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3P4A
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BU of 3p4a by Molmil
2'Fluoro modified RNA octamer fA2U2
Descriptor: 2'Fluoro modified RNA 8-MER, MAGNESIUM ION, STRONTIUM ION
Authors:Manoharan, M, Akinc, A, Pandey, R.K, Qin, J, Hadwiger, P, John, M, Mills, K, Charisse, K, Maier, M.A, Nechev, L, Greene, E.M, Pallan, P.S, Rozners, E, Rajeev, K.G, Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3P4C
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Alternatingly modified 2'Fluoro RNA octamer f/rA2U2-R32
Descriptor: 5'-R(*(CFZ)P*GP*(AF2)P*AP*(UFT)P*UP*(CFZ)P*G)-3', STRONTIUM ION
Authors:Pallan, P.S, Greene, E.M, Jicman, P.A, Pandey, R.K, Manoharan, M, Rozners, E, Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3P4B
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BU of 3p4b by Molmil
Alternatingly modified 2'Fluoro RNA octamer f/rA2U2-P3
Descriptor: 5'-R(*(CFZ)P*GP*(AF2)P*AP*(UFT)P*UP*(CFZ)P*G)-3', BARIUM ION
Authors:Pallan, P.S, Greene, E.M, Jicman, P.A, Pandey, R.K, Manoharan, M, Rozners, E, Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3P4D
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BU of 3p4d by Molmil
Alternatingly modified 2'Fluoro RNA octamer f/rC4G4
Descriptor: 5'-R(*(CFZ)P*CP*(CFZ)P*CP*(GF2)P*GP*(GF2)P*G)-3'
Authors:Pallan, P.S, Greene, E.M, Jicman, P.A, Pandey, R.K, Manoharan, M, Rozners, E, Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
8SV4
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BU of 8sv4 by Molmil
7-Deazapurines and 5-Halogenpyrimidine DNA duplex
Descriptor: 1,2-ETHANEDIOL, 2-[2-(2-ethoxyethoxy)ethoxy]ethanol, ACETATE ION, ...
Authors:Pallan, P.S, Egli, M.
Deposit date:2023-05-15
Release date:2023-10-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry.
Biochemistry, 62, 2023
8SV3
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BU of 8sv3 by Molmil
7-Deazapurines and 5-Halogenpyrimidine DNA duplex
Descriptor: GLYCEROL, MAGNESIUM ION, Modified DNA, ...
Authors:Pallan, P.S, Egli, M.
Deposit date:2023-05-15
Release date:2023-10-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry.
Biochemistry, 62, 2023
3HR3
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BU of 3hr3 by Molmil
Interplay of Structure, Hydration and Thermal Stability in Formacetal Modified Oligonucleotides: RNA May Tolerate Hydrophobic Modifications Better than DNA
Descriptor: 5'-D(*GP*CP*GP*(US4)P*(OMU))P*AP*CP*GP*C)-3'
Authors:Egli, M, Pallan, P.S.
Deposit date:2009-06-08
Release date:2009-10-27
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Interplay of structure, hydration and thermal stability in formacetal modified oligonucleotides: RNA may tolerate nonionic modifications better than DNA.
J.Am.Chem.Soc., 131, 2009
5VAJ
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BU of 5vaj by Molmil
BhRNase H - amide-RNA/DNA complex
Descriptor: ACETATE ION, DNA (5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3'), GLYCEROL, ...
Authors:Pallan, P.S, Egli, M.
Deposit date:2017-03-27
Release date:2017-09-13
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Amide linkages mimic phosphates in RNA interactions with proteins and are well tolerated in the guide strand of short interfering RNAs.
Nucleic Acids Res., 45, 2017
4O41
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Amide linked RNA
Descriptor: AMIDE LINKED RNA, STRONTIUM ION
Authors:Pallan, P.S, Egli, M.
Deposit date:2013-12-18
Release date:2014-07-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Amides are excellent mimics of phosphate internucleoside linkages and are well tolerated in short interfering RNAs.
Nucleic Acids Res., 42, 2014
2Q1O
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BU of 2q1o by Molmil
Crystal Structure Analysis of the RNA Dodecamer CGC-NF2-AAUUGGCG, with an Incorporated 2,4-Difluorotoluyl Residue (NF2)
Descriptor: RNA (5'-R(*CP*GP*CP*(NF2)P*AP*AP*UP*UP*GP*GP*CP*G)-3')
Authors:Li, F, Pallan, P.S.
Deposit date:2007-05-25
Release date:2007-10-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007
2Q1R
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BU of 2q1r by Molmil
Crystal Structure Analysis of the RNA Dodecamer CGCGAAUUAGCG, with a G-A mismatch.
Descriptor: MAGNESIUM ION, RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*AP*GP*CP*G)-3')
Authors:Li, F, Pallan, P.S.
Deposit date:2007-05-25
Release date:2007-10-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.12 Å)
Cite:Crystal structure, stability and in vitro RNAi activity of oligoribonucleotides containing the ribo-difluorotoluyl nucleotide: insights into substrate requirements by the human RISC Ago2 enzyme.
Nucleic Acids Res., 35, 2007

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PDB entries from 2024-03-27

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