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6X0P
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BU of 6x0p by Molmil
Ash1L SET domain Q2265A mutant in complex with AS-5
Descriptor: 3-[6-(aminomethyl)-1-(2-hydroxyethyl)-1H-indol-3-yl]benzene-1-carbothioamide, Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ...
Authors:Rogawski, D.S, Li, H, Borkin, D, Cierpicki, T, Grembecka, J.
Deposit date:2020-05-17
Release date:2021-04-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.
Nat Commun, 12, 2021
4YPA
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BU of 4ypa by Molmil
ASH1L SET domain Q2265A mutant in complex with S-adenosyl methionine (SAM)
Descriptor: Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ZINC ION
Authors:Rogawski, D.S, Ndoj, J, Cho, H.J, Maillard, I, Grembecka, J, Cierpicki, T.
Deposit date:2015-03-12
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
Biochemistry, 54, 2015
4YNP
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BU of 4ynp by Molmil
ASH1L SET domain S2259M mutant in complex with S-adenosyl methionine (SAM)
Descriptor: Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ZINC ION
Authors:Rogawski, D.S, Ndoj, J, Cho, H.-J, Maillard, I, Grembecka, J, Cierpicki, T.
Deposit date:2015-03-10
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
Biochemistry, 54, 2015
4YPE
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BU of 4ype by Molmil
ASH1L SET domain H2193F mutant in complex with S-adenosyl methionine (SAM)
Descriptor: Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ZINC ION
Authors:Rogawski, D.S, Ndoj, J, Cho, H.J, Maillard, I, Grembecka, J, Cierpicki, T.
Deposit date:2015-03-12
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
Biochemistry, 54, 2015
4YNM
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BU of 4ynm by Molmil
ASH1L wild-type SET domain in complex with S-adenosyl methionine (SAM)
Descriptor: Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ZINC ION
Authors:Rogawski, D.S, Ndoj, J, Cho, H.-J, Maillard, I, Grembecka, J, Cierpicki, T.
Deposit date:2015-03-10
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
Biochemistry, 54, 2015
4YPU
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BU of 4ypu by Molmil
ASH1L SET domain K2264L mutant in complex with S-adenosyl methionine (SAM)
Descriptor: Histone-lysine N-methyltransferase ASH1L, S-ADENOSYLMETHIONINE, ZINC ION
Authors:Rogawski, D.S, Ndoj, J, Cho, H.J, Maillard, I, Grembecka, J, Cierpicki, T.
Deposit date:2015-03-13
Release date:2015-09-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Two Loops Undergoing Concerted Dynamics Regulate the Activity of the ASH1L Histone Methyltransferase.
Biochemistry, 54, 2015
5KCI
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BU of 5kci by Molmil
Crystal Structure of HTC1
Descriptor: GLYCEROL, SULFATE ION, Uncharacterized protein YPL067C, ...
Authors:Martin, R.M, Horowitz, S, Koepnick, B, Cooper, S, Flatten, J, Rogawski, D.S, Koropatkin, N.M, Beinlich, F.R.M, Players, F, Students, U.M, Popovic, Z, Baker, D, Khatib, F, Bardwell, J.C.A.
Deposit date:2016-06-06
Release date:2016-09-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.833 Å)
Cite:Determining crystal structures through crowdsourcing and coursework.
Nat Commun, 7, 2016
6WZW
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BU of 6wzw by Molmil
Ash1L SET domain in complex with AS-85
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Histone-lysine N-methyltransferase ASH1L, N-{[3-(3-carbamothioylphenyl)-1-{1-[(trifluoromethyl)sulfonyl]piperidin-4-yl}-1H-indol-6-yl]methyl}azetidine-3-carboxamide, ...
Authors:Li, H, Deng, J, Cierpicki, T, Grembecka, J.
Deposit date:2020-05-14
Release date:2021-04-07
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity.
Nat Commun, 12, 2021
6KQQ
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BU of 6kqq by Molmil
NSD1 SET domain in complex with BT3 and SAM
Descriptor: 2-azanyl-6-[(2-azanyl-4-oxidanyl-1,3-benzothiazol-6-yl)disulfanyl]-1,3-benzothiazol-4-ol, 2-azanyl-6-sulfanyl-1,3-benzothiazol-4-ol, CALCIUM ION, ...
Authors:Cho, H.J, Cierpicki, T.
Deposit date:2019-08-18
Release date:2020-09-02
Last modified:2022-03-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Covalent inhibition of NSD1 histone methyltransferase.
Nat.Chem.Biol., 16, 2020
6KQP
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BU of 6kqp by Molmil
NSD1 SET domain in complex with SAM
Descriptor: Histone-lysine N-methyltransferase, H3 lysine-36 and H4 lysine-20 specific, S-ADENOSYLMETHIONINE, ...
Authors:Cho, H.J, Cierpicki, T.
Deposit date:2019-08-18
Release date:2020-09-02
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Covalent inhibition of NSD1 histone methyltransferase.
Nat.Chem.Biol., 16, 2020

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PDB entries from 2024-03-27

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