Author results

3Q4F
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CRYSTAL STRUCTURE OF XRCC4/XLF-CERNUNNOS COMPLEX
Descriptor:Non-homologous end-joining factor 1, DNA repair protein XRCC4
Authors:Ropars, V., Legrand, P., Charbonnier, J.B.
Deposit date:2010-12-23
Release date:2011-08-03
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (5.5 Å)
Cite:Structural characterization of filaments formed by human Xrcc4-Cernunnos/XLF complex involved in nonhomologous DNA end-joining.
Proc.Natl.Acad.Sci.USA, 108, 2011
5HMO
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MYOSIN X MOTOR ACTIVITY
Descriptor:Unconventional myosin-X
Authors:Ropars, V., Blanc, F., Samazan, F., Houdusse, A.
Deposit date:2016-01-16
Release date:2016-09-07
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (3.493 Å)
Cite:The myosin X motor is optimized for movement on actin bundles.
Nat Commun, 7, 2016
5HMP
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MYOSIN VC PRE-POWERSTROKE STATE
Descriptor:Unconventional myosin-Vc, MAGNESIUM ION, VANADATE ION, ...
Authors:Ropars, V., Pylypenko, O., Sweeney, H.L., Houdusse, A.
Deposit date:2016-01-16
Release date:2016-09-07
Last modified:2016-09-14
Method:X-RAY DIFFRACTION (2.397 Å)
Cite:The myosin X motor is optimized for movement on actin bundles.
Nat Commun, 7, 2016
4ZG4
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MYOSIN VC PRE-POWERSTROKE
Descriptor:myosin-Vc, MAGNESIUM ION, VANADATE ION, ...
Authors:Ropars, V., Pylypenko, O., Sweeney, L., Houdusse, A.
Deposit date:2015-04-22
Release date:2016-03-23
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Force-producing ADP state of myosin bound to actin.
Proc.Natl.Acad.Sci.USA, 113, 2016
6GY2
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CRYSTAL STRUCTURE OF HUMAN PLK1-PBD IN COMPLEX WITH WSSSLATPPTLSSPTVLI PHOSPHOPEPTIDE FROM BRCA2
Descriptor:Serine/threonine-protein kinase PLK1, Phosphopeptide of BRCA2, GLYCEROL
Authors:Miron, S., Ropars, V., Zinn-Justin, S.
Deposit date:2018-06-28
Release date:2019-07-10
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1
To Be Published
4ANJ
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MYOSIN VI (MDINSERT2-GFP FUSION) PRE-POWERSTROKE STATE (MG.ADP.ALF4)
Descriptor:UNCONVENTIONAL MYOSIN-VI, GREEN FLUORESCENT PROTEIN, CALMODULIN, ...
Authors:Menetrey, J., Isabet, T., Ropars, V., Mukherjea, M., Pylypenko, O., Liu, X., Perez, J., Vachette, P., Sweeney, H.L., Houdusse, A.M.
Deposit date:2012-03-19
Release date:2012-10-17
Last modified:2018-06-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin Vi.
Mol.Cell, 48, 2012
6ERF
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COMPLEX OF APLF FACTOR AND KU HETERODIMER BOUND TO DNA
Descriptor:X-ray repair cross-complementing protein 6, X-ray repair cross-complementing protein 5, DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*TP*TP*GP*GP*GP*CP*GP*CP*G)-3'), ...
Authors:Nemoz, C., Legrand, P., Ropars, V., Charbonnier, J.B.
Deposit date:2017-10-18
Release date:2018-10-17
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nat. Struct. Mol. Biol., 25, 2018
6ERG
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COMPLEX OF XLF AND HETERODIMER KU BOUND TO DNA
Descriptor:X-ray repair cross-complementing protein 6, X-ray repair cross-complementing protein 5, Non-homologous end-joining factor 1, ...
Authors:Nemoz, C., Legrand, P., Ropars, V., Charbonnier, J.B.
Deposit date:2017-10-18
Release date:2018-10-17
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nat. Struct. Mol. Biol., 25, 2018
6ERH
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COMPLEX OF XLF AND HETERODIMER KU BOUND TO DNA
Descriptor:X-ray repair cross-complementing protein 6, X-ray repair cross-complementing protein 5, DNA (34-MER), ...
Authors:Nemoz, C., Legrand, P., Ropars, V., Charbonnier, J.B.
Deposit date:2017-10-18
Release date:2018-10-17
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:XLF and APLF bind Ku80 at two remote sites to ensure DNA repair by non-homologous end joining.
Nat. Struct. Mol. Biol., 25, 2018
6GHD
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STRUCTURAL ANALYSIS OF THE TERNARY COMPLEX BETWEEN LAMIN A/C, BAF AND EMERIN IDENTIFIES AN INTERFACE DISRUPTED IN AUTOSOMAL RECESSIVE PROGEROID DISEASES
Descriptor:Emerin, Barrier-to-autointegration factor, Prelamin-A/C, ...
Authors:Samson, C., Petitalot, A., Celli, F., Herrada, I., Ropars, V., Ledu, M.H., Nhiri, N., Arteni, A.A., Buendia, B., ZinnJustin, S.
Deposit date:2018-05-07
Release date:2018-08-08
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural analysis of the ternary complex between lamin A/C, BAF and emerin identifies an interface disrupted in autosomal recessive progeroid diseases.
Nucleic Acids Res., 46, 2018
5I0H
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CRYSTAL STRUCTURE OF MYOSIN X MOTOR DOMAIN IN PRE-POWERSTROKE STATE
Descriptor:Unconventional myosin-X, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Isabet, T., Blanc, F., Sweeney, H.L., Houdusse, A.
Deposit date:2016-02-04
Release date:2016-09-07
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The myosin X motor is optimized for movement on actin bundles.
Nat Commun, 7, 2016
5I0I
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CRYSTAL STRUCTURE OF MYOSIN X MOTOR DOMAIN WITH 2IQ MOTIFS IN PRE-POWERSTROKE STATE
Descriptor:Unconventional myosin-X, Calmodulin, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ...
Authors:Isabet, T., Sweeney, H.L., Houdusse, A.
Deposit date:2016-02-04
Release date:2016-09-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:The myosin X motor is optimized for movement on actin bundles.
Nat Commun, 7, 2016
5KG8
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RIGOR MYOSIN X CO-COMPLEXED WITH AN ACTIN FILAMENT
Descriptor:Unconventional myosin-X, Actin, alpha skeletal muscle
Authors:Sindelar, C.V., Houdusse, A., Sweeney, L.
Deposit date:2016-06-12
Release date:2016-09-07
Last modified:2017-09-13
Method:ELECTRON MICROSCOPY (9.1 Å)
Cite:The myosin X motor is optimized for movement on actin bundles.
Nat Commun, 7, 2016
4E7S
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MYOSIN VI D23R I24R R569E (MD) PRE-POWERSTROKE STATE
Descriptor:Myosin-VI, ADENOSINE-5'-DIPHOSPHATE, VANADATE ION, ...
Authors:Isabet, T., Sweeney, H.L., Houdusse, A.
Deposit date:2012-03-19
Release date:2012-09-19
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI.
Mol.Cell, 48, 2012
4E7Z
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MYOSIN VI (MD) PRE-POWERSTROKE STATE, P21 CRYSTAL FORM
Descriptor:Myosin-VI, ADENOSINE-5'-DIPHOSPHATE, VANADATE ION, ...
Authors:Isabet, T., Sweeney, H.L., Houdusse, A.
Deposit date:2012-03-19
Release date:2012-09-19
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Processive Steps in the Reverse Direction Require Uncoupling of the Lead Head Lever Arm of Myosin VI.
Mol.Cell, 48, 2012
4PFO
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MYOSIN VI MOTOR DOMAIN IN THE PI RELEASE STATE, SPACE GROUP P212121
Descriptor:Unconventional myosin-VI, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Isabet, T., Benisty, H., Llinas, P., Sweeney, H.L., Houdusse, A.
Deposit date:2014-04-30
Release date:2015-04-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PFP
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MYOSIN VI MOTOR DOMAIN IN THE PI RELEASE STATE (WITH PI) SPACE GROUP P21
Descriptor:Unconventional myosin-VI, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Isabet, T., Benisty, H., Llinas, P., Sweeney, H.L., Houdusse, A.
Deposit date:2014-04-30
Release date:2015-04-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PJJ
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MYOSIN VI (MD-INSERT2-CAM, DELTA-INSERT1) POST-RIGOR STATE - LONG SOAKING WITH PO4
Descriptor:Unconventional myosin-VI, Calmodulin, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Isabet, T., Benisty, H., Llinas, P., Sweeney, H.L., Houdusse, A.
Deposit date:2014-05-12
Release date:2015-04-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PJK
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DICTY MYOSIN II R238E.E459R MUTANT (WITH ADP.PI) IN THE PI RELEASE STATE
Descriptor:Myosin-2 heavy chain, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Isabet, T., Benisty, H., Llinas, P., Sweeney, H.L., Houdusse, A.
Deposit date:2014-05-12
Release date:2015-04-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PJL
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MYOSIN VI MOTOR DOMAIN A458E MUTANT IN THE PI RELEASE STATE, SPACE GROUP P212121 -
Descriptor:Unconventional myosin-VI, MAGNESIUM ION, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:Isabet, T., Benisty, H., Llinas, P., Sweeney, H.L., Houdusse, A.
Deposit date:2014-05-12
Release date:2015-04-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PJM
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MYOSIN VI MOTOR DOMAIN IN THE PI RELEASE STATE, SPACE GROUP P212121 - SOAKED WITH PO4 - LOCATED IN THE ACTIVE SITE
Descriptor:Unconventional myosin-VI, PHOSPHATE ION, MAGNESIUM ION, ...
Authors:Isabet, T., Benisty, H., Llinas, P., Sweeney, H.L., Houdusse, A.
Deposit date:2014-05-12
Release date:2015-04-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PJN
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MYOSIN VI MOTOR DOMAIN IN THE PI RELEASE STATE, SPACE GROUP P212121 - SHORTLY SOAKED WITH PO4
Descriptor:Unconventional myosin-VI, GLYCEROL, PHOSPHATE ION, ...
Authors:Isabet, T., Benisty, H., Llinas, P., Sweeney, H.L., Houdusse, A.
Deposit date:2014-05-12
Release date:2015-04-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
4PK4
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MYOSIN VI MOTOR DOMAIN IN THE PPS STATE - FROM A PI RELEASE STATE CRYSTAL, SPACE GROUP P212121 AFTER LONG SOAKING WITH PO4
Descriptor:Unconventional myosin-VI, ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Isabet, T., Benisty, H., Llinas, P., Sweeney, H.L., Houdusse, A.
Deposit date:2014-05-13
Release date:2015-04-29
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:How actin initiates the motor activity of Myosin.
Dev.Cell, 33, 2015
5M05
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CHICKEN SMOOTH MUSCLE MYOSIN MOTOR DOMAIN CO-CRYSTALLIZED WITH THE SPECIFIC CK-571 INHIBITOR, MGADP FORM
Descriptor:Myosin-11, 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, MAGNESIUM ION, ...
Authors:Sirigu, S., Hartman, J., Houdusse, A.
Deposit date:2016-10-03
Release date:2016-11-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.675 Å)
Cite:Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016
5T45
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CHICKEN SMOOTH MUSCLE MYOSIN MOTOR DOMAIN CO-CRYSTALLIZED WITH THE SPECIFIC CK-571 INHIBITOR, MGADP.BEFX FORM
Descriptor:Myosin-11, 4-{[(2-chloro-3-fluorobenzyl)carbamoyl](methyl)amino}-3,4-dideoxy-5-O-(isoquinolin-3-ylcarbamoyl)-D-erythro-pentitol, MAGNESIUM ION, ...
Authors:Sirigu, S., Planelles-Herrero, V.J., Hartman, J., Houdusse, A.
Deposit date:2016-08-29
Release date:2016-11-16
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Highly selective inhibition of myosin motors provides the basis of potential therapeutic application.
Proc. Natl. Acad. Sci. U.S.A., 113, 2016