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4C6Y
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ANCESTRAL PNCA (LAST COMMON ANCESTORS OF GRAM-POSITIVE AND GRAM- NEGATIVE BACTERIA) BETA-LACTAMASE CLASS A
Descriptor:BETA-LACTAMASE, TETRAETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Gavira, J.A., Risso, V.A., Sanchez-Ruiz, J.M.
Deposit date:2013-09-19
Release date:2014-04-16
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.799 Å)
Cite:Phenotypic Comparisons of Consensus Variants Versus Laboratory Resurrections of Precambrian Proteins.
Proteins, 82, 2014
4C75
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CONSENSUS (ALL-CON) BETA-LACTAMASE CLASS A
Descriptor:BETA-LACTAMASE, SULFATE ION, ACETATE ION, ...
Authors:Gavira, J.A., Risso, V.A., Sanchez-Ruiz, J.M.
Deposit date:2013-09-19
Release date:2014-04-16
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Phenotypic Comparisons of Consensus Variants Versus Laboratory Resurrections of Precambrian Proteins.
Proteins, 82, 2014
3SOI
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CRYSTALLOGRAPHIC STRUCTURE OF BACILLUS LICHENIFORMIS BETA-LACTAMASE W210F/W229F/W251F AT 1.73 ANGSTROM RESOLUTION
Descriptor:Beta-lactamase, CITRIC ACID
Authors:Acierno, J.P., Capaldi, S., Risso, V.A., Monaco, H.L., Ermacora, M.R.
Deposit date:2011-06-30
Release date:2011-12-14
Last modified:2012-09-12
Method:X-RAY DIFFRACTION (1.729 Å)
Cite:X-ray evidence of a native state with increased compactness populated by tryptophan-less B. licheniformis beta-lactamase.
Protein Sci., 21, 2012
3ZDJ
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ANCESTRAL (ENCA) BETA-LACTAMASE CLASS A
Descriptor:ENCA BETA-LACTAMASE, SULFATE ION
Authors:Gavira, J.A., Risso, V.A., Sanchez-Ruiz, J.M.
Deposit date:2012-11-27
Release date:2013-02-20
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian Beta-Lactamases.
J.Am.Chem.Soc., 135, 2013
4B88
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ANCESTRAL (GNCA) BETA-LACTAMASE CLASS A
Descriptor:BETA-LACTAMASE, FORMIC ACID
Authors:Gavira, J.A., Risso, V.A., Sanchez-Ruiz, J.M.
Deposit date:2012-08-24
Release date:2013-02-20
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian Beta-Lactamases.
J.Am.Chem.Soc., 135, 2013
4UHU
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W229D MUTANT OF THE LAST COMMON ANCESTOR OF GRAM-NEGATIVE BACTERIA (GNCA) BETA-LACTAMASE CLASS A
Descriptor:GNCA LACTAMASE W229D, FORMIC ACID, ACETATE ION
Authors:Gavira, J.A., Risso, V.A., Martinez-Rodriguez, S., Sanchez-Ruiz, J.M.
Deposit date:2015-03-25
Release date:2016-04-13
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.305 Å)
Cite:De novo active sites for resurrected Precambrian enzymes.
Nat Commun, 8, 2017
4ULX
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CRYSTAL STRUCTURE OF ANCESTRAL THIOREDOXIN, RELATIVE TO THE LAST COMMON ANCESTOR OF THE CYANOBACTERIAL, DEINOCOCCUS AND THERMUS GROUPS, LPBCA-L89K MUTANT.
Descriptor:LPBCA-L89K THIOREDOXIN, CHLORIDE ION
Authors:Gavira, J.A., Risso, V.A., Ibarra-Molero, B., Sanchez-Ruiz, J.M.
Deposit date:2014-05-14
Release date:2014-11-26
Last modified:2015-02-04
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Mutational Studies on Resurrected Ancestral Proteins Reveal Conservation of Site-Specific Amino Acid Preferences Throughout Evolutionary History.
Mol.Biol.Evol., 32, 2015
5FQI
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W229D AND F290W MUTANT OF THE LAST COMMON ANCESTOR OF GRAM-NEGATIVE BACTERIA (GNCA4) BETA-LACTAMASE CLASS A
Descriptor:GNCA4 LACTAMASE W229D AND F290W, GLYCEROL, 1,2-ETHANEDIOL, ...
Authors:Gavira, J.A., Risso, V.A., Martinez-Rodriguez, S., Sanchez-Ruiz, J.M.
Deposit date:2015-12-11
Release date:2016-12-21
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:De novo active sites for resurrected Precambrian enzymes.
Nat Commun, 8, 2017
5FQJ
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W229D MUTANT OF THE LAST COMMON ANCESTOR OF GRAM-NEGATIVE BACTERIA (GNCA) BETA-LACTAMASE BOUND TO 5(6)-NITROBENZOTRIAZOLE (TS-ANALOG)
Descriptor:GNCA LACTAMASE W229D, 6-NITROBENZOTRIAZOLE
Authors:Gavira, J.A., Martinez-Rodriguez, S., Risso, V.A., Sanchez-Ruiz, J.M.
Deposit date:2015-12-11
Release date:2016-12-21
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.271 Å)
Cite:De novo active sites for resurrected Precambrian enzymes.
Nat Commun, 8, 2017
5FQK
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W229D AND F290W MUTANT OF THE LAST COMMON ANCESTOR OF GRAM-NEGATIVE BACTERIA (GNCA4) BETA-LACTAMASE CLASS A BOUND TO 5(6)-NITROBENZOTRIAZOLE (TS-ANALOG)
Descriptor:GNCA4 LACTAMASE W229D AND F290W, 6-NITROBENZOTRIAZOLE
Authors:Gavira, J.A., Risso, V.A., Martinez-Rodriguez, S., Sanchez-Ruiz, J.M.
Deposit date:2015-12-11
Release date:2016-12-21
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.767 Å)
Cite:De novo active sites for resurrected Precambrian enzymes.
Nat Commun, 8, 2017
5FQM
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LAST COMMON ANCESTOR OF GRAM NEGATIVE BACTERIA (GNCA) CLASS A BETA- LACTAMASE
Descriptor:GNCA BETA LACTAMASE, SULFATE ION, GLYCEROL
Authors:Martinez Rodriguez, S., Gavira, J.A., Risso, V.A., Sanchez Ruiz, J.M.
Deposit date:2015-12-12
Release date:2017-01-18
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:De novo active sites for resurrected Precambrian enzymes.
Nat Commun, 8, 2017
5FQQ
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LAST COMMON ANCESTOR OF GRAM-NEGATIVE BACTERIA (GNCA4) BETA-LACTAMASE CLASS A
Descriptor:GNCA4 LACTAMASE, 2-(2-METHOXYETHOXY)ETHANOL, DI(HYDROXYETHYL)ETHER
Authors:Gavira, J.A., Martinez-Rodriguez, S., Risso, V.A., Sanchez-Ruiz, J.M.
Deposit date:2015-12-14
Release date:2016-12-28
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:De novo active sites for resurrected Precambrian enzymes.
Nat Commun, 8, 2017