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1CVU
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CRYSTAL STRUCTURE OF ARACHIDONIC ACID BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2
Descriptor:PROSTAGLANDIN H2 SYNTHASE-2, PROTEIN (9-MER), N-ACETYL-D-GLUCOSAMINE, ...
Authors:Kiefer, J.R., Pawlitz, J.L., Moreland, K.T., Stegeman, R.A., Gierse, J.K., Stevens, A.M., Goodwin, D.C., Rowlinson, S.W., Marnett, L.J., Stallings, W.C., Kurumbail, R.G.
Deposit date:1999-08-24
Release date:2000-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature, 405, 2000
4RRY
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CRYSTAL STRUCTURE OF APO MURINE H90W CYCLOOXYGENASE-2
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.429 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRW
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CRYSTAL STRUCTURE OF APO MURINE CYCLOOXYGENASE-2
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.569 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRZ
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CRYSTAL STRUCTURE OF APO MURINE H90W CYCLOOXYGENASE-2 COMPLEXED WITH LUMIRACOXIB
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, {2-[(2-chloro-6-fluorophenyl)amino]-5-methylphenyl}acetic acid
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.569 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RRX
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CRYSTAL STRUCTURE OF APO MURINE V89W CYCLOOXYGENASE-2 COMPLEXED WITH LUMIRACOXIB
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
4RS0
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CRYSTAL STRUCTURE OF MURINE H90W CYCLOOXYGENASE-2 COMPLEXED WITH S-IBUPROFEN
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Xu, S., Blobaum, A.L., Banerjee, S., Marnett, L.J.
Deposit date:2014-11-06
Release date:2015-04-08
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.807 Å)
Cite:Action at a Distance: MUTATIONS OF PERIPHERAL RESIDUES TRANSFORM RAPID REVERSIBLE INHIBITORS TO SLOW, TIGHT BINDERS OF CYCLOOXYGENASE-2.
J.Biol.Chem., 290, 2015
1PXX
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CRYSTAL STRUCTURE OF DICLOFENAC BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2
Descriptor:Prostaglandin G/H synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Kiefer, J.R., Rowlinson, S.W., Prusakiewicz, J.J., Pawlitz, J.L., Kozak, K.R., Kalgutkar, A.S., Stallings, W.C., Marnett, L.J., Kurumbail, R.G.
Deposit date:2003-07-07
Release date:2003-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A Novel Mechanism of Cyclooxygenase-2 Inhibition Involving Interactions with Ser-530 and Tyr-385.
J.Biol.Chem., 278, 2003
1DDX
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CRYSTAL STRUCTURE OF A MIXTURE OF ARACHIDONIC ACID AND PROSTAGLANDIN BOUND TO THE CYCLOOXYGENASE ACTIVE SITE OF COX-2: PROSTAGLANDIN STRUCTURE
Descriptor:PROTEIN (PROSTAGLANDIN H2 SYNTHASE-2), N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Kiefer, J.R., Pawlitz, J.L., Moreland, K.T., Stegeman, R.A., Gierse, J.K., Stevens, A.M., Goodwin, D.C., Rowlinson, S.W., Marnett, L.J., Stallings, W.C., Kurumbail, R.G.
Deposit date:1999-11-11
Release date:2000-05-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural insights into the stereochemistry of the cyclooxygenase reaction.
Nature, 405, 2000