Author results

1AHA
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THE N-GLYCOSIDASE MECHANISM OF RIBOSOME-INACTIVATING PROTEINS IMPLIED BY CRYSTAL STRUCTURES OF ALPHA-MOMORCHARIN
Descriptor:ALPHA-MOMORCHARIN, ADENINE
Authors:Ren, J., Wang, Y., Dong, Y., Stuart, D.I.
Deposit date:1994-01-07
Release date:1994-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The N-glycosidase mechanism of ribosome-inactivating proteins implied by crystal structures of alpha-momorcharin.
Structure, 2, 1994
1AHB
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THE N-GLYCOSIDASE MECHANISM OF RIBOSOME-INACTIVATING PROTEINS IMPLIED BY CRYSTAL STRUCTURES OF ALPHA-MOMORCHARIN
Descriptor:ALPHA-MOMORCHARIN, FORMYCIN-5'-MONOPHOSPHATE
Authors:Ren, J., Wang, Y., Dong, Y., Stuart, D.I.
Deposit date:1994-01-07
Release date:1994-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The N-glycosidase mechanism of ribosome-inactivating proteins implied by crystal structures of alpha-momorcharin.
Structure, 2, 1994
1AHC
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THE N-GLYCOSIDASE MECHANISM OF RIBOSOME-INACTIVATING PROTEINS IMPLIED BY CRYSTAL STRUCTURES OF ALPHA-MOMORCHARIN
Descriptor:ALPHA-MOMORCHARIN
Authors:Ren, J., Wang, Y., Dong, Y., Stuart, D.I.
Deposit date:1994-01-07
Release date:1994-06-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The N-glycosidase mechanism of ribosome-inactivating proteins implied by crystal structures of alpha-momorcharin.
Structure, 2, 1994
1HML
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ALPHA_LACTALBUMIN POSSESSES A DISTINCT ZINC BINDING SITE
Descriptor:ALPHA-LACTALBUMIN, CALCIUM ION, ZINC ION, ...
Authors:Ren, J., Stuart, D.I., Acharya, K.R.
Deposit date:1994-09-29
Release date:1995-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Alpha-lactalbumin possesses a distinct zinc binding site.
J.Biol.Chem., 268, 1993
1VRT
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HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, MAGNESIUM ION, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Esnouf, R., Garman, E., Somers, D., Ross, C., Kirby, I., Keeling, J., Darby, G., Jones, Y., Stuart, D., Stammers, D.
Deposit date:1995-04-19
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:High resolution structures of HIV-1 RT from four RT-inhibitor complexes.
Nat.Struct.Biol., 2, 1995
1VRU
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HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, ALPHA-(2,6-DICHLOROPHENYL)-ALPHA-(2-ACETYL-5-METHYLANILINO)ACETAMIDE
Authors:Ren, J., Esnouf, R., Garman, E., Somers, D., Ross, C., Kirby, I., Keeling, J., Darby, G., Jones, Y., Stuart, D., Stammers, D.
Deposit date:1995-04-19
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:High resolution structures of HIV-1 RT from four RT-inhibitor complexes.
Nat.Struct.Biol., 2, 1995
1RTH
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HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, 6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE
Authors:Ren, J., Esnouf, R., Garman, E., Somers, D., Ross, C., Kirby, I., Keeling, J., Darby, G., Jones, Y., Stuart, D., Stammers, D.
Deposit date:1995-05-03
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:High resolution structures of HIV-1 RT from four RT-inhibitor complexes.
Nat.Struct.Biol., 2, 1995
1RTI
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HIGH RESOLUTION STRUCTURES OF HIV-1 RT FROM FOUR RT-INHIBITOR COMPLEXES
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, 1-(2-HYDROXYETHYLOXYMETHYL)-6-PHENYL THIOTHYMINE
Authors:Ren, J., Esnouf, R., Garman, E., Somers, D., Ross, C., Kirby, I., Keeling, J., Darby, G., Jones, Y., Stuart, D., Stammers, D.
Deposit date:1995-05-03
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:High resolution structures of HIV-1 RT from four RT-inhibitor complexes.
Nat.Struct.Biol., 2, 1995
1RTJ
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MECHANISM OF INHIBITION OF HIV-1 REVERSE TRANSCRIPTASE BY NON-NUCLEOSIDE INHIBITORS
Descriptor:HIV-1 REVERSE TRANSCRIPTASE
Authors:Ren, J., Esnouf, R., Ross, C., Jones, Y., Stammers, D., Stuart, D.
Deposit date:1995-05-03
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors.
Nat.Struct.Biol., 2, 1995
1REV
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HIV-1 REVERSE TRANSCRIPTASE
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, MAGNESIUM ION, 4-CHLORO-8-METHYL-7-(3-METHYL-BUT-2-ENYL)-6,7,8,9-TETRAHYDRO-2H-2,7,9A-TRIAZA-BENZO[CD]AZULENE-1-THIONE
Authors:Ren, J., Esnouf, R., Hopkins, A., Ross, C., Jones, Y., Stammers, D., Stuart, D.
Deposit date:1995-09-17
Release date:1996-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure of HIV-1 reverse transcriptase complexed with 9-chloro-TIBO: lessons for inhibitor design.
Structure, 3, 1995
1RT1
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH MKC-442
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, 6-BENZYL-1-ETHOXYMETHYL-5-ISOPROPYL URACIL
Authors:Ren, J., Esnouf, R., Hopkins, A., Willcox, B., Jones, Y., Ross, C., Stammers, D., Stuart, D.
Deposit date:1996-03-16
Release date:1997-04-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.
J.Med.Chem., 39, 1996
1RT2
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH TNK-651
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL
Authors:Ren, J., Esnouf, R., Hopkins, A., Willcox, B., Jones, Y., Ross, C., Stammers, D., Stuart, D.
Deposit date:1996-03-16
Release date:1997-04-21
Last modified:2018-04-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors.
J.Med.Chem., 39, 1996
1KLM
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HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH BHAP U-90152
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, (1-(5-METHANSULPHONAMIDO-1H-INDOL-2-YL-CARBONYL)4-[METHYLAMINO)PYRIDINYL]PIPERAZINE
Authors:Ren, J., Esnouf, R.M., Stammers, D.K., Stuart, D.I.
Deposit date:1997-03-17
Release date:1998-03-18
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine (BHAP) U-90152 explain resistance mutations for this nonnucleoside inhibitor.
Proc.Natl.Acad.Sci.USA, 94, 1997
1A4V
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ALPHA-LACTALBUMIN
Descriptor:ALPHA-LACTALBUMIN, CALCIUM ION
Authors:Chandra, N., Acharya, K.R.
Deposit date:1998-02-05
Release date:1999-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural evidence for the presence of a secondary calcium binding site in human alpha-lactalbumin.
Biochemistry, 37, 1998
1RT3
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AZT DRUG RESISTANT HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH 1051U91
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, 6,11-DIHYDRO-11-ETHYL-6-METHYL-9-NITRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE
Authors:Ren, J., Stammers, D.K., Stuart, D.I.
Deposit date:1998-06-29
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes.
Proc.Natl.Acad.Sci.USA, 95, 1998
1RT4
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HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC781
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE
Authors:Ren, J., Stammers, D.K., Stuart, D.I.
Deposit date:1998-07-29
Release date:1999-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives.
Biochemistry, 37, 1998
1RT5
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HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC10
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, N-[4-CLORO-3-(T-BUTYLOXOME)PHENYL-2-METHYL-3-FURAN-CARBOTHIAMIDE
Authors:Ren, J., Stammers, D.K., Stuart, D.I.
Deposit date:1998-07-29
Release date:1999-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives.
Biochemistry, 37, 1998
1RT6
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HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC38
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 1-METHYL ETHYL 2-CHLORO-5-[[[(1-METHYLETHOXY)THIOOXO]METHYL]AMINO]-BENZOATE
Authors:Ren, J., Stammers, D.K., Stuart, D.I.
Deposit date:1998-07-29
Release date:1999-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives.
Biochemistry, 37, 1998
1RT7
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HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH UC84
Descriptor:HIV-1 REVERSE TRANSCRIPTASE, PHOSPHATE ION, 1-METHYL ETHYL 1-CHLORO-5-[[(5,6DIHYDRO-2-METHYL-1,4-OXATHIIN-3-YL)CARBONYL]AMINO]BENZOATE
Authors:Ren, J., Stammers, D.K., Stuart, D.I.
Deposit date:1998-07-29
Release date:1999-07-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of HIV-1 reverse transcriptase in complex with carboxanilide derivatives.
Biochemistry, 37, 1998
1C0T
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+21.1326
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), (R)-(+)9B-(3-METHYL)PHENYL-2,3-DIHYDROTHIAZOLO[2,3-A]ISOINDOL-5(9BH)-ONE
Authors:Ren, J., Esnouf, R.M., Hopkins, A.L., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-19
Release date:2000-07-19
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.
J.Med.Chem., 42, 1999
1C0U
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH BM+50.0934
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), (R)-(+) 5(9BH)-OXO-9B-PHENYL-2,3-DIHYDROTHIAZOLO[2,3-A]ISOINDOL-3-CARBOXYLIC ACID METHYL ESTER
Authors:Ren, J., Esnouf, R.M., Hopkins, A.L., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-19
Release date:2000-07-19
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystallographic analysis of the binding modes of thiazoloisoindolinone non-nucleoside inhibitors to HIV-1 reverse transcriptase and comparison with modeling studies.
J.Med.Chem., 42, 1999
1C1B
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH GCA-186
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), 6-(3',5'-DIMETHYLBENZYL)-1-ETHOXYMETHYL-5-ISOPROPYLURACIL
Authors:Hopkins, A.L., Ren, J., Tanaka, H., Baba, B., Okamato, M., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-21
Release date:2000-07-21
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
J.Med.Chem., 42, 1999
1C1C
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-6123
Descriptor:HIV-1 REVERSE TRANSCRIPTASE (A-CHAIN), HIV-1 REVERSE TRANSCRIPTASE (B-CHAIN), 6-(cyclohexylsulfanyl)-1-(ethoxymethyl)-5-(1-methylethyl)pyrimidine-2,4(1H,3H)-dione
Authors:Hopkins, A.L., Ren, J., Tanaka, H., Baba, M., Okamato, M., Stuart, D.I., Stammers, D.K.
Deposit date:1999-07-21
Release date:2000-07-21
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design of MKC-442 (emivirine) analogues with improved activity against drug-resistant HIV mutants.
J.Med.Chem., 42, 1999
1DRT
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CRYSTAL STRUCTURE OF CLAVAMINATE SYNTHASE IN COMPLEX WITH FE(II), 2-OXOGLUTARATE AND PROCLAVAMINIC ACID
Descriptor:CLAVAMINATE SYNTHASE 1, 5-AMINO-3-HYDROXY-2-(2-OXO-AZETIDIN-1-YL)-PENTANOIC ACID, FE (II) ION, ...
Authors:Zhang, Z.H., Ren, J., Stammers, D.K., Baldwin, J.E., Harlos, K., Schofield, C.J.
Deposit date:2000-01-06
Release date:2000-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.
Nat.Struct.Biol., 7, 2000
1DRY
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CRYSTAL STRUCTURE OF CLAVAMINATE SYNTHASE IN COMPLEX WITH FE(II), 2-OXOGLUTARATE AND N-ALPHA-L-ACETYL ARGININE
Descriptor:CLAVAMINATE SYNTHASE 1, N-ALPHA-L-ACETYL-ARGININE, FE (II) ION, ...
Authors:Zhang, Z.H., Ren, J., Stammers, D.K., Baldwin, J.E., Harlos, K., Schofield, C.J.
Deposit date:2000-01-06
Release date:2000-07-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structural origins of the selectivity of the trifunctional oxygenase clavaminic acid synthase.
Nat.Struct.Biol., 7, 2000