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6TPR
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PQSR (MVFR) BOUND TO INHIBITORY COMPOUND 40
Descriptor:Transcriptional regulator MvfR, 2-[(5-methyl-[1,2,4]triazino[5,6-b]indol-3-yl)sulfanyl]-~{N}-(4-pyridin-2-yloxyphenyl)ethanamide
Authors:Richardson, W.K., Emsley, J.
Deposit date:2019-12-14
Release date:2020-05-13
Last modified:2020-05-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Hit Identification of New Potent PqsR Antagonists as Inhibitors of Quorum Sensing in Planktonic and Biofilm GrownPseudomonas aeruginosa.
Front Chem, 8, 2020
6YZ3
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PQSR (MVFR) IN COMPLEX WITH ANTAGONIST 19
Descriptor:LysR family transcriptional regulator, 1,2-ETHANEDIOL, 6-chloranyl-3-[(2-hexyl-2,3-dihydro-1,3-thiazol-4-yl)methyl]quinazolin-4-one
Authors:Richardson, W.K., Emsley, J.
Deposit date:2020-05-06
Release date:2020-09-16
Last modified:2020-09-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR.
Eur.J.Med.Chem., 208, 2020
6Z07
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PQSR (MVFR) IN COMPLEX WITH ANTAGONIST 12
Descriptor:Transcriptional regulator MvfR, 3-[(2-~{tert}-butyl-1,3-thiazol-4-yl)methyl]-6-chloranyl-quinazolin-4-one, GLYCEROL
Authors:Richardson, W.K., Emsley, J.
Deposit date:2020-05-07
Release date:2020-09-16
Last modified:2020-09-23
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR.
Eur.J.Med.Chem., 208, 2020
6Z17
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PQSR (MVFR) IN COMPLEX WITH ANTAGONIST 6
Descriptor:Transcriptional regulator MvfR, 6-chloranyl-3-[(2-propan-2-yl-2,3-dihydro-1,3-thiazol-4-yl)methyl]quinazolin-4-one
Authors:Richardson, W.K., Emsley, J.
Deposit date:2020-05-12
Release date:2020-09-16
Last modified:2020-09-23
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR.
Eur.J.Med.Chem., 208, 2020
6Z5K
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PQSR (MVFR) IN COMPLEX WITH ANTAGONIST 18
Descriptor:Transcriptional regulator MvfR, 6-chloranyl-3-[(2-pentyl-2,3-dihydro-1,3-thiazol-4-yl)methyl]quinazolin-4-one
Authors:Richardson, W.K., Emsley, J.
Deposit date:2020-05-26
Release date:2020-09-16
Last modified:2020-09-23
Method:X-RAY DIFFRACTION (3.201 Å)
Cite:Novel quinazolinone inhibitors of the Pseudomonas aeruginosa quorum sensing transcriptional regulator PqsR.
Eur.J.Med.Chem., 208, 2020
169117
PDB entries from 2020-09-23