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4PGZ
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BU of 4pgz by Molmil
Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, Mast/stem cell growth factor receptor Kit
Authors:Reshetnyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J.
Deposit date:2014-05-03
Release date:2015-03-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Mol.Cell, 57, 2015
7MZY
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BU of 7mzy by Molmil
Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 673-986
Descriptor: ACETATE ION, ALK tyrosine kinase receptor
Authors:Reshetnyak, A.V, Sowaileh, M, Miller, D.J, Rossi, P, Myasnikov, A.G, Kalodimos, C.G.
Deposit date:2021-05-24
Release date:2021-11-24
Last modified:2021-12-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Nature, 600, 2021
7N00
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BU of 7n00 by Molmil
Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with AUG-alpha
Descriptor: ALK and LTK ligand 2, ALK tyrosine kinase receptor
Authors:Reshetnyak, A.V, Myasnikov, A.G, Rossi, P, Miller, D.J, Kalodimos, C.G.
Deposit date:2021-05-24
Release date:2021-11-24
Last modified:2021-12-15
Method:ELECTRON MICROSCOPY (2.27 Å)
Cite:Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Nature, 600, 2021
7MZX
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BU of 7mzx by Molmil
AUGalpha - FAM150B - ALKL2 77-152
Descriptor: ALK and LTK ligand 2
Authors:Rossi, P, Sowaileh, M, Reshetnyak, A.V, Kalodimos, C.G.
Deposit date:2021-05-24
Release date:2021-11-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Nature, 600, 2021
7MZW
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BU of 7mzw by Molmil
Anaplastic lymphoma kinase (ALK) extracellular ligand binding region 673-1025
Descriptor: ALK tyrosine kinase receptor
Authors:Rossi, P, Sowaileh, M, Reshetnyak, A.V, Kalodimos, C.G.
Deposit date:2021-05-24
Release date:2021-12-08
Last modified:2021-12-15
Method:SOLUTION NMR
Cite:Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Nature, 600, 2021
7MZZ
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BU of 7mzz by Molmil
AUGbeta - FAM150A - ALKL1 60-128
Descriptor: ALK and LTK ligand 1
Authors:Rossi, P, Sowaileh, M, Reshetnyak, A.V, Kalodimos, C.G.
Deposit date:2021-05-24
Release date:2021-11-24
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Nature, 600, 2021
4K94
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BU of 4k94 by Molmil
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab19 heavy chain, Fab19 light chain, ...
Authors:Resheynyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J.
Deposit date:2013-04-19
Release date:2013-10-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc.Natl.Acad.Sci.USA, 110, 2013
4K9E
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BU of 4k9e by Molmil
Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Mast/stem cell growth factor receptor Kit, heavy chain, ...
Authors:Resheynyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J.
Deposit date:2013-04-19
Release date:2013-10-16
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc.Natl.Acad.Sci.USA, 110, 2013
7MK7
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BU of 7mk7 by Molmil
Augmentor domain of augmentor-beta
Descriptor: ALK and LTK ligand 1,Maltodextrin-binding protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose
Authors:Krimmer, S.G, Reshetnyak, A.V, Puleo, D.E, Schlessinger, J.
Deposit date:2021-04-21
Release date:2021-11-24
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.42815185 Å)
Cite:Structural basis for ligand reception by anaplastic lymphoma kinase.
Nature, 600, 2021

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