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1EP3
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CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE B. DATA COLLECTED UNDER CRYOGENIC CONDITIONS.
分子名称:DIHYDROOROTATE DEHYDROGENASE B (PYRD SUBUNIT), DIHYDROOROTATE DEHYDROGENASE B (PYRK SUBUNIT), FLAVIN MONONUCLEOTIDE, ...
著者Rowland, P., Norager, S., Jensen, K.F., Larsen, S.
登録日2000-03-27
公開日2001-01-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster.
Structure Fold.Des., 8, 2000
1DOR
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DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS
分子名称:DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE
著者Rowland, P., Larsen, S.
登録日1997-01-14
公開日1997-04-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of the flavin containing enzyme dihydroorotate dehydrogenase A from Lactococcus lactis.
Structure, 5, 1997
1EP1
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CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE B
分子名称:DIHYDROOROTATE DEHYDROGENASE B (PYRD SUBUNIT), DIHYDROOROTATE DEHYDROGENASE B (PYRK SUBUNIT), FLAVIN MONONUCLEOTIDE, ...
著者Rowland, P., Norager, S., Jensen, K.F., Larsen, S.
登録日2000-03-27
公開日2001-01-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster.
Structure Fold.Des., 8, 2000
1EP2
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CRYSTAL STRUCTURE OF LACTOCOCCUS LACTIS DIHYDROOROTATE DEHYDROGENASE B COMPLEXED WITH OROTATE
分子名称:DIHYDROOROTATE DEHYDROGENASE B (PYRD SUBUNIT), DIHYDROOROTATE DEHYDROGENASE B (PYRK SUBUNIT), FLAVIN MONONUCLEOTIDE, ...
著者Rowland, P., Norager, S., Jensen, K.F., Larsen, S.
登録日2000-03-27
公開日2001-01-17
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure of dihydroorotate dehydrogenase B: electron transfer between two flavin groups bridged by an iron-sulphur cluster.
Structure Fold.Des., 8, 2000
2DOR
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DIHYDROOROTATE DEHYDROGENASE A FROM LACTOCOCCUS LACTIS COMPLEXED WITH OROTATE
分子名称:DIHYDROOROTATE DEHYDROGENASE A, FLAVIN MONONUCLEOTIDE, OROTIC ACID
著者Rowland, P., Larsen, S.
登録日1998-05-11
公開日1998-08-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function.
Protein Sci., 7, 1998
2F9Q
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CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 2D6
分子名称:Cytochrome P450 2D6, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
著者Rowland, P.
登録日2005-12-06
公開日2005-12-20
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.002 Å)
主引用文献Crystal Structure of Human Cytochrome P450 2D6
J.Biol.Chem., 281, 2006
1DPG
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GLUCOSE 6-PHOSPHATE DEHYDROGENASE FROM LEUCONOSTOC MESENTEROIDES
分子名称:GLUCOSE 6-PHOSPHATE DEHYDROGENASE, PHOSPHATE ION
著者Adams, M.J., Rowland, P., Gover, S.
登録日1995-12-04
公開日1996-03-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The three-dimensional structure of glucose 6-phosphate dehydrogenase from Leuconostoc mesenteroides refined at 2.0 A resolution.
Structure, 2, 1994
6QM7
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LEISHMANIA TARENTOLAE PROTEASOME 20S SUBUNIT COMPLEXED WITH GSK3494245
分子名称:Proteasome alpha1 chain, Proteasome alpha2 chain, Proteasome alpha3 chain, ...
著者Rowland, P., Goswami, P.
登録日2019-02-01
公開日2019-04-17
最終更新日2019-05-22
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc.Natl.Acad.Sci.USA, 116, 2019
6QM8
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LEISHMANIA TARENTOLAE PROTEASOME 20S SUBUNIT APO STRUCTURE
分子名称:Proteasome alpha1 chain, Proteasome alpha2 chain, Proteasome alpha3 chain, ...
著者Rowland, P., Goswami, P.
登録日2019-02-01
公開日2019-04-17
最終更新日2019-05-22
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.
Proc.Natl.Acad.Sci.USA, 116, 2019
5NA5
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PSEUDOMONAS FLUORESCENS KYNURENINE 3-MONOOXYGENASE (KMO) APO STRUCTURE
分子名称:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ...
著者Rowland, P.
登録日2017-02-27
公開日2017-06-21
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Nat Commun, 8, 2017
5NAB
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PSEUDOMONAS FLUORESCENS KYNURENINE 3-MONOOXYGENASE (KMO) IN COMPLEX WITH 3-(5-CHLORO-6-METHYL-2-OXO-2,3-DIHYDRO-1,3-BENZOXAZOL-3-YL)PROPANOIC ACID
分子名称:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ...
著者Rowland, P.
登録日2017-02-27
公開日2017-06-21
実験手法X-RAY DIFFRACTION (1.63 Å)
主引用文献Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Nat Commun, 8, 2017
5NAE
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PSEUDOMONAS FLUORESCENS KYNURENINE 3-MONOOXYGENASE (KMO) IN COMPLEX WITH 3-{5-CHLORO-2-OXO-6-[(1R)-1-(PYRIDIN-2-YL)ETHOXY]-2,3-DIHYDRO-1,3-BENZOXAZOL-3-YL}PROPANOIC ACID
分子名称:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, 3-[5-chloranyl-2-oxidanylidene-6-[(1~{R})-1-pyridin-2-ylethoxy]-1,3-benzoxazol-3-yl]propanoic acid
著者Rowland, P.
登録日2017-02-27
公開日2017-06-21
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Nat Commun, 8, 2017
5NAG
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PSEUDOMONAS FLUORESCENS KYNURENINE 3-MONOOXYGENASE (KMO) IN COMPLEX WITH 3-{5-CHLORO-6-[(1R)-1-(PYRIDIN-2-YL)ETHOXY]-1,2-BENZOXAZOL-3-YL}PROPANOIC ACID
分子名称:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, 3-[5-chloranyl-6-[(1~{R})-1-pyridin-2-ylethoxy]-1,2-benzoxazol-3-yl]propanoic acid
著者Rowland, P.
登録日2017-02-27
公開日2017-06-21
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Nat Commun, 8, 2017
5NAH
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PSEUDOMONAS FLUORESCENS KYNURENINE 3-MONOOXYGENASE (KMO) IN COMPLEX WITH 3-{5-CHLORO-6-[(1R)-1-(6-METHYLPYRIDAZIN-3-YL)ETHOXY]-1,2-BENZOXAZOL-3-YL}PROPANOIC ACID
分子名称:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, 3-[5-chloranyl-6-[(1~{R})-1-(6-methylpyridazin-3-yl)ethoxy]-1,2-benzoxazol-3-yl]propanoic acid
著者Rowland, P.
登録日2017-02-27
公開日2017-06-21
最終更新日2017-07-19
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase.
Nat Commun, 8, 2017
2O0U
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CRYSTAL STRUCTURE OF HUMAN JNK3 COMPLEXED WITH N-{3-CYANO-6-[3-(1-PIPERIDINYL)PROPANOYL]-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDIN-2-YL}-1-NAPHTHALENECARBOXAMIDE
分子名称:Mitogen-activated protein kinase 10, N-{3-CYANO-6-[3-(1-PIPERIDINYL)PROPANOYL]-4,5,6,7-TETRAHYDROTHIENO[2,3-C]PYRIDIN-2-YL}1-NAPHTHALENECARBOXAMIDE
著者Rowland, P., Somers, D.
登録日2006-11-28
公開日2007-02-27
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献N-(3-Cyano-4,5,6,7-tetrahydro-1-benzothien-2-yl)amides as potent, selective, inhibitors of JNK2 and JNK3.
Bioorg.Med.Chem.Lett., 17, 2007
4CQ8
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE (DHODH) IN COMPLEX WITH GENZ-669178
分子名称:DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ...
著者Rowland, P.
登録日2014-02-12
公開日2014-04-30
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth.
J.Biol.Chem., 289, 2014
4CQ9
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE (DHODH) IN COMPLEX WITH IDI-6253
分子名称:DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ...
著者Rowland, P.
登録日2014-02-12
公開日2014-04-30
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.72 Å)
主引用文献In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth.
J.Biol.Chem., 289, 2014
4CQA
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE (DHODH) IN COMPLEX WITH IDI-6273
分子名称:DIHYDROOROTATE DEHYDROGENASE, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ...
著者Rowland, P.
登録日2014-02-12
公開日2014-04-30
最終更新日2019-05-08
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献In Vitro Resistance Selections for Plasmodium Falciparum Dihydroorotate Dehydrogenase Inhibitors Give Mutants with Multiple Point Mutations in the Drug-Binding Site and Altered Growth.
J.Biol.Chem., 289, 2014
5L72
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PI3 KINASE DELTA IN COMPLEX WITH N-[6-(5-METHANESULFONAMIDO-6-METHOXYPYRIDIN-3-YL)-1,3-DIHYDRO-2-BENZOFURAN-4-YL]-2-(MORPHOLIN-4-YL)ACETAMIDE
分子名称:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform, N-[6-(5-methanesulfonamido-6-methoxypyridin-3-yl)-1,3-dihydro-2-benzofuran-4-yl]-2-(morpholin-4-yl)acetamide
著者Rowland, P.
登録日2016-06-01
公開日2016-07-27
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献Evolution of a Novel, Orally Bioavailable Series of PI3K delta Inhibitors from an Inhaled Lead for the Treatment of Respiratory Disease.
J.Med.Chem., 59, 2016
5MZC
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PSEUDOMONAS FLUORESCENS KYNURENINE 3-MONOOXYGENASE (KMO) IN COMPLEX WITH 3-(5-CHLORO-6-ETHOXY-2-OXO-2,3-DIHYDRO-1,3-BENZOXAZOL-3-YL)PROPANOIC ACID
分子名称:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ...
著者Rowland, P.
登録日2017-01-31
公開日2017-04-19
最終更新日2017-05-10
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
J. Med. Chem., 60, 2017
5MZI
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PSEUDOMONAS FLUORESCENS KYNURENINE 3-MONOOXYGENASE (KMO) IN COMPLEX WITH 3-(5-CHLORO-6-CYCLOPROPOXY-2-OXO-2,3-DIHYDRO-1,3-BENZOXAZOL-3-YL)PROPANOIC ACID
分子名称:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ...
著者Rowland, P.
登録日2017-01-31
公開日2017-04-19
最終更新日2017-05-10
実験手法X-RAY DIFFRACTION (1.71 Å)
主引用文献Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
J. Med. Chem., 60, 2017
5MZK
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PSEUDOMONAS FLUORESCENS KYNURENINE 3-MONOOXYGENASE (KMO) IN COMPLEX WITH 3-[5-CHLORO-6-(CYCLOBUTYLMETHOXY)-2-OXO-2,3-DIHYDRO-1,3-BENZOXAZOL-3-YL]PROPANOIC ACID
分子名称:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ...
著者Rowland, P.
登録日2017-01-31
公開日2017-04-19
最終更新日2017-05-10
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Development of a Series of Kynurenine 3-Monooxygenase Inhibitors Leading to a Clinical Candidate for the Treatment of Acute Pancreatitis.
J. Med. Chem., 60, 2017
5N7T
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PSEUDOMONAS FLUORESCENS KYNURENINE 3-MONOOXYGENASE (KMO) IN COMPLEX WITH 3-(5,6-DICHLORO-2-OXO-2,3-DIHYDRO-1,3-BENZOXAZOL-3-YL)PROPANOIC ACID
分子名称:Kynurenine 3-monooxygenase, FLAVIN-ADENINE DINUCLEOTIDE, CHLORIDE ION, ...
著者Rowland, P.
登録日2017-02-21
公開日2017-06-14
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献The discovery of potent and selective kynurenine 3-monooxygenase inhibitors for the treatment of acute pancreatitis.
Bioorg. Med. Chem. Lett., 27, 2017
6GJG
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PLASMODIUM FALCIPARUM DIHYDROOROTATE DEHYDROGENASE DHODH IN COMPLEX WITH 3,6-DIMETHYL-N-(4-(TRIFLUOROMETHYL)PHENYL)-(1,2)OXAZOLO(5,4-D)PYRIMIDIN-4-AMINE
分子名称:Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
著者Rowland, P.
登録日2018-05-16
公開日2018-09-19
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Isoxazolopyrimidine-Based Inhibitors ofPlasmodium falciparumDihydroorotate Dehydrogenase with Antimalarial Activity.
ACS Omega, 3, 2018
1LY9
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THE IMPACT OF THE PHYSICAL AND CHEMICAL ENVIRONMENT ON THE MOLECULAR STRUCTURE OF COPRINUS CINEREUS PEROXIDASE
分子名称:Peroxidase, CALCIUM ION, PROTOPORPHYRIN IX CONTAINING FE
著者Houborg, K., Harris, P., Petersen, J.F.W., Rowland, P., Poulsen, J.-C.N., Schneider, P., Vind, J., Larsen, S.
登録日2002-06-07
公開日2002-06-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Impact of the physical and chemical environment on the molecular structure of Coprinus cinereus peroxidase.
Acta Crystallogr.,Sect.D, 59, 2003