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4RIL
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BU of 4ril by Molmil
Structure of the amyloid forming segment, GAVVTGVTAVA, from the NAC domain of Parkinson's disease protein alpha-synuclein, residues 68-78, determined by electron diffraction
Descriptor: Alpha-synuclein
Authors:Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S.
Deposit date:2014-10-06
Release date:2015-08-26
Last modified:2023-09-20
Method:ELECTRON CRYSTALLOGRAPHY (1.43 Å)
Cite:Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
4ZNN
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BU of 4znn by Molmil
MicroED structure of the segment, GVVHGVTTVA, from the A53T familial mutant of Parkinson's disease protein, alpha-synuclein residues 47-56
Descriptor: Alpha-synuclein
Authors:Rodriguez, J.A, Ivanova, M, Sawaya, M.R, Cascio, D, Reyes, F, Shi, D, Johnson, L, Guenther, E, Sangwan, S, Hattne, J, Nannenga, B, Brewster, A.S, Messerschmidt, M, Boutet, S, Sauter, N.K, Gonen, T, Eisenberg, D.S.
Deposit date:2015-05-05
Release date:2015-09-09
Last modified:2024-03-06
Method:ELECTRON CRYSTALLOGRAPHY (1.41 Å)
Cite:Structure of the toxic core of alpha-synuclein from invisible crystals.
Nature, 525, 2015
6WX1
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BU of 6wx1 by Molmil
Antigen Binding Fragment of OKT9
Descriptor: GLYCEROL, OKT9 Fab Heavy Chain, OKT9 Fab Light Chain
Authors:Rodriguez, J.A, Helguera, G, Sawaya, M, Cascio, D, Collazo, M, Flores, M, Zink, S, Ferrero, S, Payes, C, Fuentes, D, Short, C.
Deposit date:2020-05-09
Release date:2021-05-26
Last modified:2021-08-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Antibody-Based Inhibition of Pathogenic New World Hemorrhagic Fever Mammarenaviruses by Steric Occlusion of the Human Transferrin Receptor 1 Apical Domain.
J.Virol., 95, 2021
5VOS
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BU of 5vos by Molmil
VGSNKGAIIGL from Amyloid Beta determined by MicroED
Descriptor: Amyloid beta A4 protein
Authors:Rodriguez, J.A, Sawaya, M.R, Cascio, D, Eisenberg, D.S, Griner, S.L, Gonen, T.
Deposit date:2017-05-03
Release date:2018-01-03
Last modified:2024-03-13
Method:ELECTRON CRYSTALLOGRAPHY (1.42 Å)
Cite:Common fibrillar spines of amyloid-beta and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors.
J. Biol. Chem., 293, 2018
8T1N
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BU of 8t1n by Molmil
Micro-ED Structure of a Novel Domain of Unknown Function Solved with AlphaFold
Descriptor: DUF1842 domain-containing protein
Authors:Miller, J.E, Cascio, D, Sawaya, M.R, Cannon, K.A, Rodriguez, J.A, Yeates, T.O.
Deposit date:2023-06-02
Release date:2024-01-17
Last modified:2024-03-20
Method:ELECTRON CRYSTALLOGRAPHY (3 Å)
Cite:AlphaFold-assisted structure determination of a bacterial protein of unknown function using X-ray and electron crystallography.
Acta Crystallogr D Struct Biol, 2024
6AXZ
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BU of 6axz by Molmil
Segment from bank vole prion protein 168-176 QYNNQNNFV
Descriptor: Major prion protein
Authors:Glynn, C, Rodriguez, J.A, Boyer, D.R, Gallagher-Jones, M.
Deposit date:2017-09-07
Release date:2018-01-17
Last modified:2024-03-13
Method:ELECTRON CRYSTALLOGRAPHY (0.75 Å)
Cite:Sub-angstrom cryo-EM structure of a prion protofibril reveals a polar clasp.
Nat. Struct. Mol. Biol., 25, 2018
6BWZ
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BU of 6bwz by Molmil
SYSGYS from low-complexity domain of FUS, residues 37-42
Descriptor: SYSGYS peptide from low-complexity domain of FUS
Authors:Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Tamir, G, Eisenberg, D.S.
Deposit date:2017-12-15
Release date:2018-04-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
6BTK
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BU of 6btk by Molmil
Segment from bank vole prion protein 168-176 QYNNQNNFV
Descriptor: Major prion protein
Authors:Glynn, C, Rodriguez, J.A, Boyer, D.R, Gallagher-Jones, M.
Deposit date:2017-12-06
Release date:2018-01-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Sub-angstrom cryo-EM structure of a prion protofibril reveals a polar clasp.
Nat. Struct. Mol. Biol., 25, 2018
6BZP
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BU of 6bzp by Molmil
STGGYG from low-complexity domain of FUS, residues 77-82
Descriptor: 2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXYL, RNA-binding protein FUS
Authors:Hughes, M.P, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Gonen, T, Eisenberg, D.S.
Deposit date:2017-12-25
Release date:2018-04-04
Last modified:2024-03-13
Method:ELECTRON CRYSTALLOGRAPHY (1.1 Å)
Cite:Atomic structures of low-complexity protein segments reveal kinked beta sheets that assemble networks.
Science, 359, 2018
1OZU
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BU of 1ozu by Molmil
Crystal Structure of Familial ALS Mutant S134N of human Cu,Zn Superoxide Dismutase (CuZnSOD) to 1.3A resolution
Descriptor: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Elam, J.S, Taylor, A.B, Strange, R, Antonyuk, S, Doucette, P.A, Rodriguez, J.A, Hasnain, S.S, Hayward, L.J, Valentine, J.S, Yeates, T.O, Hart, P.J.
Deposit date:2003-04-09
Release date:2003-05-27
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Amyloid-like Filaments and Water-filled Nanotubes Formed by SOD1 Mutant Proteins Linked to Familial ALS
Nat.Struct.Biol., 10, 2003
1OZT
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BU of 1ozt by Molmil
Crystal Structure of apo-H46R Familial ALS Mutant human Cu,Zn Superoxide Dismutase (CuZnSOD) to 2.5A resolution
Descriptor: Superoxide dismutase [Cu-Zn]
Authors:Elam, J.S, Taylor, A.B, Strange, R, Antonyuk, S, Doucette, P.A, Rodriguez, J.A, Hasnain, S.S, Hayward, L.J, Valentine, J.S, Yeates, T.O, Hart, P.J.
Deposit date:2003-04-09
Release date:2003-05-27
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Amyloid-like Filaments and Water-filled Nanotubes Formed by SOD1 Mutant Proteins Linked to Familial ALS
Nat.Struct.Biol., 10, 2003
1P1V
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BU of 1p1v by Molmil
Crystal Structure of FALS-associated human Copper-Zinc Superoxide Dismutase (CuZnSOD) Mutant D125H to 1.4A
Descriptor: SULFATE ION, Superoxide dismutase [Cu-Zn], ZINC ION
Authors:Elam, J.S, Malek, K, Rodriguez, J.A, Doucette, P.A, Taylor, A.B, Hayward, L.J, Cabelli, D.E, Valentine, J.S, Hart, P.J.
Deposit date:2003-04-14
Release date:2003-08-26
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:An Alternative Mechanism of Bicarbonate-mediated Peroxidation by Copper-Zinc Superoxide Dismutase: RATES ENHANCED VIA PROPOSED ENZYME-ASSOCIATED PEROXYCARBONATE INTERMEDIATE
J.Biol.Chem., 278, 2003
1HLK
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BU of 1hlk by Molmil
METALLO-BETA-LACTAMASE FROM BACTEROIDES FRAGILIS IN COMPLEX WITH A TRICYCLIC INHIBITOR
Descriptor: 7,8-DIHYDROXY-1-METHOXY-3-METHYL-10-OXO-4,10-DIHYDRO-1H,3H-PYRANO[4,3-B]CHROMENE-9-CARBOXYLIC ACID, BETA-LACTAMASE, TYPE II, ...
Authors:Payne, D.J, Hueso-Rodriguez, J.A, Boyd, H, Concha, N.O, Janson, C.A, Gilpin, M, Bateson, J.H, Chever, C, Niconovich, N.L, Pearson, S, Rittenhouse, S, Tew, D, Diez, E, Perez, P, de la Fuente, J, Rees, M, Rivera-Sagredo, A.
Deposit date:2000-12-01
Release date:2001-11-30
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Identification of a series of tricyclic natural products as potent broad spectrum inhibitors of metallo-beta-lactamases
Antimicrob.Agents Chemother., 46, 2002
8G2V
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BU of 8g2v by Molmil
Cryo-EM structure of recombinant human LECT2 amyloid fibril core
Descriptor: Leukocyte cell-derived chemotaxin-2
Authors:Richards, L.S, Flores, M.D, Zink, S, Schibrowsky, N.A, Sawaya, M.R, Rodriguez, J.A.
Deposit date:2023-02-06
Release date:2023-08-16
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.715 Å)
Cite:Cryo-EM structure of a human LECT2 amyloid fibril reveals a network of polar ladders at its core.
Structure, 31, 2023
1UXL
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BU of 1uxl by Molmil
I113T mutant of human SOD1
Descriptor: COPPER (II) ION, SULFATE ION, SUPEROXIDE DISMUTASE [CU-ZN], ...
Authors:Hough, M.A, Grossmann, J.G, Antonyuk, S.V, Strange, R.W, Doucette, P.A, Rodriguez, J.A, Whitson, L.J, Hart, P.J, Hayward, L.J, Valentine, J.S, Hasnain, S.S.
Deposit date:2004-02-25
Release date:2004-03-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Dimer Destabilization in Superoxide Dismutase May Result in Disease-Causing Properties: Structures of Motor Neuron Disease Mutants
Proc.Natl.Acad.Sci.USA, 101, 2004
1UXM
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BU of 1uxm by Molmil
A4V mutant of human SOD1
Descriptor: COPPER (II) ION, SUPEROXIDE DISMUTASE [CU-ZN], ZINC ION
Authors:Hough, M.A, Grossmann, J.G, Antonyuk, S.V, Strange, R.W, Doucette, P.A, Rodriguez, J.A, Whitson, L.J, Hart, P.J, Hayward, L.J, Valentine, J.S, Hasnain, S.S.
Deposit date:2004-02-26
Release date:2004-03-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Dimer Destabilization in Superoxide Dismutase May Result in Disease-Causing Properties: Structures of Motor Neuron Disease Mutants
Proc.Natl.Acad.Sci.USA, 101, 2004
6O4J
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BU of 6o4j by Molmil
Amyloid Beta KLVFFAENVGS 16-26 D23N Iowa mutation
Descriptor: Amyloid-beta precursor protein
Authors:Griner, S.L, Sawaya, M.R, Rodriguez, J.A, Cascio, D, Gonen, T.
Deposit date:2019-02-28
Release date:2019-10-30
Last modified:2023-10-11
Method:ELECTRON CRYSTALLOGRAPHY (1.402 Å)
Cite:Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau.
Elife, 8, 2019
5G37
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BU of 5g37 by Molmil
MR structure of the binary mosquito larvicide BinAB at pH 5
Descriptor: 41.9 KDA INSECTICIDAL TOXIN, LARVICIDAL TOXIN 51 KDA PROTEIN
Authors:Colletier, J.P, Sawaya, M.R, Gingery, M, Rodriguez, J.A, Cascio, D, Brewster, A.S, Michels-Clark, T, Boutet, S, Williams, G.J, Messerschmidt, M, DePonte, D.P, Sierra, R.G, Laksmono, H, Koglin, J.E, Hunter, M.S, W Park, H, Uervirojnangkoorn, M, Bideshi, D.L, Brunger, A.T, Federici, B.A, Sauter, N.K, Eisenberg, D.S.
Deposit date:2016-04-24
Release date:2016-10-05
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:De Novo Phasing with X-Ray Laser Reveals Mosquito Larvicide Binab Structure.
Nature, 539, 2016
6M9I
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BU of 6m9i by Molmil
L-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712
Descriptor: Ice nucleation protein
Authors:Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A.
Deposit date:2018-08-23
Release date:2019-03-27
Last modified:2024-03-13
Method:ELECTRON CRYSTALLOGRAPHY (0.9 Å)
Cite:Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.
IUCrJ, 6, 2019
6M7M
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BU of 6m7m by Molmil
rac-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712
Descriptor: L-GSTSTA from ice nucleation protein, inaZ, and its enantiomer, ...
Authors:Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A.
Deposit date:2018-08-20
Release date:2019-04-03
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.101 Å)
Cite:Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.
IUCrJ, 6, 2019
6M9J
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BU of 6m9j by Molmil
Racemic-GSTSTA from degenerate octameric repeats in InaZ, residues 707-712
Descriptor: Ice nucleation protein
Authors:Zee, C, Glynn, C, Gallagher-Jones, M, Miao, J, Santiago, C.G, Cascio, D, Gonen, T, Sawaya, M.R, Rodriguez, J.A.
Deposit date:2018-08-23
Release date:2019-03-27
Last modified:2024-03-13
Method:ELECTRON CRYSTALLOGRAPHY (0.9 Å)
Cite:Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ.
IUCrJ, 6, 2019
6MXF
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BU of 6mxf by Molmil
MicroED structure of thiostrepton at 1.9 A resolution
Descriptor: Thiostrepton
Authors:Jones, C.G, Martynowycz, M.W, Hattne, J, Fulton, T, Stoltz, B.M, Rodriguez, J.A, Nelson, H.M, Gonen, T.
Deposit date:2018-10-30
Release date:2018-11-21
Last modified:2023-11-15
Method:ELECTRON CRYSTALLOGRAPHY (1.91 Å)
Cite:The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination.
ACS Cent Sci, 4, 2018
5V5B
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BU of 5v5b by Molmil
KVQIINKKLD, Structure of the amyloid spine from microtubule associated protein tau Repeat 2
Descriptor: Microtubule-associated protein tau
Authors:Seidler, P.M, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S, Cascio, D, Boyer, D.R.
Deposit date:2017-03-13
Release date:2018-02-07
Last modified:2024-03-13
Method:ELECTRON CRYSTALLOGRAPHY (1.5 Å)
Cite:Structure-based inhibitors of tau aggregation.
Nat Chem, 10, 2018
5V5C
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BU of 5v5c by Molmil
VQIINK, Structure of the amyloid-spine from microtubule associated protein tau Repeat 2
Descriptor: Microtubule-associated protein tau
Authors:Seidler, P.M, Sawaya, M.R, Rodriguez, J.A, Eisenberg, D.S, Cascio, D, Boyer, D.R.
Deposit date:2017-03-14
Release date:2018-02-07
Last modified:2024-03-13
Method:ELECTRON CRYSTALLOGRAPHY (1.25 Å)
Cite:Structure-based inhibitors of tau aggregation.
Nat Chem, 10, 2018
5KO0
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BU of 5ko0 by Molmil
Human Islet Amyloid Polypeptide Segment 15-FLVHSSNNFGA-25 Determined by MicroED
Descriptor: THIOCYANATE ION, hIAPP(15-25)WT
Authors:Krotee, P.A.L, Rodriguez, J.A, Sawaya, M.R, Cascio, D, Shi, D, Nannenga, B.L, Hattne, J, Reyes, F.E, Gonen, T, Eisenberg, D.S.
Deposit date:2016-06-28
Release date:2016-12-21
Last modified:2024-03-06
Method:ELECTRON CRYSTALLOGRAPHY (1.4 Å)
Cite:Atomic structures of fibrillar segments of hIAPP suggest tightly mated beta-sheets are important for cytotoxicity.
Elife, 6, 2017

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