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3P45
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CRYSTAL STRUCTURE OF APO-CASPASE-6 AT PHYSIOLOGICAL PH
Descriptor:caspase-6
Authors:Mueller, I., Lamers, M.B.A.C., Ritchie, A.J., Dominguez, C., Munoz, I., Maillard, M., Kiselyov, A.
Deposit date:2010-10-06
Release date:2011-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Crystal structures of active and inhibitor-bound human Casp6
To be Published
3P4U
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CRYSTAL STRUCTURE OF ACTIVE CASPASE-6 IN COMPLEX WITH AC-VEID-CHO INHIBITOR
Descriptor:Caspase-6, Ac-VEID-CHO inhibitor
Authors:Mueller, I., Lamers, M.B.A.C., Ritchie, A.J., Dominguez, C., Munoz, I., Maillard, M., Kiselyov, A.
Deposit date:2010-10-07
Release date:2011-09-28
Last modified:2015-12-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of active and inhibitor-bound human Casp6
To be Published
3QNW
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CASPASE-6 IN COMPLEX WITH Z-VAD-FMK INHIBITOR
Descriptor:Caspase-6, Z-VAD-FMK
Authors:Mueller, I., Lamers, M., Ritchie, A., Park, H., Dominguez, C., Munoz, I., Maillard, M., Kiselyov, A.
Deposit date:2011-02-09
Release date:2011-09-21
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structure of human caspase-6 in complex with Z-VAD-FMK: New peptide binding mode observed for the non-canonical caspase conformation.
Bioorg.Med.Chem.Lett., 21, 2011
4J0R
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A 3,5-DIMETHYLISOXAZOL LIGAND
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(R)-hydroxy(phenyl)methyl]phenol, ...
Authors:Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., Hewings, D.S., von Delft, F., Conway, S.J., Bountra, C., Arrowsmith, C.H., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-01-31
Release date:2013-02-13
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands.
J.Med.Chem., 56, 2013
4J0S
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CRYSTAL STRUCTURE OF THE FIRST BROMODOMAIN OF HUMAN BRD4 IN COMPLEX WITH A 3,5-DIMETHYLISOXAZOL LIGAND
Descriptor:Bromodomain-containing protein 4, 1,2-ETHANEDIOL, 3-(3,5-dimethyl-1,2-oxazol-4-yl)-5-[(S)-hydroxy(phenyl)methyl]phenol
Authors:Filippakopoulos, P., Picaud, S., Qi, J., Felletar, I., Hewings, D.S., von Delft, F., Conway, S.J., Bountra, C., Arrowsmith, C.H., Edwards, A., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2013-01-31
Release date:2013-02-13
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands.
J.Med.Chem., 56, 2013
1HXB
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HIV-1 PROTEINASE COMPLEXED WITH RO 31-8959
Descriptor:HIV-1 PROTEASE, (2S)-N-[(2S,3R)-4-[(2S,3S,4aS,8aS)-3-(tert-butylcarbamoyl)-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinolin-2-yl]-3-hydroxy-1-phenyl-butan-2-yl]-2-(quinolin-2-ylcarbonylamino)butanediamide
Authors:Graves, B.J., Hatada, M.H., Crowther, R.L.
Deposit date:1996-09-13
Release date:1997-03-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Novel binding mode of highly potent HIV-proteinase inhibitors incorporating the (R)-hydroxyethylamine isostere.
J.Med.Chem., 34, 1991
3ZTN
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STRUCTURE OF INFLUENZA A NEUTRALIZING ANTIBODY SELECTED FROM CULTURES OF SINGLE HUMAN PLASMA CELLS IN COMPLEX WITH HUMAN H1 INFLUENZA HAEMAGGLUTININ.
Descriptor:HAEMAGGLUTININ, FI6V3 ANTIBODY LIGHT CHAIN, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hubbard, P.A., Ritchie, A.J., Corti, D., Voss, J.E., Gamblin, S.J., Codoni, G., Macagno, A., Jarrossay, D., Pinna, D., Minola, A., Vanzetta, F., Silacci, C., Fernandez-Rodriguez, B.M., Agatic, G., Giacchetto-Sasselli, I., Vachieri, S.G., Sallusto, F., Collins, P.J., Haire, L.F., Temperton, N., Langedijk, J.P.M., Skehel, J.J., Lanzavecchia, A.
Deposit date:2011-07-12
Release date:2011-08-10
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (3.001 Å)
Cite:A Neutralizing Antibody Selected from Plasma Cells that Binds to Group 1 and Group 2 Influenza a Hemagglutinins.
Science, 333, 2011