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2AZE
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BU of 2aze by Molmil
Structure of the Rb C-terminal domain bound to an E2F1-DP1 heterodimer
Descriptor: Retinoblastoma-associated protein, Transcription factor Dp-1, Transcription factor E2F1
Authors:Rubin, S.M, Gall, A.L, Zheng, N, Pavletich, N.P.
Deposit date:2005-09-10
Release date:2006-01-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release.
Cell(Cambridge,Mass.), 123, 2005
1LLS
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BU of 1lls by Molmil
CRYSTAL STRUCTURE OF UNLIGANDED MALTOSE BINDING PROTEIN WITH XENON
Descriptor: Maltose-binding periplasmic protein, XENON
Authors:Rubin, S.M, Lee, S.-Y, Ruiz, E.J, Pines, A, Wemmer, D.E.
Deposit date:2002-04-30
Release date:2002-09-18
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:DETECTION AND CHARACTERIZATION OF XENON-BINDING SITES IN PROTEINS BY 129XE NMR SPECTROSCOPY
J.MOL.BIOL., 322, 2002
1PA4
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BU of 1pa4 by Molmil
Solution structure of a putative ribosome-binding factor from Mycoplasma pneumoniae (MPN156)
Descriptor: Probable ribosome-binding factor A
Authors:Rubin, S.M, Pelton, J.G, Yokota, H, Kim, R, Wemmer, D.E, Berkeley Structural Genomics Center (BSGC)
Deposit date:2003-05-13
Release date:2004-03-02
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of a putative ribosome binding protein from Mycoplasma pneumoniae and comparison to a distant homolog.
J.STRUCT.FUNCT.GENOM., 4, 2003
8CUR
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BU of 8cur by Molmil
Crystal structure of Cdk2 in complex with Cyclin A inhibitor 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid
Descriptor: 6-[(E)-2-(4-chlorophenyl)ethenyl]-2-{[(2R)-3-(4-hydroxyphenyl)-1-methoxy-1-oxopropan-2-yl]carbamoyl}quinoline-4-carboxylic acid, Cyclin-dependent kinase 2
Authors:Tripathi, S.M, Tambo, C.S, Kiss, G, Rubin, S.M.
Deposit date:2022-05-17
Release date:2023-04-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Biolayer Interferometry Assay for Cyclin-Dependent Kinase-Cyclin Association Reveals Diverse Effects of Cdk2 Inhibitors on Cyclin Binding Kinetics.
Acs Chem.Biol., 18, 2023
7N40
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BU of 7n40 by Molmil
Crystal structure of LIN9-RbAp48-LIN37, a MuvB subcomplex
Descriptor: Histone-binding protein RBBP4, Isoform 2 of Protein lin-9 homolog, Protein lin-37 homolog
Authors:Asthana, A, Ramanan, P, Tripathi, S.M, Rubin, S.M.
Deposit date:2021-06-02
Release date:2022-02-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The MuvB complex binds and stabilizes nucleosomes downstream of the transcription start site of cell-cycle dependent genes.
Nat Commun, 13, 2022
7SMF
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BU of 7smf by Molmil
p107 pocket domain complexed with mutated HDAC1-3X peptide
Descriptor: Histone deacetylase 1, Retinoblastoma-like protein 1, SULFATE ION
Authors:Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M.
Deposit date:2021-10-25
Release date:2022-06-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family.
Structure, 30, 2022
7SME
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BU of 7sme by Molmil
p107 pocket domain complexed with HDAC1 peptide
Descriptor: Histone deacetylase 1, Retinoblastoma-like protein 1, SULFATE ION
Authors:Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M.
Deposit date:2021-10-25
Release date:2022-06-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family.
Structure, 30, 2022
7SMC
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BU of 7smc by Molmil
p107 pocket domain complexed with ARID4A peptide
Descriptor: AT-rich interactive domain-containing protein 4A, Retinoblastoma-like protein 1, SULFATE ION
Authors:Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M.
Deposit date:2021-10-25
Release date:2022-06-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family.
Structure, 30, 2022
7SMD
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BU of 7smd by Molmil
p107 pocket domain complexed with EID1 peptide
Descriptor: EP300-interacting inhibitor of differentiation 1, Retinoblastoma-like protein 1, SULFATE ION
Authors:Putta, S, Fernandez, S.M, Tripathi, S.M, Muller, G.A, Rubin, S.M.
Deposit date:2021-10-25
Release date:2022-06-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural basis for tunable affinity and specificity of LxCxE-dependent protein interactions with the retinoblastoma protein family.
Structure, 30, 2022
6C48
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BU of 6c48 by Molmil
Crystal structure of B-Myb-LIN9-LIN52 complex
Descriptor: Myb-related protein B, Protein lin-52 homolog, Protein lin-9 homolog, ...
Authors:Guiley, K.Z, Tripathi, S.M, Rubin, S.M.
Deposit date:2018-01-11
Release date:2018-09-19
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural mechanism of Myb-MuvB assembly.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5FD3
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BU of 5fd3 by Molmil
Structure of Lin54 tesmin domain bound to DNA
Descriptor: DNA (5'-D(*CP*AP*GP*TP*TP*TP*CP*AP*AP*AP*CP*TP*C)-3'), DNA (5'-D(*GP*AP*GP*TP*TP*TP*GP*AP*AP*AP*CP*T)-3'), Protein lin-54 homolog, ...
Authors:Marceau, A.H, Felthousen, J.G, Goetsch, P.D, Lee, H, Tripathi, S.M, Strome, S, Litovchick, L, Rubin, S.M.
Deposit date:2015-12-15
Release date:2016-08-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural basis for LIN54 recognition of CHR elements in cell cycle-regulated promoters.
Nat Commun, 7, 2016
6P8F
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BU of 6p8f by Molmil
Crystal structure of CDK4 in complex with CyclinD1 and P27
Descriptor: Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1B, G1/S-specific cyclin-D1
Authors:Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M.
Deposit date:2019-06-07
Release date:2019-12-25
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.
Science, 366, 2019
6P8H
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BU of 6p8h by Molmil
Crystal structure of CDK4 in complex with CyclinD1 and P21
Descriptor: Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1, G1/S-specific cyclin-D1
Authors:Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M.
Deposit date:2019-06-07
Release date:2019-12-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.
Science, 366, 2019
6P8G
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BU of 6p8g by Molmil
Crystal structure of CDK4 in complex with CyclinD1 and P27
Descriptor: Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1B, G1/S-specific cyclin-D1
Authors:Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M.
Deposit date:2019-06-07
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.
Science, 366, 2019
6P8E
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BU of 6p8e by Molmil
Crystal structure of CDK4 in complex with CyclinD1 and P27
Descriptor: Cyclin-dependent kinase 4, Cyclin-dependent kinase inhibitor 1B, G1/S-specific cyclin-D1, ...
Authors:Guiley, K.Z, Stevenson, J.W, Lou, K, Barkovich, K.J, Bunch, K, Tripathi, S.M, Shokat, K.M, Rubin, S.M.
Deposit date:2019-06-07
Release date:2019-12-25
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:p27 allosterically activates cyclin-dependent kinase 4 and antagonizes palbociclib inhibition.
Science, 366, 2019
1ZDM
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BU of 1zdm by Molmil
Crystal Structure of Activated CheY Bound to Xe
Descriptor: Chemotaxis protein cheY, MANGANESE (II) ION, XENON
Authors:Lowery, T.J, Doucleff, M, Ruiz, E.J, Rubin, S.M, Pines, A, Wemmer, D.E.
Deposit date:2005-04-14
Release date:2005-04-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Distinguishing multiple chemotaxis Y protein conformations with laser-polarized 129Xe NMR.
Protein Sci., 14, 2005
6U1Q
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BU of 6u1q by Molmil
Crystal Structure of VpsO (VC0937) Kinase domain
Descriptor: O-PHOSPHOTYROSINE, VpsO
Authors:Tripathi, S.M, Schwechheimer, C, Herbert, K, Porcella, M.E, Brown, E.R, Yildiz, F.H, Rubin, S.M.
Deposit date:2019-08-16
Release date:2020-08-19
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae.
Plos Pathog., 16, 2020
6U1P
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BU of 6u1p by Molmil
Crystal structure of VpsU (VC0916) from Vibrio cholerae
Descriptor: GLYCEROL, Low molecular weight phosphotyrosine protein phosphatase
Authors:Tripathi, S.M, Schwechheimer, C, Herbert, K, Osorio, J, Yildiz, F.H, Rubin, S.M.
Deposit date:2019-08-16
Release date:2020-08-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:A tyrosine phosphoregulatory system controls exopolysaccharide biosynthesis and biofilm formation in Vibrio cholerae.
Plos Pathog., 16, 2020
6OSW
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BU of 6osw by Molmil
An order-to-disorder structural switch activates the FoxM1 transcription factor
Descriptor: Forkhead box M1
Authors:Marceau, A.H, Rubin, S.M, Nerli, S, McShane, A.C, Sgourakis, N.G.
Deposit date:2019-05-02
Release date:2019-05-29
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:An order-to-disorder structural switch activates the FoxM1 transcription factor.
Elife, 8, 2019
4LPA
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BU of 4lpa by Molmil
Crystal structure of a Cdc6 phosphopeptide in complex with Cks1
Descriptor: Cyclin-dependent kinases regulatory subunit
Authors:McGrath, D.A, Balog, E.R.M, Koivomagi, M, Lucena, R, Mai, M.V, Hirschi, A, Kellogg, D.R, Loog, M, Rubin, S.M.
Deposit date:2013-07-15
Release date:2013-11-06
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Cks confers specificity to phosphorylation-dependent CDK signaling pathways.
Nat.Struct.Mol.Biol., 20, 2013
4YOO
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BU of 4yoo by Molmil
p107 pocket domain in complex with LIN52 P29A peptide
Descriptor: LIN52 peptide, Retinoblastoma-like protein 1,Retinoblastoma-like protein 1, SULFATE ION
Authors:Guiley, K.Z, Liban, T.J, Felthousen, J.G, Ramanan, P, Tripathi, S, Litovchick, L, Rubin, S.M.
Deposit date:2015-03-12
Release date:2015-05-13
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural mechanisms of DREAM complex assembly and regulation.
Genes Dev., 29, 2015
4YOZ
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BU of 4yoz by Molmil
p107 pocket domain in complex with HPV E7 peptide
Descriptor: HPV E7 peptide, Retinoblastoma-like protein 1,Retinoblastoma-like protein 1, SULFATE ION
Authors:Liban, T.J, Guiley, K.Z, Felthousen, J.G, Ramanan, P, Litovchick, L, Rubin, S.M.
Deposit date:2015-03-12
Release date:2015-06-24
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.245 Å)
Cite:Structural mechanisms of DREAM complex assembly and regulation.
Genes Dev., 29, 2015
4YOS
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BU of 4yos by Molmil
p107 pocket domain complexed with LIN52 peptide
Descriptor: 1,2-ETHANEDIOL, Protein lin-52 homolog, Retinoblastoma-like protein 1,Retinoblastoma-like protein 1, ...
Authors:Guiley, K.Z, Liban, T.J, Felthousen, J.G, Ramanan, P, Tripathi, S, Litovchick, L, Rubin, S.M.
Deposit date:2015-03-12
Release date:2015-05-27
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural mechanisms of DREAM complex assembly and regulation.
Genes Dev., 29, 2015
5C9H
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BU of 5c9h by Molmil
Structural Basis of Template Boundary Definition in Tetrahymena Telomerase
Descriptor: MAGNESIUM ION, RNA (5'-R(P*AP*GP*AP*AP*CP*UP*GP*UP*CP*A)-3'), RNA (5'-R(P*UP*CP*AP*UP*UP*CP*AP*GP*UP*UP*CP*U)-3'), ...
Authors:Jansson, L.I, Akiyama, B.M, Ooms, A, Lu, C, Rubin, S.M, Stone, M.D.
Deposit date:2015-06-26
Release date:2015-10-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of template-boundary definition in Tetrahymena telomerase.
Nat.Struct.Mol.Biol., 22, 2015
5TUV
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BU of 5tuv by Molmil
Crystal structure of the E2F5-DP1-p107 ternary complex
Descriptor: Retinoblastoma-like protein 1, Transcription factor DP1, Transcription factor E2F5
Authors:Liban, T.J, Tripathi, S.M, Rubin, S.M.
Deposit date:2016-11-07
Release date:2017-05-03
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Conservation and divergence of C-terminal domain structure in the retinoblastoma protein family.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017

 

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