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3E8U
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CRYSTAL STRUCTURE AND THERMODYNAMIC ANALYSIS OF DIAGNOSTIC FAB 106.3 COMPLEXED WITH BNP 5-13 (C10A) REVEAL BASIS OF SELECTIVE MOLECULAR RECOGNITION
分子名称:Fab 106.3 heavy chain, Fab 106.3 light chain, BNP peptide epitope
著者Longenecker, K.L., Ruan, Q., Fry, E.H., Saldana, S.S., Brophy, S.E., Richardson, P.L., Tetin, S.Y.
登録日2008-08-20
公開日2009-07-07
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure and thermodynamic analysis of diagnostic mAb 106.3 complexed with BNP 5-13 (C10A).
Proteins, 76, 2009
4OCX
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FAB COMPLEX WITH METHOTREXATE
分子名称:Fab ADD056 Heavy Chain, Fab ADD056 Light Chain, N-(4-{[(2,4-DIAMINOPTERIDIN-1-IUM-6-YL)METHYL](METHYL)AMINO}BENZOYL)-L-GLUTAMIC ACID
著者Longenecker, K.L., Judge, R.A., Gayda, S., Manoj, S., Saldana, S., Ruan, Q., Swift, K., Tetin, S.
登録日2014-01-09
公開日2014-07-02
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Water channel in the binding site of a high affinity anti-methotrexate antibody.
Biochemistry, 53, 2014
4OCY
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FAB FOR METHOTREXATE (UNBOUND APO)
分子名称:Fab ADD058 Heavy Chain, Fab ADD058 Light Chain
著者Longenecker, K.L., Judge, R.A., Gayda, S., Manoj, S., Saldana, S., Ruan, Q., Swift, K., Tetin, S.
登録日2014-01-09
公開日2014-07-02
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Water channel in the binding site of a high affinity anti-methotrexate antibody.
Biochemistry, 53, 2014
5VLR
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CRYSTAL STRUCTURE OF PI3K DELTA IN COMPLEX WITH A TRIFLUORO-ETHYL-PYRAZOL-PYROLOTRIAZINE INHIBITOR
分子名称:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 4-acetyl-1-(3-{4-amino-5-[1-(2,2,2-trifluoroethyl)-1H-pyrazol-5-yl]pyrrolo[2,1-f][1,2,4]triazin-7-yl}phenyl)-3,3-dimethylpiperazin-2-one
著者Sack, J.S.
登録日2017-04-26
公開日2017-06-07
最終更新日2017-07-05
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Identification of a Potent, Selective, and Efficacious Phosphatidylinositol 3-Kinase delta (PI3K delta ) Inhibitor for the Treatment of Immunological Disorders.
J. Med. Chem., 60, 2017
4NWM
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CRYSTAL STRUCTURE OF BRUTON AGAMMAGLOBULINEMIA TYROSINE KINASE COMPLEXED WITH BMS-809959 AKA 4-TERT-BUTYL-N-[2-ME THYL-3-(6-{[4-(MORPHOLINE-4-CARBONYL)PHENYL]AMINO}-9H- PURIN-2-YL)PHENYL]BENZAMIDE
分子名称:Tyrosine-protein kinase BTK, 4-tert-butyl-N-[2-methyl-3-(6-{[4-(morpholin-4-ylcarbonyl)phenyl]amino}-7H-purin-2-yl)phenyl]benzamide
著者Muckelbauer, J.K.
登録日2013-12-06
公開日2014-04-02
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.03 Å)
主引用文献Purine derivatives as potent Bruton's tyrosine kinase (BTK) inhibitors for autoimmune diseases.
Bioorg.Med.Chem.Lett., 24, 2014
6O8I
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BTK IN COMPLEX WITH INHIBITOR
分子名称:Tyrosine-protein kinase BTK, 4-[(3S)-3-{[(2E)-but-2-enoyl]amino}piperidin-1-yl]-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide
著者Pokross, M., Tebben, A.J., Watterson, S.H.
登録日2019-03-11
公開日2019-04-03
最終更新日2019-04-24
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Discovery of Branebrutinib (BMS-986195): A Strategy for Identifying a Highly Potent and Selective Covalent Inhibitor Providing Rapid in Vivo Inactivation of Bruton's Tyrosine Kinase (BTK).
J. Med. Chem., 62, 2019
4C8B
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STRUCTURE OF THE KINASE DOMAIN OF HUMAN RIPK2 IN COMPLEX WITH PONATINIB
分子名称:RECEPTOR-INTERACTING SERINE/THREONINE-PROTEIN KINASE 2, 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, 1,2-ETHANEDIOL
著者Canning, P., Krojer, T., Bradley, A., Mahajan, P., Goubin, S., von Delft, F., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Bullock, A.
登録日2013-09-30
公開日2013-10-16
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors.
Chem. Biol., 22, 2015
4F41
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PROTELOMERASE TELA MUTANT R255A COMPLEXED WITH CTTG HAIRPIN DNA
分子名称:Protelomerase, DNA hairpin
著者Shi, K., Aihara, H.
登録日2012-05-09
公開日2012-06-13
最終更新日2012-08-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Linear Chromosome-generating System of Agrobacterium tumefaciens C58: PROTELOMERASE GENERATES AND PROTECTS HAIRPIN ENDS.
J.Biol.Chem., 287, 2012
4F43
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PROTELOMERASE TELA MUTANT R255A COMPLEXED WITH CAAG HAIRPIN DNA
分子名称:Protelomerase, DNA hairpin
著者Shi, K., Aihara, H.
登録日2012-05-10
公開日2012-06-13
最終更新日2012-08-29
実験手法X-RAY DIFFRACTION (2.354 Å)
主引用文献Linear Chromosome-generating System of Agrobacterium tumefaciens C58: PROTELOMERASE GENERATES AND PROTECTS HAIRPIN ENDS.
J.Biol.Chem., 287, 2012