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1YSL
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BU of 1ysl by Molmil
Crystal structure of HMG-CoA synthase from Enterococcus faecalis with AcetoAcetyl-CoA ligand.
Descriptor: ACETOACETIC ACID, COENZYME A, GLYCEROL, ...
Authors:Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V.
Deposit date:2005-02-08
Release date:2005-11-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA.
Biochemistry, 44, 2005
1T02
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BU of 1t02 by Molmil
Crystal structure of a Statin bound to class II HMG-CoA reductase
Descriptor: (3R,5R)-7-((1R,2R,6S,8R,8AS)-2,6-DIMETHYL-8-{[(2R)-2-METHYLBUTANOYL]OXY}-1,2,6,7,8,8A-HEXAHYDRONAPHTHALEN-1-YL)-3,5-DIHYDROXYHEPTANOIC ACID, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION
Authors:Tabernero, L, Rodwell, V.W, Stauffacher, C.
Deposit date:2004-04-07
Release date:2004-08-03
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of a statin bound to a class II hydroxymethylglutaryl-CoA reductase.
J.Biol.Chem., 278, 2003
1X9E
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BU of 1x9e by Molmil
Crystal structure of HMG-CoA synthase from Enterococcus faecalis
Descriptor: HMG-CoA synthase, SULFATE ION
Authors:Steussy, C.N, Vartia, A.A, Burgner II, J.W, Sutherlin, A, Rodwell, V.W, Stauffacher, C.V.
Deposit date:2004-08-20
Release date:2005-11-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-ray Crystal Structures of HMG-CoA Synthase from Enterococcus faecalis and a Complex with Its Second Substrate/Inhibitor Acetoacetyl-CoA
Biochemistry, 44, 2005
4I4B
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BU of 4i4b by Molmil
HMG-CoA Reductase from Pseudomonas mevalonii complexed with NAD and intermediate hemiacetal form of HMG-CoA
Descriptor: (3R,5R,9R,19R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-sulfanyl-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, (3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, ...
Authors:Stauffacher, C.V, Steussy, C.N, Critchelow, C.J, Schmidt, T, Min, J, Wrensford, L.V, Burgner, J.W, Rodwell, V.W.
Deposit date:2012-11-27
Release date:2013-07-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I56
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BU of 4i56 by Molmil
HMG-CoA reductase from pseudomonas mevalonii complexed with dithio-HMG-coa
Descriptor: (3S,5S,9R,21S)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9,21-tetrahydroxy-8,8,21-trimethyl-10,14-dioxo-19-thioxo-2,4,6-trioxa-18-thia-11,15-diaza-3,5-diphosphatricosan-23-oic acid 3,5-dioxide, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ...
Authors:Steussy, C.N, Stauffacher, C.V, Schmidt, T, Crichelow, C.J, Rodwell, V.W, Wrensford, L.V, Min, J, Burgner II, J.W.
Deposit date:2012-11-28
Release date:2013-07-17
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I64
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BU of 4i64 by Molmil
3-hydroxy-3-methylglutaryl Coenzyme A reductase from Pseudomonas mevalonii, a high resolution native structure
Descriptor: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION
Authors:Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J.
Deposit date:2012-11-29
Release date:2013-07-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I6A
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BU of 4i6a by Molmil
3-hydroxy-3-methylglutaryl (HMG) Coenzyme A reductase from Pseudomonas mevalonii complexed with HMG-CoA
Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, SULFATE ION
Authors:Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J.
Deposit date:2012-11-29
Release date:2013-07-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I6W
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BU of 4i6w by Molmil
3-hydroxy-3-methylglutaryl (HMG) Coenzyme-A reductase complexed with thiomevalonate
Descriptor: (3S)-3-hydroxy-3-methyl-5-sulfanylpentanoic acid, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ...
Authors:Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J.
Deposit date:2012-11-30
Release date:2013-07-17
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
4I6Y
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BU of 4i6y by Molmil
3-hydroxy-3-methyl (HMG) Coenzyme A Reductase bound to R-Mevalonate
Descriptor: (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, ...
Authors:Steussy, C.N, Stauffacher, C.V, Schmidt, T, Burgner II, J.W, Rodwell, V.W, Wrensford, L.V, Critchelow, C.J, Min, J.
Deposit date:2012-11-30
Release date:2013-07-17
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:A Novel Role for Coenzyme A during Hydride Transfer in 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase.
Biochemistry, 52, 2013
1R31
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BU of 1r31 by Molmil
HMG-CoA reductase from Pseudomonas mevalonii complexed with HMG-CoA
Descriptor: (R)-MEVALONATE, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, COENZYME A, ...
Authors:Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V.
Deposit date:2003-09-30
Release date:2003-10-14
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-CoA Reductase.
To be Published
1QAY
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BU of 1qay by Molmil
TERNARY COMPLEX OF PSEUDOMONAS MEVALONII HMG-COA REDUCTASE WITH MEVALONATE AND NAD+
Descriptor: (R)-MEVALONATE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE)
Authors:Tabernero, L, Bochar, D.A, Rodwell, V.W, Stauffacher, C.V.
Deposit date:1999-04-07
Release date:1999-06-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl-CoA reductase.
Proc.Natl.Acad.Sci.USA, 96, 1999
1QAX
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BU of 1qax by Molmil
TERNARY COMPLEX OF PSEUDOMONAS MEVALONII HMG-COA REDUCTASE WITH HMG-COA AND NAD+
Descriptor: 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (3-HYDROXY-3-METHYLGLUTARYL-COENZYME A REDUCTASE)
Authors:Tabernero, L, Bochar, D.A, Rodwell, V.W, Stauffacher, C.V.
Deposit date:1999-04-06
Release date:1999-06-18
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Substrate-induced closure of the flap domain in the ternary complex structures provides insights into the mechanism of catalysis by 3-hydroxy-3-methylglutaryl-CoA reductase.
Proc.Natl.Acad.Sci.USA, 96, 1999
1R7I
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BU of 1r7i by Molmil
HMG-CoA Reductase from P. mevalonii, native structure at 2.2 angstroms resolution.
Descriptor: 3-hydroxy-3-methylglutaryl-coenzyme A reductase, GLYCEROL, SULFATE ION
Authors:Watson, J.M, Steussy, C.N, Burgner, J.W, Lawrence, C.M, Tabernero, L, Rodwell, V.W, Stauffacher, C.V.
Deposit date:2003-10-21
Release date:2003-11-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Structural Investigations of the Basis for Stereoselectivity from the Binary Complex of HMG-COA Reductase.
To be Published
2HDB
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BU of 2hdb by Molmil
HMG-CoA synthase from Enterococcus faecalis. Mutation alanine 110 to glycine
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HMG-CoA synthase, SULFATE ION
Authors:Steussy, C.N, Sutherlin, A, Stauffacher, C.V.
Deposit date:2006-06-20
Release date:2007-03-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A structural limitation on enzyme activity: the case of HMG-CoA synthase.
Biochemistry, 45, 2006
7M1Z
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BU of 7m1z by Molmil
Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor
Descriptor: (R)-MEVALONATE, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ACETATE ION, ...
Authors:Bose, S, Steussy, C.N, Stauffacher, C.V.
Deposit date:2021-03-15
Release date:2022-09-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor
Nat Commun, 2023
7M66
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BU of 7m66 by Molmil
Targeting Enterococcus faecalis HMG-CoA reductase with a novel non-statin inhibitor
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
Authors:Bose, S, Steussy, C.N.
Deposit date:2021-03-25
Release date:2022-09-28
Last modified:2023-04-12
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Targeting Enterococcus faecalis HMG-CoA reductase with a non-statin inhibitor.
Commun Biol, 6, 2023

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