315F mutant
Descriptor: CALCIUM ION, Lugdulysin E242Q Y315F, ZINC ION
Authors:Ruff, M, Prevost, G, Prola, K, Levy, N.
Deposit date:2020-12-17
Release date:2022-07-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal structure of Lugdulysin E242Q Y315F mutant
To Be Published
7BB8
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BU of 7bb8 by Molmil
Crystal structure of Lugdulysin, a Staphylococcus lugdunensis M30 zinc metallopeptidase
Descriptor: ACETATE ION, CACODYLATE ION, CALCIUM ION, ...
Authors:Ruff, M, Prevost, G, Prola, K, Levy, N.
Deposit date:2020-12-17
Release date:2022-07-13
Method:X-RAY DIFFRACTION (1.506 Å)
Cite:Crystal structure of Staphylococcus lugdunensis protease, Lugdulysin
To Be Published
6G9P
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BU of 6g9p by Molmil
Structural basis for the inhibition of E. coli PBP2
Descriptor: Peptidoglycan D,D-transpeptidase MrdA
Authors:Ruff, M, Levy, N.
Deposit date:2018-04-11
Release date:2019-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design.
J.Med.Chem., 62, 2019
6G9S
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BU of 6g9s by Molmil
Structural basis for the inhibition of E. coli PBP2
Descriptor: (3~{R},6~{S})-6-(aminomethyl)-4-(1,3-oxazol-5-yl)-3-(sulfooxyamino)-3,6-dihydro-2~{H}-pyridine-1-carboxylic acid, Peptidoglycan D,D-transpeptidase MrdA
Authors:Ruff, M, Levy, N.
Deposit date:2018-04-11
Release date:2019-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.001 Å)
Cite:Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design.
J.Med.Chem., 62, 2019
6G9F
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BU of 6g9f by Molmil
Structural basis for the inhibition of E. coli PBP2
Descriptor: (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Peptidoglycan D,D-transpeptidase MrdA
Authors:Ruff, M, Levy, N.
Deposit date:2018-04-10
Release date:2019-05-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for E. coli Penicillin Binding Protein (PBP) 2 Inhibition, a Platform for Drug Design.
J.Med.Chem., 62, 2019
1QKU
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BU of 1qku by Molmil
WILD TYPE ESTROGEN NUCLEAR RECEPTOR LIGAND BINDING DOMAIN COMPLEXED WITH ESTRADIOL
Descriptor: ESTRADIOL, ESTRADIOL RECEPTOR
Authors:Ruff, M, Gangloff, M, Eiler, S, Duclaud, S, Wurtz, J.M, Moras, D.
Deposit date:1999-08-05
Release date:2000-08-18
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of a mutant hERalpha ligand-binding domain reveals key structural features for the mechanism of partial agonism.
J. Biol. Chem., 276, 2001
1QKT
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BU of 1qkt by Molmil
MUTANT ESTROGEN NUCLEAR RECEPTOR LIGAND BINDING DOMAIN COMPLEXED WITH ESTRADIOL
Descriptor: ESTRADIOL, ESTRADIOL RECEPTOR
Authors:Ruff, M, Gangloff, M, Eiler, S, Duclaud, S, Wurtz, J.M, Moras, D.
Deposit date:1999-08-05
Release date:2000-08-18
Last modified:2022-11-02
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of a Mutant Heralpha Ligand- Binding Domain Reveals Key Structural Features for the Mechanism of Partial Agonism
J.Biol.Chem., 276, 2001
6T6I
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BU of 6t6i by Molmil
Crystal Structure of the C-terminal domain of the HIV-1 Integrase (subtype A2)
Descriptor: NICKEL (II) ION, Pol protein
Authors:Ruff, M, Negroni, M.
Deposit date:2019-10-18
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.203 Å)
Cite:NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases.
J.Virol., 94, 2020
6T6E
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BU of 6t6e by Molmil
Crystal Structure of the C-terminal domain of the HIV-1 Integrase (PNL4-3)
Descriptor: NICKEL (II) ION, Pol protein
Authors:Ruff, M, Negroni, M.
Deposit date:2019-10-18
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.302 Å)
Cite:NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases.
J.Virol., 94, 2020
6T6J
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BU of 6t6j by Molmil
Crystal Structure of the C-terminal domain of the HIV-1 Integrase (subtype A2, mutant N254K, K340Q)
Descriptor: NICKEL (II) ION, Pol protein
Authors:Ruff, M, Negroni, M.
Deposit date:2019-10-18
Release date:2020-07-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:NKNK: a New Essential Motif in the C-Terminal Domain of HIV-1 Group M Integrases.
J.Virol., 94, 2020
4LH5
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BU of 4lh5 by Molmil
Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration
Descriptor: (2S)-tert-butoxy[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]ethanoic acid, Integrase, MAGNESIUM ION
Authors:Ruff, M, Levy, N, Eiler, S.
Deposit date:2013-06-30
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
Retrovirology, 10, 2013
4LH4
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BU of 4lh4 by Molmil
Dual inhibition of HIV-1 replication by Integrase-LEDGF allosteric inhibitors is predominant at post-integration stage during virus production rather than at integration
Descriptor: Integrase, MAGNESIUM ION
Authors:Ruff, M, Levy, N, Eiler, S.
Deposit date:2013-06-30
Release date:2013-12-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Dual inhibition of HIV-1 replication by integrase-LEDGF allosteric inhibitors is predominant at the post-integration stage.
Retrovirology, 10, 2013
5OI8
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BU of 5oi8 by Molmil
Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
Descriptor: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-4-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, MAGNESIUM ION, Pol protein, ...
Authors:Ruff, M, Benarous, R.
Deposit date:2017-07-18
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
J. Biol. Chem., 293, 2018
5OI5
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BU of 5oi5 by Molmil
Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
Descriptor: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-2-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, MAGNESIUM ION
Authors:Ruff, M, Benarous, R.
Deposit date:2017-07-18
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
J. Biol. Chem., 293, 2018
5OI3
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BU of 5oi3 by Molmil
Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
Descriptor: Integrase, MAGNESIUM ION
Authors:Ruff, M, Benarous, R.
Deposit date:2017-07-18
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
J. Biol. Chem., 293, 2018
5OIA
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BU of 5oia by Molmil
Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
Descriptor: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-2-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, MAGNESIUM ION, Pol protein, ...
Authors:Ruff, M, Benarous, R.
Deposit date:2017-07-18
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
J. Biol. Chem., 293, 2018
5OI2
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BU of 5oi2 by Molmil
Dissociation of biochemical and antiretroviral activities of Integrase-LEDGF Allosteric Inhibitors revealed by resistance of A125 polymorphic HIV-1
Descriptor: (2~{S})-2-[4-(4,4-dimethylcyclohexen-1-yl)-2-methyl-5-pyridin-4-yl-thiophen-3-yl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, MAGNESIUM ION, ...
Authors:Ruff, M, Benarous, R.
Deposit date:2017-07-18
Release date:2018-03-07
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-function analyses unravel distinct effects of allosteric inhibitors of HIV-1 integrase on viral maturation and integration.
J. Biol. Chem., 293, 2018
8BV2
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BU of 8bv2 by Molmil
Biological and structural analysis of new potent Integrase-LEDGF allosteric HIV-1 inhibitors
Descriptor: (2S)-2-[3-cyclopropyl-2-(3,4-dihydro-2H-chromen-6-yl)-6-methyl-phenyl]-2-[(2-methylpropan-2-yl)oxy]ethanoic acid, Integrase, MAGNESIUM ION, ...
Authors:Ruff, M, Benarous, R.
Deposit date:2022-12-01
Release date:2023-06-07
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Biological and Structural Analyses of New Potent Allosteric Inhibitors of HIV-1 Integrase.
Antimicrob.Agents Chemother., 67, 2023
2LBD
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BU of 2lbd by Molmil
LIGAND-BINDING DOMAIN OF THE HUMAN RETINOIC ACID RECEPTOR GAMMA BOUND TO ALL-TRANS RETINOIC ACID
Descriptor: RETINOIC ACID, RETINOIC ACID RECEPTOR GAMMA
Authors:Renaud, J.-P, Rochel, N, Ruff, M, Moras, D, Structural Proteomics in Europe (SPINE)
Deposit date:1997-08-19
Release date:1997-11-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid.
Nature, 378, 1995
5HY8
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BU of 5hy8 by Molmil
Glycation restrains allosteric transition in hemoglobin: The molecular basis of oxidative stress under hyperglycemic conditions in diabetes
Descriptor: Hemoglobin subunit alpha, Hemoglobin subunit beta, OXYGEN MOLECULE, ...
Authors:Saraswathi, N.T, Pannu, N.S, Syakhovich, V.E, Saurabh, A, Bokut, S.B, Moras, D, Ruff, M.
Deposit date:2016-02-01
Release date:2017-02-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Glycation restrains allosteric transition in hemoglobin: The molecular basis of oxidative stress under hyperglycemic conditions in diabetes
To Be Published
1BH8
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BU of 1bh8 by Molmil
HTAFII18/HTAFII28 HETERODIMER CRYSTAL STRUCTURE
Descriptor: TAFII18, TAFII28
Authors:Birck, C, Poch, O, Romier, C, Ruff, M, Mengus, G, Lavigne, A.-C, Davidson, I, Moras, D.
Deposit date:1998-06-16
Release date:1999-06-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family.
Cell(Cambridge,Mass.), 94, 1998
1BH9
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BU of 1bh9 by Molmil
HTAFII18/HTAFII28 HETERODIMER CRYSTAL STRUCTURE WITH BOUND PCMBS
Descriptor: PARA-MERCURY-BENZENESULFONIC ACID, TAFII18, TAFII28
Authors:Birck, C, Poch, O, Romier, C, Ruff, M, Mengus, G, Lavigne, A.-C, Davidson, I, Moras, D.
Deposit date:1998-06-16
Release date:1999-06-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family.
Cell(Cambridge,Mass.), 94, 1998
3B75
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BU of 3b75 by Molmil
Crystal Structure of Glycated Human Haemoglobin
Descriptor: Hemoglobin subunit alpha, Hemoglobin subunit beta, OXYGEN MOLECULE, ...
Authors:Saraswathi, N.T, Syakhovich, V.E, Bokut, S.B, Moras, D, Ruff, M.
Deposit date:2007-10-30
Release date:2008-10-14
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The effect of hemoglobin glycosylation on diabete linked oxidative stress
To be Published
4DMA
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BU of 4dma by Molmil
Crystal structure of ERa LBD in complex with RU100132
Descriptor: 2'-bromo-6'-(furan-3-yl)-4'-(hydroxymethyl)biphenyl-4-ol, Estrogen receptor, Nuclear receptor coactivator 1
Authors:Osz, J, Brelivet, Y, Peluso-Iltis, C, Cura, V, Eiler, S, Ruff, M, Bourguet, W, Rochel, N, Moras, D.
Deposit date:2012-02-07
Release date:2012-03-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors.
Proc.Natl.Acad.Sci.USA, 109, 2012

 

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