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2VQZ
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BU of 2vqz by Molmil
Structure of the cap-binding domain of influenza virus polymerase subunit PB2 with bound m7GTP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, POLYMERASE BASIC PROTEIN 2
Authors:Guilligay, D, Tarendeau, F, Resa-Infante, P, Coloma, R, Crepin, T, Sehr, P, Lewis, J, Ruigrok, R.W.H, Ortin, J, Hart, D.J, Cusack, S.
Deposit date:2008-03-21
Release date:2008-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Structural Basis for CAP Binding by Influenza Virus Polymerase Subunit Pb2.
Nat.Struct.Mol.Biol., 15, 2008
5M3J
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BU of 5m3j by Molmil
Influenza B polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD
Descriptor: DNA-directed RNA polymerase subunit, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Lukarska, M, Pflug, A, Cusack, S.
Deposit date:2016-10-14
Release date:2016-12-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
Nature, 541, 2017
5M3H
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BU of 5m3h by Molmil
Bat influenza A/H17N10 polymerase bound to four heptad repeats of serine 5 phosphorylated Pol II CTD
Descriptor: PHOSPHATE ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Lukarska, M, Pflug, A, Cusack, S.
Deposit date:2016-10-14
Release date:2016-12-21
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of an essential interaction between influenza polymerase and Pol II CTD.
Nature, 541, 2017
6EVJ
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BU of 6evj by Molmil
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and capped RNA primer
Descriptor: Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-D(*(GDM))-R(P*AP*AP*U)-3'), ...
Authors:Pflug, A, Cusack, S.
Deposit date:2017-11-01
Release date:2017-12-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUX
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BU of 6eux by Molmil
Structure of the midlink and cap-binding domains of influenza B polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Descriptor: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2
Authors:Cusack, S, Gaudon, S.
Deposit date:2017-10-31
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUV
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BU of 6euv by Molmil
Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindole cap-binding inhibitor (VX-787)
Descriptor: (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, NICKEL (II) ION, Polymerase basic protein 2
Authors:Cusack, S, Lethier, M.
Deposit date:2017-10-31
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUY
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BU of 6euy by Molmil
Structure of the midlink and cap-binding domains of influenza A polymerase PB2 subunit with a bound azaindazole cap-binding inhibitor
Descriptor: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2, SULFATE ION
Authors:Cusack, S, Gaudon, S.
Deposit date:2017-10-31
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EUW
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BU of 6euw by Molmil
Crystal structure of the cap-binding domain of the PB2 subunit of influenza A/H5N1 polymerase bound to an azaindazole inhibitor
Descriptor: (2~{S},3~{S})-3-[[5-fluoranyl-2-(5-fluoranyl-1~{H}-pyrazolo[3,4-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, GLYCEROL, Polymerase basic protein 2
Authors:Cusack, S, Gaudon, S.
Deposit date:2017-10-31
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018
6EVK
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BU of 6evk by Molmil
Crystal structure of bat influenza A/H17N10 polymerase with viral RNA promoter and cap analogue m7GTP
Descriptor: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE, PHOSPHATE ION, Polymerase acidic protein, ...
Authors:Pflug, A, Cusack, S.
Deposit date:2017-11-01
Release date:2017-12-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Capped RNA primer binding to influenza polymerase and implications for the mechanism of cap-binding inhibitors.
Nucleic Acids Res., 46, 2018

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