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Crystal structure of human caspase-1 with a naturally-occurring Arg240->Gln substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Rosen-Wolff, A, Roesler, J, Romanowski, M.J.
Deposit date:	2008-05-19
Release date:	2010-03-02
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published

Crystal structure of human caspase-1 with a naturally-occurring Lys319->Arg substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Rosen-Wolff, A, Roesler, J, Romanowski, M.J.
Deposit date:	2008-05-19
Release date:	2010-03-02
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008

Crystal structure of human caspase-1 with a naturally-occurring Asn263->Ser substitution in complex with 3-[2-(2-benzyloxycarbonylamino-3-methyl-butyrylamino)-propionylamino]-4-oxo-pentanoic acid (z-VAD-FMK)
Descriptor:	Caspase-1, Caspase-1 precursor, N-[(benzyloxy)carbonyl]-L-valyl-N-[(2S)-1-carboxy-4-fluoro-3-oxobutan-2-yl]-L-alaninamide
Authors:	Rosen-Wolff, A, Roesler, J, Romanowski, M.J.
Deposit date:	2008-05-19
Release date:	2010-03-02
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Mutated, structurally altered caspase-1 with decreased enzymatic and increased RIP2-meditated inflammatory activity leads to a new type of periodic fever (ICE fever). To be Published, 2008